LOCUS       NM_025371               1459 bp    mRNA    linear   ROD 04-OCT-2024
DEFINITION  Mus musculus aminoacylase 1 (Acy1), transcript variant 1, mRNA.
ACCESSION   NM_025371
VERSION     NM_025371.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1459)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1459)
  AUTHORS   Benson,M.D., Eisman,A.S., Tahir,U.A., Katz,D.H., Deng,S., Ngo,D.,
            Robbins,J.M., Hofmann,A., Shi,X., Zheng,S., Keyes,M., Yu,Z.,
            Gao,Y., Farrell,L., Shen,D., Chen,Z.Z., Cruz,D.E., Sims,M.,
            Correa,A., Tracy,R.P., Durda,P., Taylor,K.D., Liu,Y., Johnson,W.C.,
            Guo,X., Yao,J., Chen,Y.I., Manichaikul,A.W., Jain,D., Yang,Q.,
            Bouchard,C., Sarzynski,M.A., Rich,S.S., Rotter,J.I., Wang,T.J.,
            Wilson,J.G., Clish,C.B., Sarkar,I.N., Natarajan,P. and
            Gerszten,R.E.
  CONSRTM   NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
  TITLE     Protein-metabolite association studies identify novel proteomic
            determinants of metabolite levels in human plasma
  JOURNAL   Cell Metab 35 (9), 1646-1660 (2023)
   PUBMED   37582364
REFERENCE   3  (bases 1 to 1459)
  AUTHORS   Wen,D., Zheng,Z., Surapaneni,A., Yu,B., Zhou,L., Zhou,W., Xie,D.,
            Shou,H., Avila-Pacheco,J., Kalim,S., He,J., Hsu,C.Y., Parsa,A.,
            Rao,P., Sondheimer,J., Townsend,R., Waikar,S.S., Rebholz,C.M.,
            Denburg,M.R., Kimmel,P.L., Vasan,R.S., Clish,C.B., Coresh,J.,
            Feldman,H.I., Grams,M.E. and Rhee,E.P.
  CONSRTM   CKD Biomarkers Consortium and CRIC Study Investigators
  TITLE     Metabolite profiling of CKD progression in the chronic renal
            insufficiency cohort study
  JOURNAL   JCI Insight 7 (20), e161696 (2022)
   PUBMED   36048534
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1459)
  AUTHORS   Lai,Q., Liu,F.M., Rao,W.L., Yuan,G.Y., Fan,Z.Y., Zhang,L., Fu,F.,
            Kou,J.P., Yu,B.Y. and Li,F.
  TITLE     Aminoacylase-1 plays a key role in myocardial fibrosis and the
            therapeutic effects of 20(S)-ginsenoside Rg3 in mouse heart failure
  JOURNAL   Acta Pharmacol Sin 43 (8), 2003-2015 (2022)
   PUBMED   34916608
  REMARK    GeneRIF: Aminoacylase-1 plays a key role in myocardial fibrosis and
            the therapeutic effects of 20(S)-ginsenoside Rg3 in mouse heart
            failure.
REFERENCE   5  (bases 1 to 1459)
  AUTHORS   Araujo,D.J., Anderson,A.G., Berto,S., Runnels,W., Harper,M.,
            Ammanuel,S., Rieger,M.A., Huang,H.C., Rajkovich,K., Loerwald,K.W.,
            Dekker,J.D., Tucker,H.O., Dougherty,J.D., Gibson,J.R. and
            Konopka,G.
  TITLE     FoxP1 orchestration of ASD-relevant signaling pathways in the
            striatum
  JOURNAL   Genes Dev 29 (20), 2081-2096 (2015)
   PUBMED   26494785
REFERENCE   6  (bases 1 to 1459)
  AUTHORS   Threadgill,D.S. and Womack,J.E.
  TITLE     Mapping HSA 3 loci in cattle: additional support for the ancestral
            synteny of HSA 3 and 21
  JOURNAL   Genomics 11 (4), 1143-1148 (1991)
   PUBMED   1783381
REFERENCE   7  (bases 1 to 1459)
  AUTHORS   Nadeau,J.H.
  TITLE     A chromosomal segment conserved since divergence of lineages
            leading to man and mouse: the gene order of aminoacylase-1,
            transferrin, and beta-galactosidase on mouse chromosome 9
  JOURNAL   Genet Res 48 (3), 175-178 (1986)
   PUBMED   3106151
  REMARK    Erratum:[Genet Res 1987 Aug;50(1):77]
REFERENCE   8  (bases 1 to 1459)
  AUTHORS   Womack,J.E. and Moll,Y.D.
  TITLE     Gene map of the cow: conservation of linkage with mouse and man
  JOURNAL   J Hered 77 (1), 2-7 (1986)
   PUBMED   3082971
REFERENCE   9  (bases 1 to 1459)
  AUTHORS   Antonucci,T.K., Von Deimling,O.H., Rosenblum,B.B., Skow,L.C. and
            Meisler,M.H.
  TITLE     Conserved linkage within a 4-cM region of mouse chromosome 9 and
            human chromosome 11
  JOURNAL   Genetics 107 (3), 463-475 (1984)
   PUBMED   6735174
REFERENCE   10 (bases 1 to 1459)
  AUTHORS   Naylor,S.L., Shows,T.B. and Klebe,R.J.
  TITLE     Bioautographic visualization of aminoacylase-1: assignment of the
            structural gene ACY-1 to chromosome 3 in man
  JOURNAL   Somatic Cell Genet 5 (1), 11-21 (1979)
   PUBMED   373141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK003703.1 and BX529990.1.
            
            On Feb 13, 2013 this sequence version replaced NM_025371.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005631.1, AK003703.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1431              AK003703.1         2-1432
            1432-1459           BX529990.1         396-423
FEATURES             Location/Qualifiers
     source          1..1459
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.49 cM"
     gene            1..1459
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /note="aminoacylase 1"
                     /db_xref="GeneID:109652"
                     /db_xref="MGI:MGI:87913"
     exon            1..104
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            105..213
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1346
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /EC_number="3.5.1.14"
                     /note="N-acyl-L-amino-acid amidohydrolase"
                     /codon_start=1
                     /product="aminoacylase-1"
                     /protein_id="NP_079647.1"
                     /db_xref="CCDS:CCDS23477.1"
                     /db_xref="GeneID:109652"
                     /db_xref="MGI:MGI:87913"
                     /translation="MTTKDPESEHPSVTLFRQYLRICTVQPNPDYGGAITFLEERARQ
                     LGLSCQKIEVVPGFVITVLTWPGTNPSLPSILLNSHTDVVPVFKEHWHHDPFEAFKDS
                     EGYIYARGSQDMKSVSIQYLEAVRRLKSEGHRFPRTIHMTFVPDEEVGGHKGMELFVK
                     RPEFQALRAGFVLDEGLANPTDAFTVFYSERSPWWVQVTSTGKPGHASRFIEDTAAEK
                     LHKVISSILAFREKERQRLQANPHLKEGAVTSVNLTKLEGGVAYNVVPATMSASFDFR
                     VAPDVDMKAFEKQLQRWCQEAGEGVTFEFAQKFTEPRMTPTDDSDPWWAAFSGACKAM
                     NLTLEPEIFPAATDSRFIRAVGIPALGFSPMNRTPVLLHDHNERLHEDIFLRGVDIYT
                     GLLSALASVPTLPSES"
     exon            214..278
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            279..383
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            384..478
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..555
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..645
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..702
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..776
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..826
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..971
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1040
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1120
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1181
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1446
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1415..1420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /note="hexamer: AATAAA"
     polyA_site      1437
                     /gene="Acy1"
                     /gene_synonym="1110014J22Rik; Acy-1"
                     /note="major polyA site"
ORIGIN      
        1 gggcggcccc gggcggtttt gagattggga gcgacctcgg tggaccctga gttccggcca
       61 cagtctgaga ggaaagcaca ggactgagac gtggagagag caagccagca cgcggcgcca
      121 tgaccaccaa ggatcccgag tctgagcacc cctccgtgac gctcttccgc cagtacctgc
      181 gcatctgcac tgtgcaaccc aatccagact atggaggggc catcaccttc ctggaggaga
      241 gagcccgcca gctgggtctg agctgtcaga aaatagaggt ggtgcctggc tttgtgatca
      301 ctgtgctgac ctggccaggc accaacccgt cactcccctc catcttgcta aactcccaca
      361 cagatgtggt acctgtcttc aaggaacatt ggcatcacga cccctttgag gccttcaagg
      421 attccgaggg ctacatctat gctaggggct cccaggacat gaagagtgtc agcatccagt
      481 acctggaagc tgtgaggagg ctgaagagcg agggccaccg attccctagg accatccaca
      541 tgacctttgt gcctgacgag gaggtcggag gtcacaaggg gatggagttg tttgtgaaga
      601 ggcctgagtt ccaggctctg cgggcaggct tcgttctgga cgagggcctg gccaacccca
      661 cggatgcctt tactgtcttt tatagtgagc ggagtccttg gtgggtacag gttaccagca
      721 ctgggaagcc aggccatgcc tcacgcttca ttgaggatac agctgcagag aagttgcata
      781 aggttataag ctccatcttg gcattccggg agaaggaaag gcagaggctg caggcgaacc
      841 ctcacctgaa ggaaggcgcc gtgacttcgg tgaatctgac caagcttgaa ggtggcgtgg
      901 cctataatgt ggtacctgcc actatgagtg ccagctttga cttccgagtg gcaccagatg
      961 tagacatgaa ggccttcgag aagcagctgc agagatggtg ccaggaagca ggagaggggg
     1021 tcacctttga gtttgctcag aagtttacag agcctcgaat gacacccacg gatgattcag
     1081 atccctggtg ggcagctttc agcggagcct gcaaggcaat gaacctcact ctggagccag
     1141 agatctttcc tgctgccact gacagccgct ttatccgggc ggtggggatc ccagctctgg
     1201 gcttctcgcc catgaaccgc acacctgtcc tgctacatga ccataatgaa cggctgcatg
     1261 aggatatatt tctccgtggg gttgacatat atacaggcct cctctctgca cttgctagtg
     1321 tgcccaccct gcctagtgaa agctgagccc cagggcttcc aactcttgta ctctcagtcc
     1381 taccactgcc aaggatctgt ttcccctgcc cagtaataaa gccagcattg gatgggatgt
     1441 tcttaaaaaa aaaaaaaaa
//
