LOCUS       NM_007394               3067 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus activin A receptor, type 1 (Acvr1), transcript variant
            2, mRNA.
ACCESSION   NM_007394
VERSION     NM_007394.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3067)
  AUTHORS   Shen,H., Gao,Y., Ge,D., Tan,M., Yin,Q., Wei,T.W., He,F., Lee,T.Y.,
            Li,Z., Chen,Y., Yang,Q., Liu,Z., Li,X., Chen,Z., Yang,Y., Zhang,Z.,
            Thistlethwaite,P.A., Wang,J., Malhotra,A., Yuan,J.X., Shyy,J.Y. and
            Gong,K.
  TITLE     BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells:
            Implication in Pulmonary Hypertension
  JOURNAL   Circulation 150 (2), 132-150 (2024)
   PUBMED   38557054
  REMARK    GeneRIF: BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells:
            Implication in Pulmonary Hypertension.
REFERENCE   2  (bases 1 to 3067)
  AUTHORS   Yang,J., Zhu,L., Pan,H., Ueharu,H., Toda,M., Yang,Q., Hallett,S.A.,
            Olson,L.E. and Mishina,Y.
  TITLE     A BMP-controlled metabolic/epigenetic signaling cascade directs
            midfacial morphogenesis
  JOURNAL   J Clin Invest 134 (8), e165787 (2024)
   PUBMED   38466355
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3067)
  AUTHORS   Liu,L., Zhang,X., Geng,H.R., Qiao,Y.N., Gui,Y.H. and Zhao,J.Y.
  TITLE     High paternal homocysteine causes ventricular septal defects in
            mouse offspring
  JOURNAL   iScience 27 (4), 109447 (2024)
   PUBMED   38523790
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3067)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3067)
  AUTHORS   Burdick,L.N., DelVichio,A.H., Hanson,L.R., Griffith,B.B.,
            Bouchard,K.R., Hunter,J.W. and Goldhamer,D.J.
  TITLE     Sex as a Critical Variable in Basic and Pre-Clinical Studies of
            Fibrodysplasia Ossificans Progressiva
  JOURNAL   Biomolecules 14 (2), 177 (2024)
   PUBMED   38397414
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3067)
  AUTHORS   Schmitt,J., Mielke,R. and Schrewe,H.
  TITLE     Genomic organization of a mouse type I activin receptor
  JOURNAL   Biochem Biophys Res Commun 213 (1), 211-217 (1995)
   PUBMED   7639738
REFERENCE   7  (bases 1 to 3067)
  AUTHORS   Verschueren,K., Dewulf,N., Goumans,M.J., Lonnoy,O., Feijen,A.,
            Grimsby,S., Vandi Spiegle,K., ten Dijke,P., Moren,A.,
            Vanscheeuwijck,P., Heldin,C.H., Miyazono,K., Mummery,C., Van Den
            Eijnden-Van Raaij,J. and Huylebroeck,D.
  TITLE     Expression of type I and type IB receptors for activin in
            midgestation mouse embryos suggests distinct functions in
            organogenesis
  JOURNAL   Mech Dev 52 (1), 109-123 (1995)
   PUBMED   7577669
REFERENCE   8  (bases 1 to 3067)
  AUTHORS   Roelen,B.A., Lin,H.Y., Knezevic,V., Freund,E. and Mummery,C.L.
  TITLE     Expression of TGF-beta s and their receptors during implantation
            and organogenesis of the mouse embryo
  JOURNAL   Dev Biol 166 (2), 716-728 (1994)
   PUBMED   7813789
REFERENCE   9  (bases 1 to 3067)
  AUTHORS   Nakamura,T., Sugino,K., Kurosawa,N., Sawai,M., Takio,K., Eto,Y.,
            Iwashita,S., Muramatsu,M., Titani,K. and Sugino,H.
  TITLE     Isolation and characterization of activin receptor from mouse
            embryonal carcinoma cells. Identification of its
            serine/threonine/tyrosine protein kinase activity
  JOURNAL   J Biol Chem 267 (26), 18924-18928 (1992)
   PUBMED   1326537
REFERENCE   10 (bases 1 to 3067)
  AUTHORS   Mathews,L.S. and Vale,W.W.
  TITLE     Expression cloning of an activin receptor, a predicted
            transmembrane serine kinase
  JOURNAL   Cell 65 (6), 973-982 (1991)
   PUBMED   1646080
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK150014.1, BC058718.1 and BQ030975.1.
            
            On Oct 31, 2007 this sequence version replaced NM_007394.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150014.1, AK150075.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-500               AK150014.1         1-500
            501-2778            BC058718.1         222-2499
            2779-3067           BQ030975.1         1-289               c
FEATURES             Location/Qualifiers
     source          1..3067
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 33.05 cM"
     gene            1..3067
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /note="activin A receptor, type 1"
                     /db_xref="GeneID:11477"
                     /db_xref="MGI:MGI:87911"
     exon            1..42
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /inference="alignment:Splign:2.1.0"
     exon            43..138
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /inference="alignment:Splign:2.1.0"
     exon            139..415
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /inference="alignment:Splign:2.1.0"
     exon            416..489
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..1952
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /EC_number="2.7.11.30"
                     /note="activin receptor type-1; TSR-I; TSK-7L; activin
                     receptor type I; TGF-B superfamily receptor type I;
                     serine/threonine-protein kinase receptor R1"
                     /codon_start=1
                     /product="activin receptor type-1 precursor"
                     /protein_id="NP_031420.2"
                     /db_xref="CCDS:CCDS16050.1"
                     /db_xref="GeneID:11477"
                     /db_xref="MGI:MGI:87911"
                     /translation="MVDGVMILPVLMMMAFPSPSVEDEKPKVNQKLYMCVCEGLSCGN
                     EDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRN
                     ITAQLPTKGKSFPGTQNFHLEVGLIILSVVFAVCLLACILGVALRKFKRRNQERLNPR
                     DVEYGTIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGR
                     YGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSS
                     TQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAH
                     RDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQ
                     VDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCV
                     DQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTD
                     C"
     exon            490..753
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /inference="alignment:Splign:2.1.0"
     exon            754..965
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1065
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1212
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1488
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1686
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1817
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..3053
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3032..3037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /note="hexamer: AATAAA"
     polyA_site      3053
                     /gene="Acvr1"
                     /gene_synonym="ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2;
                     Alk-2; ALK2; Alk8; D330013D15Rik; SKR1; Tsk7L"
                     /note="major polyA site"
ORIGIN      
        1 ccgcctcccc gggttcagca cccgaccgcc gctggaccag aggaacaaag gagctgcccc
       61 cgtgtcaccc agcccttcag tggaagtctg gaaaaggaac agaggtgata ttgcagtgga
      121 tgagcagaga gaagccggcc tctggtgctc ttgagctggt ctgcccatag ggagcctgct
      181 gggagaaggt acagcttccg gaagactcct cccggagcgc ctctcccatc ctcctctccc
      241 ttggagcagt cagtacctct ctgctggagg atctgggctg ggtgtgccgg gagctggctt
      301 taactgtagc cctgtcaggc tttccccgga cctcgcggaa gagcgtcacc agcccccacg
      361 gctttccaac acatcacctc ttttcatgcc gtttggcaca gatcgaatct acaggttata
      421 caatggtcga tggagtaatg atccttcctg tgctaatgat gatggctttc ccttccccga
      481 gtgtggaaga tgagaagccc aaggtcaacc agaaacttta catgtgtgtg tgtgagggcc
      541 tctcctgcgg gaacgaggac cactgtgaag gccagcagtg tttttcttct ctgagcatca
      601 acgatggctt ccacgtctac cagaagggct gctttcaggt ttatgagcag gggaagatga
      661 cgtgtaagac cccgccgtca cctggccagg ctgtggagtg ctgccaaggg gactggtgta
      721 acaggaacat cacggcccag ctgcccacta aagggaagtc cttccccgga acacagaatt
      781 tccacctgga agttggcctt atcatcctct cggtggtgtt tgcagtatgt cttttagctt
      841 gcatccttgg agttgctctc aggaagttta agagacgcaa tcaagagcgc ctgaacccca
      901 gagacgtgga gtatggtacc attgaagggc tcatcaccac caatgtggga gacagcactc
      961 tagcggaact actagatcac tcgtgtacat caggaagtgg ctccggtctt cctttcctgg
     1021 tacagagaac ggtggctcgc cagataaccc tgttggagtg tgtcgggaag ggccggtatg
     1081 gagaagtatg gaggggcagc tggcaaggcg aaaatgtcgc tgtgaagatc ttctcctccc
     1141 gagacgagaa gtcatggttc agggagacgg aattgtacaa cactgtgatg ttgaggcatg
     1201 aaaatatctt aggtttcatc gcttcagaca tgacctccag acactccagt acccagctgt
     1261 ggctcatcac acattaccat gaaatgggat cgttgtatga ctaccttcag ctcactactc
     1321 tggatacggt tagctgcctt cggattgtac tgtccatagc cagcggcctt gcccatttgc
     1381 acatagagat atttgggacc caagggaagt ccgccattgc ccatcgagat ctgaagagca
     1441 aaaacatcct ggtgaagaag aatggacagt gctgcatagc agatttgggc ctggcagtca
     1501 tgcattccca gagcacaaac cagcttgatg tgggaaacaa cccccgtgtg gggaccaagc
     1561 gctacatggc tccggaagtg ctcgatgaaa ccatccaagt ggattgcttt gattcttata
     1621 agagggtcga tatttgggcc tttggccttg ttctgtggga agtggccagg cgaatggtga
     1681 gcaatggtat agtggaagat tacaagccac cattctatga tgtggttccc aatgacccaa
     1741 gttttgaaga tatgaggaaa gttgtctgtg tggatcaaca gaggccaaac atacctaaca
     1801 gatggttctc agacccgaca ttaacttctc tggcgaagct gatgaaagag tgctggtatc
     1861 agaacccatc cgcaagactc acagctctac gtatcaaaaa gactttgacc aaaatcgata
     1921 attccctaga caaattaaaa actgactgtt gaccttgtca ccggtgtcaa gaaggagagt
     1981 caatgctgtc cttgtccagc tgggacctaa tgctggcctg actggttgtc agaacagaat
     2041 ccatctgacc cccttcccga agtggctgct ttgacggaag cagatgtctc ttcccagcca
     2101 tgttccaggg ggagacacca aaaccaccct aacctcgctc aaaaactgtg actcgagccc
     2161 tcgatgaact gttcacacca caaagactta acggtgggca ggtctggtgg caagggggag
     2221 ggaagtggag gaacccggaa agatcctgca ggcgatctgg gcattaagac agtggctctc
     2281 tgcgtatctt tcgcgggtct cctagacact ccccacggga agctcaagga ggcggtgaat
     2341 tcgtaatcag caatatcggc tgcatctact cttcgttgca ctaggaattc tgtgcattcc
     2401 ttacttgcac tgtggccctt aatcttaaag acccaacttg ccaaaacatt ggctgcgtac
     2461 tccactggcc tgtctctgga taataggaat tcaatctggc aacacaaaaa tgtaccgttg
     2521 gactctgctg cattttacac acgtgctgat gtttacaagg atgcgaacat taggaattgt
     2581 ttagacacaa ctttgcaaat tatttattac tggtgcactt agcggtttgt ttgaaaccgc
     2641 ctcgtgcata tgttaaagct tatttttatg tggtcttatg attttattac cgaaatgttt
     2701 ttaacaccca actctgaaac ggacattttc ttttattatc agttaaattc acatttaagt
     2761 gcttcacatt ttttttttta aatgtgtgta gactgtaact ttcttttcag ttcgtatgca
     2821 gaacatattt agccattacc catgcaacac cacccgatat attactgatt tagaagcaaa
     2881 gatttcagta gaattttagt cccaaacgct gtggggggaa atgcatcttc ttcggaatta
     2941 tccattacgt gcatttaaac tctgccagaa aaaaaaataa ctattttgtt ttaatctact
     3001 ttttgtattt agtagttatt tgtataaatt aaataaactg ttttcaagtc aaaaaaaaaa
     3061 aaaaaaa
//
