LOCUS       NM_001360550            3940 bp    mRNA    linear   ROD 18-APR-2023
DEFINITION  Mus musculus actinin alpha 4 (Actn4), transcript variant 4, mRNA.
ACCESSION   NM_001360550
VERSION     NM_001360550.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3940)
  AUTHORS   Broadway-Stringer S, Jiang H, Wadmore K, Hooper C, Douglas G,
            Steeples V, Azad AJ, Singer E, Reyat JS, Galatik F, Ehler E,
            Bennett P, Kalisch-Smith JI, Sparrow DB, Davies B, Djinovic-Carugo
            K, Gautel M, Watkins H and Gehmlich K.
  TITLE     Insights into the Role of a Cardiomyopathy-Causing Genetic Variant
            in ACTN2
  JOURNAL   Cells 12 (5), 721 (2023)
   PUBMED   36899856
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3940)
  AUTHORS   Wu T, Xu Y, Zhang L, Liang Z, Zhou X, Evans SM and Chen J.
  TITLE     Filamin C is Essential for mammalian myocardial integrity
  JOURNAL   PLoS Genet 19 (1), e1010630 (2023)
   PUBMED   36706168
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3940)
  AUTHORS   Tseng CC, Zheng RH, Lin TW, Chou CC, Shih YC, Liang SW and Lee HH.
  TITLE     alpha-Actinin-4 recruits Shp2 into focal adhesions to potentiate
            ROCK2 activation in podocytes
  JOURNAL   Life Sci Alliance 5 (11), e202201557 (2022)
   PUBMED   36096674
  REMARK    GeneRIF: alpha-Actinin-4 recruits Shp2 into focal adhesions to
            potentiate ROCK2 activation in podocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3940)
  AUTHORS   Rudolf MA, Andreeva A, Kim CE, DeNovio AC, Koshar AN, Baker W,
            Cartagena-Rivera AX and Corwin JT.
  TITLE     Stiffening of Circumferential F-Actin Bands Correlates With
            Regenerative Failure and May Act as a Biomechanical Brake in the
            Mammalian Inner Ear
  JOURNAL   Front Cell Neurosci 16, 859882 (2022)
   PUBMED   35602553
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3940)
  AUTHORS   Li Y, Gong W, Liu J, Chen X, Suo Y, Yang H and Gao X.
  TITLE     Angiopoietin-like protein 4 promotes hyperlipidemia-induced renal
            injury by down-regulating the expression of ACTN4
  JOURNAL   Biochem Biophys Res Commun 595, 69-75 (2022)
   PUBMED   35101665
  REMARK    GeneRIF: Angiopoietin-like protein 4 promotes
            hyperlipidemia-induced renal injury by down-regulating the
            expression of ACTN4.
REFERENCE   6  (bases 1 to 3940)
  AUTHORS   Huttelmaier S, Illenberger S, Grosheva I, Rudiger M, Singer RH and
            Jockusch BM.
  TITLE     Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and
            microfilament attachment proteins
  JOURNAL   J Cell Biol 155 (5), 775-786 (2001)
   PUBMED   11724819
REFERENCE   7  (bases 1 to 3940)
  AUTHORS   Piao Y, Ko NT, Lim MK and Ko MS.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 3940)
  AUTHORS   Mills M, Yang N, Weinberger R, Vander Woude DL, Beggs AH, Easteal S
            and North K.
  TITLE     Differential expression of the actin-binding proteins,
            alpha-actinin-2 and -3, in different species: implications for the
            evolution of functional redundancy
  JOURNAL   Hum Mol Genet 10 (13), 1335-1346 (2001)
   PUBMED   11440986
REFERENCE   9  (bases 1 to 3940)
  AUTHORS   Dear TN, Meier NT, Hunn M and Boehm T.
  TITLE     Gene structure, chromosomal localization, and expression pattern of
            Capn12, a new member of the calpain large subunit gene family
  JOURNAL   Genomics 68 (2), 152-160 (2000)
   PUBMED   10964513
REFERENCE   10 (bases 1 to 3940)
  AUTHORS   Araki N, Hatae T, Yamada T and Hirohashi S.
  TITLE     Actinin-4 is preferentially involved in circular ruffling and
            macropinocytosis in mouse macrophages: analysis by fluorescence
            ratio imaging
  JOURNAL   J Cell Sci 113 (Pt 18), 3329-3340 (2000)
   PUBMED   10954430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166357.3.
            
            [WARNING] On Apr 26, 2023 this sequence was replaced by
            NM_001360550.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.661667.1,
                                           SRR7345562.2952866.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               AC166357.3         21782-22095
            315-429             AC166357.3         65046-65160
            430-549             AC166357.3         65323-65442
            550-591             AC166357.3         67868-67909
            592-636             AC166357.3         67910-67954
            637-724             AC166357.3         68814-68901
            725-803             AC166357.3         70658-70736
            804-885             AC166357.3         71793-71874
            886-971             AC166357.3         72539-72624
            972-1057            AC166357.3         74126-74211
            1058-1150           AC166357.3         77050-77142
            1151-1381           AC166357.3         78659-78889
            1382-1529           AC166357.3         79426-79573
            1530-1680           AC166357.3         82087-82237
            1681-1789           AC166357.3         85386-85494
            1790-1930           AC166357.3         85635-85775
            1931-2113           AC166357.3         85863-86045
            2114-2248           AC166357.3         86131-86265
            2249-2428           AC166357.3         87059-87238
            2429-2575           AC166357.3         87879-88025
            2576-2641           AC166357.3         88928-88993
            2642-2800           AC166357.3         89455-89613
            2801-3940           AC166357.3         89727-90866
FEATURES             Location/Qualifiers
     source          1..3940
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..3940
                     /gene="Actn4"
                     /note="actinin alpha 4"
                     /db_xref="GeneID:60595"
                     /db_xref="MGI:MGI:1890773"
     exon            1..314
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            315..429
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            430..549
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            550..636
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            637..724
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            725..803
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            804..885
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            886..971
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1057
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     CDS             1010..2959
                     /gene="Actn4"
                     /note="isoform 4 is encoded by transcript variant 4;
                     alpha-actinin-4; non-muscle alpha-actinin 4; F-actin
                     cross-linking protein"
                     /codon_start=1
                     /product="alpha-actinin-4 isoform 4"
                     /protein_id="NP_001347479.1"
                     /db_xref="GeneID:60595"
                     /db_xref="MGI:MGI:1890773"
                     /translation="MTYVSCFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYERL
                     ASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNT
                     LQTKLRLSNRPAFMPSEGRMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEK
                     FRQKASIHEAWTDGKEAMLKQRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAA
                     IAQELNELDYYDSHNVNTRCQKICDQWDNLGSLTHSRREALEKTEKQLETIDQLHLEY
                     AKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIH
                     KEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEH
                     LRRQFASQANMVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPSLDLL
                     EQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQE
                     QMQEFRASFNHFDKKQTGSMDSDDFRALLISTGYSLGDAEFNRIMSVVDPNHSGLVTF
                     QAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPY
                     QGPDAAPGALDYKSFSTALYGESDL"
     exon            1058..1150
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1381
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1529
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1680
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1789
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1930
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2113
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2248
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2249..2428
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2575
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2641
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2800
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..3940
                     /gene="Actn4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgcgcagg cgcggcaagt gaactgcgca ggcgtcagtc ttgggcgggc tgaaagcagc
       61 tgaagcggcg gccgagtcgg agcctccggc acaggggcgg gagctgaggc ggtagcggac
      121 cggctggcgg gctagcgaaa ggcggcggaa tggtggacta ccacgcagcg aaccaggcgt
      181 accagtacgg cccgaacagc ggcggcggca atggcgcggg tggcggcgga agcatgggcg
      241 actacatggc ccaggaggat gactgggacc gggacctgct gttggacccg gcctgggaga
      301 agcagcagcg caagaccttc acagcctggt gcaactctca tcttcggaag gctggcactc
      361 agatcgagaa tatcgatgag gacttcaggg atgggctcaa acttatgctt ctgttggagg
      421 tcatttcagg ggagcgtttg cctaagccag agcgggggaa gatgcgagtg cacaagatca
      481 acaatgtaaa caaagccctg gacttcatcg ccagcaaggg agtcaagctg gtgtccatcg
      541 gggcagaaga gattgtggat ggcaatgcaa agatgaccct gggaatgatc tggaccatca
      601 tcctcagatt tgccatccag gacatctctg tggaagagac ctctgctaag gaaggactcc
      661 tcctctggtg ccagagaaag acagccccat ataaaaacgt caacgtccag aacttccata
      721 tcagctggaa ggacgggctg gccttcaatg cactcatcca ccggcacagg cctgagctga
      781 ttgagtatga caagctgcgg aaggatgatc cagtcaccaa cctaaacaat gcatttgaag
      841 tggctgagaa atacctcgat atccccaaga tgttggatgc tgaggacatc gtgaacacag
      901 cccggcccga cgagaaggcc ataatgacat atgtgtccag cttctaccat gccttttcag
      961 gagcgcagaa gatattgtag gcactctgag gccagatgag aaggccatca tgacttacgt
     1021 gtcctgcttc taccacgcct tctcgggggc ccagaaggct gagaccgctg ccaaccggat
     1081 ctgcaaggtg ctggctgtga accaggaaaa tgagcacctg atggaagact atgaacgcct
     1141 ggccagtgat cttctagagt ggattcggcg caccatcccc tggctggagg accgggtgcc
     1201 tcagaagacc atccaggaaa tgcagcagaa gctggaggac ttccgagact ataggcgtgt
     1261 gcacaagccg cccaaggtgc aggagaagtg tcagctggag atcaacttca acacactgca
     1321 gaccaagctg cggctcagca accggcctgc cttcatgccc tccgagggca ggatggtctc
     1381 cgacatcaac aatggatggc agcacctgga gcaggctgag aagggctatg aagaatggct
     1441 gctgaatgaa atccgtaggc tggaacggct tgaccacctg gcagagaagt tccggcagaa
     1501 ggcttccatc cacgaggcct ggactgatgg gaaggaggcc atgctgaagc aacgggacta
     1561 cgagacagcc accctgtcag acatcaaagc tctgatccga aaacatgagg cctttgaaag
     1621 tgacctggct gcacaccagg accgagtgga gcagattgct gcaattgctc aggagctcaa
     1681 cgagctggac tactatgact cccacaacgt caacacacgg tgccagaaga tctgcgacca
     1741 gtgggataac ctgggctctc tgacacacag tcgcagggaa gccttggaga aaacagagaa
     1801 acagctagag accatcgacc agctacattt ggagtatgcc aagcgggctg cacccttcaa
     1861 caactggatg gagagtgcca tggaggacct gcaggacatg ttcatcgtcc acaccatcga
     1921 ggagatcgag ggcctgatct cagcccatga ccagttcaag tccaccctgc cagatgctga
     1981 cagggagcgt gaggccatcc tggccatcca caaggaggcc cagaggatcg ctgagagcaa
     2041 tcacatcaag ctgtcgggca gcaatcccta caccactgtt accccccaga tcatcaactc
     2101 caagtgggag aaggtgcagc agctggtgcc aaagagggac catgcactcc tggaggagca
     2161 gagcaagcag caatccaatg agcaccttcg ccgacagttc gccagccaag ccaatatggt
     2221 ggggccgtgg atccagacca agatggagga gatcgggcgc atctccattg agatgaacgg
     2281 gactctggaa gaccagctga gccacctgaa gcagtacgag cgcagcatcg tggactacaa
     2341 gcccagcctg gacctgctgg agcagcagca ccagctcatc caggaggccc tcatcttcga
     2401 caacaagcac accaactaca caatggagca tatccgtgtg ggctgggagc agctgctcac
     2461 gaccattgcc cgcaccatca atgaggtgga aaaccagatc ctcacccgag atgccaaggg
     2521 tatcagccag gagcagatgc aggagttccg ggcatccttc aaccattttg acaagaagca
     2581 gacaggcagc atggactcag atgacttcag ggccctgctt atctccacag gatacagcct
     2641 gggtgatgct gagttcaacc ggatcatgag tgtggttgat cccaaccata gtggcctcgt
     2701 gaccttccaa gccttcattg acttcatgtc aagggagacc acagacacag acacagctga
     2761 tcaggtcatc gcctccttca aggtcctggc aggagacaag aacttcatca ctgctgagga
     2821 actgcggaga gagctgcccc ccgaccaggc cgagtactgc atcgcccgca tggcacccta
     2881 ccaggggcct gatgctgctc ctggcgccct tgactacaag tccttctcca cagccctcta
     2941 tggggagagc gacctgtgag gcccttggcc accctgaaca gagactccct tggcctcccg
     3001 gaggggctga ggagccctgc ccccaccctg actctgtatc tatgcaaaga gctctttgtg
     3061 gtccttctag ggggtcaggc agggaggggc taggcaggcc tctctttctc agtcttgtag
     3121 gggagggagg cttggcaatc agcatttctg gtctgctaaa tatatacgct gtgctgtggg
     3181 ttcttagccg attggagggg acaacggact cctgtgcccc agagatacct tcctatccca
     3241 ggtcccctct gcccctgagg ccccttcaaa gcctctcaca tctaggccaa agccccatgt
     3301 gccttgtcca ggaaccgcct gccctaagaa gtccagcaga gggcacccag ctcccctgga
     3361 ccagattcca gtggctcctc ccaggagcag aggacctgcc atagcccttc tctgcctcag
     3421 gagtggctgc ggggcaatca gccccagccc acctggcctc tgagtctcag attttctaag
     3481 gaccaaaacc aacaaaacac aaagaatgga acagaaacaa acaaaaaaat catttaaaaa
     3541 aaaaaaaagg aaaaaaaaaa cttaaaaaaa aaaagaaaac tttaaaaact taagaccttc
     3601 cagagaatta ctatttactt tattaactta cggatttatt atataaatat atatccatct
     3661 agctgcatat ctctgccacc tctctcactc tcataatgaa gacatagctg attcaatgcc
     3721 ctccccagtc cctcctgatt ttcccctcgt ggcggtgggc agaggtctct ggggaccttc
     3781 tgaggtggag gcaggctgct ggcctgcctg cctggtcgtt aatgggtttc tctccactcg
     3841 cccccttgag tttattctga ttgattttta ttttcttggt ttctggataa accaccctct
     3901 ggggatggga gaataaaaca tgtaatattt ttaagaagga
//
