LOCUS       NM_001409485            2995 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus ADAM metallopeptidase domain 15 (Adam15), transcript
            variant 9, mRNA.
ACCESSION   NM_001409485
VERSION     NM_001409485.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2995)
  AUTHORS   Krishnan,V., Atanasova,N., Aujla,P.K., Hupka,D., Owen,C.A. and
            Kassiri,Z.
  TITLE     Loss of ADAM15 in female mice does not worsen pressure overload
            cardiomyopathy, independent of ovarian hormones
  JOURNAL   Am J Physiol Heart Circ Physiol 327 (2), H409-H416 (2024)
   PUBMED   38607341
  REMARK    GeneRIF: Loss of ADAM15 in female mice does not worsen pressure
            overload cardiomyopathy, independent of ovarian hormones.
REFERENCE   2  (bases 1 to 2995)
  AUTHORS   Li,Y., Xue,J., Zhang,W., Wang,Y. and Wang,W.
  TITLE     ADAM15 in Fibroblasts: Improving the Matrix Remodeling by Blocking
            the Action of Transforming Growth Factor-beta1
  JOURNAL   Ann Clin Lab Sci 54 (3), 363-370 (2024)
   PUBMED   39048163
  REMARK    GeneRIF: ADAM15 in Fibroblasts: Improving the Matrix Remodeling by
            Blocking the Action of Transforming Growth Factor-beta1.
REFERENCE   3  (bases 1 to 2995)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   4  (bases 1 to 2995)
  AUTHORS   Zhou,J., Wang,A., Cai,T., Li,Y., Du,W., Zhang,Y., Zhang,R.,
            Zhang,W., Zhu,J., Zeng,Y., Huang,J.A. and Liu,Z.
  TITLE     Integrin alpha3/alpha6 and alphaV are implicated in
            ADAM15-activated FAK and EGFR signalling pathway individually and
            promote non-small-cell lung cancer progression
  JOURNAL   Cell Death Dis 13 (5), 486 (2022)
   PUBMED   35597804
  REMARK    GeneRIF: Integrin alpha3/alpha6 and alphaV are implicated in
            ADAM15-activated FAK and EGFR signalling pathway individually and
            promote non-small-cell lung cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2995)
  AUTHORS   Chute,M., Aujla,P.K., Li,Y., Jana,S., Zhabyeyev,P., Rasmuson,J.,
            Owen,C.A., Abraham,T., Oudit,G.Y. and Kassiri,Z.
  TITLE     ADAM15 is required for optimal collagen cross-linking and scar
            formation following myocardial infarction
  JOURNAL   Matrix Biol 105, 127-143 (2022)
   PUBMED   34995785
  REMARK    GeneRIF: ADAM15 is required for optimal collagen cross-linking and
            scar formation following myocardial infarction.
REFERENCE   6  (bases 1 to 2995)
  AUTHORS   Abram,C.L., Seals,D.F., Pass,I., Salinsky,D., Maurer,L., Roth,T.M.
            and Courtneidge,S.A.
  TITLE     The adaptor protein fish associates with members of the ADAMs
            family and localizes to podosomes of Src-transformed cells
  JOURNAL   J Biol Chem 278 (19), 16844-16851 (2003)
   PUBMED   12615925
REFERENCE   7  (bases 1 to 2995)
  AUTHORS   Eto,K., Huet,C., Tarui,T., Kupriyanov,S., Liu,H.Z.,
            Puzon-McLaughlin,W., Zhang,X.P., Sheppard,D., Engvall,E. and
            Takada,Y.
  TITLE     Functional classification of ADAMs based on a conserved motif for
            binding to integrin alpha 9beta 1: implications for sperm-egg
            binding and other cell interactions
  JOURNAL   J Biol Chem 277 (20), 17804-17810 (2002)
   PUBMED   11882657
REFERENCE   8  (bases 1 to 2995)
  AUTHORS   Seldin,M.F., Hirohata,S. and Apte,S.S.
  TITLE     Chromosomal mapping of Adam9, Adam15 and Adam21
  JOURNAL   Matrix Biol 19 (2), 185-187 (2000)
   PUBMED   10842103
REFERENCE   9  (bases 1 to 2995)
  AUTHORS   Howard,L., Nelson,K.K., Maciewicz,R.A. and Blobel,C.P.
  TITLE     Interaction of the metalloprotease disintegrins MDC9 and MDC15 with
            two SH3 domain-containing proteins, endophilin I and SH3PX1
  JOURNAL   J Biol Chem 274 (44), 31693-31699 (1999)
   PUBMED   10531379
REFERENCE   10 (bases 1 to 2995)
  AUTHORS   Lum,L., Reid,M.S. and Blobel,C.P.
  TITLE     Intracellular maturation of the mouse metalloprotease disintegrin
            MDC15
  JOURNAL   J Biol Chem 273 (40), 26236-26247 (1998)
   PUBMED   9748307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171273.1.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. This gene is prominently expressed in
            vascular cells, the endocardium, hypertrophic cells in developing
            bone, and specific areas of hippocampus and cerebellum. The encoded
            preproprotein undergoes proteolytic processing to generate a
            mature, functional protein. Mice lacking the encoded protein have
            increased bone mass resulting from osteoblast proliferation, and
            exhibit reduced neovascularization in a mouse model for
            retinopathy. Alternative splicing results in multiple transcript
            variants encoding different isoforms that may undergo similar
            processing. [provided by RefSeq, May 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.4939788.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC171273.1         192184-192364
            182-322             AC171273.1         193515-193655
            323-399             AC171273.1         194228-194304
            400-478             AC171273.1         194688-194766
            479-555             AC171273.1         194945-195021
            556-745             AC171273.1         195107-195296
            746-811             AC171273.1         196165-196230
            812-880             AC171273.1         196336-196404
            881-1050            AC171273.1         196511-196680
            1051-1135           AC171273.1         196810-196894
            1136-1284           AC171273.1         197319-197467
            1285-1459           AC171273.1         197574-197748
            1460-1552           AC171273.1         197963-198055
            1553-1857           AC171273.1         198196-198500
            1858-2053           AC171273.1         198590-198785
            2054-2131           AC171273.1         198983-199060
            2132-2204           AC171273.1         199812-199884
            2205-2343           AC171273.1         200098-200236
            2344-2413           AC171273.1         200596-200665
            2414-2488           AC171273.1         201236-201310
            2489-2560           AC171273.1         201701-201772
            2561-2685           AC171273.1         201994-202118
            2686-2995           AC171273.1         202220-202529
FEATURES             Location/Qualifiers
     source          1..2995
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.07 cM"
     gene            1..2995
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /note="ADAM metallopeptidase domain 15"
                     /db_xref="GeneID:11490"
                     /db_xref="MGI:MGI:1333882"
     exon            1..181
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            182..322
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..2728
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /note="isoform i is encoded by transcript variant 9; a
                     disintegrin and metalloprotease domain 15 (metargidin);
                     disintegrin and metalloproteinase domain-containing
                     protein 15; a disintegrin and metallopeptidase domain 15
                     (metargidin); metalloprotease RGD disintegrin protein;
                     metalloproteinase-like, disintegrin-like, and
                     cysteine-rich protein 15"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 15 isoform i"
                     /protein_id="NP_001396414.1"
                     /db_xref="GeneID:11490"
                     /db_xref="MGI:MGI:1333882"
                     /translation="MESRVVQDSPPMSLADVLQTGLPEALRISLELDSESHVLELLQN
                     RDLIPGRPTLVWYQPDGTRMVSEGYSLENCCYRGRVQGHPSSWVSLCACSGIRGLIVL
                     SPERGYTLELGPGDLQRPVISRIQDHLLLGHTCAPSWHASVPTRAGPDLLLEQHHAHR
                     LKRDVVTETKIVELVIVADNSEVRKYPDFQQLLNRTLEAALLLDTFFQPLNVRVALVG
                     LEAWTQHNLIEMSSNPAVLLDNFLRWRRTDLLPRLPHDSAQLVTVTSFSGPMVGMAIQ
                     NSICSPDFSGGVNMDHSTSILGVASSIAHELGHSLGLDHDSPGHSCPCPGPAPAKSCI
                     MEASTDFLPGLNFSNCSRQALEKALLEGMGSCLFERQPSLAPMSSLCGNMFVDPGEQC
                     DCGFPDECTDPCCDHFTCQLRPGAQCASDGPCCQNCKLHPAGWLCRPPTDDCDLPEFC
                     PGDSSQCPSDIRLGDGEPCASGEAVCMHGRCASYARQCQSLWGPGAQPAAPLCLQTAN
                     TRGNAFGSCGRSPGGSYMPCAPRDVMCGQLQCQWGRSQPLLGSVQDRLSEVLEANGTQ
                     LNCSWVDLDLGNDVAQPLLALPGTACGPGLVCIGHRCQPVDLLGAQECRRKCHGHGVC
                     DSSGHCRCEEGWAPPDCMTQLKATSSLTTGLLLSLLLLLVLVLLGASYWHRARLHQRL
                     CQLKGSSCQYRAPQSCPPERPGPPQRAQQMTGTKQASVVSFPVPPSRPLPPNPVPKKL
                     QAALADRSNPPTRPLPADPVVRRPKSQGPTKPPPPRKPLPANPQGQHPPGDLPGPGDG
                     SLPLVVPSRPAPPPPAASSLYL"
     exon            323..399
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            400..478
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            479..555
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            556..745
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            746..811
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            812..880
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1050
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1135
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1284
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1459
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1552
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1857
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..2053
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2131
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2204
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2343
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2413
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2488
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2560
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2685
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2995
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2975..2980
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /note="hexamer: AATAAA"
     polyA_site      2995
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /note="major polyA site"
ORIGIN      
        1 agttgctgcg ctgcaccgag ctggtgtccg gcggggccgt ggctgctcct ccacgcgtag
       61 ccccgcacct gctgccccag tccagcccgg agctccgcgg ccatgcggct ggcgctgctc
      121 tgggctctgg gactcctggg cgcgggcagc cctcggccct ccccgccgct gccaaatata
      181 gcaatctctt aggatgttct gggaccctgc aggaggcact gaggaagagc agcaagccag
      241 cccagagagg acgctgagtg gatccatgga gagccgggtt gttcaggaca gccccccaat
      301 gagcctagca gacgtgcttc agactggttt acctgaggcc ctgaggattt ccttggagct
      361 ggacagtgag agtcatgtcc tggagcttct acaaaataga gatctaatcc ctggccgccc
      421 aactctggtg tggtaccagc ctgatggcac ccgaatggtc agcgagggct acagtctaga
      481 aaactgctgc taccgaggac gagtgcaggg ccaccccagc tcctgggtgt ccctctgtgc
      541 ctgctctggg atcagggggc tcattgtcct gtccccagag agaggctata cactggagct
      601 gggccctggg gaccttcagc gtcctgtcat ttctcggatc caagaccacc tgttgctggg
      661 ccacacctgt gccccaagct ggcatgcctc tgtgcccact cgggcaggac cagacctcct
      721 tctggaacag catcacgctc acaggcttaa gcgagatgta gtaacagaga cgaaaattgt
      781 ggagttggtg attgtggctg ataattcaga ggtcagaaag taccctgact tccaacaact
      841 gctgaaccgg acactagaag cggctctctt gctagacacg ttcttccagc ccttgaatgt
      901 ccgggtagcc cttgtgggcc tagaggcatg gacccagcac aacctgatag aaatgagctc
      961 caacccagct gtcctgctag acaacttcct ccgctggcgc cggacagact tgctgcctcg
     1021 actgccccat gacagtgccc aactggtgac tgtaacttcc ttctctggtc ccatggtggg
     1081 catggccatt cagaattcca tctgttcccc tgacttctcc ggaggtgtga atatggacca
     1141 ctccacaagc atcttaggcg ttgcctcctc gattgcccat gaattgggcc acagtctggg
     1201 tttggaccat gattctcccg ggcacagctg tccctgtcca ggtccagccc cggctaagag
     1261 ctgcatcatg gaggcctcca cagacttcct accaggtttg aacttcagca actgcagccg
     1321 acaggccctg gaaaaggccc tcctggaagg aatgggcagc tgcctcttcg aacggcaacc
     1381 cagcctggcc cctatgtcct ctttgtgtgg aaatatgttt gtggaccccg gagagcagtg
     1441 tgactgtggc ttcccagatg aatgcactga tccctgctgt gaccatttca cctgccagct
     1501 gaggccagga gcgcagtgtg catctgatgg accctgttgt caaaactgca agttgcaccc
     1561 agctggttgg ctgtgccgcc ctcccacaga cgattgtgat ctgcctgagt tctgcccagg
     1621 agatagctct cagtgcccgt ctgacatcag acttggggac ggtgagcctt gtgctagtgg
     1681 agaggctgtg tgtatgcatg ggcgctgtgc ctcctatgcc cggcagtgcc agtcactttg
     1741 gggacccggg gcccagcctg ctgcgccact ttgcctccaa acagccaaca ctcggggtaa
     1801 tgcctttggg agctgtgggc gcagccctgg tggtagctac atgccttgtg cccctagaga
     1861 tgtcatgtgt gggcaactgc agtgccagtg gggtaggagc cagcctctgt tgggctcagt
     1921 ccaagatcgg ctctcggagg tcctggaagc caacgggaca cagttaaact gcagctgggt
     1981 ggacctggac ctgggcaatg atgtggccca gcctcttctg gctctgcctg gcactgcctg
     2041 tggtcctggc ctggtgtgca tcggccaccg atgccagccc gtggatctcc tgggagcaca
     2101 ggaatgtcga agaaaatgcc acggccatgg ggtctgtgac agcagcgggc actgccgctg
     2161 tgaagagggc tgggcacctc cagactgcat gacccagctc aaagcaacca gctccctgac
     2221 cacaggcctg ctcctcagcc tcctgttgtt attggtcctc gtactacttg gtgccagcta
     2281 ctggcaccgt gcccgcctgc atcagcggct ctgccagctt aagggatcca gctgccaata
     2341 tagggcaccc caatcctgtc ctcctgaacg accaggacct ccacagcggg cacagcagat
     2401 gacaggcact aagcaagcta gtgtggtcag ctttccagtg cccccctcca ggccgctgcc
     2461 acctaacccc gtgcccaaga aactccaggc tgcgctggct gaccgatcca atccccccac
     2521 tcgccctctg cccgctgacc ctgtggtgag gcgcccaaag tctcaggggc ctaccaaacc
     2581 cccaccccca agaaagccac tgcctgccaa cccacagggc cagcacccac caggtgacct
     2641 gcctggccca ggagatggaa gcttgccgct ggtggtgccc tccaggccag ctccaccacc
     2701 ccctgcagca tcttcgctct acctctgacc tctggagatt tggctgcctc cttctcaagc
     2761 tctaagactc aaagaaatgg aacctctgcc ccaaacacta gagaagcagg agaacagaca
     2821 atctggtgtc cagccctaaa gaaccaccag gcgctgttaa gcaatacctg gggacgcact
     2881 aaaatagctg cagcgggatg ctggggaggg gccgaagccg gggctggagt aggtggcgga
     2941 aggacatgga cactgtctat ctctgctctg ttgtaataaa tgtgagatct tggaa
//
