LOCUS       NM_001409482            2907 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus ADAM metallopeptidase domain 15 (Adam15), transcript
            variant 6, mRNA.
ACCESSION   NM_001409482
VERSION     NM_001409482.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2907)
  AUTHORS   Krishnan,V., Atanasova,N., Aujla,P.K., Hupka,D., Owen,C.A. and
            Kassiri,Z.
  TITLE     Loss of ADAM15 in female mice does not worsen pressure overload
            cardiomyopathy, independent of ovarian hormones
  JOURNAL   Am J Physiol Heart Circ Physiol 327 (2), H409-H416 (2024)
   PUBMED   38607341
  REMARK    GeneRIF: Loss of ADAM15 in female mice does not worsen pressure
            overload cardiomyopathy, independent of ovarian hormones.
REFERENCE   2  (bases 1 to 2907)
  AUTHORS   Li,Y., Xue,J., Zhang,W., Wang,Y. and Wang,W.
  TITLE     ADAM15 in Fibroblasts: Improving the Matrix Remodeling by Blocking
            the Action of Transforming Growth Factor-beta1
  JOURNAL   Ann Clin Lab Sci 54 (3), 363-370 (2024)
   PUBMED   39048163
  REMARK    GeneRIF: ADAM15 in Fibroblasts: Improving the Matrix Remodeling by
            Blocking the Action of Transforming Growth Factor-beta1.
REFERENCE   3  (bases 1 to 2907)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   4  (bases 1 to 2907)
  AUTHORS   Zhou,J., Wang,A., Cai,T., Li,Y., Du,W., Zhang,Y., Zhang,R.,
            Zhang,W., Zhu,J., Zeng,Y., Huang,J.A. and Liu,Z.
  TITLE     Integrin alpha3/alpha6 and alphaV are implicated in
            ADAM15-activated FAK and EGFR signalling pathway individually and
            promote non-small-cell lung cancer progression
  JOURNAL   Cell Death Dis 13 (5), 486 (2022)
   PUBMED   35597804
  REMARK    GeneRIF: Integrin alpha3/alpha6 and alphaV are implicated in
            ADAM15-activated FAK and EGFR signalling pathway individually and
            promote non-small-cell lung cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2907)
  AUTHORS   Chute,M., Aujla,P.K., Li,Y., Jana,S., Zhabyeyev,P., Rasmuson,J.,
            Owen,C.A., Abraham,T., Oudit,G.Y. and Kassiri,Z.
  TITLE     ADAM15 is required for optimal collagen cross-linking and scar
            formation following myocardial infarction
  JOURNAL   Matrix Biol 105, 127-143 (2022)
   PUBMED   34995785
  REMARK    GeneRIF: ADAM15 is required for optimal collagen cross-linking and
            scar formation following myocardial infarction.
REFERENCE   6  (bases 1 to 2907)
  AUTHORS   Abram,C.L., Seals,D.F., Pass,I., Salinsky,D., Maurer,L., Roth,T.M.
            and Courtneidge,S.A.
  TITLE     The adaptor protein fish associates with members of the ADAMs
            family and localizes to podosomes of Src-transformed cells
  JOURNAL   J Biol Chem 278 (19), 16844-16851 (2003)
   PUBMED   12615925
REFERENCE   7  (bases 1 to 2907)
  AUTHORS   Eto,K., Huet,C., Tarui,T., Kupriyanov,S., Liu,H.Z.,
            Puzon-McLaughlin,W., Zhang,X.P., Sheppard,D., Engvall,E. and
            Takada,Y.
  TITLE     Functional classification of ADAMs based on a conserved motif for
            binding to integrin alpha 9beta 1: implications for sperm-egg
            binding and other cell interactions
  JOURNAL   J Biol Chem 277 (20), 17804-17810 (2002)
   PUBMED   11882657
REFERENCE   8  (bases 1 to 2907)
  AUTHORS   Seldin,M.F., Hirohata,S. and Apte,S.S.
  TITLE     Chromosomal mapping of Adam9, Adam15 and Adam21
  JOURNAL   Matrix Biol 19 (2), 185-187 (2000)
   PUBMED   10842103
REFERENCE   9  (bases 1 to 2907)
  AUTHORS   Howard,L., Nelson,K.K., Maciewicz,R.A. and Blobel,C.P.
  TITLE     Interaction of the metalloprotease disintegrins MDC9 and MDC15 with
            two SH3 domain-containing proteins, endophilin I and SH3PX1
  JOURNAL   J Biol Chem 274 (44), 31693-31699 (1999)
   PUBMED   10531379
REFERENCE   10 (bases 1 to 2907)
  AUTHORS   Lum,L., Reid,M.S. and Blobel,C.P.
  TITLE     Intracellular maturation of the mouse metalloprotease disintegrin
            MDC15
  JOURNAL   J Biol Chem 273 (40), 26236-26247 (1998)
   PUBMED   9748307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171273.1.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. This gene is prominently expressed in
            vascular cells, the endocardium, hypertrophic cells in developing
            bone, and specific areas of hippocampus and cerebellum. The encoded
            preproprotein undergoes proteolytic processing to generate a
            mature, functional protein. Mice lacking the encoded protein have
            increased bone mass resulting from osteoblast proliferation, and
            exhibit reduced neovascularization in a mouse model for
            retinopathy. Alternative splicing results in multiple transcript
            variants encoding different isoforms that may undergo similar
            processing. [provided by RefSeq, May 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.2590466.1,
                                           SRR7345562.4087118.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC171273.1         192184-192364
            182-291             AC171273.1         193546-193655
            292-368             AC171273.1         194228-194304
            369-447             AC171273.1         194688-194766
            448-524             AC171273.1         194945-195021
            525-714             AC171273.1         195107-195296
            715-780             AC171273.1         196165-196230
            781-849             AC171273.1         196336-196404
            850-1019            AC171273.1         196511-196680
            1020-1104           AC171273.1         196810-196894
            1105-1253           AC171273.1         197319-197467
            1254-1428           AC171273.1         197574-197748
            1429-1521           AC171273.1         197963-198055
            1522-1826           AC171273.1         198196-198500
            1827-2022           AC171273.1         198590-198785
            2023-2100           AC171273.1         198983-199060
            2101-2173           AC171273.1         199812-199884
            2174-2312           AC171273.1         200098-200236
            2313-2382           AC171273.1         200596-200665
            2383-2457           AC171273.1         201236-201310
            2458-2529           AC171273.1         201701-201772
            2530-2597           AC171273.1         202051-202118
            2598-2907           AC171273.1         202220-202529
FEATURES             Location/Qualifiers
     source          1..2907
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.07 cM"
     gene            1..2907
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /note="ADAM metallopeptidase domain 15"
                     /db_xref="GeneID:11490"
                     /db_xref="MGI:MGI:1333882"
     exon            1..181
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..2640
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /note="isoform f precursor is encoded by transcript
                     variant 6; a disintegrin and metalloprotease domain 15
                     (metargidin); disintegrin and metalloproteinase
                     domain-containing protein 15; a disintegrin and
                     metallopeptidase domain 15 (metargidin); metalloprotease
                     RGD disintegrin protein; metalloproteinase-like,
                     disintegrin-like, and cysteine-rich protein 15"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 15 isoform f precursor"
                     /protein_id="NP_001396411.1"
                     /db_xref="GeneID:11490"
                     /db_xref="MGI:MGI:1333882"
                     /translation="MRLALLWALGLLGAGSPRPSPPLPNIGGTEEEQQASPERTLSGS
                     MESRVVQDSPPMSLADVLQTGLPEALRISLELDSESHVLELLQNRDLIPGRPTLVWYQ
                     PDGTRMVSEGYSLENCCYRGRVQGHPSSWVSLCACSGIRGLIVLSPERGYTLELGPGD
                     LQRPVISRIQDHLLLGHTCAPSWHASVPTRAGPDLLLEQHHAHRLKRDVVTETKIVEL
                     VIVADNSEVRKYPDFQQLLNRTLEAALLLDTFFQPLNVRVALVGLEAWTQHNLIEMSS
                     NPAVLLDNFLRWRRTDLLPRLPHDSAQLVTVTSFSGPMVGMAIQNSICSPDFSGGVNM
                     DHSTSILGVASSIAHELGHSLGLDHDSPGHSCPCPGPAPAKSCIMEASTDFLPGLNFS
                     NCSRQALEKALLEGMGSCLFERQPSLAPMSSLCGNMFVDPGEQCDCGFPDECTDPCCD
                     HFTCQLRPGAQCASDGPCCQNCKLHPAGWLCRPPTDDCDLPEFCPGDSSQCPSDIRLG
                     DGEPCASGEAVCMHGRCASYARQCQSLWGPGAQPAAPLCLQTANTRGNAFGSCGRSPG
                     GSYMPCAPRDVMCGQLQCQWGRSQPLLGSVQDRLSEVLEANGTQLNCSWVDLDLGNDV
                     AQPLLALPGTACGPGLVCIGHRCQPVDLLGAQECRRKCHGHGVCDSSGHCRCEEGWAP
                     PDCMTQLKATSSLTTGLLLSLLLLLVLVLLGASYWHRARLHQRLCQLKGSSCQYRAPQ
                     SCPPERPGPPQRAQQMTGTKQASVVSFPVPPSRPLPPNPVPKKLQAALADRSNPPTRP
                     LPADPVVRRPKGQHPPGDLPGPGDGSLPLVVPSRPAPPPPAASSLYL"
     exon            182..291
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            292..368
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            369..447
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            448..524
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            525..714
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            715..780
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            781..849
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1019
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1104
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1253
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1428
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1521
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1826
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..2022
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2100
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2173
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2312
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2382
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2457
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2529
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2597
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     exon            2598..2907
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2887..2892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /note="hexamer: AATAAA"
     polyA_site      2907
                     /gene="Adam15"
                     /gene_synonym="AD56; MDC15"
                     /note="major polyA site"
ORIGIN      
        1 agttgctgcg ctgcaccgag ctggtgtccg gcggggccgt ggctgctcct ccacgcgtag
       61 ccccgcacct gctgccccag tccagcccgg agctccgcgg ccatgcggct ggcgctgctc
      121 tgggctctgg gactcctggg cgcgggcagc cctcggccct ccccgccgct gccaaatata
      181 ggaggcactg aggaagagca gcaagccagc ccagagagga cgctgagtgg atccatggag
      241 agccgggttg ttcaggacag ccccccaatg agcctagcag acgtgcttca gactggttta
      301 cctgaggccc tgaggatttc cttggagctg gacagtgaga gtcatgtcct ggagcttcta
      361 caaaatagag atctaatccc tggccgccca actctggtgt ggtaccagcc tgatggcacc
      421 cgaatggtca gcgagggcta cagtctagaa aactgctgct accgaggacg agtgcagggc
      481 caccccagct cctgggtgtc cctctgtgcc tgctctggga tcagggggct cattgtcctg
      541 tccccagaga gaggctatac actggagctg ggccctgggg accttcagcg tcctgtcatt
      601 tctcggatcc aagaccacct gttgctgggc cacacctgtg ccccaagctg gcatgcctct
      661 gtgcccactc gggcaggacc agacctcctt ctggaacagc atcacgctca caggcttaag
      721 cgagatgtag taacagagac gaaaattgtg gagttggtga ttgtggctga taattcagag
      781 gtcagaaagt accctgactt ccaacaactg ctgaaccgga cactagaagc ggctctcttg
      841 ctagacacgt tcttccagcc cttgaatgtc cgggtagccc ttgtgggcct agaggcatgg
      901 acccagcaca acctgataga aatgagctcc aacccagctg tcctgctaga caacttcctc
      961 cgctggcgcc ggacagactt gctgcctcga ctgccccatg acagtgccca actggtgact
     1021 gtaacttcct tctctggtcc catggtgggc atggccattc agaattccat ctgttcccct
     1081 gacttctccg gaggtgtgaa tatggaccac tccacaagca tcttaggcgt tgcctcctcg
     1141 attgcccatg aattgggcca cagtctgggt ttggaccatg attctcccgg gcacagctgt
     1201 ccctgtccag gtccagcccc ggctaagagc tgcatcatgg aggcctccac agacttccta
     1261 ccaggtttga acttcagcaa ctgcagccga caggccctgg aaaaggccct cctggaagga
     1321 atgggcagct gcctcttcga acggcaaccc agcctggccc ctatgtcctc tttgtgtgga
     1381 aatatgtttg tggaccccgg agagcagtgt gactgtggct tcccagatga atgcactgat
     1441 ccctgctgtg accatttcac ctgccagctg aggccaggag cgcagtgtgc atctgatgga
     1501 ccctgttgtc aaaactgcaa gttgcaccca gctggttggc tgtgccgccc tcccacagac
     1561 gattgtgatc tgcctgagtt ctgcccagga gatagctctc agtgcccgtc tgacatcaga
     1621 cttggggacg gtgagccttg tgctagtgga gaggctgtgt gtatgcatgg gcgctgtgcc
     1681 tcctatgccc ggcagtgcca gtcactttgg ggacccgggg cccagcctgc tgcgccactt
     1741 tgcctccaaa cagccaacac tcggggtaat gcctttggga gctgtgggcg cagccctggt
     1801 ggtagctaca tgccttgtgc ccctagagat gtcatgtgtg ggcaactgca gtgccagtgg
     1861 ggtaggagcc agcctctgtt gggctcagtc caagatcggc tctcggaggt cctggaagcc
     1921 aacgggacac agttaaactg cagctgggtg gacctggacc tgggcaatga tgtggcccag
     1981 cctcttctgg ctctgcctgg cactgcctgt ggtcctggcc tggtgtgcat cggccaccga
     2041 tgccagcccg tggatctcct gggagcacag gaatgtcgaa gaaaatgcca cggccatggg
     2101 gtctgtgaca gcagcgggca ctgccgctgt gaagagggct gggcacctcc agactgcatg
     2161 acccagctca aagcaaccag ctccctgacc acaggcctgc tcctcagcct cctgttgtta
     2221 ttggtcctcg tactacttgg tgccagctac tggcaccgtg cccgcctgca tcagcggctc
     2281 tgccagctta agggatccag ctgccaatat agggcacccc aatcctgtcc tcctgaacga
     2341 ccaggacctc cacagcgggc acagcagatg acaggcacta agcaagctag tgtggtcagc
     2401 tttccagtgc ccccctccag gccgctgcca cctaaccccg tgcccaagaa actccaggct
     2461 gcgctggctg accgatccaa tccccccact cgccctctgc ccgctgaccc tgtggtgagg
     2521 cgcccaaagg gccagcaccc accaggtgac ctgcctggcc caggagatgg aagcttgccg
     2581 ctggtggtgc cctccaggcc agctccacca ccccctgcag catcttcgct ctacctctga
     2641 cctctggaga tttggctgcc tccttctcaa gctctaagac tcaaagaaat ggaacctctg
     2701 ccccaaacac tagagaagca ggagaacaga caatctggtg tccagcccta aagaaccacc
     2761 aggcgctgtt aagcaatacc tggggacgca ctaaaatagc tgcagcggga tgctggggag
     2821 gggccgaagc cggggctgga gtaggtggcg gaaggacatg gacactgtct atctctgctc
     2881 tgttgtaata aatgtgagat cttggaa
//
