LOCUS       NM_009613               4651 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 11 (Adam11),
            transcript variant 2, mRNA.
ACCESSION   NM_009613
VERSION     NM_009613.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4651)
  AUTHORS   Yang,Q., Cao,Q., Yu,Y., Lai,X., Feng,J., Li,X., Jiang,Y., Sun,Y.,
            Zhou,Z.W. and Li,X.
  TITLE     Epigenetic and transcriptional landscapes during cerebral cortex
            development in a microcephaly mouse model
  JOURNAL   J Genet Genomics 51 (4), 419-432 (2024)
   PUBMED   37923173
REFERENCE   2  (bases 1 to 4651)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4651)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4651)
  AUTHORS   Kole,M.J., Qian,J., Waase,M.P., Klassen,T.L., Chen,T.T.,
            Augustine,G.J. and Noebels,J.L.
  TITLE     Selective Loss of Presynaptic Potassium Channel Clusters at the
            Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals
            Their Role in Ephaptic Control of Purkinje Cell Firing
  JOURNAL   J Neurosci 35 (32), 11433-11444 (2015)
   PUBMED   26269648
  REMARK    GeneRIF: In the ADAM11 mutant, GABAergic release was not altered,
            but the ultrarapid electrical signal was absent, demonstrating that
            the dense presynaptic cluster of Kv1 ion channels at these
            terminals mediate electrical transmission.
REFERENCE   5  (bases 1 to 4651)
  AUTHORS   Chen,N., Koopmans,F., Gordon,A., Paliukhovich,I., Klaassen,R.V.,
            van der Schors,R.C., Peles,E., Verhage,M., Smit,A.B. and Li,K.W.
  TITLE     Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the
            presence of two Caspr2 isoforms with overlapping interactomes
  JOURNAL   Biochim Biophys Acta 1854 (7), 827-833 (2015)
   PUBMED   25707359
  REMARK    GeneRIF: Interaction proteomics revealed the interactors of Caspr2,
            including CNTN2, KCNAs, members of the ADAM family (ADAM22, ADAM23
            and ADAM11), members of LGI family and MAGUKs (DLGs and MPPs).
REFERENCE   6  (bases 1 to 4651)
  AUTHORS   Small,C.L., Shima,J.E., Uzumcu,M., Skinner,M.K. and Griswold,M.D.
  TITLE     Profiling gene expression during the differentiation and
            development of the murine embryonic gonad
  JOURNAL   Biol Reprod 72 (2), 492-501 (2005)
   PUBMED   15496517
REFERENCE   7  (bases 1 to 4651)
  AUTHORS   Hauck,S.J., Aaron,J.M., Wright,C., Kopchick,J.J. and Bartke,A.
  TITLE     Antioxidant enzymes, free-radical damage, and response to paraquat
            in liver and kidney of long-living growth hormone receptor/binding
            protein gene-disrupted mice
  JOURNAL   Horm Metab Res 34 (9), 481-486 (2002)
   PUBMED   12384824
REFERENCE   8  (bases 1 to 4651)
  AUTHORS   Rybnikova,E., Karkkainen,I., Pelto-Huikko,M. and Huovila,A.P.
  TITLE     Developmental regulation and neuronal expression of the cellular
            disintegrin ADAM11 gene in mouse nervous system
  JOURNAL   Neuroscience 112 (4), 921-934 (2002)
   PUBMED   12088751
REFERENCE   9  (bases 1 to 4651)
  AUTHORS   Sagane,K., Yamazaki,K., Mizui,Y. and Tanaka,I.
  TITLE     Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23
  JOURNAL   Gene 236 (1), 79-86 (1999)
   PUBMED   10433968
REFERENCE   10 (bases 1 to 4651)
  AUTHORS   Inoue,D., Reid,M., Lum,L., Kratzschmar,J., Weskamp,G., Myung,Y.M.,
            Baron,R. and Blobel,C.P.
  TITLE     Cloning and initial characterization of mouse meltrin beta and
            analysis of the expression of four metalloprotease-disintegrins in
            bone cells
  JOURNAL   J Biol Chem 273 (7), 4180-4187 (1998)
   PUBMED   9461614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK157926.1, AL929067.8,
            CD353697.1 and BC054536.1.
            
            On May 5, 2016 this sequence version replaced NM_009613.2.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. The encoded preproprotein undergoes
            proteolytic processing to generate a mature, functional protein.
            The protein encoded by this gene is believed to lack
            metalloproteinase activity due to the lack of a critical catalytic
            motif. Mice lacking the encoded protein exhibit defects in spatial
            learning, motor coordination and altered perception of pain.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms that may undergo similar processing.
            [provided by RefSeq, May 2016].
            
            Transcript Variant: This variant (2) lacks an internal segment in
            the 3' region, as compared to variant 1. The encoded isoform (2)
            has a shorter and different C-terminus, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB009676.1, SRR9219379.4856.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-357               AK157926.1         2-358
            358-358             AL929067.8         19109-19109
            359-2492            AK157926.1         360-2493
            2493-3057           CD353697.1         90-654
            3058-4651           BC054536.1         3396-4989
FEATURES             Location/Qualifiers
     source          1..4651
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.48 cM"
     gene            1..4651
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /note="a disintegrin and metallopeptidase domain 11"
                     /db_xref="GeneID:11488"
                     /db_xref="MGI:MGI:1098667"
     exon            1..250
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..2508
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /note="isoform 2 preproprotein is encoded by transcript
                     variant 2; disintegrin and metalloproteinase
                     domain-containing protein 11; metalloproteinase-like,
                     disintegrin-like, and cysteine-rich protein; a disintegrin
                     and metalloprotease domain (ADAM) 11"
                     /codon_start=1
                     /product="disintegrin and metalloproteinase
                     domain-containing protein 11 isoform 2 preproprotein"
                     /protein_id="NP_033743.2"
                     /db_xref="CCDS:CCDS25503.1"
                     /db_xref="GeneID:11488"
                     /db_xref="MGI:MGI:1098667"
                     /translation="MRRLRRWAIAALLLLPLLPPPGLGALGPRGALHWRSSAHVGSPE
                     SPEGSEVTEPSRLVRQSSGGEVRKPQLDTRVRQDPPRGTPVHLAQVSFVIPAFDSNFT
                     LDLELNHHLLSSQYVERHFSREGTRQHSTGAGDHCYYHGKLRGNPQSFAALSTCQGLH
                     GVFSDGNLTYIVEPKEIAGPWGPPQGPLPHLIYRTPLLPAPLGCREPGCLFAVPAQSA
                     LPNWPKLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNL
                     ADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLF
                     SGRTFQSTSSGAAYVGGICSLSRGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSS
                     AGDCKCPDIWLGCIMEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPE
                     CGNGFVEAGEECDCGSVQECSRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCR
                     EAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQALWGHAA
                     ADRFCYEKLNVEGTERGNCGRKGSGWVQCSKQDVLCGFLLCVNISGAPRLGDLGGDIS
                     SVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCP
                     GSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPPTGETERYKGPSGTNII
                     IGSIAGAVLVAAIVLGGTGWGFKNIRRGRSGGA"
     exon            251..435
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            436..512
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            513..579
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            580..665
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            666..741
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            742..808
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            809..876
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            877..951
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1023
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1190
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1275
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1366
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1418
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1518
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1519..1590
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1683
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1764
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1815
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1879
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1979
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2099
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2268
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2383
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2474
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2492
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..4624
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4584..4589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /note="hexamer: ATTAAA"
     polyA_site      4624
                     /gene="Adam11"
                     /gene_synonym="Mdc"
                     /note="major polyA site"
ORIGIN      
        1 ggccgcggcc agagcgcact gagcccggcg ccgctctctc gcgacccccg cccggcccgc
       61 gcgcccgccc cgctcgccgc cggcgtcgcc cgcccccgcc ctcctccctc cctttctcgc
      121 tccctccctc cctccccgcg ccgctcgcag ccgcagcccc cggacccgga ggattatgag
      181 cgaaccatga ggcggctgcg gcgctgggcg atcgcggctc tgctgctgtt accgcttctc
      241 cccccgcccg gtcttggggc cctgggtccc agaggagctc tgcactggag gagctcagcc
      301 catgtgggga gcccagagag tccagagggc tctgaggtca cagagcccag ccggctggta
      361 aggcagagct ccgggggaga ggtccgaaag ccacagttgg acaccagggt ccgccaggat
      421 ccgcccaggg ggacgcctgt gcacctggcc caggtgagtt tcgtcatccc ggccttcgac
      481 tcaaacttca ctctggacct ggagctgaac catcacctcc tgtcctcgca gtatgtggag
      541 cgccacttca gccgggaggg aacaagacaa cacagcactg gggctggaga ccactgctac
      601 taccatggga aactccgggg caacccacag tcctttgctg cactctctac atgccagggg
      661 ctgcatgggg tcttctctga tggcaacctg acttacatcg tagagcctaa ggagatagct
      721 gggccctggg gacccccaca gggacccctt ccccacctca tttaccggac ccctctcctc
      781 ccagcccccc ttggatgcag ggagccaggc tgcctgtttg ctgtccctgc ccagtctgct
      841 ctccccaact ggcccaagct aagaaggaaa aggcaggtcc gcaggggcca ccccacagtg
      901 cacagcgaga ccaagtatgt ggagttgatt gtaatcaatg accaccagct gtttgagcag
      961 atgcggcagt cagtggtcct caccagcaac tttgcaaaat ctgttgtgaa cctggcagat
     1021 gtgatataca aggaacagct caacacaaga attgttctgg ttgccatgga aacgtgggca
     1081 gatggggaca agatccaggt gcaggatgac ctactggaga ccctggcccg gcttatggtc
     1141 taccggcggg agggtctgcc tgagcccagt gatgccaccc acctcttctc gggtagaacc
     1201 ttccagagca ccagcagcgg ggcggcctac gtgggaggca tctgttcact gtcccggggt
     1261 ggaggtgtga acgagtatgg caacatgggt gccatggcgg tgaccctggc ccagacgcta
     1321 gggcagaact tgggcatgat gtggaataag caccggagct cagcagggga ctgcaagtgt
     1381 ccagacattt ggctgggctg catcatggag gacactgggt tctatttgcc ccgcaagttc
     1441 tcgcgctgca gcatcgacga atacaaccag tttctgcagg agggaggcgg gagctgcctg
     1501 ttcaacaagc ccctcaagct tctggaccct cccgagtgcg gaaacggctt cgtggaggcg
     1561 ggagaggagt gcgactgcgg gtcggtgcag gagtgcagcc gagcaggggg caactgctgc
     1621 aaaaaatgca ccttgacgca cgacgccatg tgcagcgatg ggctctgttg tcgccgctgc
     1681 aagtatgagc cacgaggtgt ctcctgccga gaagcggtga atgagtgtga cattgcagag
     1741 acctgcaccg gcgactcaag ccagtgtccc cctaaccttc acaagctgga cggttactac
     1801 tgtgatcatg agcagggtcg ttgctatgga ggccgctgta aaacccggga ccggcagtgc
     1861 caagccctat ggggccatgc ggctgcggat cgtttctgct atgagaagct gaacgtggag
     1921 gggacagagc gtggaaactg tggacgcaag ggatctggtt gggtccagtg cagtaagcag
     1981 gatgtgctct gtggcttcct tctgtgcgtc aacatctctg gagctccgcg gctaggggat
     2041 ctggggggcg acatcagcag tgtcaccttc taccaccagg gcaaggagtt ggactgcagg
     2101 ggaggccacg tgcagctagc tgatggctcg gacctgagct atgtggagga cggcacggcc
     2161 tgtgggccca acatgttgtg cctagatcac cgctgcctgc cagcctctgc cttcaacttc
     2221 agcacctgcc ctggaagtgg agagcgaagg atctgctccc atcatggggt ttgcagcaac
     2281 gaggggaagt gtatctgtca gccagactgg acaggcaaag actgcagtat tcacaaccca
     2341 ctgcccacgt cccctcccac tggggagact gagagataca aaggtcccag cggtaccaac
     2401 atcatcattg gctccatcgc cggggctgtc ctggtcgcag ccatcgtcct gggcggcacg
     2461 ggctggggat ttaaaaacat ccgtcgtgga aggtccggag gggcctaagt gccaccctgc
     2521 tccctccgag cctggcaccc accatctcgg ccctgaacca cgaggctgcc tccaccctgc
     2581 cacagaggga ggcaccgtgc aaatgtcttc cgggtccgaa cccttcaact cctggctgca
     2641 caggggttgg gggttgggac tgtgatatcg cctttcagac cacctgggta gaggggccgg
     2701 gaggaggacg cttcctgccc agttccccat cccacctcat gcggctttgg ccttgcacac
     2761 gtctccccct gtgaatgtag cctccatcat cacagactgc cacagctcac gttggggcct
     2821 ggaccggtgc ctggtgggga cagctgggtg gcccctcttc aaaaccaggc agctggaacc
     2881 aggggagtag ctcccctgga cctcacggga aggggctgat ctacattttc tctctctctc
     2941 tctctctctc tctctctctc tctctctccc tctttctctc tctctttctc tctctctctt
     3001 ttgttttact acttaatctt aactgatgaa tgtaaccttt gggttgcttg gggccagggg
     3061 gcaattgtag ggatgttttg acacttacag gagggcctcc tgggcccgag gccttgagac
     3121 ctcccacatc cctccctggg aggcccaaac gaatcctgtc agggaaccca gctggggcag
     3181 ggcagccctg cttgccccac ctctgcccag cttagtagaa gtcagagtgc tgattcaaac
     3241 caaagctgcc tgtcccgtgc ccactgccta gctcatggga ctctgtccca gactgtcttc
     3301 gattccaaac tgaccatcct gtccctgcca gggtgcatgc attcgggggt atagaaaaat
     3361 atagtcccta aaataaaact ccacctttcc cctttcaaga agggtgattc tggggctgtc
     3421 tcagggttca ggtgccccct gatgtggcct ggctgttctg gagcaggcta tcgtagcagg
     3481 gaggactctc agtagggaga accaggggtg gccctgtgcc ccagggttag tgcctgtgat
     3541 gtgtatgagg agatggggaa agggcaggcc tcgtggatgg ttataggtga ctaggaaaat
     3601 tctcaagtcc tcaatccata cccacccccg tcacaagttt tattcacctg tagtctaggg
     3661 ctgagtagta agtttacaga tgttcctgtc tgccctcctg actggtcctt gctgccgccc
     3721 agcctgagag ctggaccaag gctggcagag ctgctcagcc ctcccacagt ccagcagggc
     3781 cagccttcac aaccctatgt gagacacaca cgctctggct ccatgcccta agagctggcg
     3841 gggcaagata gagcaggctc tcttatggac gaaaaccaca atgtaaggaa gccccttcta
     3901 ggggacaccc cactcaggct aagtagtagt tctaggtacc ccagagacag agggttaccc
     3961 gtttgtgtac ctcctatttc tgaggactct tcaaggaagg ctaatggaga aaatggcttc
     4021 atttatctaa accaacccag tggccggcac cttggagcct acggcccact ggcagctttg
     4081 ggggtagcca gatggtgttg gccacagtgg ggtcctcagt gctgagcccc aggtgccact
     4141 gtcctagtga caacaggaca gatgcaggcc accagcccca ctagctgagg tcaggggaaa
     4201 ggctgcattt tgcattgttg ctgggatacc tcgagacctc catcaggtgg cacatgcaca
     4261 cacaggtggc agtgcacctg ggtgcagaca tgtgaatcca cgcctctgca ccactgtgaa
     4321 ggcctctgca tacaagggca tgaccatgtg tgtcctcgtg tccttggtga agaacacaag
     4381 acttcctgtg gccagtccac ccgaggcgtc caacttcctg catccccttg ccccacccta
     4441 gcagtgcctg gcctggcagc acctaggaaa gaaagagagg aggggggctg cattcacctg
     4501 gcccagacct gggtccctcc gcatcctgta aatatgtcat ctgggctggg ttggggaggc
     4561 agggcccggg gcccacatta aagattaaag atcacattct gggcttccat tgagctcaca
     4621 ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
