LOCUS       NM_001243888            1748 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus actin maturation protease (Actmap), transcript variant
            1, mRNA.
ACCESSION   NM_001243888 XM_003084679 XM_003086577 XM_003086578
VERSION     NM_001243888.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1748)
  AUTHORS   Haahr,P., Galli,R.A., van den Hengel,L.G., Bleijerveld,O.B.,
            Kazokaite-Adomaitiene,J., Song,J.Y., Kroese,L.J., Krimpenfort,P.,
            Baltissen,M.P., Vermeulen,M., Ottenheijm,C.A.C. and
            Brummelkamp,T.R.
  TITLE     Actin maturation requires the ACTMAP/C19orf54 protease
  JOURNAL   Science 377 (6614), 1533-1537 (2022)
   PUBMED   36173861
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157561.10.
            
            On or before Sep 2, 2011 this sequence version replaced
            XM_003086578.1, XM_003086577.1, XM_003084679.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1967671.1,
                                           SRR7652917.431025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               AC157561.10        22122-22448
            328-788             AC157561.10        23247-23707
            789-857             AC157561.10        26895-26963
            858-982             AC157561.10        27361-27485
            983-1112            AC157561.10        28749-28878
            1113-1183           AC157561.10        28968-29038
            1184-1748           AC157561.10        30097-30661
FEATURES             Location/Qualifiers
     source          1..1748
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.84 cM"
     gene            1..1748
                     /gene="Actmap"
                     /note="actin maturation protease"
                     /db_xref="GeneID:414069"
                     /db_xref="MGI:MGI:3041247"
     exon            1..327
                     /gene="Actmap"
                     /inference="alignment:Splign:2.1.0"
     exon            328..788
                     /gene="Actmap"
                     /inference="alignment:Splign:2.1.0"
     CDS             436..1521
                     /gene="Actmap"
                     /note="isoform 1 is encoded by transcript variant 1; actin
                     aminopeptidase ACTMAP; UPF0692 protein C19orf54 homolog"
                     /codon_start=1
                     /product="actin maturation protease isoform 1"
                     /protein_id="NP_001230817.1"
                     /db_xref="CCDS:CCDS57529.1"
                     /db_xref="GeneID:414069"
                     /db_xref="MGI:MGI:3041247"
                     /translation="MTSPCSFPLKPTISPIIHETPDTNIPPPLPLNPPDLALPSPPCS
                     LHTSISSPLPPPPPPPAPPPPPPPPPLPSAVEPVLPHVYGLKNSQLLKEALEKAGPAP
                     KGKEDVKRLLKLHKDRFRSDLQWILFCADLPSCIQEGPQCGLVALWMAEALLSTPDSV
                     SLERLVQVAKERGYTAQGEMFSVADMAKLAQETLDCQAELLCGGLGGPNRERVLQHLI
                     TGHPLLIPYDEDFNHEPCQKKGHKAHWAVSAGVLIGVQNVPSPGYIEDSELPGLFHPV
                     PGAPHQPPSFPEESSPGALFLLSKQGKSWHYQLWDYSQVRESNLQLTDFSPARAADGQ
                     VYVVPAGGVEAGLCGQALLLRPQEGSH"
     exon            789..857
                     /gene="Actmap"
                     /inference="alignment:Splign:2.1.0"
     exon            858..982
                     /gene="Actmap"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1112
                     /gene="Actmap"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1183
                     /gene="Actmap"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1748
                     /gene="Actmap"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1565
                     /gene="Actmap"
     polyA_site      1589
                     /gene="Actmap"
                     /note="major polyA site"
ORIGIN      
        1 gtcccggcag gcggagcaca ccgagcggcg cttcccatta gtccacgtgc gcgaaaggcg
       61 tcccgggagg aaaaaagacc ccggatgtcg gagccagtta agaaagtagg ggccgacttg
      121 gaacatccta gtctctcaaa gagaggcctc ccgaagtgct ccacccgcct ccccggcgcc
      181 gagcagcgtc tacaacccgc gggaacccac cacctgagcc gtcgctcccg ccgacaacgc
      241 ccgccgagct acgctgcaca gacacacaac tatcttcccc ggcaacggct tctcccttcc
      301 gcgagctaat cacggcgggc aaactcgatc tcaatgtgca ggcctgaata tctctcatcc
      361 agttccttta aaaactgaaa atctccatcc ttgggagatt tggggagagc ctcttattct
      421 tcctgtagac cccaaatgac ttctccatgc tctttccccc taaaacccac aatctctcca
      481 ataattcatg agaccccaga caccaacatt ccacctcctt tacctctaaa tcccccggac
      541 ctagctttac catcccctcc ttgtagtctc catacatcta tttcatcccc actgccgccc
      601 cctccccccc ctcctgctcc tccccctccc cctccccctc cccctctacc ctctgctgtg
      661 gagcctgttc tccctcatgt ctatggcctg aagaacagcc agctcctgaa ggaggcctta
      721 gagaaggctg gcccagcccc caaaggcaaa gaggatgtga agaggctcct gaagctgcac
      781 aaggaccggt ttcgaagtga cctgcagtgg atcctctttt gtgctgacct gccatcatgc
      841 atccaggaag gccctcagtg tggactggtg gccttgtgga tggcagaagc tcttctgtca
      901 acacctgaca gcgtctctct ggaaagacta gtgcaggtgg ccaaggagag aggctacacc
      961 gcacagggag aaatgttctc agtggctgac atggccaaac tggcccagga gactttggac
     1021 tgccaggctg agctcctgtg tggtggcttg ggtggtccca acagagaacg agttctacag
     1081 cacctcatca ctggacatcc cctgctcatt ccctatgatg aggatttcaa ccacgagccg
     1141 tgtcaaaaga aaggccataa ggcccactgg gcagtgagtg caggggtcct gataggtgtg
     1201 cagaatgtgc caagccctgg ctacattgaa gactctgagc taccaggcct cttccaccca
     1261 gtgcctggtg caccccacca accaccatcc ttcccagagg aaagctcccc aggtgccctc
     1321 ttccttctct ccaagcaggg caagagttgg cattaccagc tgtgggacta cagccaagtc
     1381 cgggagagca acctgcagct gacagacttc tcacccgcaa gggctgccga tggacaggtg
     1441 tacgtggtac ctgctggtgg ggtagaggct ggcctctgtg gccaggccct gctgctcaga
     1501 ccacaggagg gaagccatta gctggggctg ggacacctgc attgaactta actctatcaa
     1561 cattagaatg cttcagcttc ttcccctaat gtgacatttt cagtccagtt agtttcattt
     1621 gatgagagta tcttgaaggc cgcctgcccg gaaatctttc actagatcac cccatatatg
     1681 gagtcacaag cttgaccact gtccaaagtc taaactagtt accttcagaa tcaagcattc
     1741 ctttgact
//
