LOCUS       NM_025914               1708 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus ARP6 actin-related protein 6 (Actr6), transcript
            variant 1, mRNA.
ACCESSION   NM_025914
VERSION     NM_025914.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1708)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1708)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1708)
  AUTHORS   Munger,S.C., Aylor,D.L., Syed,H.A., Magwene,P.M., Threadgill,D.W.
            and Capel,B.
  TITLE     Elucidation of the transcription network governing mammalian sex
            determination by exploiting strain-specific susceptibility to sex
            reversal
  JOURNAL   Genes Dev 23 (21), 2521-2536 (2009)
   PUBMED   19884258
REFERENCE   4  (bases 1 to 1708)
  AUTHORS   Ruhl,D.D., Jin,J., Cai,Y., Swanson,S., Florens,L., Washburn,M.P.,
            Conaway,R.C., Conaway,J.W. and Chrivia,J.C.
  TITLE     Purification of a human SRCAP complex that remodels chromatin by
            incorporating the histone variant H2A.Z into nucleosomes
  JOURNAL   Biochemistry 45 (17), 5671-5677 (2006)
   PUBMED   16634648
REFERENCE   5  (bases 1 to 1708)
  AUTHORS   Goodson,H.V. and Hawse,W.F.
  TITLE     Molecular evolution of the actin family
  JOURNAL   J Cell Sci 115 (Pt 13), 2619-2622 (2002)
   PUBMED   12077353
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008409.1 and CJ221252.1.
            
            On Jan 13, 2018 this sequence version replaced NM_025914.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008409.1, AK088571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1703              AK008409.1         2-1704
            1704-1708           CJ221252.1         386-390
FEATURES             Location/Qualifiers
     source          1..1708
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 45.14 cM"
     gene            1..1708
                     /gene="Actr6"
                     /gene_synonym="2010200J04Rik; Arp6; ArpX; CDA12"
                     /note="ARP6 actin-related protein 6"
                     /db_xref="GeneID:67019"
                     /db_xref="MGI:MGI:1914269"
     exon            1..122
                     /gene="Actr6"
                     /gene_synonym="2010200J04Rik; Arp6; ArpX; CDA12"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1245
                     /gene="Actr6"
                     /gene_synonym="2010200J04Rik; Arp6; ArpX; CDA12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     actin-related protein 6; mArp6; ARP6 actin-related protein
                     6 homolog"
                     /codon_start=1
                     /product="actin-related protein 6 isoform 1"
                     /protein_id="NP_080190.1"
                     /db_xref="CCDS:CCDS24118.1"
                     /db_xref="GeneID:67019"
                     /db_xref="MGI:MGI:1914269"
                     /translation="MTTLVLDNGAYNAKIGYSHDSVSVIPNCQFRSKTARLKTFTANQ
                     IDEIKDPSGLFYILPFQKGYLVNWDVQRQVWDYLFGKEMYQVDFLDTNIIITEPYFNF
                     TSIQESMNEILFEEYQFQAVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPY
                     CRSKKKKEAIIRINVGGKLLTNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFYR
                     DMDIAKLKGEDNTVMIDYVLPDFSTIKKGFCKPREEMVLSGKYKFGEQILRLANERFA
                     VPEILFNPSDIGIQEMGIPEAIVYSIQNLPEEMQPHFFKNIVLTGGNSLFPGFRERVY
                     SEVRCLTPTDYDVSVVLPENPITYSWEGGKLISENDDFEDMVVTREDYEENGHSVCEE
                     KFDI"
     exon            123..240
                     /gene="Actr6"
                     /gene_synonym="2010200J04Rik; Arp6; ArpX; CDA12"
                     /inference="alignment:Splign:2.1.0"
     exon            241..309
                     /gene="Actr6"
                     /gene_synonym="2010200J04Rik; Arp6; ArpX; CDA12"
                     /inference="alignment:Splign:2.1.0"
     exon            310..433
                     /gene="Actr6"
                     /gene_synonym="2010200J04Rik; Arp6; ArpX; CDA12"
                     /inference="alignment:Splign:2.1.0"
     exon            434..569
                     /gene="Actr6"
                     /gene_synonym="2010200J04Rik; Arp6; ArpX; CDA12"
                     /inference="alignment:Splign:2.1.0"
     exon            570..626
                     /gene="Actr6"
                     /gene_synonym="2010200J04Rik; Arp6; ArpX; CDA12"
                     /inference="alignment:Splign:2.1.0"
     exon            627..725
                     /gene="Actr6"
                     /gene_synonym="2010200J04Rik; Arp6; ArpX; CDA12"
                     /inference="alignment:Splign:2.1.0"
     exon            726..804
                     /gene="Actr6"
                     /gene_synonym="2010200J04Rik; Arp6; ArpX; CDA12"
                     /inference="alignment:Splign:2.1.0"
     exon            805..976
                     /gene="Actr6"
                     /gene_synonym="2010200J04Rik; Arp6; ArpX; CDA12"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1115
                     /gene="Actr6"
                     /gene_synonym="2010200J04Rik; Arp6; ArpX; CDA12"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1708
                     /gene="Actr6"
                     /gene_synonym="2010200J04Rik; Arp6; ArpX; CDA12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1680..1685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Actr6"
                     /gene_synonym="2010200J04Rik; Arp6; ArpX; CDA12"
                     /note="hexamer: AATAAA"
     polyA_site      1706
                     /gene="Actr6"
                     /gene_synonym="2010200J04Rik; Arp6; ArpX; CDA12"
                     /note="major polyA site"
ORIGIN      
        1 gaggagattc aaacagtggg aaagcgactc cgctgcagcg tggtgcgtgc cgaaatgacg
       61 accctagttc tggataatgg agcttacaac gccaaaatcg gttacagcca tgacagtgtc
      121 tcggttattc ccaattgtca gttcagatcc aaaacagcac gtcttaaaac atttactgct
      181 aaccagattg atgaaataaa agacccttca ggactctttt atatccttcc ttttcaaaag
      241 ggatacttgg tgaattggga tgtccagcga caagtttggg attatctttt tggaaaagaa
      301 atgtatcagg ttgatttttt agatactaat attattataa cagaaccata ttttaacttc
      361 acttcaatcc aagaatcaat gaatgaaatc ctattcgaag aatatcagtt ccaagcagta
      421 ttaagagtaa atgccggtgc tctcagcgca cacaggtatt tccgagataa cccttctgag
      481 ctgtgctgca tcattgtcga cagtggctat tccttcacgc acattgttcc ttactgtaga
      541 agcaaaaaga aaaaagaagc aattattcgg ataaatgtgg gtggaaagct cttaacgaac
      601 catctaaaag agatcatatc ctacaggcag ctgcatgtga tggatgaaac tcatgtgatt
      661 aatcaagtga aagaagacgt atgctacgtg tctcaggatt tttacagaga catggacatt
      721 gccaagttaa aaggagaaga caatacagtg atgattgact atgttctgcc tgacttcagc
      781 acaattaaaa agggcttctg taagcccaga gaagagatgg tgctgagtgg gaagtataaa
      841 ttcggggaac agattcttcg ccttgccaac gagagatttg ctgtgccaga aatactcttt
      901 aacccctctg acatcggcat tcaggagatg gggatcccag aagccattgt ctattcaatc
      961 caaaacctac ctgaagaaat gcagccacat ttttttaaga acatcgtttt gacgggagga
     1021 aattcccttt tccccggatt cagagagcgt gtttactcag aagttcggtg tttgacgcca
     1081 acagactatg acgtttctgt cgtgttgcct gagaacccca tcacttactc ctgggaaggt
     1141 gggaagttga tatctgaaaa cgatgacttt gaagatatgg tggttacaag agaagattat
     1201 gaagaaaatg gacatagtgt ctgtgaagag aaatttgata tttaaaagac atttctgaat
     1261 aatagtcttg gaaagtttat ttcaaagttc cttttatagg aggctaagac ctaactatgt
     1321 tacttttcat tgtaagataa agtttactta tgtaaatatt ccgagtcatg gctggtatgc
     1381 acaggcttct tatgtgggtt attacagtaa actaatcagc cgtggttcat tacttagtta
     1441 gatactaagt aatacttata ctgttcctga gaatagattc tttttcatga gaaagtgaaa
     1501 gagcaaatgt ttaattcttc atacttgaaa acacaaactg aaatatctca cccatcagtt
     1561 ttccttgggt tttcactttg tgtagttctg actgtgctta actaaagtat ttgcagactg
     1621 ttaagattct gtttagaact aagtatttta tttaaagttt gttattctta tttgtacata
     1681 ataaaatttg aaatatcaat attaaata
//
