LOCUS       NM_001291871            4470 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 17 (Adam17),
            transcript variant 4, mRNA.
ACCESSION   NM_001291871 XM_006514950
VERSION     NM_001291871.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4470)
  AUTHORS   Defamie,V., Aliar,K., Sarkar,S., Vyas,F., Shetty,R., Reddy
            Narala,S., Fang,H., Saw,S., Tharmapalan,P., Sanchez,O., Knox,J.J.,
            Waterhouse,P.D. and Khokha,R.
  TITLE     Metalloproteinase inhibitors regulate biliary progenitor cells
            through sDLK1 in organoid models of liver injury
  JOURNAL   J Clin Invest 135 (3), e164997 (2024)
   PUBMED   39699962
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4470)
  AUTHORS   Srinivas,A.N., Suresh,D., Vishwanath,P.M., Satish,S.,
            Santhekadur,P.K., Koka,S. and Kumar,D.P.
  TITLE     TACE inhibition: a promising therapeutic intervention against
            AATF-mediated steatohepatitis to hepatocarcinogenesis
  JOURNAL   Mol Oncol 18 (8), 1940-1957 (2024)
   PUBMED   38558505
  REMARK    GeneRIF: TACE inhibition: a promising therapeutic intervention
            against AATF-mediated steatohepatitis to hepatocarcinogenesis.
REFERENCE   3  (bases 1 to 4470)
  AUTHORS   Babendreyer,A., Kieselhorst,J., Rinkens,C., Lyashenko,A.M.,
            Dusterhoft,S., Jahr,H., Craveiro,R.B., Wolf,M. and Ludwig,A.
  TITLE     Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes
            osteoclast differentiation
  JOURNAL   Cell Commun Signal 22 (1), 322 (2024)
   PUBMED   38863060
  REMARK    GeneRIF: Downregulation of the metalloproteinases ADAM10 or ADAM17
            promotes osteoclast differentiation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4470)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4470)
  AUTHORS   Ding,H., Feng,Z. and Hu,K.
  TITLE     GRWD1 Over-Expression Promotes Gastric Cancer Progression by
            Activating Notch Signaling Pathway via Up-Regulation of ADAM17
  JOURNAL   Dig Dis Sci 69 (3), 821-834 (2024)
   PUBMED   38172445
  REMARK    GeneRIF: GRWD1 Over-Expression Promotes Gastric Cancer Progression
            by Activating Notch Signaling Pathway via Up-Regulation of ADAM17.
REFERENCE   6  (bases 1 to 4470)
  AUTHORS   Buxbaum,J.D., Liu,K.N., Luo,Y., Slack,J.L., Stocking,K.L.,
            Peschon,J.J., Johnson,R.S., Castner,B.J., Cerretti,D.P. and
            Black,R.A.
  TITLE     Evidence that tumor necrosis factor alpha converting enzyme is
            involved in regulated alpha-secretase cleavage of the Alzheimer
            amyloid protein precursor
  JOURNAL   J Biol Chem 273 (43), 27765-27767 (1998)
   PUBMED   9774383
REFERENCE   7  (bases 1 to 4470)
  AUTHORS   Amour,A., Slocombe,P.M., Webster,A., Butler,M., Knight,C.G.,
            Smith,B.J., Stephens,P.E., Shelley,C., Hutton,M., Knauper,V.,
            Docherty,A.J. and Murphy,G.
  TITLE     TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3
  JOURNAL   FEBS Lett 435 (1), 39-44 (1998)
   PUBMED   9755855
REFERENCE   8  (bases 1 to 4470)
  AUTHORS   Yamazaki,K., Mizui,Y., Sagane,K. and Tanaka,I.
  TITLE     Genetic mapping of mouse tumor necrosis factor-alpha converting
            enzyme (TACE) to chromosome 12
  JOURNAL   Genomics 49 (2), 336-337 (1998)
   PUBMED   9598327
REFERENCE   9  (bases 1 to 4470)
  AUTHORS   Moss,M.L., Jin,S.L., Milla,M.E., Bickett,D.M., Burkhart,W.,
            Carter,H.L., Chen,W.J., Clay,W.C., Didsbury,J.R., Hassler,D.,
            Hoffman,C.R., Kost,T.A., Lambert,M.H., Leesnitzer,M.A.,
            McCauley,P., McGeehan,G., Mitchell,J., Moyer,M., Pahel,G.,
            Rocque,W., Overton,L.K., Schoenen,F., Seaton,T., Su,J.L.,
            Becherer,J.D. et al.
  TITLE     Cloning of a disintegrin metalloproteinase that processes precursor
            tumour-necrosis factor-alpha
  JOURNAL   Nature 385 (6618), 733-736 (1997)
   PUBMED   9034191
  REMARK    Erratum:[Nature 1997 Apr 17;386(6626):738]
REFERENCE   10 (bases 1 to 4470)
  AUTHORS   Black,R.A., Rauch,C.T., Kozlosky,C.J., Peschon,J.J., Slack,J.L.,
            Wolfson,M.F., Castner,B.J., Stocking,K.L., Reddy,P., Srinivasan,S.,
            Nelson,N., Boiani,N., Schooley,K.A., Gerhart,M., Davis,R.,
            Fitzner,J.N., Johnson,R.S., Paxton,R.J., March,C.J. and
            Cerretti,D.P.
  TITLE     A metalloproteinase disintegrin that releases tumour-necrosis
            factor-alpha from cells
  JOURNAL   Nature 385 (6618), 729-733 (1997)
   PUBMED   9034190
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC140457.3, AK142441.1,
            BC094655.1, BM248808.2 and AC156032.4.
            
            On May 6, 2014 this sequence version replaced XM_006514950.1.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. The encoded preproprotein undergoes
            proteolytic processing to generate a mature enzyme that is involved
            in the proteolytic release of membrane-bound proteins in a process
            called ectodomain shedding. Mice lacking the encoded protein die in
            utero or fail to survive beyond one week of age. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms, some of which may undergo similar processing. [provided
            by RefSeq, May 2016].
            
            Transcript Variant: This variant (4) uses an alternate 5' splice
            site, lacks a portion of the 5' coding region, and initiates
            translation at a downstream start codon, compared to variant 1. The
            encoded protein (isoform 4) has a shorter N-terminus than isoform
            1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142441.1, SRR9219381.337722.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC140457.3         171883-171943
            62-3121             AK142441.1         2-3061
            3122-4173           BC094655.1         3017-4068
            4174-4442           BM248808.2         5-273               c
            4443-4470           AC156032.4         142104-142131       c
FEATURES             Location/Qualifiers
     source          1..4470
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.3 cM"
     gene            1..4470
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /note="a disintegrin and metallopeptidase domain 17"
                     /db_xref="GeneID:11491"
                     /db_xref="MGI:MGI:1096335"
     exon            1..297
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            298..430
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            431..561
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            562..650
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     exon            651..819
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    799..801
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /note="upstream in-frame stop codon"
     exon            820..972
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /inference="alignment:Splign:2.1.0"
     CDS             934..2703
                     /gene="Adam17"
                     /gene_synonym="CD156b; Tace"
                     /EC_number="3.4.24.86"
                     /note="isoform 4 is encoded by transcript variant 4;
                     TNF-alpha converting enzyme; disintegrin and
                     metalloproteinase domain-containing protein 17; TNF-alpha
                     convertase"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 17 isoform 4"
                     /protein_id="NP_001278800.1"
                     /db_xref="GeneID:11491"
                     /db_xref="MGI:MGI:1096335"
                     /tr
