LOCUS       NM_029428               1962 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus adenosine deaminase domain containing 2 (Adad2), mRNA.
ACCESSION   NM_029428 XM_001481313 XM_486166 XM_915766
VERSION     NM_029428.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1962)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1962)
  AUTHORS   Chukrallah,L.G., Potgieter,S., Chueh,L. and Snyder,E.M.
  TITLE     Two RNA binding proteins, ADAD2 and RNF17, interact to form a
            heterogeneous population of novel meiotic germ cell granules with
            developmentally dependent organelle association
  JOURNAL   PLoS Genet 19 (7), e1010519 (2023)
   PUBMED   37428816
  REMARK    GeneRIF: Two RNA binding proteins, ADAD2 and RNF17, interact to
            form a heterogeneous population of novel meiotic germ cell granules
            with developmentally dependent organelle association.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1962)
  AUTHORS   Xiong,M., Yin,L., Gui,Y., Lv,C., Ma,X., Guo,S., Wu,Y., Feng,S.,
            Fan,X., Zhou,S., Wang,L., Wen,Y., Wang,X., Xie,Q., Namekawa,S.H.
            and Yuan,S.
  TITLE     ADAD2 interacts with RNF17 in P-bodies to repress the Ping-pong
            cycle in pachytene piRNA biogenesis
  JOURNAL   J Cell Biol 222 (5) (2023)
   PUBMED   36930220
REFERENCE   4  (bases 1 to 1962)
  AUTHORS   Lu,Y., Nagamori,I., Kobayashi,H., Kojima-Kita,K., Shirane,K.,
            Chang,H.Y., Nishimura,T., Koyano,T., Yu,Z., Castaneda,J.M.,
            Matsuyama,M., Kuramochi-Miyagawa,S., Matzuk,M.M. and Ikawa,M.
  TITLE     ADAD2 functions in spermiogenesis and piRNA biogenesis in mice
  JOURNAL   Andrology 11 (4), 698-709 (2023)
   PUBMED   36698249
  REMARK    GeneRIF: ADAD2 functions in spermiogenesis and piRNA biogenesis in
            mice.
REFERENCE   5  (bases 1 to 1962)
  AUTHORS   Snyder,E., Chukrallah,L., Seltzer,K., Goodwin,L. and Braun,R.E.
  TITLE     ADAD1 and ADAD2, testis-specific adenosine deaminase
            domain-containing proteins, are required for male fertility
  JOURNAL   Sci Rep 10 (1), 11536 (2020)
   PUBMED   32665638
  REMARK    GeneRIF: ADAD1 and ADAD2, testis-specific adenosine deaminase
            domain-containing proteins, are required for male fertility.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1962)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1962)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104882.30.
            
            On Mar 7, 2019 this sequence version replaced NM_029428.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137980.1, AK015063.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-420               AC104882.30        105899-106318
            421-561             AC104882.30        107281-107421
            562-609             AC104882.30        107930-107977
            610-735             AC104882.30        108089-108214
            736-886             AC104882.30        108298-108448
            887-1054            AC104882.30        108526-108693
            1055-1284           AC104882.30        108797-109026
            1285-1528           AC104882.30        109119-109362
            1529-1649           AC104882.30        109595-109715
            1650-1962           AC104882.30        109800-110112
FEATURES             Location/Qualifiers
     source          1..1962
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 68.05 cM"
     gene            1..1962
                     /gene="Adad2"
                     /gene_synonym="4930403J07Rik"
                     /note="adenosine deaminase domain containing 2"
                     /db_xref="GeneID:75773"
                     /db_xref="MGI:MGI:1923023"
     exon            1..420
                     /gene="Adad2"
                     /gene_synonym="4930403J07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1754
                     /gene="Adad2"
                     /gene_synonym="4930403J07Rik"
                     /codon_start=1
                     /product="adenosine deaminase domain-containing protein 2"
                     /protein_id="NP_083704.1"
                     /db_xref="CCDS:CCDS52683.1"
                     /db_xref="GeneID:75773"
                     /db_xref="MGI:MGI:1923023"
                     /translation="MASVDEGGRRRPRLAASLQISPGPWKPSGGQEPTEAGDAAPRTA
                     EHGVAGAQEAHREACKALGGSVLSPGPAGDFPGALHGLSMLPKDPPPAQAVALLTQCM
                     ANLGVSLTFLEDQTAGPGSSFSVCADLDGLVCPAGTGSSKLEAKQQAALSALQYIQKQ
                     LERPEPLVTPRQPLLTSLSIETILTHEQRCAAVVSAGLDRLLSESSPYQACKGTVAAV
                     ILEREVQGSIGHSKETYELVALGTGSSSCAGWLEFSGRRLHDCHGLVIARRALLRFFF
                     RQLLLVTQGGPKGQERSVLTPQPGPGPPFALKPGVFLHLYVSNTPKGAAHDIYLPLAS
                     EDSVLHSPAFRLQAHVCGQLKPVSYVAPALRDTHVGCLSASDKLARWAILGLGGGLLA
                     HFLPPLYATSLVLADPCHDPSTLNRVIHSRPRLDSVLGSCLPCPYVRTTLHLFAGPLV
                     APSDPGPSTCHSLSLNWSLGDPDIEVVDVATGRVKTDSSVGPPSRLCKAAFLSAFRQV
                     ARALEKPQLLSLQTYEAAKAVPYREARQQLSLLLDQQGLGAWPSKPLVGKFRH"
     exon            421..561
                     /gene="Adad2"
                     /gene_synonym="4930403J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            562..609
                     /gene="Adad2"
                     /gene_synonym="4930403J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            610..735
                     /gene="Adad2"
                     /gene_synonym="4930403J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            736..886
                     /gene="Adad2"
                     /gene_synonym="4930403J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1054
                     /gene="Adad2"
                     /gene_synonym="4930403J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1284
                     /gene="Adad2"
                     /gene_synonym="4930403J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1528
                     /gene="Adad2"
                     /gene_synonym="4930403J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1649
                     /gene="Adad2"
                     /gene_synonym="4930403J07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1962
                     /gene="Adad2"
                     /gene_synonym="4930403J07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1944..1949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adad2"
                     /gene_synonym="4930403J07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1962
                     /gene="Adad2"
                     /gene_synonym="4930403J07Rik"
                     /note="major polyA site"
ORIGIN      
        1 atagttagct ccgtcccacg cacgtgctcc acgtgaaaaa gagcgcgggg acgagacctg
       61 gtgcagccat ggcgagtgtg gacgagggtg ggcgcaggag acctcgactg gcagcgtcgc
      121 tgcagatcag ccccgggcct tggaagccct caggagggca ggagcccacg gaggctgggg
      181 atgcggcccc taggaccgct gagcatgggg tggctggggc acaagaggcc cacagggagg
      241 cctgcaaggc cctggggggc tcagttctga gcccggggcc tgcgggcgac ttccccgggg
      301 ccctccatgg gctcagcatg ctgcccaagg acccaccccc ggcccaagcc gtggccctgc
      361 tcacccagtg catggctaac ctgggtgtct ctctcacctt tttggaggac cagactgcag
      421 gtcctggctc ctccttctct gtgtgtgcag acctggatgg gttggtctgt cctgcgggga
      481 cagggagcag caagctggaa gccaaacagc aggcagcgct ctctgccctt cagtacatcc
      541 agaagcagct ggagagacca gagcccctgg tgactccccg ccagcctctg ctcacctctc
      601 tcagcataga gactatcctg acccacgagc agcgctgtgc agccgtggtc agtgccggct
      661 tggaccgact cctgagtgag agctcaccgt accaggcctg taaggggacg gtggctgcag
      721 tcatcctgga gagagaggtc caaggcagca ttggccactc caaagagacc tatgagctgg
      781 tggcactagg cacaggcagc agcagctgcg ccggctggct ggagttctca ggccgtcggc
      841 tccacgactg ccatggtctg gtcatcgccc gcagggccct gctgaggttc ttcttccggc
      901 agctcctact ggtcacacag gggggtccca agggccagga gcggtcagtg ctgacccccc
      961 agcccgggcc tgggcccccc ttcgcactca agcctggggt cttcctgcac ctgtatgtga
     1021 gcaacacccc caagggggca gcccatgaca tctatctccc actggcctca gaagacagcg
     1081 tcctgcacag cccagccttc cgcctacagg cccatgtgtg tggacagctg aagcctgtat
     1141 cctatgtggc gcctgccctc cgagataccc acgtgggctg cctctcagcc agcgacaagc
     1201 tggcccgttg ggccatcctt gggctgggag gtgggctgct agcccacttc ctgccgccac
     1261 tctacgccac cagccttgtt ctagctgatc cctgccacga cccctcaact ctgaaccggg
     1321 tcattcattc ccggcctaga ctagacagtg tcttgggatc gtgtcttcca tgtccctatg
     1381 tccgcaccac cttgcacctg tttgctgggc ctctggtcgc cccctctgac cccgggccca
     1441 gcacctgcca cagcctgagc ctcaactgga gcctggggga ccctgacatc gaagttgttg
     1501 atgtggccac cggacgtgtg aagactgact ccagcgttgg gcccccctcc cgtctctgca
     1561 aagccgcctt cctctcagca ttccgccagg ttgccagagc tctggagaag ccccagcttc
     1621 tatctctgca gacctatgag gctgccaagg ctgtccccta cagggaagct cgccagcagc
     1681 tctctctcct cctggaccag cagggcctgg gggcctggcc ctcaaagcca ttggtgggta
     1741 aattcagaca ctgatccaga cttcaaggga caaggaccct agtggagttg aacctcaaca
     1801 gcggaagaac atactgggag cagactgggg tggagtaggg tgggggaaga gcataccggg
     1861 tgagggtggg actagaactg gggcctgggg agtcctgtga cacctaactg ctgaggagta
     1921 gaggggcttg tatgtctagt tttaataaag aaattgtctc ta
//
