LOCUS       NM_007395               4437 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus activin A receptor, type 1B (Acvr1b), mRNA.
ACCESSION   NM_007395
VERSION     NM_007395.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4437)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4437)
  AUTHORS   Saeki,K., Wood,I.S., Wang,W.C.K., Patil,S., Sun,Y., Schaeffer,D.F.,
            Su,G.H. and Kopp,J.L.
  TITLE     Acvr1b Loss Increases Formation of Pancreatic Precancerous Lesions
            From Acinar and Ductal Cells of Origin
  JOURNAL   Cell Mol Gastroenterol Hepatol 18 (5), 101387 (2024)
   PUBMED   39111635
  REMARK    GeneRIF: Acvr1b Loss Increases Formation of Pancreatic Precancerous
            Lesions From Acinar and Ductal Cells of Origin.
REFERENCE   3  (bases 1 to 4437)
  AUTHORS   Lee,E.S., Guo,T., Srivastava,R.K., Shabbir,A. and Ibanez,C.F.
  TITLE     Activin receptor ALK4 promotes adipose tissue hyperplasia by
            suppressing differentiation of adipocyte precursors
  JOURNAL   J Biol Chem 299 (1), 102716 (2023)
   PUBMED   36403856
REFERENCE   4  (bases 1 to 4437)
  AUTHORS   Hillege,M.M.G., Shi,A., Galli,R.A., Wu,G., Bertolino,P.,
            Hoogaars,W.M.H. and Jaspers,R.T.
  TITLE     Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre
            hypertrophy and accelerates muscle regeneration
  JOURNAL   Elife 11, e77610 (2022)
   PUBMED   35323108
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4437)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4437)
  AUTHORS   Mishina,Y., Crombie,R., Bradley,A. and Behringer,R.R.
  TITLE     Multiple roles for activin-like kinase-2 signaling during mouse
            embryogenesis
  JOURNAL   Dev Biol 213 (2), 314-326 (1999)
   PUBMED   10479450
REFERENCE   7  (bases 1 to 4437)
  AUTHORS   Gu,Z., Nomura,M., Simpson,B.B., Lei,H., Feijen,A., van den
            Eijnden-van Raaij,J., Donahoe,P.K. and Li,E.
  TITLE     The type I activin receptor ActRIB is required for egg cylinder
            organization and gastrulation in the mouse
  JOURNAL   Genes Dev 12 (6), 844-857 (1998)
   PUBMED   9512518
REFERENCE   8  (bases 1 to 4437)
  AUTHORS   Renucci,A., Lemarchandel,V. and Rosa,F.
  TITLE     An activated form of type I serine/threonine kinase receptor
            TARAM-A reveals a specific signalling pathway involved in fish head
            organiser formation
  JOURNAL   Development 122 (12), 3735-3743 (1996)
   PUBMED   9012495
REFERENCE   9  (bases 1 to 4437)
  AUTHORS   Schmitt,J., Mielke,R. and Schrewe,H.
  TITLE     Genomic organization of a mouse type I activin receptor
  JOURNAL   Biochem Biophys Res Commun 213 (1), 211-217 (1995)
   PUBMED   7639738
REFERENCE   10 (bases 1 to 4437)
  AUTHORS   Verschueren,K., Dewulf,N., Goumans,M.J., Lonnoy,O., Feijen,A.,
            Grimsby,S., Vandi Spiegle,K., ten Dijke,P., Moren,A.,
            Vanscheeuwijck,P., Heldin,C.H., Miyazono,K., Mummery,C., Van Den
            Eijnden-Van Raaij,J. and Huylebroeck,D.
  TITLE     Expression of type I and type IB receptors for activin in
            midgestation mouse embryos suggests distinct functions in
            organogenesis
  JOURNAL   Mech Dev 52 (1), 109-123 (1995)
   PUBMED   7577669
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC145775.1, AK157910.1, AK078525.1, AC161812.3 and BC059832.1.
            
            On Mar 28, 2018 this sequence version replaced NM_007395.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145775.1, AK154578.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2351              BC145775.1         1-2351
            2352-3330           AK157910.1         2300-3278
            3331-3615           AK078525.1         575-859
            3616-3616           AC161812.3         10847-10847         c
            3617-3876           AK078525.1         861-1120
            3877-4437           BC059832.1         3557-4117
FEATURES             Location/Qualifiers
     source          1..4437
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 56.48 cM"
     gene            1..4437
                     /gene="Acvr1b"
                     /gene_synonym="6820432J04; ActR-IB; ActRIB; Acvrlk4;
                     ALK-4; Alk4; SKR2"
                     /note="activin A receptor, type 1B"
                     /db_xref="GeneID:11479"
                     /db_xref="MGI:MGI:1338944"
     exon            1..164
                     /gene="Acvr1b"
                     /gene_synonym="6820432J04; ActR-IB; ActRIB; Acvrlk4;
                     ALK-4; Alk4; SKR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1591
                     /gene="Acvr1b"
                     /gene_synonym="6820432J04; ActR-IB; ActRIB; Acvrlk4;
                     ALK-4; Alk4; SKR2"
                     /EC_number="2.7.11.30"
                     /note="activin receptor type-1B; activin receptor type IB;
                     activin receptor-like kinase 4; serine/threonine-protein
                     kinase receptor R2"
                     /codon_start=1
                     /product="activin receptor type-1B precursor"
                     /protein_id="NP_031421.1"
                     /db_xref="CCDS:CCDS27846.1"
                     /db_xref="GeneID:11479"
                     /db_xref="MGI:MGI:1338944"
                     /translation="MAESAGASSFFPLVVLLLAGSGGSGPRGIQALLCACTSCLQTNY
                     TCETDGACMVSIFNLDGVEHHVRTCIPKVELVPAGKPFYCLSSEDLRNTHCCYIDFCN
                     KIDLRVPSGHLKEPAHPSMWGPVELVGIIAGPVFLLFLIIIIVFLVINYHQRVYHNRQ
                     RLDMEDPSCEMCLSKDKTLQDLVYDLSTSGSGSGLPLFVQRTVARTIVLQEIIGKGRF
                     GEVWRGRWRGGDVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWT
                     QLWLVSDYHEHGSLFDYLNRYTVTIEGMIKLALSAASGLAHLHMEIVGTQGKPGIAHR
                     DLKSKNILVKKNGMCAIADLGLAVRHDAVTDTIDIAPNQRVGTKRYMAPEVLDETINM
                     KHFDSFKCADIYALGLVYWEIARRCNSGGVHEDYQLPYYDLVPSDPSIEEMRKVVCDQ
                     KLRPNVPNWWQSYEALRVMGKMMRECWYANGAARLTALRIKKTLSQLSVQEDVKI"
     exon            165..404
                     /gene="Acvr1b"
                     /gene_synonym="6820432J04; ActR-IB; ActRIB; Acvrlk4;
                     ALK-4; Alk4; SKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            405..653
                     /gene="Acvr1b"
                     /gene_synonym="6820432J04; ActR-IB; ActRIB; Acvrlk4;
                     ALK-4; Alk4; SKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..884
                     /gene="Acvr1b"
                     /gene_synonym="6820432J04; ActR-IB; ActRIB; Acvrlk4;
                     ALK-4; Alk4; SKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1052
                     /gene="Acvr1b"
                     /gene_synonym="6820432J04; ActR-IB; ActRIB; Acvrlk4;
                     ALK-4; Alk4; SKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1209
                     /gene="Acvr1b"
                     /gene_synonym="6820432J04; ActR-IB; ActRIB; Acvrlk4;
                     ALK-4; Alk4; SKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1334
                     /gene="Acvr1b"
                     /gene_synonym="6820432J04; ActR-IB; ActRIB; Acvrlk4;
                     ALK-4; Alk4; SKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1465
                     /gene="Acvr1b"
                     /gene_synonym="6820432J04; ActR-IB; ActRIB; Acvrlk4;
                     ALK-4; Alk4; SKR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..4413
                     /gene="Acvr1b"
                     /gene_synonym="6820432J04; ActR-IB; ActRIB; Acvrlk4;
                     ALK-4; Alk4; SKR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4391..4396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acvr1b"
                     /gene_synonym="6820432J04; ActR-IB; ActRIB; Acvrlk4;
                     ALK-4; Alk4; SKR2"
                     /note="hexamer: ATTAAA"
     polyA_site      4411
                     /gene="Acvr1b"
                     /gene_synonym="6820432J04; ActR-IB; ActRIB; Acvrlk4;
                     ALK-4; Alk4; SKR2"
                     /note="major polyA site"
ORIGIN      
        1 gagggaggga gggagagagg cgccgggggc gcgcgcgcgc gctgggcgct gctgggctgc
       61 ggcggcggtt actatggcgg agtcggccgg agcctcctcc ttcttccccc ttgttgtcct
      121 cctgctcgcc ggcagcggcg ggtccgggcc ccgggggatc caggctctgc tgtgtgcgtg
      181 caccagctgc ctacagacca actacacctg tgagacagat ggggcttgca tggtctccat
      241 ctttaacctg gatggcgtgg agcaccatgt acgtacctgc atccccaagg tggagctggt
      301 tcctgctgga aagcccttct actgcctgag ttcagaggat ctgcgcaaca cacactgctg
      361 ctatattgac ttctgcaaca agattgacct cagggtcccc agcggacacc tcaaggagcc
      421 tgcgcacccc tccatgtggg gccctgtgga gctggtcggc atcatcgccg gccccgtctt
      481 cctcctcttc cttatcatta tcatcgtctt cctggtcatc aactatcacc agcgtgtcta
      541 ccataaccgc cagaggttgg acatggagga cccctcttgc gagatgtgtc tctccaaaga
      601 caagacgctc caggatctcg tctacgacct ctccacgtca gggtctggct cagggttacc
      661 cctttttgtc cagcgcacag tggcccgaac cattgtttta caagagatta tcggcaaggg
      721 ccggttcggg gaagtatggc gtggtcgctg gaggggtggt gacgtggctg tgaaaatctt
      781 ctcttctcgt gaagaacggt cttggttccg tgaagcagag atctaccaga ccgtcatgct
      841 gcgccatgaa aacatccttg gctttattgc tgctgacaat aaagataatg gcacctggac
      901 ccagctgtgg cttgtctctg actatcacga gcatggctca ctgtttgatt atctgaaccg
      961 ctacacagtg accattgagg gaatgattaa gctagccttg tctgcagcca gtggtttggc
     1021 acacctgcat atggagattg tgggcactca agggaagccg ggaattgctc atcgagactt
     1081 gaagtcaaag aacatcctgg tgaaaaaaaa tggcatgtgt gccattgcag acctgggcct
     1141 ggctgtccgt catgatgcgg tcactgacac catagacatt gctccaaatc agagggtggg
     1201 gaccaaacga tacatggctc ctgaagtcct tgacgagaca atcaacatga agcactttga
     1261 ctccttcaaa tgtgccgaca tctatgccct cgggcttgtc tactgggaga ttgcacgaag
     1321 atgcaattct ggaggagtcc atgaagacta tcaactgccg tattacgact tagtgccctc
     1381 cgacccttcc attgaggaga tgcgaaaggt tgtatgtgac cagaagctac ggcccaatgt
     1441 ccccaactgg tggcagagtt atgaggcctt gcgagtgatg ggaaagatga tgcgggagtg
     1501 ctggtacgcc aatggtgctg cccgtctgac agctctgcgc atcaagaaga ctctgtccca
     1561 gctaagcgtg caggaagatg tgaagattta agctgttcct ctgcctacac aaagaacctg
     1621 ggcagtgagg atgactgcag ccaccgtgca agcgtcgtgg aggcctacct cttgtttctg
     1681 cccggccctc tggccagagc cctggcctgc aagagggaca gagcctggga gacgcgcact
     1741 cccgttgggt ttgagacaga cactttttat atttacctcc tgatggcatg gagactctga
     1801 gcaaatcatg tagacaactc aatgccacaa ctcaaactgc ttgcagtggg aagtacagag
     1861 agcccagtgc atctggcgtg ttgccaggag cggtgaaggg tgctgggctc gcccaggagc
     1921 ggcccccata ccttgtggtc cactgggctg caggttttcc tccagggacc agtcaactgg
     1981 catcaagata ttgagaggaa ccggaagttt cctccctcct tcccgtaggc agtcctgagc
     2041 cacaccatcc cttctcatgg acatccggag ggactgcccc tagagacaca acctgctgcc
     2101 tgtctgtcca gccaagtgcg catgtgccga ggtgtgtccc acattgtgcc tggtctgtgc
     2161 cacgcccgtg tgtgtgtgtg tgtgtgtgag tgagtgtgtg tgtgtacact taacctgctt
     2221 gagctttctg tgcatgtgta ggccagggtg tggtggccat actgtctctg agtgctgctg
     2281 cttctcagtg agcagcatgt agttaacctg gtgccctcct aggtgtctcc tgtccccaga
     2341 ccccatcagt cagggaggtt ctgtcttctc agcaggctgc ttgcccaccc tgtgtcacag
     2401 gccctcctct tccatttcag accagaacca aagctggccc acttgtccat ggtaggagaa
     2461 gcttttgggt caaaatgagg gggacttgat gagcagagag agaatgtagg tggaagtctt
     2521 gggtgctgtg tttcagcatc agccatggga aatgagccag cccaagggca tcttccttga
     2581 cagctgtgag gaagggccga ggaatccgaa gccagagctt gggactcaga ttggaatgta
     2641 acatctgttt atgtcccacc ccagattctg caaactgcag tgtatatttt tggtggtggg
     2701 tttggggtgg gaagggatgg gttgcagggc gtggggaggg aggctggggt gggagggagg
     2761 catctgcatg ggcttcttgt actggattct ctgatcaggg tagagaagag gcaaggcttg
     2821 catccacttc agggtcccta ctgaggagag tgagcggtcc gagctgaata tggtgtttaa
     2881 cctaagttta gtatttaatg aattctagaa gcctggctgt gggtggtgat ttggtcagca
     2941 tatcttaggt atataataac tttgaagcca taacttttta actggagtgg tttattttaa
     3001 ttcagtttat tttattttat tttgggggga gggtcaggat tttaacttta atattgttaa
     3061 gttttgtaaa aggagaacca tctctgtgac aattacctct tagtctgttt gtttttaaag
     3121 aaatccctaa aacaaacaaa acacaaaaat tctccagact caaacgcaca tagttcagtc
     3181 actggaaacg cttgtctttg cacctgagcc tgatcccgct gagcagtgag ggctgctttt
     3241 ccccatgggg gcttgctgtc tcgtactccc tgcaccctcg gccccatccc gtgagcacct
     3301 cggccctctg cacattgccc ggctggttgg accctttcca gatacttgct cagcaaatgt
     3361 gggctgcgag cctgctgagc gctggcccgg gaggatctcc tcagggtggg gcaggcttgg
     3421 gcgctgctct gctcctctac cactggaggg aatggaatca tgcgatgggc gagcacctgc
     3481 tgtggagacc agaagtgctc atggctggtc ctgagagcct tgatgagcta ggatcactgt
     3541 tcttaaagac cactgaaact ggaaggggga cctgtatccc cttgggaaga gaagcccctg
     3601 gcaagcagtg ggtcctggag actgggttca ttgtgagcct ttcctgccag gggaggcatg
     3661 agtctttgca gggaaactgt ctcctccagc ttctcctgcc ttggtctccc catattctta
     3721 gcctttctat ttatttcctg gtgtataact ttccttgctt taaagggatc ttcctttaat
     3781 tccttgggcc aatttactgg ccattgaaca gtgtcccttg agtcccaact gtgtctctgg
     3841 ggaacctcct tacccacccc tgctgacctc ccacttccca ccctgcagct gagtatccgt
     3901 gattacaggc gattgaactg tagagtcctc tctgcctctg tacctgccag cagcagcctc
     3961 acagtgaccc ccacgccact ggacaactcc caggagacct gtgcgctccg tgcagctcag
     4021 ctcagccgcc tctcaggaag cctggagcag gtctggggga cccccccccc atcactcttt
     4081 acattaagct gagagttggg agaagctgtg ctttggctcc ctgaggccac cctgatccac
     4141 ggggcacccg cacctctgcg ttctggattc acagaccaag tctaaagccc gttcgttcct
     4201 gagttgccgt caaggcccct gaacggtact ctcggtactt ctgtttgttt tttgtacaat
     4261 ttattagaaa ggactgtaaa atagccactt agacacttta cctctccagt atgcaaatgt
     4321 aaatatattg taatatagga aatttttgtt ttaatataag aatgagcctg tccagtttct
     4381 gctgtacatt attaaagttt tattcacaga actaaaaaaa aaaaaaaaaa aaaaaaa
//
