LOCUS       NM_023735               2746 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus ARP3 actin-related protein 3 (Actr3), transcript
            variant 1, mRNA.
ACCESSION   NM_023735
VERSION     NM_023735.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2746)
  AUTHORS   Aloisio,F.M. and Barber,D.L.
  TITLE     Arp2/3 complex activity is necessary for mouse ESC differentiation,
            times formative pluripotency, and enables lineage specification
  JOURNAL   Stem Cell Reports 17 (6), 1318-1333 (2022)
   PUBMED   35658973
  REMARK    GeneRIF: Arp2/3 complex activity is necessary for mouse ESC
            differentiation, times formative pluripotency, and enables lineage
            specification.
REFERENCE   2  (bases 1 to 2746)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2746)
  AUTHORS   Ma,W., Chang,J., Tong,J., Ho,U., Yau,B., Kebede,M.A. and Thorn,P.
  TITLE     Arp2/3 nucleates F-actin coating of fusing insulin granules in
            pancreatic beta cells to control insulin secretion
  JOURNAL   J Cell Sci 133 (6) (2020)
   PUBMED   32079655
  REMARK    GeneRIF: Arp2/3 nucleates F-actin coating of fusing insulin
            granules in pancreatic beta cells to control insulin secretion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2746)
  AUTHORS   Tessier,S., Doolittle,A.C., Sao,K., Rotty,J.D., Bear,J.E.,
            Ulici,V., Loeser,R.F., Shapiro,I.M., Diekman,B.O. and Risbud,M.V.
  TITLE     Arp2/3 inactivation causes intervertebral disc and cartilage
            degeneration with dysregulated TonEBP-mediated osmoadaptation
  JOURNAL   JCI Insight 5 (4), 131382 (2020)
   PUBMED   31961823
  REMARK    GeneRIF: Arp2/3 inactivation causes intervertebral disc and
            cartilage degeneration with dysregulated TonEBP-mediated
            osmoadaptation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2746)
  AUTHORS   Roper,S.I., Wasim,L., Malinova,D., Way,M., Cox,S. and Tolar,P.
  TITLE     B cells extract antigens at Arp2/3-generated actin foci
            interspersed with linear filaments
  JOURNAL   Elife 8, e48093 (2019)
   PUBMED   31815664
  REMARK    GeneRIF: The actin foci are generated by Arp2/3-mediated
            branched-actin polymerization and stochastically associate with
            antigen clusters to mediate internalization.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2746)
  AUTHORS   Gavard,J., Lambert,M., Grosheva,I., Marthiens,V., Irinopoulou,T.,
            Riou,J.F., Bershadsky,A. and Mege,R.M.
  TITLE     Lamellipodium extension and cadherin adhesion: two cell responses
            to cadherin activation relying on distinct signalling pathways
  JOURNAL   J Cell Sci 117 (Pt 2), 257-270 (2004)
   PUBMED   14657280
REFERENCE   7  (bases 1 to 2746)
  AUTHORS   Magdalena,J., Millard,T.H., Etienne-Manneville,S., Launay,S.,
            Warwick,H.K. and Machesky,L.M.
  TITLE     Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in
            scratch wound models
  JOURNAL   Mol Biol Cell 14 (2), 670-684 (2003)
   PUBMED   12589062
  REMARK    GeneRIF: Scar2 and the Arp2/3 complex appear to be involved in the
            establishment and maintenance of Golgi polarity during directed
            migration
REFERENCE   8  (bases 1 to 2746)
  AUTHORS   Uruno,T., Liu,J., Zhang,P., Fan,Yx., Egile,C., Li,R., Mueller,S.C.
            and Zhan,X.
  TITLE     Activation of Arp2/3 complex-mediated actin polymerization by
            cortactin
  JOURNAL   Nat Cell Biol 3 (3), 259-266 (2001)
   PUBMED   11231575
REFERENCE   9  (bases 1 to 2746)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   10 (bases 1 to 2746)
  AUTHORS   Weed,S.A., Karginov,A.V., Schafer,D.A., Weaver,A.M., Kinley,A.W.,
            Cooper,J.A. and Parsons,J.T.
  TITLE     Cortactin localization to sites of actin assembly in lamellipodia
            requires interactions with F-actin and the Arp2/3 complex
  JOURNAL   J Cell Biol 151 (1), 29-40 (2000)
   PUBMED   11018051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124528.4, AK145536.1 and AV137086.1.
            
            On Apr 20, 2011 this sequence version replaced NM_023735.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004554.1, BC005557.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC124528.4         76602-76781
            181-2743            AK145536.1         1-2563
            2744-2746           AV137086.1         290-292
FEATURES             Location/Qualifiers
     source          1..2746
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 54.7 cM"
     gene            1..2746
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /note="ARP3 actin-related protein 3"
                     /db_xref="GeneID:74117"
                     /db_xref="MGI:MGI:1921367"
     exon            1..443
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..1656
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /note="ARP3 actin-related protein 3 homolog; actin-like
                     protein 3"
                     /codon_start=1
                     /product="actin-related protein 3"
                     /protein_id="NP_076224.1"
                     /db_xref="CCDS:CCDS15242.1"
                     /db_xref="GeneID:74117"
                     /db_xref="MGI:MGI:1921367"
                     /translation="MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVG
                     DQAQRRVMKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLR
                     AEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGE
                     RTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPE
                     QSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGVNAISKKEFSIDVGYERF
                     LGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRR
                     LQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQ
                     VCHTKKDYEEIGPSICRHNPVFGVMS"
     exon            444..499
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            500..624
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            625..735
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            736..831
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            832..939
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1083
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1257
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1350
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1476
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1560
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..2746
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2385..2390
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /note="hexamer: AATAAA"
     polyA_site      2409
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /note="major polyA site"
     regulatory      2721..2726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /note="hexamer: AATAAA"
     polyA_site      2742
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /note="major polyA site"
ORIGIN      
        1 gggagcgatc gcggcctggg gcctggcctg gccggggcgt cggcagcggc ggccatcttg
       61 gctccccgcg gaaaggcagt gcgaggggga agaagttgta gggtgggggc gggagcgagg
      121 aggaggagga ggagggcgga gagcggaggg gtagaggagg aggccgcggc agggtagggc
      181 ggggacagcc agcctgccgg ccggccagcc tgctgggctt gcggaagtac tagccgactg
      241 ctcactcgct cctgctcggg cttcccacag ctccctccct tcctccctcc ctcccgaccg
      301 agggcggccc gggccggtgc atggtcagcc agctcccatc tctagctccc cggcctctca
      361 gcagcacgga acggacggca gcggcgggcg aggaggaaga tggcgggacg gctgccggcc
      421 tgtgtggtgg actgtggcac gggatataca aaactaggat atgctggaaa tacagagcca
      481 cagtttatca tcccatcatg tattgccatt aaagagtctg caaaagtggg tgaccaagcc
      541 cagaggaggg tgatgaaagg cgtggatgac ctagacttct tcattggtga tgaagcaata
      601 gaaaagccca catatgcaac aaagtggcca attcgccatg gtatagttga agactgggac
      661 ttaatggaaa ggtttatgga gcaagtgatt tttaaatatt taagggcaga acctgaagat
      721 cattactttc ttttgactga acctccactg aatactccag aaaacaggga atatactgct
      781 gaaataatgt ttgaatcctt caatgttcca ggcttgtaca ttgctgtgca ggctgttctt
      841 gccttagctg catcctggac ctcaagacaa gtaggagagc ggacgctgac gggtacagta
      901 atagacagtg gagacggagt cactcatgtc attcctgtgg ctgaaggata tgttatcggc
      961 agctgtatta aacacattcc aatcgcagga agagatataa catattttat tcagcaactg
     1021 ctgcgagacc gagaagtagg aatccctcct gagcagtcct tggaaactgc gaaagcagtg
     1081 aaggaacgct acagttatgt ctgcccagat ttagtaaaag agtttaacaa gtatgacacc
     1141 gatgggtcaa agtggatcaa acagtacacc ggagtcaacg ccatctcaaa gaaagagttt
     1201 tctattgatg ttggctatga gcgattcctg ggacccgaga tctttttcca tccagagttt
     1261 gctaatccag attttacaca acctatctca gaagttgtag atgaagtcat tcagaattgc
     1321 cccattgatg tccggcgtcc tctctacaag aacattgtcc tctctggtgg ttcaaccatg
     1381 ttcagggact ttggacgtcg tttgcaaaga gatttgaaga gaactgtaga tgccaggctg
     1441 aagttaagcg aggagctgag tggtggtaga ttgaagccca agcctattga tgtacaagtt
     1501 attacacacc atatgcagcg gtatgcagtc tggtttggag ggtcaatgct ggcttccacg
     1561 cctgagttct accaagtatg ccacaccaaa aaggattatg aagaaattgg acctagcatt
     1621 tgtcgtcaca atccagtgtt tggagtcatg tcctaaagtt gacttcttgt tgattgggtt
     1681 agggagatgg aaatgagata atctttctga tgacctgttt ttgtctgaat ggatggttct
     1741 gaggttttta accaaacatg atcatacagg aatatttaat gagtgtgtca acatgcagat
     1801 gtagaagaga gctaagacga ttgttttcct ttaggttgaa tatttgaatc ttatgtgtat
     1861 caaaaaagaa atgggtttta gttctttctt tgccctgata ttttgtatat tattgactta
     1921 cccagtgtgc tgggctcagt gggtgtgtag agagctctgt aatgcctgat tgggcactgc
     1981 tgagtgggta gtgcctgagc ttgtttatat ttcatacttt tttatacttt gaggaaaaaa
     2041 agtcaaagaa aaactgtagt attggaggga aacaatgtga ccaaggaaaa gatgagttca
     2101 acaagcagcc tcatgggact tggcgcacac tctgggttcc agttatctcg agctgctcca
     2161 cccctcccca gcccaacggt tctctctgca aatgcttgga tctaagaagc tagtctcctg
     2221 ggttagccga tgcctgccct gctttctggt tacttacatt ctgtttcttg ctttaaaaga
     2281 aggacaagac tgttggacca gtattgcaat tctgtagagt cgtttcttat taaaacaata
     2341 atgtgattac caaaattggc atatttaagg cctaatgcca ttctaataaa ggcaaaaaat
     2401 ttctttttac tacttgtttc aggctctttg atctctttat aagttaacta atacgtctat
     2461 tttcttcaga ttctgcagta gctctttaaa agcacagcgg ttggatagca agctgacttt
     2521 tttatgtgct ctgtacaaat aattgtgaac ttttaatatg ttgagtgctt tcattttgat
     2581 aactggatct ccatttgata tttcatttgt ataactcatt tgcagtctga atttttttta
     2641 gtgccagtcc ctgacatatc atgaaaagtt ggttttcttt gcattttcaa atatctggat
     2701 catgaagaaa aagtgatgac aataaattaa aattgaatta cccttc
//
