LOCUS       NM_009350               1972 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus adenosine deaminase domain containing 1 (Adad1), mRNA.
ACCESSION   NM_009350 XM_203180
VERSION     NM_009350.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1972)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1972)
  AUTHORS   Potgieter,S., Eddy,C., Badrinath,A., Chukrallah,L., Lo,T.,
            Mohanty,G., Visconti,P.E. and Snyder,E.M.
  TITLE     ADAD1 is required for normal translation of nuclear pore and
            transport protein transcripts in spermatids of Mus musculusdagger
  JOURNAL   Biol Reprod 109 (3), 340-355 (2023)
   PUBMED   37399121
  REMARK    GeneRIF: ADAD1 is required for normal translation of nuclear pore
            and transport protein transcripts in spermatids of Mus
            musculusdagger.
REFERENCE   3  (bases 1 to 1972)
  AUTHORS   Lu,Y., Nagamori,I., Kobayashi,H., Kojima-Kita,K., Shirane,K.,
            Chang,H.Y., Nishimura,T., Koyano,T., Yu,Z., Castaneda,J.M.,
            Matsuyama,M., Kuramochi-Miyagawa,S., Matzuk,M.M. and Ikawa,M.
  TITLE     ADAD2 functions in spermiogenesis and piRNA biogenesis in mice
  JOURNAL   Andrology 11 (4), 698-709 (2023)
   PUBMED   36698249
REFERENCE   4  (bases 1 to 1972)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   5  (bases 1 to 1972)
  AUTHORS   Snyder,E., Chukrallah,L., Seltzer,K., Goodwin,L. and Braun,R.E.
  TITLE     ADAD1 and ADAD2, testis-specific adenosine deaminase
            domain-containing proteins, are required for male fertility
  JOURNAL   Sci Rep 10 (1), 11536 (2020)
   PUBMED   32665638
  REMARK    GeneRIF: ADAD1 and ADAD2, testis-specific adenosine deaminase
            domain-containing proteins, are required for male fertility.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1972)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1972)
  AUTHORS   Connolly,C.M., Dearth,A.T. and Braun,R.E.
  TITLE     Disruption of murine Tenr results in teratospermia and male
            infertility
  JOURNAL   Dev Biol 278 (1), 13-21 (2005)
   PUBMED   15649457
  REMARK    GeneRIF: Targeted mutation of the Tenr gene causes male sterility.
            Tenr mutant males have a reduced sperm count, and Tenr-/- sperm
            show a decrease in motility and an increase in malformed heads.
REFERENCE   8  (bases 1 to 1972)
  AUTHORS   Pascal,J.M., Hart,P.J., Hecht,N.B. and Robertus,J.D.
  TITLE     Crystal structure of TB-RBP, a novel RNA-binding and regulating
            protein
  JOURNAL   J Mol Biol 319 (5), 1049-1057 (2002)
   PUBMED   12079346
  REMARK    GeneRIF: 2.65 A crystal structure of mouse TB-RBP
REFERENCE   9  (bases 1 to 1972)
  AUTHORS   Lyons,P.A., Armitage,N., Argentina,F., Denny,P., Hill,N.J.,
            Lord,C.J., Wilusz,M.B., Peterson,L.B., Wicker,L.S. and Todd,J.A.
  TITLE     Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb
            region of mouse chromosome 3: identification of a candidate segment
            of ancestral DNA by haplotype mapping
  JOURNAL   Genome Res 10 (4), 446-453 (2000)
   PUBMED   10779485
REFERENCE   10 (bases 1 to 1972)
  AUTHORS   Schumacher,J.M., Lee,K., Edelhoff,S. and Braun,R.E.
  TITLE     Distribution of Tenr, an RNA-binding protein, in a lattice-like
            network within the spermatid nucleus in the mouse
  JOURNAL   Biol Reprod 52 (6), 1274-1283 (1995)
   PUBMED   7543294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662823.12.
            
            On Jul 26, 2007 this sequence version replaced NM_009350.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X84693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               AL662823.12        35023-35207
            186-365             AL662823.12        35548-35727
            366-554             AL662823.12        36437-36625
            555-722             AL662823.12        38542-38709
            723-791             AL662823.12        41324-41392
            792-917             AL662823.12        47981-48106
            918-1041            AL662823.12        51155-51278
            1042-1212           AL662823.12        54550-54720
            1213-1442           AL662823.12        56295-56524
            1443-1680           AL662823.12        63227-63464
            1681-1813           AL662823.12        77499-77631
            1814-1972           AL662823.12        82721-82879
FEATURES             Location/Qualifiers
     source          1..1972
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 18.3 cM"
     gene            1..1972
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /note="adenosine deaminase domain containing 1"
                     /db_xref="GeneID:21744"
                     /db_xref="MGI:MGI:103258"
     exon            1..185
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1927
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /note="testis nuclear RNA binding protein; adenosine
                     deaminase domain containing 1 (testis specific)"
                     /codon_start=1
                     /product="adenosine deaminase domain-containing protein 1"
                     /protein_id="NP_033376.2"
                     /db_xref="CCDS:CCDS17315.1"
                     /db_xref="GeneID:21744"
                     /db_xref="MGI:MGI:103258"
                     /translation="MATAGGSRRAPVPGPRLGLPLAAHLPASLGGEGAKDSVGGEKTS
                     GNNDWFQSSRVPSFAQMLKKNLPVQPSAQTVTLPTGYSSESCSLSNMASKVTQVTGNF
                     PEPLLSKGLSSISNPVLPPKKLPKEFIMKYKRGEINPVSALHQFAQMQRVQLDLKETV
                     TTGNVMGPYFAFCAVVDGIQYKTGLGQNKKESRSNAAKLALDELLQLDEPEPRVLEPA
                     GPPPIPAEPVVTPEAAYVSKVQYEGRQVQYAKISQLVKETFGQLISNHSQYLKCSSSL
                     AAFIIERAGHHEVVAIGTGEYNYSQCIKPNGRVLHDTHAVVTARRSLLRYFYRQLLLF
                     YSKNPAMMEKSIFCTEPASNLLTLKQNINLYLYMNQLPKGSAQIKSQLRLNPHSISAF
                     EANEELSLHVAVEGKIYLTVYCSADGVNRVNSMSSSDKLTRWEVLGVQGALLSHFIQP
                     VYISSILVGDGNCNDTRGLEIAINQRVDDALTSKLPMFYLVNRPHISLVPTAYPLQIN
                     LDHKSLSLNWAQGDNSLEIVDGLNGKITESSPFKSGLSMASRLCKAAMLSRFNLLAKE
                     AKTDDLLEARTYHAAKCMSGPYQEAKALLKAYLQQHGYGSWIVKSPCIEQFSM"
     exon            186..365
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /inference="alignment:Splign:2.1.0"
     exon            366..554
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /inference="alignment:Splign:2.1.0"
     exon            555..722
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /inference="alignment:Splign:2.1.0"
     exon            723..791
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /inference="alignment:Splign:2.1.0"
     exon            792..917
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1041
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1212
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1442
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1680
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1813
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1972
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1947..1952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /note="hexamer: ATTAAA"
     polyA_site      1972
                     /gene="Adad1"
                     /gene_synonym="Tenr"
                     /note="major polyA site"
ORIGIN      
        1 gaaagacgcg actgaccgcg tggcccgcag aggtctgagg cgagaggtcg acggtggcag
       61 cgcagcaatg gcgaccgcgg gcggcagccg acgagccccg gtcccgggcc ctcggctcgg
      121 cctgcctctg gcagctcacc tgccggcgag cctgggcggg gagggcgcga aggacagcgt
      181 cgggggagag aaaacttctg gaaacaatga ctggtttcag agttccaggg ttcccagctt
      241 tgctcagatg ctgaaaaaga atttgccagt tcagccatca gctcagacag taactttgcc
      301 cactggatat tcctctgaaa gttgtagtct gtcgaatatg gcatccaagg ttacgcaagt
      361 gacaggtaat tttccagagc cattgctttc caaaggtctt tcatctattt caaatcctgt
      421 ccttcctcca aaaaaactac ctaaagagtt tataatgaaa tacaaacgtg gagagatcaa
      481 tcccgtgtcg gccttgcacc agtttgcaca aatgcagcgt gttcagcttg accttaagga
      541 aactgtaaca acaggaaatg ttatgggacc atattttgct ttttgtgctg tggtggatgg
      601 tattcagtac aagacaggac tgggacagaa taaaaaggaa tcaagatcca atgcagcaaa
      661 gttagctctt gacgagcttc tacaactgga tgagcctgaa ccgagagttt tagaaccagc
      721 aggaccacct cctatccctg cagaacctgt tgttacacct gaagcagcat atgtttcaaa
      781 agtgcaatat gaagggagac aagtccagta tgccaagatt tcacagcttg ttaaagaaac
      841 atttggtcaa ctaatttcta atcactcaca atatctgaaa tgtagcagtt cattggctgc
      901 tttcattatt gaaagagctg gacatcatga agttgtggct ataggcacag gcgaatacaa
      961 ctacagccag tgcatcaagc caaatggaag ggtgctgcac gatactcatg cagttgttac
     1021 agcaagaagg tctctcctta ggtactttta tagacagctt ctgctcttct atagcaaaaa
     1081 tcctgctatg atggaaaagt caatcttttg tacagaacca gcttctaatc tacttactct
     1141 gaaacaaaac atcaaccttt acctctatat gaaccagttg ccgaaaggat cagcccagat
     1201 taagtcacag ttacgcctta atccacattc tatttctgcg tttgaagcca atgaagagct
     1261 gagtctccat gtggctgttg aaggcaaaat ttatcttact gtttactgtt ctgcagacgg
     1321 ggttaataga gtaaacagta tgtcctcaag tgacaagctg acaagatggg aggtgcttgg
     1381 tgtacaggga gccttgctga gtcactttat acagccagtt tatatcagca gtatacttgt
     1441 tggtgatggg aattgcaatg acacaagagg cttagaaatc gcaataaacc agcgtgttga
     1501 tgacgcactc acatcaaaac tgcccatgtt ttacttggtc aacagacctc atattagctt
     1561 agtgcccacc gcatatcctc tgcagataaa cttggaccat aaatcactca gtttgaattg
     1621 ggcacaaggg gacaattctt tggagattgt ggatggccta aatgggaaga ttactgaaag
     1681 ttctccattt aaaagtggtt tatcaatggc aagtcggctt tgtaaggctg caatgttaag
     1741 tcgatttaat ctgcttgcca aggaagctaa aacagatgat ttacttgaag ctcggacata
     1801 ccacgcggct aagtgtatgt ctggacccta tcaagaagca aaggcgttac tgaaggccta
     1861 cttgcagcag catggctatg gctcctggat tgtgaaatct ccctgtatag agcaatttag
     1921 tatgtgaagt agacaacaca ttgcatatta aaaatccttt atttttggtg ta
//
