LOCUS       NM_001313757           10594 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus activin receptor IIB (Acvr2b), transcript variant 2,
            mRNA.
ACCESSION   NM_001313757 XM_006511925
VERSION     NM_001313757.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10594)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 10594)
  AUTHORS   Jeon,J., Lee,H., Jeon,M.S., Kim,S.J., Choi,C., Kim,K.W., Yang,D.J.,
            Lee,S., Bae,Y.S., Choi,W.I., Jung,J., Eyun,S.I. and Yang,S.
  TITLE     Blockade of Activin Receptor IIB Protects Arthritis Pathogenesis by
            Non-Amplification of Activin A-ACVR2B-NOX4 Axis Pathway
  JOURNAL   Adv Sci (Weinh) 10 (14), e2205161 (2023)
   PUBMED   36950748
  REMARK    GeneRIF: Blockade of Activin Receptor IIB Protects Arthritis
            Pathogenesis by Non-Amplification of Activin A-ACVR2B-NOX4 Axis
            Pathway.
REFERENCE   3  (bases 1 to 10594)
  AUTHORS   Nagaoka,T., Katsuno,T., Fujimura,K., Tsuchida,K. and Kishi,M.
  TITLE     Functional interaction between Vangl2 and N-cadherin regulates
            planar cell polarization of the developing neural tube and cochlear
            sensory epithelium
  JOURNAL   Sci Rep 13 (1), 3905 (2023)
   PUBMED   36890135
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10594)
  AUTHORS   Liu,Y., Lehar,A., Rydzik,R., Chandok,H., Lee,Y.S., Youngstrom,D.W.,
            George,J., Matzuk,M.M., Germain-Lee,E.L. and Lee,S.J.
  TITLE     Local versus systemic control of bone and skeletal muscle mass by
            components of the transforming growth factor-beta signaling pathway
  JOURNAL   Proc Natl Acad Sci U S A 118 (33) (2021)
   PUBMED   34385332
REFERENCE   5  (bases 1 to 10594)
  AUTHORS   Lee,Y.J., Hong,K.H., Yun,J. and Oh,S.P.
  TITLE     Generation of activin receptor type IIB isoform-specific
            hypomorphic alleles
  JOURNAL   Genesis 44 (10), 487-494 (2006)
   PUBMED   16991118
REFERENCE   6  (bases 1 to 10594)
  AUTHORS   Verschueren,K., Dewulf,N., Goumans,M.J., Lonnoy,O., Feijen,A.,
            Grimsby,S., Vandi Spiegle,K., ten Dijke,P., Moren,A.,
            Vanscheeuwijck,P., Heldin,C.H., Miyazono,K., Mummery,C., Van Den
            Eijnden-Van Raaij,J. and Huylebroeck,D.
  TITLE     Expression of type I and type IB receptors for activin in
            midgestation mouse embryos suggests distinct functions in
            organogenesis
  JOURNAL   Mech Dev 52 (1), 109-123 (1995)
   PUBMED   7577669
REFERENCE   7  (bases 1 to 10594)
  AUTHORS   Ritvos,O., Tuuri,T., Eramaa,M., Sainio,K., Hilden,K., Saxen,L. and
            Gilbert,S.F.
  TITLE     Activin disrupts epithelial branching morphogenesis in developing
            glandular organs of the mouse
  JOURNAL   Mech Dev 50 (2-3), 229-245 (1995)
   PUBMED   7619733
REFERENCE   8  (bases 1 to 10594)
  AUTHORS   Nakamura,T., Sugino,K., Kurosawa,N., Sawai,M., Takio,K., Eto,Y.,
            Iwashita,S., Muramatsu,M., Titani,K. and Sugino,H.
  TITLE     Isolation and characterization of activin receptor from mouse
            embryonal carcinoma cells. Identification of its
            serine/threonine/tyrosine protein kinase activity
  JOURNAL   J Biol Chem 267 (26), 18924-18928 (1992)
   PUBMED   1326537
REFERENCE   9  (bases 1 to 10594)
  AUTHORS   Matzuk,M.M. and Bradley,A.
  TITLE     Structure of the mouse activin receptor type II gene
  JOURNAL   Biochem Biophys Res Commun 185 (1), 404-413 (1992)
   PUBMED   1318045
REFERENCE   10 (bases 1 to 10594)
  AUTHORS   Attisano,L., Wrana,J.L., Cheifetz,S. and Massague,J.
  TITLE     Novel activin receptors: distinct genes and alternative mRNA
            splicing generate a repertoire of serine/threonine kinase receptors
  JOURNAL   Cell 68 (1), 97-108 (1992)
   PUBMED   1310075
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166052.5.
            
            On Sep 1, 2015 this sequence version replaced XM_006511925.2.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            segment compared to variant 1. The encoded isoform (2) is shorter
            than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106189.1, SRR7652917.1169510.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-420               AC166052.5         45831-46250         c
            421-628             AC166052.5         20766-20973         c
            629-738             AC166052.5         20352-20461         c
            739-890             AC166052.5         20076-20227         c
            891-1034            AC166052.5         19860-20003         c
            1035-1178           AC166052.5         18420-18563         c
            1179-1327           AC166052.5         18060-18208         c
            1328-1442           AC166052.5         17090-17204         c
            1443-1581           AC166052.5         15801-15939         c
            1582-1712           AC166052.5         15585-15715         c
            1713-10594          AC166052.5         6280-15161          c
FEATURES             Location/Qualifiers
     source          1..10594
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..10594
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /note="activin receptor IIB"
                     /db_xref="GeneID:11481"
                     /db_xref="MGI:MGI:87912"
     exon            1..420
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..1907
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /EC_number="2.7.11.30"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; activin receptor type-2B; activin receptor type
                     IIB"
                     /codon_start=1
                     /product="activin receptor type-2B isoform 2 precursor"
                     /protein_id="NP_001300686.1"
                     /db_xref="CCDS:CCDS90681.1"
                     /db_xref="GeneID:11481"
                     /db_xref="MGI:MGI:87912"
                     /translation="MTAPWAALALLWGSLCAGSGRGEAETRECIYYNANWELERTNQS
                     GLERCEGEQDKRLHCYASWRNSSGTIELVKKGCWLDDFNCYDRQECVATEENPQVYFC
                     CCEGNFCNERFTHLPEPGGPEVTYEPPPTAPTLLTVLAYSLLPIGGLSLIVLLAFWMY
                     RHRKPPYGHVDIHEDPGPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLMNDFVAVKI
                     FPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDY
                     LKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLT
                     AVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLV
                     LWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGL
                     AQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDCLVSLVTSVTNVDLLPK
                     ESSI"
     exon            421..628
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /inference="alignment:Splign:2.1.0"
     exon            629..738
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /inference="alignment:Splign:2.1.0"
     exon            739..890
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1034
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1178
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1327
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1442
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1581
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1712
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..10594
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10564..10569
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /note="hexamer: AATAAT"
     regulatory      10567..10572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /note="hexamer: AATAAT"
     regulatory      10574..10579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /note="hexamer: AATAAA"
     polyA_site      10580
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
                     /note="major polyA site"
     polyA_site      10583
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
     polyA_site      10594
                     /gene="Acvr2b"
                     /gene_synonym="4930516B21Rik; ActRIIB; AI047905"
ORIGIN      
        1 aggtcccctc ccccacccct cccccgttca tggcccctcc ggactcggcc cctgcgcccg
       61 gggcccgggc ccagccccgt tgcgccatgc ccgcgtcggg cgcgccctgg cccgcgcccc
      121 gccgccgccc cccggctccc gcgtcgcccc atagcccggg ccgcactgcg cgccgcccgc
      181 agcggccctg agcccctatc tccgcatact gcctgggaac cgaagcgcag aagcgcgcgc
      241 tcctggaagc gagacccaga gaaggagcgg gaagcagagc gcagccgccg ccgggccctg
      301 cgcgccccgg gagcgcagcg cggccctgcc cgcgggctcc gggtgtccgc ggggcggcgc
      361 cgcggaacat gacggcgccc tgggcggccc tcgcccttct ctggggatcg ctgtgcgccg
      421 gttccgggcg aggggaggct gagactcggg agtgcatcta ctacaacgcc aactgggagc
      481 tggagcgcac caaccagagc ggcctggagc gctgcgaggg ggaacaggac aagcggctgc
      541 actgctacgc ctcgtggcgc aacagctcgg gcaccatcga gctggtgaag aagggctgct
      601 ggctagatga cttcaattgc tacgacaggc aggagtgtgt ggccaccgag gagaaccccc
      661 aggtgtactt ctgctgctgc gaaggcaact tctgcaacga gcgcttcacc cacttgccgg
      721 agcctggggg cccagaagtc acgtacgagc cacccccgac agcccccacc ctgctcacgg
      781 tgctggccta ctcgctgctg cccattggag gcctctctct catcgtcctg ctggccttct
      841 ggatgtatcg tcatcggaag cctccctacg gccatgtgga catccatgag gacccggggc
      901 ctccgccccc atcccctctg gtgggcctga agccactaca gctgctggag atcaaggctc
      961 ggggccgctt tggctgcgtt tggaaagctc agctcatgaa cgactttgtg gctgtgaaga
     1021 tcttcccact tcaggacaag cagtcgtggc agagtgaacg ggaaatcttc agcacacccg
     1081 gcatgaagca cgaaaacttg ttgcagttca ttgctgccga gaaacgaggc tccaacctgg
     1141 aggtggagct gtggctcatc acagccttcc acgacaaggg ctccctcacg gattacctca
     1201 aggggaacat catcacgtgg aacgaactgt gccacgtggc ggagacgatg tcacgaggcc
     1261 tctcatacct gcatgaggat gtgccgtggt gtcgtggtga gggccacaag ccttctattg
     1321 cccacaggga cttcaaaagc aagaatgtac tgctgaagag cgacctcacc gcggtgctgg
     1381 ctgacttcgg cctggctgtt cggtttgagc cagggaagcc tcctggggat acccatggac
     1441 aggttggcac cagacggtac atggcccctg aggtgctgga aggagccatc aacttccaga
     1501 gagacgcctt cctgcgtatc gacatgtacg ccatgggcct ggtgctgtgg gagctcgtct
     1561 ctcggtgcaa ggctgcagac gggcctgtcg atgagtacat gctgcccttc gaggaggaga
     1621 ttggccagca cccttcgctg gaggagcttc aggaggtggt tgtccacaag aagatgaggc
     1681 ccacgattaa ggatcactgg ctgaaacacc cgggcctggc ccagctctgc gtgaccatcg
     1741 aggagtgctg ggaccatgat gcagaggctc gcctttctgc aggctgtgta gaagagcggg
     1801 tatccctgat caggaggtcg gtcaacggca ctacctcgga ctgtctcgtc tctctggtga
     1861 cctccgtcac caatgtggac ctgctcccta aagagtccag catctaagcc cgggacacgt
     1921 agcgtctctc cagactcagt ggatctgaag aaaaaaaaaa ggaaaaaaaa aaaaaagaat
     1981 tgtgttttgt tttggaaatc ccataaaacc aacaaacaca taaaatgcag ctgctatttt
     2041 accttgactt ttattattat tataattatt ataattatta ttaataatat tatttttgga
     2101 ttggatcagt ttttaccagc atattgttct actgtattgc aaacagcgga cacgtcagca
     2161 ggcgttgcgg tgctgagctg tgaacgcaga agcggcgcca tgctgaagag cctcagccac
     2221 ctcctgtccc tcggattcat ctcccctctt tctctgtcgt ctcagaacct gtaacacaaa
     2281 gaaactcctg tcttaggaaa ctcaatgctg cagttctcta ctagaggaac ctttgaagac
     2341 tgttacacgg acacaccctt cctccgaaga gggcccccca cccccacccc tttattttgc
     2401 gtttctccca cctcaggccg tgagcttaag aaacggcggc tgtgtttgtc ttcgtgggtg
     2461 taatgggtgt cgtcctgacc cagcctcggg gaactgcgat caggagggcg gtctagtctg
     2521 aagccagaag ggaggcttct gggtagggtg cggagcagag ctacactgga cttgggcaca
     2581 tttggagcaa cacccttggc tatggaggct actttctcag gtaacaaggg gttgagggca
     2641 aggaccttgt ggaggccaag cggtaataat agcaagcaca ggatttggag aaggcccaag
     2701 agcaagggtc aggttgcccc acctgtctgg tttcttccca ctgacgggct tggccatggg
     2761 agaagacgca accttgctcc tgtgttagga ccaggtgagg gcgtgacagt ttagtggaca
     2821 ttcttcgtta tacatgacgc tgtagagctc tttcatggag gaaataccga gctgcagttt
     2881 cctcttggca gtttggggag atgcctgtgg ccgaccctgc acagcgtgga tgggccagag
     2941 gatccctggt ggggaccatg ccagcctgca gctttggcat ggccccatgc agtgcggcat
     3001 taccgagtcc tctctgaggc tcacgggtgc ggctttctcc agaccctttt aaagtggtgc
     3061 atattcttaa actgtgtttc tcttacacca taacctcgct cgctccaggc ggtgaatgtt
     3121 cttaatgctg ctgtttcgac attggatttt tttttttttt aatttatgaa acatgctaag
     3181 gttttttttt tttttttttt tcagacagaa cacacacatc cacatatata cacatgcttt
     3241 gctgtgtggc ttccgaggct taaattttaa aaagtgaaag aagtaacttc acggccacag
     3301 accacctcaa accagaaata cctcagaatt ttctacttgt gtatgtttta ttaattatat
     3361 attttgttag ttgtgttgtc ttgtaggaag tatattttaa tgtaagttga cttttatgac
     3421 gaggaagttt aaaagaaata gagaaaaaga aaaaaaaagt ttgtgtcttc tagtcagtac
     3481 taccatcttt gtttgataaa agcgcccttg tgaatagcag gcaccagctg taggttggct
     3541 gtctgggctg agacgggcat tcatctggtt ttgactgtat cattaaaact gcacacctct
     3601 tgaccttgag ggtagatagg ccacttcctc ccggattgct tagaggtcca ctgggtagca
     3661 cttggaacaa cacgcccact ttaccttggt ggtagcacgg ccctcagacc caccggaggt
     3721 aacagtctgt gacattcagt tctttcagca gcagcagcag gtggaattct gtccggccag
     3781 taactgcgct gtgatgtctg ggagggcacg gctcacagct gggcagccgc tccctcggcg
     3841 tgttgtgtgt ggtgcctgag ttgttcctgg gcttgttttt ctctgtgggt gtttgtgcac
     3901 agggtgctga ggaaggctaa gtggtttccc ttcctctcag acttagtatg tttccgtggg
     3961 tcagtgtggg ctggctgagg agttcagggg acgtggactc tgtctctcta agctatgtct
     4021 gtccctcccc cccacccccc accccatctg attttgtgct gtggtatttt cttgtctcag
     4081 aatactttcc actggttaac aagtcttaga gcagttgctt tcttttccat ttgtttcttt
     4141 aaggagcttt aactatttat tgaaaagtgc catatatctc ctttctctag ctttctcctc
     4201 aggcggtggg aacacccctt cttctaaccc ttaacaaacc aaccactaag gaatgtagct
     4261 ctttcgctgc aggagtgacc cagtcaccag tcacatacag tgccaaactc taaaacccag
     4321 ctccctgagt ggtgtcagga ccctgggtgg cttttctctt gtgttgctgg ttgtcagaag
     4381 catcctggcc tggctgagct ctggtatggg acatcccagt gagccctgtg tccagccacg
     4441 gcagtgtcct tgtcagacct cttgtcagaa tggattgatt gtcaagacag ggttcctgtt
     4501 ttgtggccag gaaagaggag gagcttgggt gctggtgtct ctgagtaggg gctgtagact
     4561 ccctcttgcc ttcaggtaac atacccagct gctcatagct ggaaggtggg tgatattcca
     4621 gggtgtggcc cggaagctta acttccttcc tccctccctt cttttccttc tagtttcctt
     4681 cttgtgccca gttgagacct gaggcttctg cctcacactt tcctgcaggt tttgtatcta
     4741 ttcccctctc cctctttttg gacgaccaag gaggaagtcc ctctgtgtgg caaaggatga
     4801 gacatggggg ggggggggga agggctgcgg gtgcttcctc cttccttcac tccaaacaga
     4861 gcccatgacc accagccttg gcagagaatg ttccggttga tacctgtgac agcgaaaagt
     4921 cacctgttga gggaaatgtc tgtgagtcag agacagacaa agcaagtaaa ggcaaggtcg
     4981 ctgagtctcg aacactcact gacaaggttg ccgaggaagg ctgtcagcag ttgttagcat
     5041 ctgggctagc atgggctagc atgggctggc ctggtatcac ggacaccaga tgcaggggga
     5101 aatgtgggcc ttctgctcat acatccacag ggaagggcgg atccctttct catcactggg
     5161 ctaccaggcc tgctgggcct tcctgaccag gcttgagctt ctagcaaggt gcgtgatcct
     5221 gtctgttctg gtctctcttc atccctggca ttgaccatgc ccttgactct ctgtcttgct
     5281 actctaccct actctgccct agggcttagg ctctgtgaag gatttttctt ggtggccagc
     5341 ctacataggt atttaatggt tgccatgtgc tcttcggctc agagagcctg tcatgtggca
     5401 tttcctatgc tcggccactg aggcaaagaa gtgactgtcc catctagagc tggagggccg
     5461 gatggttctc tcacacacag actttggttc tctcacacac agacttttac ctttgtagtg
     5521 tatgaagttc ctggtgcatc ctggtggcta ggagaatgtc ctcgttgttt ttcctactta
     5581 actaatgcag taaaagctta ctgtgctgtg agttgaattc ctgccgttgt tcttaggaca
     5641 tggttcatta gatgaatccc tgaatctgag gagctctcag gtcgctcagc ttggtctctg
     5701 gcatcagctg ttgcatcttt ttgggctttt ggagacacag ctttggacgt gatcaagcct
     5761 ggtccacatc tcaggcagga cttgtagagg acagctttcc taaaagtgtg ggaaaccgcc
     5821 aggaagggat ggtgtcccag gaatcctttc ctctcagaac ctggagacat ggctttttct
     5881 tcatccctgg ctgtctgtaa aggctaaatt gagaagtgct cagcagctgg cttgtccagc
     5941 gcagtgatga ggttaaacct cagctaacat catgttatat aagtaggccc agtaactcag
     6001 ctgatgggtt tcttagaatc tagatgctaa acgctccatg cattcaagat taaatgccta
     6061 gttcttcttc acacacagtt ctgggtagtt gactcgtagc cagcagccct cctgtggatg
     6121 taccccagac ctttagaaag atgttgagga aagtgctttt tgcgatacca atttagtttt
     6181 ataggaaaaa gaaactgaag gtcaaaacac tcccttggaa atcaactagt tggttcaacc
     6241 acgttaaaga agaaaggaag aaggaaagag agtttaagag gcgcgtgaac tatcgtatca
     6301 ataagtatgc ccaagttctt ttgtgggatc cttgggatag tgctatttgg acctatctgt
     6361 gattaatgac tgtgaaccac tgttgggctg accgtttgca gtgagatcag gaatgcctgc
     6421 gtctgctggc actaaaccaa gctgtagcat tttcatgctg gcatcttcca ggtgtgaagg
     6481 aagcaagact ttgccctcct ggtgctccgt ggagctcctt agtgcccaga ccagcgccat
     6541 ttcccccatc cacggcagct ccgggccatg atttccccaa gaattaaagt tcctgttcct
     6601 catgccggtg aggggtagtg ggctctgcgc tgaccccttg ctctccaggc cggtgtctac
     6661 actgcttagg ctgagttagt gtgtgcagcc ctatgggtgc gtgtggtaat cgattcagac
     6721 gggtgttctg aacacctgca gagaacagtt actgcattcg gttgtagact ttgtgctttt
     6781 gagtttacag ttgggggaag tgtgacccat tagttttttc aggcacgtga aggtgggtta
     6841 ttgtgaataa acgagcattg cctcaagtcc tggggcaccc accctgcatg ggcccattct
     6901 ggctcctggt cactttacac cagtgttgtt agatagtgct gtaaataaga gtaagttata
     6961 taacagacgc cacttgaaat tttactttaa gaagtctata gctccacaca tatatttagt
     7021 tatatctctt gacagattgc ctccacacag tatggagatt gttttatacc acagattatt
     7081 tttataaact agtgagtcga agtgagaatg cgtctgtaat ccaagccaat gagctttact
     7141 gtcaggatta tgtgcaccct ggagccgagt gctgggagct tagcttagtg catgcatagc
     7201 ttcctgaata cactggcagc ctggagttgg cttacgggtt cccctttggc agtggtatct
     7261 gtcctgcttc ctgcctgtga gaggacagca gccaggccag gcaagggacc tggagttggt
     7321 ttgatttctg ctgaacaaag ggttctgagg ttgaaagttt gtcagctcct tccgtagaaa
     7381 gtagtcccgc aagttaaaga gcaggaggac agaagctgtg tgccccacgc ctagagaatg
     7441 attcgggcta taggaaccat tgaaatgggg attggtggcc gagttccact aaccagaact
     7501 atctaggacc aaactgagtc atcctttgga aacggcgggg cacatggatg tcatggtgga
     7561 aataagtgga gagttgctga gcaaattttg cccctttcag tcggggccat tcatcccaga
     7621 ggctgcttgc tttctgctct aactgtcgag ttaatcagga accaatggag gaagctcaga
     7681 accccagtct cctggcaggt tatctttcca gttcttgcag agggattctg taaaggccaa
     7741 gccagccatg gccagatctg aggtgcagct aaaggcctgt ccctgcatcc tgcctgctgg
     7801 ctccagcctg ctgctacaga actacactgg atggggcagc cctgctcaga gatccttagt
     7861 gtgtcagtca aaaccagctg tgccctctat tcaccctggc tagaacgctg tcttacgtgc
     7921 tggtcctctt tacgtgggat ctggagtcca gatccagctg catccttgga gcccccctac
     7981 ccccccccca acacatccac acaacttctg ttccccataa aagaacactt ctctgctttg
     8041 cagccgcctg tcttggaatg taattctgtt gtgcctttgt tttctgtcac tcgcccctca
     8101 aaagcaactg ctgtaagctt gtttctaatt tgtcttttct agccccaccc cttcccccag
     8161 gctccctttt tccagcccta atttctggat gcacttgtgt catccaggta ctttaagaac
     8221 cagttacctc agatgtgatg tggaacagtg tcaccatctg gccctcttga tcctgccaac
     8281 tcttaccaca catgcaggag gccctcagag tgcagacact gacttgtttt aagcaaaact
     8341 cttcccaagt atggaaccag gggcttctgg caagcctgtc ctggcactgt ggtgggactg
     8401 gttgggagtg tcatctgaac ggtgcttcct gtgtgttctg ccattcagta ttctcatagt
     8461 ctggagagac agcaccctaa ctggctggtc tcgtatgcaa atcagctcca aagatgagct
     8521 cttcctaaca catttccagt cgctagagct cagacataga acattccttc aaacagcagg
     8581 gtagaagccc ccatccactg ccacagtgca ttctgggaag atgtctgtag tatacattgc
     8641 tgtgggatta ggccttgtgg gatatggctg cttgtcattt tgatgtattt taaataaata
     8701 aataaatata tatatatatt tttaaagagc cttttttacc agttcaaaag cttaattaac
     8761 cagctgtcac cacatctgaa tttttgtctc tggggcattg acggcaggca gagactaaaa
     8821 gtggcaactc agctatgagt tgcctgccct gggctgtcct gctgtcctgc tgaccgtggg
     8881 acaccagggc cagcgtgttc ccggtgggtt tcaactcagc cctctgggtg tttggtctct
     8941 gcctcactta gcggacttag tccttagtcc ttgtaagtgc tttagcccca gtggggtttt
     9001 cccagagcac tgccacgagt tgagtgtatg agtttagcca aataatttct ccactgggaa
     9061 aagcactatc acggaaattg tacctgcttc aaaagagacc agagtaggaa agactagttg
     9121 cctaggccgt ctgggagcaa gcagttgtca cgtgcgggca ggagatctca tctgaaaagc
     9181 taggtccacc agcaggggtg cagttgttaa aatgccagtg gcttgctttc ccatgtcccc
     9241 ccacctaccc cctgaattct gtaactgcaa aggaaactga gtggtactgg agaaccgcag
     9301 ggagggtacc acagatgaga gacaacgctt ctagacttca gttcatgcca cggatgcaca
     9361 cgatgccgtt tcaactgtac gggagaatct gcttacgaac ctgacgtcat ccctgtgatg
     9421 gcgtcagagg ccacagtttt cacacgttac catctctgca catttgtcct cgaatctgag
     9481 tcgcattatt cagtactgta aagttaactt gcgtcgagtt tgatgtcgat tcctgtgaag
     9541 aagagctttt ggcacgtgac agacagtgag ttacaaaaca cagcaaagca cggaattttt
     9601 tgcagggaca attttggaac caacagaaaa tgtcactttt tagttagcat cttatgtatc
     9661 acttttaccg gctatttcta actttggaag ggaaaccttg aagcttgtgt aacttagtgg
     9721 aaatgtgtgt gtcgccctta ggatgggtag ccaagtctca ctaagctgtg ttaatctaac
     9781 ttgtatatat gaattgtaat taagagtttg gattcacctg tttctcacgg tttaaaagtg
     9841 atgggtcatt gcgaagtctg gagatgtgac tagtctatga tttcaagctg ttagaagtca
     9901 ggaagctctc tgaaatgcta aaactaagat tctagttttg ggctcaaatt cgattaagta
     9961 ctgtttgtat gccagagtat gtgaggtgta aatgtagtgg ggtacttttc acccttgtag
    10021 ctgtaaaatt cacattttgt agaacagaaa atagcttgta ctactgaatt aacaagttat
    10081 actaaagtat catgtcttaa aaacaaaaac aaaaatacat atatctatct atatatatac
    10141 acacacacac agagttaagc ttgttgctgt taccctgtct ggatttgaaa attgtgctga
    10201 tttatataac acacacacac atacacacac acacacacac acacacccct ataatggcct
    10261 gaagcagaca tacctgtaac tacagttgca aactgcagac attttggaga gaacactgta
    10321 ccatagctca ttcattgcgt ggctctttgc tcctttttcc tgtggtcatt ttagaaacga
    10381 gtgtcaagtt tgaaattaga tctgctaagt tggggttctg ctgctgaatt ctgcactggg
    10441 tccccaaaca aaccgatgtg aatgtagttt ttccccctgt gtgaaggagc agccacagcc
    10501 ccatcagaat aggaggaaaa gtctagaagt atctcaaggt ttatcttttt gtatatgaaa
    10561 ataaataata ataaataaaa taacctcgtc tgta
//
