LOCUS       NM_146243               3688 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus actin related protein 2 (Actr2), transcript variant 2,
            mRNA.
ACCESSION   NM_146243
VERSION     NM_146243.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3688)
  AUTHORS   Aloisio,F.M. and Barber,D.L.
  TITLE     Arp2/3 complex activity is necessary for mouse ESC differentiation,
            times formative pluripotency, and enables lineage specification
  JOURNAL   Stem Cell Reports 17 (6), 1318-1333 (2022)
   PUBMED   35658973
  REMARK    GeneRIF: Arp2/3 complex activity is necessary for mouse ESC
            differentiation, times formative pluripotency, and enables lineage
            specification.
REFERENCE   2  (bases 1 to 3688)
  AUTHORS   Longatti,A., Ponzoni,L., Moretto,E., Giansante,G., Lattuada,N.,
            Colombo,M.N., Francolini,M., Sala,M., Murru,L. and Passafaro,M.
  TITLE     Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting
            Hippocampal Glutamatergic Synapses and Cognition in Mice
  JOURNAL   Mol Neurobiol 58 (12), 6092-6110 (2021)
   PUBMED   34455539
REFERENCE   3  (bases 1 to 3688)
  AUTHORS   Figueiredo,A.M., Barbacena,P., Russo,A., Vaccaro,S., Ramalho,D.,
            Pena,A., Lima,A.P., Ferreira,R.R., Fidalgo,M.A., El-Marjou,F.,
            Carvalho,Y., Vasconcelos,F.F., Lennon-Dumenil,A.M., Vignjevic,D.M.
            and Franco,C.A.
  TITLE     Endothelial cell invasion is controlled by dactylopodia
  JOURNAL   Proc Natl Acad Sci U S A 118 (18) (2021)
   PUBMED   33903241
  REMARK    GeneRIF: Endothelial cell invasion is controlled by dactylopodia.
REFERENCE   4  (bases 1 to 3688)
  AUTHORS   Ma,W., Chang,J., Tong,J., Ho,U., Yau,B., Kebede,M.A. and Thorn,P.
  TITLE     Arp2/3 nucleates F-actin coating of fusing insulin granules in
            pancreatic beta cells to control insulin secretion
  JOURNAL   J Cell Sci 133 (6) (2020)
   PUBMED   32079655
  REMARK    GeneRIF: Arp2/3 nucleates F-actin coating of fusing insulin
            granules in pancreatic beta cells to control insulin secretion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3688)
  AUTHORS   Tessier,S., Doolittle,A.C., Sao,K., Rotty,J.D., Bear,J.E.,
            Ulici,V., Loeser,R.F., Shapiro,I.M., Diekman,B.O. and Risbud,M.V.
  TITLE     Arp2/3 inactivation causes intervertebral disc and cartilage
            degeneration with dysregulated TonEBP-mediated osmoadaptation
  JOURNAL   JCI Insight 5 (4), 131382 (2020)
   PUBMED   31961823
  REMARK    GeneRIF: Arp2/3 inactivation causes intervertebral disc and
            cartilage degeneration with dysregulated TonEBP-mediated
            osmoadaptation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3688)
  AUTHORS   Strasser,G.A., Rahim,N.A., VanderWaal,K.E., Gertler,F.B. and
            Lanier,L.M.
  TITLE     Arp2/3 is a negative regulator of growth cone translocation
  JOURNAL   Neuron 43 (1), 81-94 (2004)
   PUBMED   15233919
  REMARK    GeneRIF: Arp2/3 inhibition in growth cones doesn't affect actin
            organization or inhibit lamellipodia protrusion or filopodia
            formation. Arp2/3 inhibition enhances axon elongation and causes
            defects in growth cone guidance.
REFERENCE   7  (bases 1 to 3688)
  AUTHORS   Merrifield,C.J., Qualmann,B., Kessels,M.M. and Almers,W.
  TITLE     Neural Wiskott Aldrich Syndrome Protein (N-WASP) and the Arp2/3
            complex are recruited to sites of clathrin-mediated endocytosis in
            cultured fibroblasts
  JOURNAL   Eur J Cell Biol 83 (1), 13-18 (2004)
   PUBMED   15085951
  REMARK    GeneRIF: N-WASP and the Arp2/3 complex trigger actin polymerization
            during a late step in clathrin-mediated endocytosis
REFERENCE   8  (bases 1 to 3688)
  AUTHORS   Vyas,A., Saha,B., Lai,E. and Tole,S.
  TITLE     Paleocortex is specified in mice in which dorsal telencephalic
            patterning is severely disrupted
  JOURNAL   J Comp Neurol 466 (4), 545-553 (2003)
   PUBMED   14566948
REFERENCE   9  (bases 1 to 3688)
  AUTHORS   Magdalena,J., Millard,T.H., Etienne-Manneville,S., Launay,S.,
            Warwick,H.K. and Machesky,L.M.
  TITLE     Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in
            scratch wound models
  JOURNAL   Mol Biol Cell 14 (2), 670-684 (2003)
   PUBMED   12589062
  REMARK    GeneRIF: Scar2 and the Arp2/3 complex appear to be involved in the
            establishment and maintenance of Golgi polarity during directed
            migration
REFERENCE   10 (bases 1 to 3688)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY278998.1, AK032832.1, BE448820.1 and BP753259.1.
            
            On Aug 15, 2009 this sequence version replaced NM_146243.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047530.1, SRR1660817.248990.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                BY278998.1         1-84
            85-2380             AK032832.1         3-2298
            2381-2856           BE448820.1         1-476
            2857-3265           AK032832.1         2774-3182
            3266-3688           BP753259.1         1-423               c
FEATURES             Location/Qualifiers
     source          1..3688
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 12.88 cM"
     gene            1..3688
                     /gene="Actr2"
                     /gene_synonym="4921510D23Rik; Arp2; D6Ertd746e"
                     /note="actin related protein 2"
                     /db_xref="GeneID:66713"
                     /db_xref="MGI:MGI:1913963"
     exon            1..147
                     /gene="Actr2"
                     /gene_synonym="4921510D23Rik; Arp2; D6Ertd746e"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1284
                     /gene="Actr2"
                     /gene_synonym="4921510D23Rik; Arp2; D6Ertd746e"
                     /note="isoform 2 is encoded by transcript variant 2;
                     actin-like protein 2; ARP2 actin-related protein 2
                     homolog"
                     /codon_start=1
                     /product="actin-related protein 2 isoform 2"
                     /protein_id="NP_666355.1"
                     /db_xref="CCDS:CCDS24455.1"
                     /db_xref="GeneID:66713"
                     /db_xref="MGI:MGI:1913963"
                     /translation="MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRST
                     TKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDT
                     RNCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSG
                     DGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKE
                     KLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGV
                     GVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDV
                     EKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVT
                     VR"
     exon            148..258
                     /gene="Actr2"
                     /gene_synonym="4921510D23Rik; Arp2; D6Ertd746e"
                     /inference="alignment:Splign:2.1.0"
     exon            259..474
                     /gene="Actr2"
                     /gene_synonym="4921510D23Rik; Arp2; D6Ertd746e"
                     /inference="alignment:Splign:2.1.0"
     exon            475..547
                     /gene="Actr2"
                     /gene_synonym="4921510D23Rik; Arp2; D6Ertd746e"
                     /inference="alignment:Splign:2.1.0"
     exon            548..684
                     /gene="Actr2"
                     /gene_synonym="4921510D23Rik; Arp2; D6Ertd746e"
                     /inference="alignment:Splign:2.1.0"
     exon            685..834
                     /gene="Actr2"
                     /gene_synonym="4921510D23Rik; Arp2; D6Ertd746e"
                     /inference="alignment:Splign:2.1.0"
     exon            835..980
                     /gene="Actr2"
                     /gene_synonym="4921510D23Rik; Arp2; D6Ertd746e"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1113
                     /gene="Actr2"
                     /gene_synonym="4921510D23Rik; Arp2; D6Ertd746e"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..3669
                     /gene="Actr2"
                     /gene_synonym="4921510D23Rik; Arp2; D6Ertd746e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3373..3378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Actr2"
                     /gene_synonym="4921510D23Rik; Arp2; D6Ertd746e"
                     /note="hexamer: AATAAA"
     polyA_site      3392
                     /gene="Actr2"
                     /gene_synonym="4921510D23Rik; Arp2; D6Ertd746e"
                     /note="major polyA site"
     regulatory      3650..3655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Actr2"
                     /gene_synonym="4921510D23Rik; Arp2; D6Ertd746e"
                     /note="hexamer: AATAAG"
     polyA_site      3669
                     /gene="Actr2"
                     /gene_synonym="4921510D23Rik; Arp2; D6Ertd746e"
                     /note="major polyA site"
ORIGIN      
        1 gggcggggac ttccggtttg ggcggagcgg cgggccgagg gcggggccgt gtggaggagg
       61 aagcaggcca ggccgggcgg cggctcacca ggacgaacca tggacagcca gggcaggaag
      121 gtggtggtgt gcgacaacgg cactgggttt gtgaagtgtg gatatgcagg ctctaatttt
      181 ccagaacaca tcttcccagc tttggttgga agacctatta tcagatcaac caccaaagtg
      241 ggaaacattg aaatcaagga ccttatggtt ggtgatgagg caagtgagct gcgttccatg
      301 ttggaagtga actaccccat ggagaatggc atcgtgcgga attgggatga catgaagcac
      361 ctgtgggact acacatttgg accagagaaa ctcaatatag acaccagaaa ctgcaagatt
      421 ttacttacag aacctcccat gaatccaacc aaaaacagag agaagattgt agaggtaatg
      481 tttgaaactt accagttttc tggtgtgtat gtagccatcc aggcagttct gactttgtat
      541 gctcaaggtt tactgactgg tgtagtagtg gactctggag atggcgtcac tcacatttgc
      601 ccagtatatg aaggcttttc tctccctcac cttacaagga ggctggatat tgctgggagg
      661 gatattacca ggtatcttat caagctgctg ctgttgcgag gatatgcctt caaccattct
      721 gctgattttg agacagttcg catgattaag gaaaaacttt gttatgtggg ttacaatatt
      781 gagcaggagc agaagctggc cttagagacc acagtgttag ttgagtcata tacacttcca
      841 gatggacgta tcattaaggt tggaggagaa cgatttgaag caccagaggc tttatttcag
      901 cctcatttga tcaatgtcga gggggttggt gttgctgaac tgctttttaa cacaatccag
      961 gcagccgaca ttgataccag atctgaattt tacaagcaca ttgtgctttc tggaggttct
     1021 accatgtatc ctggcctgcc atcgaggttg gaacgagagc ttaaacagct ttacttagaa
     1081 cgagttctga aaggagatgt ggaaaaactt tcaaaattta agatccgaat tgaagaccca
     1141 ccccgcagga agcacatggt gttcttgggt ggcgcagtcc tagcagacat catgaaagac
     1201 aaagacaact tttggatgac cagacaagag taccaagaaa agggtgtccg tgtgctggag
     1261 aaacttggtg taactgttcg ataaaatagc aggcttgtcc ccatcacgcc tctaatgctt
     1321 tttctttttc cctttttaaa aaaatttttc tttattgcca atctttgaag tcattcaacc
     1381 caggactgaa agaggctctc tgtccctttt gacagaaagg tcaagttttt ctctgtcttg
     1441 gggaagcatt gctaaattct tgttaatatg ggtaaatctg gttgtttaag gctaccaaat
     1501 ctttgcagac attaccaggg caaggggttg ctgctgctct gtttctttct ttgtaggcat
     1561 ttagaactgc ttgtaggctt ccaatttttg ctttcttgct ctaatgctgc tagctttagt
     1621 tttagcacag taggtggtat gtctttatta gcataagaaa aactttcaca ggagctttta
     1681 catatgctgg gtgggggtgg taaggggtgg gtgggcagcc cgagcgggag ggcctttcct
     1741 ctgtagtgtt agctttcagc aggtcactgc tgctactttt gaagtcccct gaagtgtctc
     1801 ctagtaacat cttagggaaa tattaagctc acaactaagg tgtttgggct agagttttat
     1861 gtgatggaac aaatgggtga cctttctgtt gtggcttttg aggtcttctg ctctgggtac
     1921 aaaagatgca tgaacctcat ttacaatact ctgacttggt agttttcttc tttccgtctg
     1981 cctggaactg ttcccatatg acaggaaaaa agcaagccca gtgttttatt accatctgtc
     2041 agctgggagt atatttccta tactctatca gtgaaaaagt aacattttaa aggaaatgct
     2101 ttttctaggt caaattacag atagaaaatt gctcaagggc cagcattttc taatgctgtt
     2161 gtttttcctg gaagcactaa ggaaatgaac caaccaagtt ccactcttga aagttgtact
     2221 tttatgttcc tgatcagtgc ttctcgacaa gagctactgt acagagaagt aattcatggc
     2281 tgtgggttaa ttataattgt tgtagtaaca ttcacattgg gacttggtgc cagttgtttt
     2341 gttttgtttt ttcatgagac ttgggactaa aattttagca acaacaacca caatagaaaa
     2401 tttaccagta gtcaaccatg tctgtacagt tatggaggct acttcccagc cctctttggt
     2461 tcttgcagga agagtgtttg caggcctgtc ctgttggtat tgtttgtcag ctcagaaaga
     2521 atcaggtggt acccaagtgc ggggtcttcc taacgttgaa aaatgaaacg agaagctgta
     2581 tcacagaaaa tacaaaatga tgattctgag agaaatattt tccttcattt caaatgttct
     2641 ttactaatga tgaatttgaa agaatggctt ttttcctttt ttcttttttt tttctttttt
     2701 ttttttttgg atgcttaaaa tcagaatttt taatggattt tttaagataa ctttaattag
     2761 tttatatgaa atcagcagca aaaggaagtt tgtcttaata atgcagcttc tgtgatgtta
     2821 agtatttttg cctgttttac ctcaatttga acaaatagga gaagtctgtg tgcatgctgg
     2881 acatgctcag tacacacgac agcccgccgg tgcagtgcgg tgtcagctgc tcggtgttgg
     2941 gtgcgtgact cagtcacagt ggaatcccta agcgttccta aatcatgttg tcaaattctc
     3001 cagtctcggg agttctgggc ccattacctg ctgtgcatag gactggtacc aaggactatt
     3061 gagtgtagac aaacgatcaa ctcttggctt tgaccatggc tttaaacaaa ggggtgaaaa
     3121 caagaaagaa taggatggaa tctggaataa aacagtgaaa gagcattgtt ctttgtacct
     3181 tgaatgtaga atttgttttt atttcataat tctgctagca aacatgactg ttaaaatgat
     3241 gtatttatat atgtaataat ttagaaattc cattttatag tttcctatcc taaggtgaaa
     3301 taatgaattt agtaatttgg gagttcggac atactgtatt ctattggagg tgccaggttt
     3361 gagtccttca aaaataaaaa aaatttaaaa aatctgtttt ttaaaagatc tgatttttag
     3421 ctctttgaaa cccatcgtca cttagatttc caatgctaat taaaattctt ttatttttaa
     3481 attaaaatca ccaatgcctt gagggtcttc ttagaaaata tggtattgga tattaacttt
     3541 catagttctg agcactatta gtatctatct gacaagtatt gggaagatca atggaaagct
     3601 aaatattcta aatttaacac aaatatactt ctttttaatt aagaaaataa ataagatttt
     3661 tcaacataaa aaaaaaaaaa aaaaaaaa
//
