LOCUS       NM_029475               2367 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus adenosine deaminase-like (Adal), transcript variant 1,
            mRNA.
ACCESSION   NM_029475 XM_001003523 XM_485055 XM_900839 XM_900849 XM_900856
            XM_900859 XM_900862 XM_917792 XM_925262 XM_925265 XM_925269
            XM_925272 XM_925275 XM_986097 XM_986134 XM_986169 XM_986201
            XM_986236 XM_986298
VERSION     NM_029475.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2367)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2367)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2367)
  AUTHORS   Lesscher,H.M.B., Bailey,A. and Vanderschuren,L.J.M.J.
  TITLE     Genetic Variability in Adenosine Deaminase-Like Contributes to
            Variation in Alcohol Preference in Mice
  JOURNAL   Alcohol Clin Exp Res 41 (7), 1271-1279 (2017)
   PUBMED   28449374
  REMARK    GeneRIF: genetically protective factor against alcohol consumption
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK048809.1, BC050879.1 and AK049697.1.
            
            On Mar 20, 2014 this sequence version replaced NM_029475.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a). The 5' UTR of this variant is incomplete due to lack of a
            complete transcript and splice pattern ambiguity in the upstream
            region.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050879.1, SRR1660817.85134.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AK048809.1         241-288
            49-2365             BC050879.1         1-2317
            2366-2367           AK049697.1         2467-2468
FEATURES             Location/Qualifiers
     source          1..2367
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.37 cM"
     gene            1..2367
                     /gene="Adal"
                     /gene_synonym="4930578F03Rik; Mapda"
                     /note="adenosine deaminase-like"
                     /db_xref="GeneID:75894"
                     /db_xref="MGI:MGI:1923144"
     exon            1..211
                     /gene="Adal"
                     /gene_synonym="4930578F03Rik; Mapda"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1234
                     /gene="Adal"
                     /gene_synonym="4930578F03Rik; Mapda"
                     /EC_number="3.5.4.-"
                     /note="isoform a is encoded by transcript variant 1;
                     adenosine deaminase-like protein; N6-Methyl-AMP deaminase"
                     /codon_start=1
                     /product="N6-Methyl-AMP deaminase isoform a"
                     /protein_id="NP_083751.1"
                     /db_xref="CCDS:CCDS16633.1"
                     /db_xref="GeneID:75894"
                     /db_xref="MGI:MGI:1923144"
                     /translation="MEAGQQWPGKTDFYLQLPKVELHAHLNGSISSSTMKKLIAKKPH
                     LNVHGHMTMIDKGKKRTLQECFQMFQVIHQLTTSAEDILMVTKDVIKEFADDGVKYLE
                     LRSTPREENATGMTRKTYVESVLEGIKQCKQENLDIDVRYLMAIDRRGGPTIARETVE
                     LAKEFFLSTENTVLGLDLSGDPTIGQANDFLEPLLEAKKAGLKLALHLAEIPNREKEN
                     QMLLSLLPDRIGHGTFLSASEAGALDQVDFVRQHQIPLELCLTSNIKSQTVPSYDQHH
                     FGFWYSIAHPSVICTDDKGVFATYLSQEYQLAAETFNLTPFQVWDLSYESINYIFACD
                     NTRSELRKRWTHLKQKVLNCNEVNYF"
     exon            212..342
                     /gene="Adal"
                     /gene_synonym="4930578F03Rik; Mapda"
                     /inference="alignment:Splign:2.1.0"
     exon            343..403
                     /gene="Adal"
                     /gene_synonym="4930578F03Rik; Mapda"
                     /inference="alignment:Splign:2.1.0"
     exon            404..491
                     /gene="Adal"
                     /gene_synonym="4930578F03Rik; Mapda"
                     /inference="alignment:Splign:2.1.0"
     exon            492..573
                     /gene="Adal"
                     /gene_synonym="4930578F03Rik; Mapda"
                     /inference="alignment:Splign:2.1.0"
     exon            574..700
                     /gene="Adal"
                     /gene_synonym="4930578F03Rik; Mapda"
                     /inference="alignment:Splign:2.1.0"
     exon            701..781
                     /gene="Adal"
                     /gene_synonym="4930578F03Rik; Mapda"
                     /inference="alignment:Splign:2.1.0"
     exon            782..920
                     /gene="Adal"
                     /gene_synonym="4930578F03Rik; Mapda"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1021
                     /gene="Adal"
                     /gene_synonym="4930578F03Rik; Mapda"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..2367
                     /gene="Adal"
                     /gene_synonym="4930578F03Rik; Mapda"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2344..2349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adal"
                     /gene_synonym="4930578F03Rik; Mapda"
                     /note="hexamer: ATTAAA"
     polyA_site      2365
                     /gene="Adal"
                     /gene_synonym="4930578F03Rik; Mapda"
                     /note="major polyA site"
ORIGIN      
        1 gtgaaagtga tcccagagcc acacatagtg caagtcttgt ttaaaatggc aatctgaagg
       61 aagtccagca cctcagagat tcccactttg ataagtttat cgtccaagcc gagaataaga
      121 gcaaagagaa acttttcctt ctactgaagt gatggaggcc ggacagcagt ggcctgggaa
      181 gacagacttt tatctgcaat taccaaaagt ggagctccat gcccacttga atggctccat
      241 tagttccagt accatgaaga aactgatagc caagaagcca catcttaacg ttcatggtca
      301 catgaccatg attgacaagg ggaagaaaag gactttacaa gaatgtttcc agatgttcca
      361 agttatacat cagcttacta ctagtgctga ggacatcctg atggtcacaa aagacgtcat
      421 taaggaattt gcagatgatg gtgtcaagta cctggagctg aggagcactc ccagagaaga
      481 aaatgctact ggaatgacta ggaagactta cgtggaatcc gtccttgaag gcataaaaca
      541 atgcaaacag gaaaacttag atattgatgt taggtatttg atggcaattg acagaagagg
      601 tggcccaaca atagccaggg agactgtcga acttgctaaa gagttcttcc tctctactga
      661 gaatacagtt cttggccttg acctcagtgg agatccaact ataggacaag ctaacgactt
      721 cttggagcct cttttagaag ctaaaaaagc aggtctgaag ttggcattgc atcttgccga
      781 gattccaaac agggaaaaag aaaatcagat gctgctgagt ctgctccctg acagaattgg
      841 gcatgggaca ttccttagcg cctctgaggc aggggccctg gaccaagtgg acttcgtgag
      901 gcaacaccag atacccctcg aactttgttt gacctcaaac atcaaaagcc agacagtccc
      961 ttcttatgat cagcatcact ttggattttg gtacagcatt gctcatcctt ctgtgatctg
     1021 tactgatgat aaaggtgttt ttgcgacata cctttctcaa gaatatcaac tggcagcaga
     1081 aacatttaat ttgaccccat ttcaggtgtg ggatctgtcc tatgaatcca tcaactacat
     1141 ctttgcttgt gacaacacca gatctgaact gagaaaaagg tggactcact tgaagcagaa
     1201 agtgttaaac tgtaatgagg tgaactactt ttgattatac attgtagcca agatcttcct
     1261 gccctgtgta tcctactcag ttactgccca cttgaaatga cttcccttga atttgggtag
     1321 ccaagtatat atggggtcta actccagccc cttcaactgg taagttcgag gttttgcatg
     1381 gctgcacttc catgctgctt ttgctggagg gttgtttagc cctcatttcc tagtgactct
     1441 tgtttttaca cttagtgctc tttagacatt tgtgaccgtg aaccttctga gaagttgaaa
     1501 ctctttgtct tcagggaaat ctctgttttg ttaggtttaa tcagactcct tccacttcct
     1561 tttacccttt caagtattaa cttttttaga ctgttgatgt taggtcacag tgcacacctg
     1621 aactgtttgt gtgggtgcct agttgtcagg tgactgtagt aacaaagcta gaatctggct
     1681 ttgcccttct cctaatatct ttagaaatat ataacggggg ttggagtaat cccttcagtt
     1741 taagaaaaga aaagaacgac tggcttgaag taaaaaagac acatagctgg agcttctgat
     1801 ttaaaatcag gttctatttg gcttccttgt ggaagctacc aggacctcta cagtgctagg
     1861 actctcttaa aagatctttg tagcaatggt agcattgtgg cttctagggt tcttagatca
     1921 ccaataatcc catgcccaca tgatagccta caggtataga cttatataaa cacacatata
     1981 ccatggccac attagccgac tttagcagat aacaaatgtc ttggttggtt tttttcacaa
     2041 gctagagtca tttgggaaga gggaccctca actgagaaaa tattcccaca agattggccc
     2101 aatcagtgct tgatcagtta gtgggcccat gccacagagg gtgataccac ccttagggac
     2161 atggttctgg gtggaaagca aaggaaatgg aacaaggcac gaggagcaag ccataggcaa
     2221 cactcctcca tggcttcagc tttagttcct gcctcaactt cccaggatga cagactacaa
     2281 attataagag gaaataaccc tttcctcctt acattacatt tggttatggt gttttgtcac
     2341 agcattaaaa acactaaaac aataatg
//
