LOCUS       NM_134156               3731 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus actinin, alpha 1 (Actn1), transcript variant 1, mRNA.
ACCESSION   NM_134156
VERSION     NM_134156.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3731)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3731)
  AUTHORS   Broadway-Stringer,S., Jiang,H., Wadmore,K., Hooper,C., Douglas,G.,
            Steeples,V., Azad,A.J., Singer,E., Reyat,J.S., Galatik,F.,
            Ehler,E., Bennett,P., Kalisch-Smith,J.I., Sparrow,D.B., Davies,B.,
            Djinovic-Carugo,K., Gautel,M., Watkins,H. and Gehmlich,K.
  TITLE     Insights into the Role of a Cardiomyopathy-Causing Genetic Variant
            in ACTN2
  JOURNAL   Cells 12 (5), 721 (2023)
   PUBMED   36899856
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3731)
  AUTHORS   Gan,P., Wang,Z., Morales,M.G., Zhang,Y., Bassel-Duby,R., Liu,N. and
            Olson,E.N.
  TITLE     RBPMS is an RNA-binding protein that mediates cardiomyocyte
            binucleation and cardiovascular development
  JOURNAL   Dev Cell 57 (8), 959-973 (2022)
   PUBMED   35472321
REFERENCE   4  (bases 1 to 3731)
  AUTHORS   Metzemaekers,M., Vandendriessche,S., Berghmans,N., Gouwy,M. and
            Proost,P.
  TITLE     Truncation of CXCL8 to CXCL8(9-77) enhances actin polymerization
            and in vivo migration of neutrophils
  JOURNAL   J Leukoc Biol 107 (6), 1167-1173 (2020)
   PUBMED   32272490
  REMARK    GeneRIF: Truncation of CXCL8 to CXCL8(9-77) enhances actin
            polymerization and in vivo migration of neutrophils.
REFERENCE   5  (bases 1 to 3731)
  AUTHORS   Cai,W., Zhang,J., de Lange,W.J., Gregorich,Z.R., Karp,H.,
            Farrell,E.T., Mitchell,S.D., Tucholski,T., Lin,Z., Biermann,M.,
            McIlwain,S.J., Ralphe,J.C., Kamp,T.J. and Ge,Y.
  TITLE     An Unbiased Proteomics Method to Assess the Maturation of Human
            Pluripotent Stem Cell-Derived Cardiomyocytes
  JOURNAL   Circ Res 125 (11), 936-953 (2019)
   PUBMED   31573406
REFERENCE   6  (bases 1 to 3731)
  AUTHORS   Pashmforoush,M., Pomies,P., Peterson,K.L., Kubalak,S., Ross,J. Jr.,
            Hefti,A., Aebi,U., Beckerle,M.C. and Chien,K.R.
  TITLE     Adult mice deficient in actinin-associated LIM-domain protein
            reveal a developmental pathway for right ventricular cardiomyopathy
  JOURNAL   Nat Med 7 (5), 591-597 (2001)
   PUBMED   11329061
REFERENCE   7  (bases 1 to 3731)
  AUTHORS   Edlund,M., Lotano,M.A. and Otey,C.A.
  TITLE     Dynamics of alpha-actinin in focal adhesions and stress fibers
            visualized with alpha-actinin-green fluorescent protein
  JOURNAL   Cell Motil Cytoskeleton 48 (3), 190-200 (2001)
   PUBMED   11223950
REFERENCE   8  (bases 1 to 3731)
  AUTHORS   Frey,N., Richardson,J.A. and Olson,E.N.
  TITLE     Calsarcins, a novel family of sarcomeric calcineurin-binding
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14632-14637 (2000)
   PUBMED   11114196
REFERENCE   9  (bases 1 to 3731)
  AUTHORS   Harper,B.D., Beckerle,M.C. and Pomies,P.
  TITLE     Fine mapping of the alpha-actinin binding site within cysteine-rich
            protein
  JOURNAL   Biochem J 350 Pt 1 (Pt 1), 269-274 (2000)
   PUBMED   10926853
REFERENCE   10 (bases 1 to 3731)
  AUTHORS   Nakagawa,N., Hoshijima,M., Oyasu,M., Saito,N., Tanizawa,K. and
            Kuroda,S.
  TITLE     ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific
            protein, associates with cytoskeletal proteins through the PDZ
            domain
  JOURNAL   Biochem Biophys Res Commun 272 (2), 505-512 (2000)
   PUBMED   10833443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT030161.10 and AC108401.19.
            
            On Mar 19, 2020 this sequence version replaced NM_134156.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154281.1, BC054830.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-377               CT030161.10        98712-99088         c
            378-492             CT030161.10        48084-48198         c
            493-612             CT030161.10        43687-43806         c
            613-699             CT030161.10        37706-37792         c
            700-787             AC108401.19        806-893
            788-866             AC108401.19        1346-1424
            867-948             AC108401.19        4102-4183
            949-1034            AC108401.19        5366-5451
            1035-1127           AC108401.19        12920-13012
            1128-1358           AC108401.19        14196-14426
            1359-1506           AC108401.19        16311-16458
            1507-1657           AC108401.19        19367-19517
            1658-1766           AC108401.19        20523-20631
            1767-1907           AC108401.19        21523-21663
            1908-2090           AC108401.19        23177-23359
            2091-2225           AC108401.19        23605-23739
            2226-2405           AC108401.19        24677-24856
            2406-2552           AC108401.19        25944-26090
            2553-2633           AC108401.19        27053-27133
            2634-2792           AC108401.19        28803-28961
            2793-3731           AC108401.19        29339-30277
FEATURES             Location/Qualifiers
     source          1..3731
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 36.49 cM"
     gene            1..3731
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /note="actinin, alpha 1"
                     /db_xref="GeneID:109711"
                     /db_xref="MGI:MGI:2137706"
     exon            1..377
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            378..492
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            493..612
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            613..699
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            700..787
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            788..866
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            867..948
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1034
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1127
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1358
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1506
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1657
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1766
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1907
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2090
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2225
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2405
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2552
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2633
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2792
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..3731
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3157
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /note="major polyA site"
     regulatory      3521..3526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /note="hexamer: AAGAAA"
     polyA_site      3555
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
     regulatory      3655..3660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /note="hexamer: ATTAAA"
     polyA_site      3682
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
     regulatory      3706..3711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /note="hexamer: ATTAAA"
     polyA_site      3731
                     /gene="Actn1"
                     /gene_synonym="3110023F10Rik; Actn1a"
                     /note="major polyA site"
ORIGIN      
        1 agtgtgcgtg gagattaggt ccgagcgcgc gccccaggaa ggcagtccgc gagctccagc
       61 cgccgccggc agcagcagcc tctgcgaaca gagccgcggc ggaagcgggc gcaggggagc
      121 gagcccggcc ccgccagccc agcccagccc agcccggccc agcccagccc agcccagccc
      181 tgccgacacc ctccccacac ccgggcagca gccgccgtcg cctggagaga aggtggagga
      241 agaaatccag ctcctagcac gcacgcacca tcatggacca ttatgattcc cagcagacca
      301 acgactacat gcagcctgaa gaggactggg atcgggacct gctcctggat ccggcctggg
      361 agaagcagca gaggaagacg ttcacagcct ggtgcaactc ccacctgcgc aaagcgggga
      421 cacagatcga gaacatcgaa gaggacttcc gagatggcct gaagctcatg ctgctcctgg
      481 aggtcatctc aggtgaacgc ttggccaagc cagagagagg caagatgaga gtgcacaaga
      541 tctccaacgt caacaaggcc ttggatttca tagccagcaa aggggtcaag ctggtgtcca
      601 tcggagctga agaaattgtg gatgggaatg tgaagatgac cctgggcatg atctggacca
      661 tcattctccg ctttgccatc caggacatct ccgtggaaga gacttcagct aaagaagggt
      721 tactcctgtg gtgtcagagg aagacagccc catataaaaa tgtcaacatc caaaacttcc
      781 acatcagttg gaaagatggt cttggtttct gtgccttgat ccaccgacac cggcccgagt
      841 tgattgacta tggaaagctt cgaaaggatg atccactcac aaacctgaac acggcctttg
      901 atgtggcaga gaggttcctg gacatcccta agatgctgga tgctgaagac atcgtcggaa
      961 ctgcccggcc agatgagaaa gccattatga cttatgtgtc tagcttctat catgccttct
     1021 ctggagccca gaaggcagaa acagcagcca atcgcatctg caaagtgttg gcggtcaatc
     1081 aagagaacga gcagcttatg gaagactatg agaagctggc cagtgatctg ttggagtgga
     1141 tccgccgcac catcccatgg ctggagaatc gggtgcctga gaacaccatg catgccatgc
     1201 agcagaagct ggaggacttc cgagactata gacgcctgca caagccgccc aaggtgcagg
     1261 agaagtgcca gctggagatc aactttaaca cgctgcagac caagctgcgg ctcagcaacc
     1321 ggcctgcctt catgccctcc gagggcagga tggtctcgga tatcaacaat gcctggggct
     1381 gcctggaaca ggccgagaag ggctacgagg agtggctgct gaatgagatc cggaggctag
     1441 agaggttgga ccacctggca gagaagttcc ggcagaaggc ctccatccat gaagcctgga
     1501 cggatggcaa agaagccatg cttcggcaga aggattatga gacagccacc ctgtccgaga
     1561 tcaaggcctt gctcaagaag cacgaggctt ttgagagtga tctggctgcc caccaggacc
     1621 gcgtggagca gattgcggcc attgcccagg agcttaatga gctggactac tatgactcgc
     1681 caagtgtcaa cgctcgttgc caaaagatct gtgaccagtg ggacaatcta ggggctctca
     1741 ctcagaagcg gagggaagct ttagagcgaa cagagaagct gctggaaacc atcgaccagc
     1801 tctacttaga gtacgccaag agggctgcac ccttcaacaa ttggatggag ggagccatgg
     1861 aggacctgca ggacaccttc atcgtacata ccatcgagga gatccaggga ctgaccacag
     1921 cccatgagca gttcaaggcc accctcccgg atgcagacaa ggagcgcctc gccattctgg
     1981 gcatccacaa tgaagtgtcc aagatcgtcc agacctatca tgtcaacatg gcaggcacca
     2041 acccctatac aaccatcacg cctcaggaga tcaatggcaa atgggaccat gtacggcagc
     2101 tagtgccccg gagggaccag gctctcacag aggaacatgc aaggcagcag cacaatgaga
     2161 ggctacgcaa acagtttggc gcacaagcca atgtcattgg gccctggatc cagaccaaga
     2221 tggaggagat tgggaggatt tccattgaga tgcacggcac cctggaggac caactcagcc
     2281 acctgcggca gtatgagaag agcatcgtca attacaagcc aaagattgac cagctggagt
     2341 gcgaccacca gctcatccag gaggcactta tctttgacaa taagcacacc aactacaaca
     2401 tggagcatat ccgtgtgggc tgggagcagc tgctcaccac cattgccagg accatcaatg
     2461 aagtggagaa ccagatcttg acccgggatg ccaaaggcat cagccaggaa cagatgaacg
     2521 aattccgcgc ctctttcaac cactttgacc gggatcactc cggcacgttg ggtcccgaag
     2581 agttcaaagc ctgcctcatc agcttgggtt atgatattgg caacgacccc cagggagagg
     2641 cagagtttgc ccgaatcatg agcattgtag accccaaccg cttgggggta gtgacgttcc
     2701 aggccttcat cgactttatg tcccgagaga cggcagatac tgatactgca gatcaggtca
     2761 tggcttcctt caagatcctg gctggagata agaattacat cacagaggat gagctgcgcc
     2821 gtgagctgcc ccctgaccaa gccgagtact gcatcgcaag aatggccccc tacgcgggcc
     2881 ccgactccgt gcccggtgct ttagactaca tgtccttctc cacggcactg tatggcgaga
     2941 gcgacctcta acccgcccct gcctccctcc accacccccc cacccccggc cttctgcgcg
     3001 tgcgccccac cctgctcctc ctcctcctcc gcccagtctg gctggctggg ttcattattt
     3061 tcagctcagc caccaagggg gcagagctcc gacccaggcg gcatcaagcc tccctgccca
     3121 caaagtgaca gtttacaaaa ttattttctg caaaaaagga taaaaaaaaa gttacgttaa
     3181 aaaaaaattt taaaaagaaa aaaaaaaaca aacaaaaaac tacatatttt attataaaaa
     3241 aaaaagtatt tttttctcca ccagtcttaa atggaaaaga ggaaaaatta actatttgca
     3301 ccgaaatgtt tttgttgtga cataggaaaa taaccaagca caaagttata ttccattctt
     3361 tttactgaag ttttttcctc ctacctgttc tgtctgctgt attcatttct ctaatttcat
     3421 gcccacttgg gggtggggta ggtgggtact ctcatcagag gcacattggt gcatgtgtgt
     3481 ttgctagctc acttgtccat gagaatattt tatgatatta aagaaaacct tttgaaatgg
     3541 ctgcttttca aagaagataa ttcatggctt ctcatttttc agtctcttca aaagtgtggc
     3601 tggcctgttt tatgactgca gagttgttat gttttttaat tttgaatatt gcctattaaa
     3661 gataggacaa acttggagat tatgatgttg cttggcacag actgtattaa aacaacactc
     3721 ccgtgacatt a
//
