LOCUS       NM_033268               3091 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Mus musculus actinin alpha 2 (Actn2), mRNA.
ACCESSION   NM_033268
VERSION     NM_033268.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3091)
  AUTHORS   Gladka,M.M., Kohela,A., de Leeuw,A.E., Molenaar,B., Versteeg,D.,
            Kooijman,L., van Geldorp,M., van Ham,W.B., Caliandro,R.,
            Haigh,J.J., van Veen,T.A.B. and van Rooij,E.
  TITLE     Hypoxia-responsive zinc finger E-box-binding homeobox 2 (ZEB2)
            regulates a network of calcium-handling genes in the injured heart
  JOURNAL   Cardiovasc Res 120 (15), 1869-1883 (2024)
   PUBMED   39308239
REFERENCE   2  (bases 1 to 3091)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3091)
  AUTHORS   Htet,M., Lei,S., Bajpayi,S., Gangrade,H., Arvanitis,M., Zoitou,A.,
            Murphy,S., Chen,E.Z., Koleini,N., Lin,B.L., Kwon,C. and
            Tampakakis,E.
  TITLE     A transcriptional enhancer regulates cardiac maturation
  JOURNAL   Nat Cardiovasc Res 3 (6), 666-684 (2024)
   PUBMED   39196225
REFERENCE   4  (bases 1 to 3091)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   5  (bases 1 to 3091)
  AUTHORS   Grego-Bessa,J., Gomez-Apinaniz,P., Prados,B., Gomez,M.J.,
            MacGrogan,D. and de la Pompa,J.L.
  TITLE     Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in
            Ventricular Development
  JOURNAL   Circ Res 133 (11), 927-943 (2023)
   PUBMED   37846569
REFERENCE   6  (bases 1 to 3091)
  AUTHORS   Zabludoff,S.D., Csete,M., Wagner,R., Yu,X. and Wold,B.J.
  TITLE     p27Kip1 is expressed transiently in developing myotomes and
            enhances myogenesis
  JOURNAL   Cell Growth Differ 9 (1), 1-11 (1998)
   PUBMED   9438383
REFERENCE   7  (bases 1 to 3091)
  AUTHORS   Yoon,J.K., Olson,E.N., Arnold,H.H. and Wold,B.J.
  TITLE     Different MRF4 knockout alleles differentially disrupt Myf-5
            expression: cis-regulatory interactions at the MRF4/Myf-5 locus
  JOURNAL   Dev Biol 188 (2), 349-362 (1997)
   PUBMED   9268580
REFERENCE   8  (bases 1 to 3091)
  AUTHORS   Perou,C.M., Perchellet,A., Jago,T., Pryor,R., Kaplan,J. and
            Justice,M.J.
  TITLE     Comparative mapping in the beige-satin region of mouse chromosome
            13
  JOURNAL   Genomics 39 (2), 136-146 (1997)
   PUBMED   9027500
REFERENCE   9  (bases 1 to 3091)
  AUTHORS   Schiaffino,S. and Reggiani,C.
  TITLE     Molecular diversity of myofibrillar proteins: gene regulation and
            functional significance
  JOURNAL   Physiol Rev 76 (2), 371-423 (1996)
   PUBMED   8618961
  REMARK    Review article
REFERENCE   10 (bases 1 to 3091)
  AUTHORS   Patapoutian,A., Yoon,J.K., Miner,J.H., Wang,S., Stark,K. and
            Wold,B.
  TITLE     Disruption of the mouse MRF4 gene identifies multiple waves of
            myogenesis in the myotome
  JOURNAL   Development 121 (10), 3347-3358 (1995)
   PUBMED   7588068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089579.1 and AF248643.1.
            
            On Oct 6, 2007 this sequence version replaced NM_033268.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089579.1, AF248643.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-797               BC089579.1         1-797
            798-798             AF248643.1         566-566
            799-1528            BC089579.1         799-1528
            1529-1812           AF248643.1         1297-1580
            1813-1852           BC089579.1         1813-1852
            1853-2337           AF248643.1         1621-2105
            2338-2922           BC089579.1         2338-2922
            2923-2979           AF248643.1         2691-2747
            2980-3091           BC089579.1         2980-3091
FEATURES             Location/Qualifiers
     source          1..3091
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 4.54 cM"
     gene            1..3091
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /note="actinin alpha 2"
                     /db_xref="GeneID:11472"
                     /db_xref="MGI:MGI:109192"
     exon            1..358
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..2917
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /note="F-actin cross-linking protein; alpha-actinin
                     skeletal muscle"
                     /codon_start=1
                     /product="alpha-actinin-2"
                     /protein_id="NP_150371.4"
                     /db_xref="CCDS:CCDS26239.1"
                     /db_xref="GeneID:11472"
                     /db_xref="MGI:MGI:109192"
                     /translation="MNQIEPGVQYNYVYDEDEYMIQEEEWDRDLLLDPAWEKQQRKTF
                     TAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNK
                     ALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLW
                     CQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEI
                     AEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFAGAEQAETAANRICKVLAVN
                     QENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPK
                     VQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNE
                     IRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESD
                     LAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERTE
                     KLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLP
                     EADGERQSILAIQNEVEKVIQSYSIRISSSNPYSTVTMDELRNKWDKVKQLVPVRDQS
                     LQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQLKQYE
                     HNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVET
                     QILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLGEAEFARIM
                     TLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRRELPP
                     DQAQYCIKRMPPYSGPGSVPGALDYTAFSSALYGESDL"
     exon            359..473
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            474..593
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            594..680
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            681..768
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            769..847
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            848..929
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1015
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1108
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1339
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1487
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1638
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1747
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1888
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2071
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2206
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2386
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2533
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2599
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2758
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2985
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2952..2957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2985
                     /gene="Actn2"
                     /gene_synonym="1110008F24Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtgctggtac ttcgccggag actccgcgcc caggcgtgcc gccccaggaa ccgcgagaag
       61 gtcaccgcag cccgccgcct ttccatccat ccatccatcc atccatccat ccatccatcc
      121 atccatccat tcatccatcc atccatccat ccatccatcc atccatttct ccgtccgtct
      181 gtccatccct tgcgctgtgc tcgctcccca gccgccccag ccacccagcg ccatgaatca
      241 gatagagccc ggcgtgcagt acaactatgt ctacgacgaa gatgagtata tgatccagga
      301 ggaggagtgg gaccgcgacc tgctcctcga cccggcctgg gagaagcagc agaggaagac
      361 gttcactgcc tggtgcaact cacacctgcg gaaagctggc acccagatcg agaacatcga
      421 ggaggatttc aggaacggcc tcaagctcat gctacttcta gaagtcatct caggggaaag
      481 gctgcccaaa cctgaccggg gaaaaatgcg gttccacaag attgcgaatg tcaacaaggc
      541 tctggattac atagccagca agggagtgaa gctggtatct attggagctg aagaaatagt
      601 cgatggcaat gtgaagatga ccctgggtat gatctggacc atcatcctcc gcttcgccat
      661 tcaggacatc tcagtggaag aaacatctgc caaagaaggg ctgctgctat ggtgtcagag
      721 gaagacagct ccatacagaa atgtgaatat ccagaacttc cacaccagct ggaaagatgg
      781 ccttggactc tgtgccctca tccacagaca ccggcccgac ctcattgact actcaaagct
      841 taacaaggat gaccccatag gaaacattaa cctggccatg gaaatagcag agaagcactt
      901 ggatatccct aagatgttgg atgctgaaga cattgtcaac actcccaaac ccgatgaaag
      961 agccatcatg acttacgttt cctgcttcta ccatgctttc gcgggagcgg agcaggccga
     1021 gacagcagct aacagaatat gtaaggttct tgctgtgaat caagagaatg agaggctgat
     1081 ggaagaatat gagaggctag cgagtgagct gttggagtgg attcggcgca caatcccctg
     1141 gctggagaac aggacgcctg agaagaccat gcaggccatg cagaagaagc tggaggactt
     1201 ccgggattac cgtcgtaagc ataagccccc caaggtgcag gagaagtgcc agctggagat
     1261 caacttcaac acgctgcaga ccaagcttcg gatcagcaac cggcccgcct tcatgccctc
     1321 cgagggcaag atggtgtcgg acattgctgg tgcctggcag aggttggagc aggctgagaa
     1381 gggctatgag gagtggctat tgaatgagat tcgaagactg gagcgcttgg agcacttggc
     1441 tgagaagttc aggcagaagg cctccacgca cgagacatgg gcttatggca aagaacagat
     1501 cttgctgcag aaggactacg agtctgcgtc cctgacggaa gttcgagccc tacttcggaa
     1561 gcacgaggcc tttgagagcg acctggctgc acaccaggac cgcgtggagc agatcgctgc
     1621 cattgcgcag gagctcaatg aactggacta tcacgatgct gtgaacgtca atgatcggtg
     1681 ccagaaaatt tgcgaccagt gggatagatt ggggacgctc acccagaaga ggagggaggc
     1741 cttggagaga actgagaagt tgctggaaac aatcgaccaa ctgcacctgg agtttgccaa
     1801 gagagccgcg cccttcaaca actggatgga gggagccatg gaggacctgc aggacatgtt
     1861 cattgtccac agcatcgagg agatccagag tctgatcact gcacatgagc agttcaaggc
     1921 cacactgccc gaggccgacg gggagcggca gtccatcctg gccatccaga acgaggtgga
     1981 gaaggtgatc cagagctaca gcatccggat cagctccagc aacccctaca gcactgtcac
     2041 catggatgag ctgcgcaaca agtgggacaa ggtgaagcag ctggtgccgg tccgggatca
     2101 gtccctgcag gaggagctgg ctcgccaaca tgctaatgag cgtctgcggc gccagtttgc
     2161 tgctcaggcc aatgccattg ggccctggat ccagaacaag atggaggaga tcgctcggag
     2221 ctccatccag atcaccgggg ccctggagga ccagatgaac cagctgaagc agtacgaaca
     2281 caacatcatc aactacaaga acaacatcga caagctggag ggcgaccacc agctcatcca
     2341 ggaggccctg gtcttcgaca acaagcacac gaactacacc atggagcata tccgtgtcgg
     2401 atgggagttg ctgctgacaa ctatcgccag aaccatcaat gaggtggaga cccagatcct
     2461 gacaagagat gccaagggca tcacccagga gcagatgaat gagttcagag cctccttcaa
     2521 ccactttgac aggaggaaga acggcctgat ggatcatgag gatttcagag cctgcctcat
     2581 ttccatgggc tatgacttgg gtgaagctga atttgcccgc attatgactt tggttgaccc
     2641 caacggacaa ggcacggtca ccttccagtc cttcattgac ttcatgacta gagagaccgc
     2701 agacaccgac acggcagagc aggtcatcgc ctccttccgg attctggctt ctgataagcc
     2761 ttacatcttg gcagaggagc ttcgtcgaga gctgcctccg gatcaggccc agtactgcat
     2821 caagagaatg cccccatact caggcccggg cagtgtcccc ggggccctgg actacactgc
     2881 cttctcctct gccctctacg gggaaagcga cctctaatgc tctttctgta atccctaccc
     2941 tatcagaatg caataaaggc tgaagtatag gctgttacct ggaaaaaaaa aaaaaaaaaa
     3001 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3061 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
