LOCUS       NM_001277257            3602 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus activin A receptor, type II-like 1 (Acvrl1),
            transcript variant 3, mRNA.
ACCESSION   NM_001277257
VERSION     NM_001277257.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3602)
  AUTHORS   Bhave,S., Swain,L., Qiao,X., Martin,G., Aryaputra,T., Everett,K.
            and Kapur,N.K.
  TITLE     ALK1 Deficiency Impairs the Wound-Healing Process and Increases
            Mortality in Murine Model of Myocardial Infarction
  JOURNAL   J Cardiovasc Transl Res 17 (3), 496-504 (2024)
   PUBMED   38064044
  REMARK    GeneRIF: ALK1 Deficiency Impairs the Wound-Healing Process and
            Increases Mortality in Murine Model of Myocardial Infarction.
REFERENCE   2  (bases 1 to 3602)
  AUTHORS   Chen,J., Zhang,X., DeLaughter,D.M., Trembley,M.A., Saifee,S.,
            Xiao,F., Chen,J., Zhou,P., Seidman,C.E., Seidman,J.G. and Pu,W.T.
  TITLE     Molecular and Spatial Signatures of Mouse Embryonic Endothelial
            Cells at Single-Cell Resolution
  JOURNAL   Circ Res 134 (5), 529-546 (2024)
   PUBMED   38348657
REFERENCE   3  (bases 1 to 3602)
  AUTHORS   Chovatiya,G., Li,K.N., Li,J., Ghuwalewala,S. and Tumbar,T.
  TITLE     Alk1 acts in non-endothelial VE-cadherin+ perineurial cells to
            maintain nerve branching during hair homeostasis
  JOURNAL   Nat Commun 14 (1), 5623 (2023)
   PUBMED   37699906
  REMARK    GeneRIF: Alk1 acts in non-endothelial VE-cadherin[+] perineurial
            cells to maintain nerve branching during hair homeostasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3602)
  AUTHORS   Li,K.N., Chovatiya,G., Ko,D.Y., Sureshbabu,S. and Tumbar,T.
  TITLE     Blood endothelial ALK1-BMP4 signaling axis regulates adult hair
            follicle stem cell activation
  JOURNAL   EMBO J 42 (10), e112196 (2023)
   PUBMED   36994549
  REMARK    GeneRIF: Blood endothelial ALK1-BMP4 signaling axis regulates adult
            hair follicle stem cell activation.
REFERENCE   5  (bases 1 to 3602)
  AUTHORS   Lee,S., Schleer,H., Park,H., Jang,E., Boyer,M., Tao,B.,
            Gamez-Mendez,A., Singh,A., Folta-Stogniew,E., Zhang,X., Qin,L.,
            Xiao,X., Xu,L., Zhang,J., Hu,X., Pashos,E., Tellides,G.,
            Shaul,P.W., Lee,W.L., Fernandez-Hernando,C., Eichmann,A. and
            Sessa,W.C.
  TITLE     Genetic or therapeutic neutralization of ALK1 reduces LDL
            transcytosis and atherosclerosis in mice
  JOURNAL   Nat Cardiovasc Res 2 (5), 438-448 (2023)
   PUBMED   39196046
  REMARK    GeneRIF: Genetic or therapeutic neutralization of ALK1 reduces LDL
            transcytosis and atherosclerosis in mice.
REFERENCE   6  (bases 1 to 3602)
  AUTHORS   Oh,S.P., Seki,T., Goss,K.A., Imamura,T., Yi,Y., Donahoe,P.K.,
            Li,L., Miyazono,K., ten Dijke,P., Kim,S. and Li,E.
  TITLE     Activin receptor-like kinase 1 modulates transforming growth
            factor-beta 1 signaling in the regulation of angiogenesis
  JOURNAL   Proc Natl Acad Sci U S A 97 (6), 2626-2631 (2000)
   PUBMED   10716993
REFERENCE   7  (bases 1 to 3602)
  AUTHORS   Zhang,D., Mehler,M.F., Song,Q. and Kessler,J.A.
  TITLE     Development of bone morphogenetic protein receptors in the nervous
            system and possible roles in regulating trkC expression
  JOURNAL   J Neurosci 18 (9), 3314-3326 (1998)
   PUBMED   9547239
REFERENCE   8  (bases 1 to 3602)
  AUTHORS   Roelen,B.A., van Rooijen,M.A. and Mummery,C.L.
  TITLE     Expression of ALK-1, a type 1 serine/threonine kinase receptor,
            coincides with sites of vasculogenesis and angiogenesis in early
            mouse development
  JOURNAL   Dev Dyn 209 (4), 418-430 (1997)
   PUBMED   9264265
REFERENCE   9  (bases 1 to 3602)
  AUTHORS   Wu,X., Robinson,C.E., Fong,H.W., Crabtree,J.S., Rodriguez,B.R.,
            Roe,B.A. and Gimble,J.M.
  TITLE     Cloning and characterization of the murine activin receptor like
            kinase-1 (ALK-1) homolog
  JOURNAL   Biochem Biophys Res Commun 216 (1), 78-83 (1995)
   PUBMED   7488127
REFERENCE   10 (bases 1 to 3602)
  AUTHORS   Dewulf,N., Verschueren,K., Lonnoy,O., Moren,A., Grimsby,S., Vande
            Spiegle,K., Miyazono,K., Huylebroeck,D. and Ten Dijke,P.
  TITLE     Distinct spatial and temporal expression patterns of two type I
            receptors for bone morphogenetic proteins during mouse
            embryogenesis
  JOURNAL   Endocrinology 136 (6), 2652-2663 (1995)
   PUBMED   7750489
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104834.4, BB869400.1 and AK134712.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC014291.1, SRR7345562.2143378.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC104834.4         184821-184855
            36-396              BB869400.1         2-362
            397-610             AK134712.1         191-404
            611-2146            AK134712.1         406-1941
            2147-2147           AC104834.4         200180-200180
            2148-3439           AK134712.1         1943-3234
            3440-3602           AC104834.4         201473-201635
FEATURES             Location/Qualifiers
     source          1..3602
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.41 cM"
     gene            1..3602
                     /gene="Acvrl1"
                     /gene_synonym="Acvrlk1; Alk1"
                     /note="activin A receptor, type II-like 1"
                     /db_xref="GeneID:11482"
                     /db_xref="MGI:MGI:1338946"
     exon            1..62
                     /gene="Acvrl1"
                     /gene_synonym="Acvrlk1; Alk1"
                     /inference="alignment:Splign:2.1.0"
     exon            63..199
                     /gene="Acvrl1"
                     /gene_synonym="Acvrlk1; Alk1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..298
                     /gene="Acvrl1"
                     /gene_synonym="Acvrlk1; Alk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..1743
                     /gene="Acvrl1"
                     /gene_synonym="Acvrlk1; Alk1"
                     /EC_number="2.7.11.30"
                     /note="isoform a precursor is encoded by transcript
                     variant 3; serine/threonine-protein kinase receptor R3;
                     SKR3; TSR-I; activin receptor-like kinase 1; TGF-B
                     superfamily receptor type I; activin receptor type-1-like"
                     /codon_start=1
                     /product="activin receptor type-1-like isoform a
                     precursor"
                     /protein_id="NP_001264186.1"
                     /db_xref="CCDS:CCDS37215.1"
                     /db_xref="GeneID:11482"
                     /db_xref="MGI:MGI:1338946"
                     /translation="MTLGSFRRGLLMLSVAFGLTRGDLAKPSKLVNCTCESPHCKRPF
                     CQGSWCTVVLVREQGRHPQVYRGCGSLNQELCLGRPTEFLNHHCCYRSFCNHNVSLML
                     EATQTPSEEPEVDAHLPLILGPVLALPVLVALGALGLWRVRRRQEKQRDLHSDLGESS
                     LILKASEQADSMLGDFLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRG
                     SWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLIT
                     HYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRN
                     VLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEHIRTDCFESY
                     KWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTI
                     PNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSHNPEKPKVIH"
     exon            299..544
                     /gene="Acvrl1"
                     /gene_synonym="Acvrlk1; Alk1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..756
                     /gene="Acvrl1"
                     /gene_synonym="Acvrlk1; Alk1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..856
                     /gene="Acvrl1"
                     /gene_synonym="Acvrlk1; Alk1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1003
                     /gene="Acvrl1"
                     /gene_synonym="Acvrlk1; Alk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1279
                     /gene="Acvrl1"
                     /gene_synonym="Acvrlk1; Alk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1477
                     /gene="Acvrl1"
                     /gene_synonym="Acvrlk1; Alk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1608
                     /gene="Acvrl1"
                     /gene_synonym="Acvrlk1; Alk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..3602
                     /gene="Acvrl1"
                     /gene_synonym="Acvrlk1; Alk1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3579..3584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acvrl1"
                     /gene_synonym="Acvrlk1; Alk1"
                     /note="hexamer: AATAAA"
     polyA_site      3602
                     /gene="Acvrl1"
                     /gene_synonym="Acvrlk1; Alk1"
                     /note="major polyA site"
ORIGIN      
        1 ggagcagaca ctcccagccc aaactcagct ttcttagcgc tgttccttag gagtgagcac
       61 agccccttcc cagtccccgg aggccgccgc gccagccgcg cagatcgaga cctttcccgg
      121 ccccacaggc cggctctgga cgtgagaccc cggccgcctc cggcaaggag aggcgggggt
      181 cgagtcgccc tgtccaaaga tctcaccaca tctcttctcc tatctccaag gaccatgacc
      241 ttggggagct tcagaagggg ccttttgatg ctgtcggtgg cctttggcct aaccagggga
      301 gacttggcga agccttccaa gctggtgaac tgcacttgtg agagcccaca ctgcaagaga
      361 ccattctgcc aggggtcatg gtgcacagtg gtgctggttc gggagcaggg caggcacccc
      421 caggtctatc ggggctgcgg gagcctgaac caggagctct gcttgggacg tcccacagag
      481 tttctgaacc atcactgctg ctatagatcc ttctgcaacc acaacgtgtc tctgatgctg
      541 gaggccaccc aaactccttc ggaggagcca gaagttgatg cccatctgcc tctgatcctg
      601 ggtcctgtgc tggccttgcc ggtcctggtg gccctgggtg ctctaggctt gtggcgtgtc
      661 cggcggaggc aggagaagca gcgggatttg cacagtgacc tgggcgagtc cagtctcatc
      721 ctgaaggcat ctgaacaggc agacagcatg ttgggggact tcctggacag cgactgtact
      781 acgggcagcg gctcggggct ccccttcttg gtgcagagga cggtagctcg gcaggttgcg
      841 ctggtagagt gtgtgggaaa gggccgatat ggtgaggtgt ggcgcggttc gtggcatggc
      901 gagagtgtgg cggtcaagat tttctcctca cgagatgagc agtcctggtt ccgggagacg
      961 gagatctaca acacagttct gcttagacac gacaacatcc taggcttcat cgcctccgac
     1021 atgacttcgc ggaactcgag cacgcagctg tggctcatca cccactacca tgaacacggc
     1081 tccctctatg actttctgca gaggcagacg ctggagcccc agttggccct gaggctagct
     1141 gtgtccgcgg cctgcggcct ggcgcaccta catgtggaga tctttggcac tcaaggcaaa
     1201 ccagccattg cccatcgtga cctcaagagt cgcaatgtgc tggtcaagag taacttgcag
     1261 tgttgcattg cagacctggg actggctgtg atgcactcac aaagcagcga ttacctggat
     1321 atcggcaaca acccccgagt gggtaccaaa agatacatgg cacccgaggt gctggatgag
     1381 cacatccgca cagactgctt tgagtcgtac aagtggacag acatctgggc ctttggccta
     1441 gtgctatggg agatcgcccg gcggaccatc atcaatggca ttgtggagga ttacaggcca
     1501 cctttctatg acatggtacc caatgacccc agttttgagg acatgaaaaa ggtggtgtgc
     1561 gttgaccagc agacacccac catccctaac cggctggctg cagatccggt cctctccggg
     1621 ctggcccaga tgatgagaga gtgctggtac cccaacccct ctgctcgcct caccgcactg
     1681 cgcataaaga agacattgca gaagctcagt cacaatccag agaagcccaa agtgattcac
     1741 tagcccaggg ccaccaggct tcctctgcct aaagtgtgtg ctggggcaga agacatagcc
     1801 tgtctgggta gagggagtga agagagtgtg cacgctgccc tgtgtgtgcc tgctcagctt
     1861 ggctcccagc ccatccagcc aaaaatacag ctgagctgaa attcgatctg cctccgtctg
     1921 ggctgctcaa agtggccggc tctctgacgc ctggctgggt tccccatccc caaggccagc
     1981 agggtacacc cactaccact cccagggcag ggtggccaag ccagggaatc ccgggcccgg
     2041 atcctgggct ttcactcttc cctacccttg gtcaacctta ctgaactgtc agagctgcca
     2101 ggatggcaca gggccctgtc cagcttcagc agacattcca cctgccgggg ctcagccagg
     2161 gatactcagc agcctcagtg tctctctgtg ggtgtttatt gcttctatga tgccttttag
     2221 ttgtcctgat tagagcccct ggctagtctc ttgggacagg cggtacctga ctcttccacc
     2281 ctctgtcccc ttaccatctc agctgactca ctaggtcatc aaaatccaag ggctctctga
     2341 ggagaaggtc aatcatggtg gaagcgatcg acccagcatt gctccgttcg ataggagagg
     2401 tcttcaccat cttaccatct taggttttgc ctcaatgtcc tctgaggtgt ctcagagcct
     2461 gattttcttt gaagctcagg ctgtgtgaaa gctgagtctt gtctattatg ccctgtccgc
     2521 tgtcgcttga gtcaagctgg ggtttgtaaa taacggccag gttccagcat ggcctaaagt
     2581 gccccctagg ctagtctcca ggccccagtt cttgccttaa gctatgctag cagccacctc
     2641 aggacccagg cagtacaaga acttctgact ccctctgcgg cttggccttc tgcccagggc
     2701 tcaagggtgg cttcctttgg ggtctccaat actgaaagaa acttagcccc tgtcaagaag
     2761 cctccagcaa ccagggttct gctccccacc cccacccccg gctgtgactc tctggccaaa
     2821 gcccacaccc tgggccagac cccagaaagt gagccttggg agaacgtagc ctagagaaac
     2881 acagagagtc tggtatttag aaatgtgaag ggttcaccca cgtactgaac aggtgaaact
     2941 gaagcctggg ttgatggact gaagagaagt gaactgtagg cgaggcttaa gaagggtaaa
     3001 gcagggttca ggcaagagac aaggtcagcc tccatcttgg gaagacctgg cctagaaact
     3061 attggccact gaagggagaa acggcgagag ttcatcatgc tccacacagg ccccgacctc
     3121 ttgagttcct ccagtgtgac ctcccagctc tccagcgctg ttctctctct caagcctgtc
     3181 tttcagcaat atgcaaggac caaggagaac caggaagtga aacgagacaa aaacagaaag
     3241 tagtccggct ttccccagac cagtgggggc aaagtctgaa ggttctcccg tcactggagc
     3301 cagggaatcg ctttcttgcc tgaaggattt tatttctact gaacttggga acaaatttat
     3361 ccccagactc cacagtcaga gccagaagac agtagctcct ccaaggccag gaaatcctaa
     3421 gtggaggtgg gggggggggg ttgaacaact ggaaacgtgg caaggagagt ggccctctag
     3481 agacaactat cttcaaatgc ttcccagtgc aggtgtgtga gtggaaccac acagtttgtg
     3541 ggagcacttg gcctgtgaca ggcatgtagt aggtcttcaa taaaccatgt ttgaccccct
     3601 ga
//
