LOCUS       NM_007399               4624 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Mus musculus a disintegrin and metallopeptidase domain 10 (Adam10),
            mRNA.
ACCESSION   NM_007399
VERSION     NM_007399.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4624)
  AUTHORS   Shahid,S., Hu,Y., Mohamed,F., Rizzotto,L., Layana,M.C.,
            Fleming,D.T., Papagerakis,P., Foster,B.L., Simmer,J.P. and
            Bartlett,J.D.
  TITLE     ADAM10 Expression by Ameloblasts Is Essential for Proper Enamel
            Formation
  JOURNAL   Int J Mol Sci 25 (23), 13184 (2024)
   PUBMED   39684894
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4624)
  AUTHORS   Bar,J., Fanutza,T., Reimann,C.C., Seipold,L., Grohe,M.,
            Bolter,J.R., Delfs,F., Bucher,M., Gee,C.E., Schweizer,M., Saftig,P.
            and Mikhaylova,M.
  TITLE     Non-canonical function of ADAM10 in presynaptic plasticity
  JOURNAL   Cell Mol Life Sci 81 (1), 342 (2024)
   PUBMED   39123091
  REMARK    GeneRIF: Non-canonical function of ADAM10 in presynaptic
            plasticity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4624)
  AUTHORS   Padilla-Ferrer,A., Carrete,A., Simon,A., Meffre,D. and
            Jafarian-Tehrani,M.
  TITLE     A Disintegrin And Metalloprotease 10 expression within the murine
            central nervous system
  JOURNAL   Brain Res 1834, 148888 (2024)
   PUBMED   38548249
  REMARK    GeneRIF: A Disintegrin And Metalloprotease 10 expression within the
            murine central nervous system.
REFERENCE   4  (bases 1 to 4624)
  AUTHORS   Babendreyer,A., Kieselhorst,J., Rinkens,C., Lyashenko,A.M.,
            Dusterhoft,S., Jahr,H., Craveiro,R.B., Wolf,M. and Ludwig,A.
  TITLE     Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes
            osteoclast differentiation
  JOURNAL   Cell Commun Signal 22 (1), 322 (2024)
   PUBMED   38863060
  REMARK    GeneRIF: Downregulation of the metalloproteinases ADAM10 or ADAM17
            promotes osteoclast differentiation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4624)
  AUTHORS   Song,L., Pan,Q.L., Zhou,G.F., Liu,S.W., Zhu,B.L., Lin,P.J.,
            Hu,X.T., Zha,J.S., Long,Y., Luo,B., Chen,J., Tang,Y., Tang,J.,
            Xiang,X.J., Xie,X.Y., Deng,X.J. and Chen,G.J.
  TITLE     SHMT2 Mediates Small-Molecule-Induced Alleviation of Alzheimer
            Pathology Via the 5'UTR-dependent ADAM10 Translation Initiation
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305260 (2024)
   PUBMED   38183387
  REMARK    GeneRIF: SHMT2 Mediates Small-Molecule-Induced Alleviation of
            Alzheimer Pathology Via the 5'UTR-dependent ADAM10 Translation
            Initiation.
REFERENCE   6  (bases 1 to 4624)
  AUTHORS   Hattori,M., Osterfield,M. and Flanagan,J.G.
  TITLE     Regulated cleavage of a contact-mediated axon repellent
  JOURNAL   Science 289 (5483), 1360-1365 (2000)
   PUBMED   10958785
REFERENCE   7  (bases 1 to 4624)
  AUTHORS   Schlondorff,J. and Blobel,C.P.
  TITLE     Metalloprotease-disintegrins: modular proteins capable of promoting
            cell-cell interactions and triggering signals by protein-ectodomain
            shedding
  JOURNAL   J Cell Sci 112 (Pt 21), 3603-3617 (1999)
   PUBMED   10523497
  REMARK    Review article
REFERENCE   8  (bases 1 to 4624)
  AUTHORS   Yavari,R., Adida,C., Bray-Ward,P., Brines,M. and Xu,T.
  TITLE     Human metalloprotease-disintegrin Kuzbanian regulates
            sympathoadrenal cell fate in development and neoplasia
  JOURNAL   Hum Mol Genet 7 (7), 1161-1167 (1998)
   PUBMED   9618175
REFERENCE   9  (bases 1 to 4624)
  AUTHORS   Yamazaki,K., Mizui,Y., Sagane,K. and Tanaka,I.
  TITLE     Assignment of a disintegrin and metalloproteinase domain 10
            (Adam10) gene to mouse chromosome 9
  JOURNAL   Genomics 46 (3), 528-529 (1997)
   PUBMED   9441766
REFERENCE   10 (bases 1 to 4624)
  AUTHORS   Pan,D. and Rubin,G.M.
  TITLE     Kuzbanian controls proteolytic processing of Notch and mediates
            lateral inhibition during Drosophila and vertebrate neurogenesis
  JOURNAL   Cell 90 (2), 271-280 (1997)
   PUBMED   9244301
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY205591.1, BC066207.1,
            BC057346.1, AC160636.2, AK031857.1 and BE654195.1.
            
            On May 4, 2016 this sequence version replaced NM_007399.3.
            
            Summary: This gene encodes a member of a disintegrin and
            metalloprotease (ADAM) family of endoproteases that play important
            roles in various biological processes including cell signaling,
            adhesion and migration. The encoded preproprotein undergoes
            proteolytic processing to generate a mature enzyme that is involved
            in the proteolytic release of membrane-bound proteins in a process
            called ectodomain shedding. Mice lacking the encoded protein die in
            utero with multiple defects of the developing central nervous
            system, somites, and cardiovascular system. [provided by RefSeq,
            May 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057346.1, SRR1660813.163299.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BY205591.1         6-24
            20-97               BC066207.1         6-83
            98-675              BC057346.1         41-618
            676-676             AC160636.2         100394-100394
            677-1189            BC057346.1         620-1132
            1190-1190           AC160636.2         125872-125872
            1191-3921           BC057346.1         1133-3863
            3922-4601           AK031857.1         1013-1692
            4602-4624           BE654195.1         5-27                c
FEATURES             Location/Qualifiers
     source          1..4624
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 39.53 cM"
     gene            1..4624
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /note="a disintegrin and metallopeptidase domain 10"
                     /db_xref="GeneID:11487"
                     /db_xref="MGI:MGI:109548"
     exon            1..278
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            279..429
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            430..548
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            549..707
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            708..808
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            809..961
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1054
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1238
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1402
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1586
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1737
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1921
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2030
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2251
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2378
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     exon            2379..4608
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4589..4594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /note="hexamer: AATAGA"
     polyA_site      4608
                     /gene="Adam10"
                     /gene_synonym="1700031C13Rik; kuz; kuzbanian; MADM"
                     /note="major polyA site"
ORIGIN      
        1 gagggcaggg aagcggggaa gggaggaagg aagaggccga gggggaggga gggccctgtt
       61 ttggcggagc agggcgcgcg gctgggcccc tgaagtggag cgagagggag gcgcttcgcc
      121 gggtgccact gccggggagg ctcgtcggga cccagcgccg gtcgcggctc cctcaggatc
      181 gatgcaccgc ggttaacccg tgaggaggcg gcggccgggg aagatggtgt tgccgacagt
      241 gttaattctg ctcctctcct gggcggcggg gctgggaggt cagtatggaa atcctttaaa
      301 taaatatatt agacattatg aaggattatc ttacaatgtg gattcattac accaaaaaca
      361 ccagcgtgcc aaacgagcag tctcacatga ggaccagttt ttacttctag atttccatgc
      421 tcatggaaga cagttcaacc tacgaatgaa gagggacact tcccttttta gtgatgaatt
      481 taaagtagaa acatcaaata aagtacttga ttatgatacc tctcatattt acactggaca
      541 tatttatggt gaagaaggaa gctttagtca tgggtctgtc attgatggaa gatttgaagg
      601 tttcatcaag actcgtggtg gcacgtttta cattgagcca gcagagagat acattaaaga
      661 tcgaatcctg ccatttcact ctgtcattta tcatgaagat gatattaact atccccataa
      721 atacggccca caggggggct gtgcagatca ctccgttttt gaaaggatga ggaagtacca
      781 aatgactgga gtagaggaag gagcccgggc acatccagag aagcatgctg ctagtagtgg
      841 tcctgagctc ctgaggaaaa aacgcacaac tctggctgaa agaaatactt gtcagctcta
      901 tatccagaca gatcacctgt tctttaaata ctatggaaca cgagaagctg tgattgctca
      961 gatatccagt catgttaaag caattgatac aatttaccag actacagact tctccggaat
     1021 ccgtaacatc agcttcatgg tgaaacgcat aagaatcaat acaacctctg atgaaaaaga
     1081 ccctacaaat cctttccgtt tcccaaatat tggtgtggag aagttcctgg agttgaattc
     1141 tgagcagaat catgatgact actgcctggc ctatgtcttc acagaccggg attttgatga
     1201 tggtgttctt ggtctggcct gggttggagc accttcagga agctctgggg gaatatgtga
     1261 gaaaagcaag ttgtattcag atggcaagaa gaagtcattg aacacaggca tcattactgt
     1321 tcagaactat ggctcccatg tgcctcccaa agtctctcat attacgtttg ctcatgaagt
     1381 tggacataac tttggatctc cacatgattc tggaacagag tgtactccag gagagtctaa
     1441 gaacttagga caaaaagaaa atggcaatta catcatgtat gcaagagcaa catctgggga
     1501 caaacttaac aacaacaaat tttcactctg cagcattaga aacataagcc aagtgcttga
     1561 gaagaagagg aacaactgtt ttgttgaatc tggccagcct atctgtggaa acgggatggt
     1621 ggaacaaggg gaagagtgtg actgtggcta cagtgaccag tgcaaagatg attgctgctt
     1681 cgatgccaac cagccagagg ggaagaaatg caagctgaag cctgggaagc agtgcagtcc
     1741 gagtcaagga ccctgctgta cagcacagtg tgcattcaag tcaaagtctg aaaagtgccg
     1801 ggatgattct gactgtgcaa aggaagggat atgcaatggc ttcacagccc tttgcccagc
     1861 atctgatccc aagcccaact ttacagactg taacaggcac acacaagtgt gcattaatgg
     1921 gcaatgtgca ggttctattt gtgaaaagta tgacttggag gagtgcacct gtgccagctc
     1981 tgatggcaaa gatgataagg aattatgcca tgtttgctgc atgaagaaaa tggctccatc
     2041 aacttgtgcc agtacaggct ctttgcagtg gagcaagcag ttcagtggtc ggactatcac
     2101 tctgcagccg ggctctccat gtaatgactt cagaggctac tgtgatgttt tcatgcggtg
     2161 cagattagta gatgctgatg gccctctagc taggctgaaa aaagccattt ttagtccaca
     2221 actctatgaa aacattgctg agtggattgt ggctcactgg tgggcagtac tgcttatggg
     2281 aattgccctg atcatgttaa tggctggatt tatcaagatt tgcagtgttc acactccaag
     2341 tagtaatcca aagttgccgc ctcctaaacc acttccaggc actttaaaga ggaggagacc
     2401 gccacagccc attcagcagc ccccgcgtca gaggccccga gagagttatc aaatgggaca
     2461 catgcgacgc taatgcagct tttgccttgg ttcttcctag tgcctacagt gggaaaactt
     2521 cactccaaag agaaacctgt taagtcatca tctgcaaatg atacccttac agttaatagt
     2581 tgaagaaaaa tggcaagaga tcatgtcctc agatcaggtg gaattactca aaatttaaag
     2641 cctgaaaatt ccaattttgg gggtgggggt gggatggaaa aggaacccaa ttttcttatg
     2701 aacagatatt tttaacctaa tggcacaaag tcttagaata ttattatgtg ccccatgttc
     2761 cctgttcttc gttgctgcat tttcttcact tgcagacaga cttggctctc gataaacttt
     2821 tatcacaaat tgaaatatat ttttttcaac tgccaatcaa ggctgggagg ctcgaccacc
     2881 tcaacattgg atacatcact tgccaatgta cataccttgt tatatgcaga catgtatttc
     2941 ttacgtacac tgtacttctc tgtgcaattg taaacagaaa ttgcaatatg gatgtttctt
     3001 tgtattataa atttttccgc tcttaatgaa aaattactgt ttaattgaca tactcaggat
     3061 aacagagaat ggtggtgtgc agtggtccag gattctgtaa tgctttatgc aggcagtttt
     3121 gaaatgagaa tcattttccc ttttcttatg gtggagttgg ttcttacata catttttttc
     3181 cttgttacat ggctgctgtg agcaggagag gctgtgctga agaacgcagc tgatggcttg
     3241 caaactggac agcaacagca tttggcttca gagtcagctc tttttgtaga tgtctgattt
     3301 ctgcttagta ttttatactt tctaaatcaa ttccattttt aaattgctag gtgaattttt
     3361 tcatgccttg gaattatgtt ggaaatgatt aattttcatc tgtagcctgc ttattacttt
     3421 gtgtattcca tatacttcaa gcctgctaat tctgttttta tccaatatga aaaagaaaat
     3481 cagtgtcttc attgaaatac ttggacagtt agttcttcag cactgtcact gatcactggt
     3541 aaccactaga gatgggtgat ttgctcagca ggtagttgaa attgtagata ggtttttcga
     3601 cgttgttttc cccccaacat tttagcaaca atgaaggtag acagcacagt gtcccattac
     3661 aaacttcttt tttaagcaga taaaatattg gcttttttaa agaaagagaa agcaaaagca
     3721 tttaatgtat taacaggctt atcgctatgc agaaaatgga gggggcatta aaaaatgtaa
     3781 gcttgtgaca tattcattgc ttctgttttc cagctacatc acttaaatta gaagtcagca
     3841 gcagtgatct tcctggcttt acataggagg caatctagag aaggttgaca agattactgt
     3901 gtttggcttt tttttttttt tccttttttc ttaagagtct aaggtttaca caatcactca
     3961 caatgtgacg cgagccagca aggccaaaac cgctagagaa acaatgggat ctctccttgt
     4021 aaacttgtac agtacgcggg acttttttca aaacagcttt ttgtacatga tttagagaca
     4081 aattttgtac atgaaacccc agatagacta taaataattc taacccaaca agtaggtagc
     4141 tgtgtatgac actgctttaa atcattcaaa tgcctttgtt tttggactgt gcaaaggttg
     4201 gaagtggatt tgcatttcta aaatggtgac ttttattctg caagagttct tagtaacttc
     4261 ttgagtgtgg tagactttgg aacatgtaca ttttttgctt gtaatgttat cctgtggtag
     4321 ggttttgccc tattttattt tgagtctaag ttaaatgttt tctgaagaga tacatgcact
     4381 gaactgtttc cactacaaat caagatgtgg ttaaaaaatg aaaggaccag gaccagtgag
     4441 atctaatact actgtcagtt taatgtccac tgtgttttat acagtatctt ttttttgttg
     4501 ttcactttgg aaatttttac taaaacctgc aaaaaataaa gtattgtgca aagatgtaag
     4561 gttttttgaa acttgaaatg cattaataaa tagacttgat gaaatcaaaa aaaaaaaaaa
     4621 aaaa
//
