LOCUS       NP_076224                418 aa            linear   ROD 03-JUN-2024
DEFINITION  actin-related protein 3 [Mus musculus].
ACCESSION   NP_076224
VERSION     NP_076224.1
DBSOURCE    REFSEQ: accession NM_023735.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 418)
  AUTHORS   Aloisio,F.M. and Barber,D.L.
  TITLE     Arp2/3 complex activity is necessary for mouse ESC differentiation,
            times formative pluripotency, and enables lineage specification
  JOURNAL   Stem Cell Reports 17 (6), 1318-1333 (2022)
   PUBMED   35658973
  REMARK    GeneRIF: Arp2/3 complex activity is necessary for mouse ESC
            differentiation, times formative pluripotency, and enables lineage
            specification.
REFERENCE   2  (residues 1 to 418)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 418)
  AUTHORS   Ma,W., Chang,J., Tong,J., Ho,U., Yau,B., Kebede,M.A. and Thorn,P.
  TITLE     Arp2/3 nucleates F-actin coating of fusing insulin granules in
            pancreatic beta cells to control insulin secretion
  JOURNAL   J Cell Sci 133 (6) (2020)
   PUBMED   32079655
  REMARK    GeneRIF: Arp2/3 nucleates F-actin coating of fusing insulin
            granules in pancreatic beta cells to control insulin secretion.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 418)
  AUTHORS   Tessier,S., Doolittle,A.C., Sao,K., Rotty,J.D., Bear,J.E.,
            Ulici,V., Loeser,R.F., Shapiro,I.M., Diekman,B.O. and Risbud,M.V.
  TITLE     Arp2/3 inactivation causes intervertebral disc and cartilage
            degeneration with dysregulated TonEBP-mediated osmoadaptation
  JOURNAL   JCI Insight 5 (4), 131382 (2020)
   PUBMED   31961823
  REMARK    GeneRIF: Arp2/3 inactivation causes intervertebral disc and
            cartilage degeneration with dysregulated TonEBP-mediated
            osmoadaptation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 418)
  AUTHORS   Roper,S.I., Wasim,L., Malinova,D., Way,M., Cox,S. and Tolar,P.
  TITLE     B cells extract antigens at Arp2/3-generated actin foci
            interspersed with linear filaments
  JOURNAL   Elife 8, e48093 (2019)
   PUBMED   31815664
  REMARK    GeneRIF: The actin foci are generated by Arp2/3-mediated
            branched-actin polymerization and stochastically associate with
            antigen clusters to mediate internalization.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 418)
  AUTHORS   Gavard,J., Lambert,M., Grosheva,I., Marthiens,V., Irinopoulou,T.,
            Riou,J.F., Bershadsky,A. and Mege,R.M.
  TITLE     Lamellipodium extension and cadherin adhesion: two cell responses
            to cadherin activation relying on distinct signalling pathways
  JOURNAL   J Cell Sci 117 (Pt 2), 257-270 (2004)
   PUBMED   14657280
REFERENCE   7  (residues 1 to 418)
  AUTHORS   Magdalena,J., Millard,T.H., Etienne-Manneville,S., Launay,S.,
            Warwick,H.K. and Machesky,L.M.
  TITLE     Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in
            scratch wound models
  JOURNAL   Mol Biol Cell 14 (2), 670-684 (2003)
   PUBMED   12589062
  REMARK    GeneRIF: Scar2 and the Arp2/3 complex appear to be involved in the
            establishment and maintenance of Golgi polarity during directed
            migration
REFERENCE   8  (residues 1 to 418)
  AUTHORS   Uruno,T., Liu,J., Zhang,P., Fan,Yx., Egile,C., Li,R., Mueller,S.C.
            and Zhan,X.
  TITLE     Activation of Arp2/3 complex-mediated actin polymerization by
            cortactin
  JOURNAL   Nat Cell Biol 3 (3), 259-266 (2001)
   PUBMED   11231575
REFERENCE   9  (residues 1 to 418)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   10 (residues 1 to 418)
  AUTHORS   Weed,S.A., Karginov,A.V., Schafer,D.A., Weaver,A.M., Kinley,A.W.,
            Cooper,J.A. and Parsons,J.T.
  TITLE     Cortactin localization to sites of actin assembly in lamellipodia
            requires interactions with F-actin and the Arp2/3 complex
  JOURNAL   J Cell Biol 151 (1), 29-40 (2000)
   PUBMED   11018051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124528.4, AK145536.1 and AV137086.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004554.1, BC005557.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..418
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 54.7 cM"
     Protein         1..418
                     /product="actin-related protein 3"
                     /note="ARP3 actin-related protein 3 homolog; actin-like
                     protein 3"
                     /calculated_mol_wt=47226
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P61158; propagated from
                     UniProtKB/Swiss-Prot (Q99JY9.3)"
     Region          7..410
                     /region_name="ASKHA_NBD_Arp3-like"
                     /note="nucleotide-binding domain (NBD) of actin-related
                     protein3 (Arp3) and similar proteins; cd10221"
                     /db_xref="CDD:466822"
     Site            240
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P61158; propagated from
                     UniProtKB/Swiss-Prot (Q99JY9.3)"
     Site            244
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:23806337; propagated from
                     UniProtKB/Swiss-Prot (Q99JY9.3)"
     Site            251
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P61158; propagated from
                     UniProtKB/Swiss-Prot (Q99JY9.3)"
     Site            254
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P61158; propagated from
                     UniProtKB/Swiss-Prot (Q99JY9.3)"
     CDS             1..418
                     /gene="Actr3"
                     /gene_synonym="1200003A09Rik; Arp3"
                     /coded_by="NM_023735.2:400..1656"
                     /db_xref="CCDS:CCDS15242.1"
                     /db_xref="GeneID:74117"
                     /db_xref="MGI:MGI:1921367"
ORIGIN      
        1 magrlpacvv dcgtgytklg yagntepqfi ipsciaikes akvgdqaqrr vmkgvddldf
       61 figdeaiekp tyatkwpirh givedwdlme rfmeqvifky lraepedhyf lltepplntp
      121 enreytaeim fesfnvpgly iavqavlala aswtsrqvge rtltgtvids gdgvthvipv
      181 aegyvigsci khipiagrdi tyfiqqllrd revgippeqs letakavker ysyvcpdlvk
      241 efnkydtdgs kwikqytgvn aiskkefsid vgyerflgpe iffhpefanp dftqpisevv
      301 deviqncpid vrrplykniv lsggstmfrd fgrrlqrdlk rtvdarlkls eelsggrlkp
      361 kpidvqvith hmqryavwfg gsmlastpef yqvchtkkdy eeigpsicrh npvfgvms
//
