LOCUS       NM_007396               5681 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus activin receptor IIA (Acvr2a), mRNA.
ACCESSION   NM_007396
VERSION     NM_007396.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5681)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5681)
  AUTHORS   Zhang,H., Ruan,Q., Chen,C., Yu,H., Guan,S., Hu,D., Yang,C., Lin,R.
            and Zhuo,C.
  TITLE     Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal transition
            in colon cancer by activating SMAD2
  JOURNAL   Mol Carcinog 62 (10), 1585-1598 (2023)
   PUBMED   37378449
  REMARK    GeneRIF: Activin A/ACVR2A axis inhibits epithelial-to-mesenchymal
            transition in colon cancer by activating SMAD2.
REFERENCE   3  (bases 1 to 5681)
  AUTHORS   Chee,J.M., Lanoue,L., Clary,D., Higgins,K., Bower,L., Flenniken,A.,
            Guo,R., Adams,D.J., Bosch,F., Braun,R.E., Brown,S.D.M., Chin,H.G.,
            Dickinson,M.E., Hsu,C.W., Dobbie,M., Gao,X., Galande,S.,
            Grobler,A., Heaney,J.D., Herault,Y., de Angelis,M.H., Mammano,F.,
            Nutter,L.M.J., Parkinson,H., Qin,C., Shiroishi,T., Sedlacek,R.,
            Seong,J.K., Xu,Y., Brooks,B., McKerlie,C., Lloyd,K.C.K.,
            Westerberg,H. and Moshiri,A.
  CONSRTM   International Mouse Phenotyping Consortium
  TITLE     Genome-wide screening reveals the genetic basis of mammalian
            embryonic eye development
  JOURNAL   BMC Biol 21 (1), 22 (2023)
   PUBMED   36737727
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5681)
  AUTHORS   Petrosino,J.M., Hinger,S.A., Golubeva,V.A., Barajas,J.M.,
            Dorn,L.E., Iyer,C.C., Sun,H.L., Arnold,W.D., He,C. and Accornero,F.
  TITLE     The m6A methyltransferase METTL3 regulates muscle maintenance and
            growth in mice
  JOURNAL   Nat Commun 13 (1), 168 (2022)
   PUBMED   35013323
  REMARK    GeneRIF: The m(6)A methyltransferase METTL3 regulates muscle
            maintenance and growth in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5681)
  AUTHORS   Liu,Y., Lehar,A., Rydzik,R., Chandok,H., Lee,Y.S., Youngstrom,D.W.,
            George,J., Matzuk,M.M., Germain-Lee,E.L. and Lee,S.J.
  TITLE     Local versus systemic control of bone and skeletal muscle mass by
            components of the transforming growth factor-beta signaling pathway
  JOURNAL   Proc Natl Acad Sci U S A 118 (33) (2021)
   PUBMED   34385332
REFERENCE   6  (bases 1 to 5681)
  AUTHORS   Verschueren,K., Dewulf,N., Goumans,M.J., Lonnoy,O., Feijen,A.,
            Grimsby,S., Vandi Spiegle,K., ten Dijke,P., Moren,A.,
            Vanscheeuwijck,P., Heldin,C.H., Miyazono,K., Mummery,C., Van Den
            Eijnden-Van Raaij,J. and Huylebroeck,D.
  TITLE     Expression of type I and type IB receptors for activin in
            midgestation mouse embryos suggests distinct functions in
            organogenesis
  JOURNAL   Mech Dev 52 (1), 109-123 (1995)
   PUBMED   7577669
REFERENCE   7  (bases 1 to 5681)
  AUTHORS   Manova,K., De Leon,V., Angeles,M., Kalantry,S., Giarre,M.,
            Attisano,L., Wrana,J. and Bachvarova,R.F.
  TITLE     mRNAs for activin receptors II and IIB are expressed in mouse
            oocytes and in the epiblast of pregastrula and gastrula stage mouse
            embryos
  JOURNAL   Mech Dev 49 (1-2), 3-11 (1995)
   PUBMED   7748787
REFERENCE   8  (bases 1 to 5681)
  AUTHORS   van den Eijnden-van Raaij,A.J., Feijen,A., Lawson,K.A. and
            Mummery,C.L.
  TITLE     Differential expression of inhibin subunits and follistatin, but
            not of activin receptor type II, during early murine embryonic
            development
  JOURNAL   Dev Biol 154 (2), 356-365 (1992)
   PUBMED   1330789
REFERENCE   9  (bases 1 to 5681)
  AUTHORS   Matzuk,M.M. and Bradley,A.
  TITLE     Structure of the mouse activin receptor type II gene
  JOURNAL   Biochem Biophys Res Commun 185 (1), 404-413 (1992)
   PUBMED   1318045
REFERENCE   10 (bases 1 to 5681)
  AUTHORS   Mathews,L.S. and Vale,W.W.
  TITLE     Expression cloning of an activin receptor, a predicted
            transmembrane serine kinase
  JOURNAL   Cell 65 (6), 973-982 (1991)
   PUBMED   1646080
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY014959.1, AK041246.1, AK143186.1, BG066107.2 and CK340532.1.
            
            On Nov 16, 2007 this sequence version replaced NM_007396.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK041246.1, BC138823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BY014959.1         2-49
            49-871              AK041246.1         2-824
            872-926             AK143186.1         780-834
            927-1793            AK041246.1         880-1746
            1794-5090           AK143186.1         1893-5189
            5091-5463           BG066107.2         221-593             c
            5464-5681           CK340532.1         1-218               c
FEATURES             Location/Qualifiers
     source          1..5681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 28.38 cM"
     gene            1..5681
                     /gene="Acvr2a"
                     /gene_synonym="ActrIIa; Acvr2; TactrII"
                     /note="activin receptor IIA"
                     /db_xref="GeneID:11480"
                     /db_xref="MGI:MGI:102806"
     exon            1..718
                     /gene="Acvr2a"
                     /gene_synonym="ActrIIa; Acvr2; TactrII"
                     /inference="alignment:Splign:2.1.0"
     CDS             664..2205
                     /gene="Acvr2a"
                     /gene_synonym="ActrIIa; Acvr2; TactrII"
                     /EC_number="2.7.11.30"
                     /note="ACTR-IIA; activin receptor type IIA"
                     /codon_start=1
                     /product="activin receptor type-2A precursor"
                     /protein_id="NP_031422.3"
                     /db_xref="CCDS:CCDS16021.1"
                     /db_xref="GeneID:11480"
                     /db_xref="MGI:MGI:102806"
                     /translation="MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWERDRTNQ
                     TGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYF
                     CCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWV
                     YRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAV
                     KIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLS
                     DFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNL
                     TACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGL
                     VLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAG
                     MAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPP
                     KESSL"
     exon            719..926
                     /gene="Acvr2a"
                     /gene_synonym="ActrIIa; Acvr2; TactrII"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1036
                     /gene="Acvr2a"
                     /gene_synonym="ActrIIa; Acvr2; TactrII"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1191
                     /gene="Acvr2a"
                     /gene_synonym="ActrIIa; Acvr2; TactrII"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1335
                     /gene="Acvr2a"
                     /gene_synonym="ActrIIa; Acvr2; TactrII"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1479
                     /gene="Acvr2a"
                     /gene_synonym="ActrIIa; Acvr2; TactrII"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1625
                     /gene="Acvr2a"
                     /gene_synonym="ActrIIa; Acvr2; TactrII"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1740
                     /gene="Acvr2a"
                     /gene_synonym="ActrIIa; Acvr2; TactrII"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1879
                     /gene="Acvr2a"
                     /gene_synonym="ActrIIa; Acvr2; TactrII"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2010
                     /gene="Acvr2a"
                     /gene_synonym="ActrIIa; Acvr2; TactrII"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..5681
                     /gene="Acvr2a"
                     /gene_synonym="ActrIIa; Acvr2; TactrII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2843..2848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acvr2a"
                     /gene_synonym="ActrIIa; Acvr2; TactrII"
                     /note="hexamer: AATAAA"
     polyA_site      2866
                     /gene="Acvr2a"
                     /gene_synonym="ActrIIa; Acvr2; TactrII"
                     /note="major polyA site"
ORIGIN      
        1 agcttcagga cggaaccgga agtgtagggg gcggggccgg cggaggccag gagaccgaaa
       61 acgcggccga gccgggagcc gggagccgga gccacagcct ggaccagaac ttggccgccg
      121 cctgcgccac cgtctctccc gtcgccgtct cccgcggccg cctcgcaccg ccaccgccgc
      181 gagctcggct actgtggtcc gcggactttg ggtgtccggg ttgaaggtcg gtccggacgt
      241 cggagcagct cggctcccgg accgtccggg cggctgcggg cgccgccgcc gccgcctcgt
      301 cgcctcagcc aggcgttttg ttcgctgaga cgcgagaggc gagcggagct gacagtgatt
      361 ttgacagtga ttccaacccg cttttgttgt tgttggcttt tcgttgtttg gtttggtgtg
      421 ttgtgcgtgt atgtggcggt ttttcccccg tggtacattt ttttaaattg ttgtgccttt
      481 tttttaaatc cttttttttt caaccctgtg aacgtttttt gcttccccct cccccccgcc
      541 tcggggcttc cgaatatgtt ttatgacggt tgattttaca ccaggaggtt tgtctccgag
      601 gaagacccag ggaactggat atctagcgag aacttcctac ggcttctccg gcgcctcggg
      661 aaaatgggag ctgctgcaaa gttggcgttc gccgtctttc ttatctcttg ctcttcaggt
      721 gctatacttg gcagatcaga aactcaggag tgtcttttct ttaatgctaa ttgggaaaga
      781 gacagaacca accagactgg tgttgaacct tgctatggtg ataaagataa acggcgacat
      841 tgttttgcta cctggaagaa tatttctggt tccattgaaa tagtgaagca aggttgttgg
      901 ctggatgata tcaactgcta tgacaggact gattgtatag aaaaaaaaga cagccctgaa
      961 gtgtactttt gttgctgtga gggcaatatg tgtaatgaaa agttctctta ttttccggag
     1021 atggaagtca cacagcccac ttcaaatcct gttacaccga agccacccta ttacaacatt
     1081 ctgctgtatt ccttggtacc actaatgtta attgcaggaa ttgtcatttg tgcattttgg
     1141 gtgtacagac atcacaagat ggcctaccct cctgtacttg ttcctactca agacccagga
     1201 ccacccccac cttccccatt actagggttg aagccattgc agctgttaga agtgaaagca
     1261 aggggaagat ttggttgtgt ctggaaagcc cagttgctca atgaatatgt ggctgtcaaa
     1321 atatttccaa tacaggacaa acagtcctgg cagaatgaat atgaagtcta tagtctacct
     1381 ggaatgaagc atgagaacat actacagttc attggtgcag agaaaagagg caccagtgtg
     1441 gatgtggacc tgtggctaat cacagcattt catgaaaagg gctcactgtc agactttctt
     1501 aaggctaatg tggtctcttg gaatgaactt tgtcatattg cagaaaccat ggctagagga
     1561 ttggcatatt tacatgagga tatacctggc ttaaaagatg gccacaagcc tgcaatctct
     1621 cacagggaca tcaaaagtaa aaatgtgctg ttgaaaaaca atctgacagc ttgcattgct
     1681 gactttgggt tggccttaaa gttcgaggct ggcaagtctg caggtgacac ccatgggcag
     1741 gttggtaccc ggaggtatat ggctccagag gtgttggagg gtgctataaa cttccaaagg
     1801 gacgcatttc tgaggataga tatgtacgcc atgggattag tcctatggga attggcttct
     1861 cgttgcactg ctgcagatgg acccgtagat gagtacatgt taccatttga ggaagaaatt
     1921 ggccagcatc catctcttga agatatgcag gaagttgttg tgcataaaaa aaagaggcct
     1981 gttttaagag attattggca gaaacatgca ggaatggcaa tgctctgtga aacgatagaa
     2041 gaatgttggg atcatgatgc agaagccagg ttatcagctg gatgtgtagg tgaaagaatt
     2101 actcagatgc aaagactaac aaatatcatt actacagagg acattgtaac agtggtcaca
     2161 atggtgacaa atgttgactt tcctcccaaa gaatctagtc tatgatggtg gcaccgtctg
     2221 tacacactga ggactgggac tctgaactgg agctgctaag ctaaggaaag tgcttagttg
     2281 attttctgtg tgaaatgagt aggatgcctc caggacatgt acgcaagcag ccccttgtgg
     2341 aaagcatgga tctgggagat ggatctggga aacttactgc atcgtctgca gcacagatat
     2401 gaagaggagt ctaagggaaa agctgcaaac tgtaaagaac ttctgaaaat gtactcgaag
     2461 aatgtggccc tctccaaatc aaggatcttt tggacctggc taatcaagta tttgaaaact
     2521 gacatcagat ttcttaatgt ctgtcagaag acactaattc cttaaatgaa ctactgctat
     2581 tttttttaaa tcaaaaactt ttcatttcag attttaaaaa gggtaacttt ttattgcatt
     2641 tgctgttgtt tctataaatg actattgtaa tgccaacatg acacagcttg tgaatgtgta
     2701 gtgtgctgct gttctgtgta catagtcatc aaagtggggt acagtaaaga ggcttccaag
     2761 cattacttta acctccctca acaaggtata cctcagttcc acggttgcta aattataaaa
     2821 ttgaaaacac taacagaatt tgaataaatc agtccatgtt ttataacaag gtattacaaa
     2881 ttcactgtgt tatttaagaa aaaatggtaa gctatgctta gtgccaatag taagtggcta
     2941 tttgtaaagc agtgttttag cttttcttct actggcttgt aatttaggga aaacaaagtg
     3001 ctgtctttga aatggaaaag aatatggtgt caccctaccc cccatactta tatcaaggtc
     3061 ccaaaatatt gcatacttaa gtagtacttt tttctttaag gtgtgctgtg tttgggaaat
     3121 atttgaaaac ataaagcatg atttaaaatt ttttaagtga gctgtgacac tggaaagctc
     3181 ttcatttttc ttttaaaata gatttttttt tcctatttat atatataaaa tgacggtgta
     3241 tttcttcttt tcaccaaaca gtgtgtggga tattcttatc actgttttat gatcacctca
     3301 ggaagtgtca ttactcagaa ttcttcactc tgcttctaga cttgtaactt tatcactgta
     3361 ctgcgtggtg ccatcttgtc agagtaatat ttgatgtctg tgatatggag agaattagct
     3421 taggataaag gtagtgacct ttaagaacag atttcagata ttactgcttt aagacaaatc
     3481 agggataaca agttgaactt ataatatgca atgacattaa gaggtaacca gtgctggtct
     3541 aaggaacaca acccagcttc ctccccaaat tacttttaca gctaatttta gatagttcat
     3601 gccttatcct tacgaagaaa gtggaattga tggcatgtag gtaccagagt gctttaaaaa
     3661 acattattac attagaatat aattggatct ttcctaaagc ttgcacgggc ccaagtaaaa
     3721 aattaattcc ctgaatttta aattaccaac aaatagccag tattatgtta tatacatttt
     3781 tgttgagtca ctttaacatc catacattaa ctttataaac ttctacgtta ctatcaggag
     3841 ctcactgtga atgcattatc ttcagatggt taagacatca gacactacat tttacatata
     3901 atgtgcacta atctctgggg agaataatta caaacaatac ataggtcaac agactttaag
     3961 tggggaggat aatagcattc ttgtttgtat gccacacacc atagagaact gtgcgttgtc
     4021 tctgtaccca aggtctcact gtattcgtaa ggttgccaag ttcagtgttc attgttttga
     4081 tttctacata tttggcccct caaactcttg atataggttt gcttgcactt gtaagctaat
     4141 caaggaaaac cataagaaaa tatgcatata aggaaattat tcctctccat aagcaaacta
     4201 ctactggttt taaacattca acctccttta aaagctgata aatgagggat aatacgactg
     4261 ttcggcttaa gaaagcacta cagataaatt ttaccaagac tggttcatga tataagatgc
     4321 tttgtcttta tgctaaaatt tttttttaag gaaatcttgg gtattgtatg taaatctagc
     4381 ttatcaattt taaaacttgt attctcttaa gaactacatt aacagaaagc cttttttata
     4441 agcagtaacg ttaagaatgt tccagtgact acctgccctt atacctagtc ttgttaaaac
     4501 tttcttttgc agggcatttt agtgtttggt ttacagtaag tgcagaatgg gcagataaaa
     4561 agattgagtt agggacattg aaaaagaaag atcaaagaat gaaaactttt ttttagggag
     4621 atggcaaact tggacccctg tatatcttca tgtgtatggt gctcacgatg tcttgtactt
     4681 tgcctttctg atacccacca gaactgctgc tcttactcta ccttgcccaa atctcccatg
     4741 tgagaaatgc tttatgatca actgccatag gactgactga tggagtaacc agtgtttgaa
     4801 tttatttgaa gtctatctat gccctgcaca gatcttgtat gtattttaga tgctaggagt
     4861 tttagcatgt gatttgtgac tcttgtttgg atgtttatta caggtacctt gtgaattcca
     4921 gaacagagac tgtgcctcac aattattggt cccatgaact tgcactatct ttcatggtaa
     4981 tattctaaaa atataaccag gaaaaacaaa aaacaaacac ctttggactt aaagacagaa
     5041 ttatgtatca cacacaatta tgaaaacatc gcttctgacc ctttttctta tccttaataa
     5101 ttaagtcaca tttaagtaaa attcaaatgg ttgggaaaaa caaaacaaaa caaaacaaaa
     5161 ccaaactcct caccagatag atggtagttt agtggaatag aatgattact gttttttaaa
     5221 aaaaaatgct tcatcagata ttttccagtt tctctttttt acttttttga aaaattactt
     5281 tttaggaaga tttggtataa tgtgcataaa attatttaca atttatggac aaagatacaa
     5341 gtagcatctt gattaaacat catttacctc agatattcaa ccagcagtac gttttttatg
     5401 cagtctcaac ccgtatctcc ctatttgtta cctctcaaaa tattggtaaa caattatttt
     5461 agctttactc tgtatttctt gtcagtgttt tgggcacagg ttgttgtact actgtcatat
     5521 tgtacttgct attttttttt tctgcaagta tttaacagaa agctaaaaat gaaaaaaatc
     5581 cccataaaat cccaccttga ataagtgatt gttaaatatt gtacaaataa aatgtatgct
     5641 atccccattc catccccatg ttaaataaaa aatgaatatg g
//
