LOCUS       NM_009611               1513 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus actin-like 7a (Actl7a), mRNA.
ACCESSION   NM_009611
VERSION     NM_009611.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1513)
  AUTHORS   Jin,H.J., Fan,Y., Yang,X., Dong,Y., Zhang,X.Z., Geng,X.Y., Yan,Z.,
            Wu,L., Ma,M., Li,B., Lyu,Q., Pan,Y., Liu,M., Kuang,Y. and Chen,S.R.
  TITLE     Disruption in CYLC1 leads to acrosome detachment, sperm head
            deformity, and male in/subfertility in humans and mice
  JOURNAL   Elife 13, 95054 (2024)
   PUBMED   38573307
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1513)
  AUTHORS   Zhang,Y., Tang,J., Wang,X., Sun,Y., Yang,T., Shen,X., Yang,X.,
            Shi,H., Sun,X. and Xin,A.
  TITLE     Loss of ACTL7A causes small head sperm by defective
            acrosome-acroplaxome-manchette complex
  JOURNAL   Reprod Biol Endocrinol 21 (1), 82 (2023)
   PUBMED   37667331
  REMARK    GeneRIF: Loss of ACTL7A causes small head sperm by defective
            acrosome-acroplaxome-manchette complex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1513)
  AUTHORS   Ferrer,P., Upadhyay,S., Ikawa,M. and Clement,T.M.
  TITLE     Testis-specific actin-like 7A (ACTL7A) is an indispensable protein
            for subacrosomal-associated F-actin formation, acrosomal anchoring,
            and male fertility
  JOURNAL   Mol Hum Reprod 29 (3) (2023)
   PUBMED   36734600
  REMARK    GeneRIF: Testis-specific actin-like 7A (ACTL7A) is an indispensable
            protein for subacrosomal-associated F-actin formation, acrosomal
            anchoring, and male fertility.
REFERENCE   4  (bases 1 to 1513)
  AUTHORS   Zhou,X., Liu,Z., Jia,W., Hou,M. and Zhang,X.
  TITLE     Actl7a deficiency in mice leads to male infertility and
            fertilization failure
  JOURNAL   Biochem Biophys Res Commun 623, 154-161 (2022)
   PUBMED   35921706
REFERENCE   5  (bases 1 to 1513)
  AUTHORS   Dai,J., Chen,Y., Li,Q., Zhang,T., Zhou,Q., Gong,F., Lu,G., Zheng,W.
            and Lin,G.
  TITLE     Pathogenic variant in ACTL7A causes severe teratozoospermia
            characterized by bubble-shaped acrosomes and male infertility
  JOURNAL   Mol Hum Reprod 28 (8) (2022)
   PUBMED   35863052
  REMARK    GeneRIF: Pathogenic variant in ACTL7A causes severe
            teratozoospermia characterized by bubble-shaped acrosomes and male
            infertility.
REFERENCE   6  (bases 1 to 1513)
  AUTHORS   Boeda,B., Knowles,P.P., Briggs,D.C., Murray-Rust,J., Soriano,E.,
            Garvalov,B.K., McDonald,N.Q. and Way,M.
  TITLE     Molecular recognition of the Tes LIM2-3 domains by the
            actin-related protein Arp7A
  JOURNAL   J Biol Chem 286 (13), 11543-11554 (2011)
   PUBMED   21278383
REFERENCE   7  (bases 1 to 1513)
  AUTHORS   Tanaka,H., Iguchi,N., Egydio de Carvalho,C., Tadokoro,Y.,
            Yomogida,K. and Nishimune,Y.
  TITLE     Novel actin-like proteins T-ACTIN 1 and T-ACTIN 2 are
            differentially expressed in the cytoplasm and nucleus of mouse
            haploid germ cells
  JOURNAL   Biol Reprod 69 (2), 475-482 (2003)
   PUBMED   12672658
  REMARK    GeneRIF: results suggest that T-ACTINs play important roles in
            sperm function and in the specific morphogenesis of spermatozoa
            during spermiogenesis
REFERENCE   8  (bases 1 to 1513)
  AUTHORS   Hisano,M., Yamada,S., Tanaka,H., Nishimune,Y. and Nozaki,M.
  TITLE     Genomic structure and promoter activity of the testis haploid germ
            cell-specific intronless genes, Tact1 and Tact2
  JOURNAL   Mol Reprod Dev 65 (2), 148-156 (2003)
   PUBMED   12704725
REFERENCE   9  (bases 1 to 1513)
  AUTHORS   Cuajungco,M.P., Leyne,M., Mull,J., Gill,S.P., Gusella,J.F. and
            Slaugenhaupt,S.A.
  TITLE     Cloning, characterization, and genomic structure of the mouse
            Ikbkap gene
  JOURNAL   DNA Cell Biol 20 (9), 579-586 (2001)
   PUBMED   11747609
REFERENCE   10 (bases 1 to 1513)
  AUTHORS   Chadwick,B.P., Mull,J., Helbling,L.A., Gill,S., Leyne,M.,
            Robbins,C.M., Pinkett,H.W., Makalowska,I., Maayan,C.,
            Blumenfeld,A., Axelrod,F.B., Brownstein,M., Gusella,J.F. and
            Slaugenhaupt,S.A.
  TITLE     Cloning, mapping, and expression of two novel actin genes,
            actin-like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the
            familial dysautonomia candidate region on 9q31
  JOURNAL   Genomics 58 (3), 302-309 (1999)
   PUBMED   10373328
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB023063.1 and BC049610.1.
            
            On Oct 31, 2007 this sequence version replaced NM_009611.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB023063.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1035              AB023063.1         11-1045
            1036-1497           BC049610.1         1018-1479
            1498-1513           AB023063.1         1508-1523
FEATURES             Location/Qualifiers
     source          1..1513
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 31.66 cM"
     gene            1..1513
                     /gene="Actl7a"
                     /gene_synonym="Tact2"
                     /note="actin-like 7a"
                     /db_xref="GeneID:11470"
                     /db_xref="MGI:MGI:1343051"
     exon            1..1504
                     /gene="Actl7a"
                     /gene_synonym="Tact2"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1376
                     /gene="Actl7a"
                     /gene_synonym="Tact2"
                     /note="t-actin 2; actin-like Tact2; T-actin-2;
                     actin-like-7-alpha; testis-specific actin-2"
                     /codon_start=1
                     /product="actin-like protein 7A"
                     /protein_id="NP_033741.1"
                     /db_xref="CCDS:CCDS18197.1"
                     /db_xref="GeneID:11470"
                     /db_xref="MGI:MGI:1343051"
                     /translation="MSLDGVWAPQTANIGDGPAKKASDQASMQTQVLQTASLKDGPAK
                     RAVWVRRDNAETEDPVKSTMSKDRPRLEVTKAVVVDLGTGFCKCGFAGLPKPTHKIST
                     TVGKPYMETAKTGDNRKETFVGHELFNPDIHLKLVNPLRHGIIVDWDTVQDIWEYLFR
                     QEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFNTPAMHIAYQSRLSMYSYGRTS
                     GLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTTYLMNLMNNSGKHFSEDHLGI
                     VEDIKTRCCFVALDPIEEKKIPAPEHEIHYTLPDGKEIRLGQERFLCSEMFFKPSLIK
                     SMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLRGFPNRLQKELSSMCPNDTP
                     QVNVLPERDTAVWTGGSILASLQGFQPLWVHRLEYEEHGPFFLYRRCF"
ORIGIN      
        1 ttaagtcttt caggccttgt agccagcagg atcgagagct ttctgagagc agtatgtctc
       61 tggatggtgt gtgggctcca cagacagcaa acattgggga cggacctgcc aagaaagcta
      121 gtgaccaggc ctccatgcag acacaggtcc tccaaaccgc ctccctaaaa gatggcccag
      181 caaaaagggc ggtatgggtc cgtcgggaca atgctgagac agaagaccct gttaagtcaa
      241 ctatgtccaa ggataggcca agactagagg taaccaaagc agtggttgtg gacctgggca
      301 ctggcttctg taaatgtggc tttgctggcc tgccaaagcc cactcataag atctcaacaa
      361 cagtgggcaa gccctacatg gagacggcca agacggggga taatcgcaaa gagacctttg
      421 tggggcacga gctctttaac ccagatatac atctcaagct ggtcaacccc ctgcgccatg
      481 gcatcattgt ggactgggac acagtacagg acatctggga atacctcttc cgacaggaga
      541 tgaagatcgc cccagaggaa cacgcggtcc tggtttcaga cccacccctg agtcctcata
      601 ccaacagaga gaagtacgcc gagatgctgt ttgagacctt caacacacct gcaatgcaca
      661 tcgcctacca atcccgcctg tccatgtact cctacggacg cacctctggc ctggtggtgg
      721 aggttggaca tggtgtgtcc tatgtggtcc ccatctatga gggttatcct ttgcccagca
      781 tcacggggag gctagactac gcaggttctg acctaacgac ctacctgatg aacctgatga
      841 acaactctgg aaaacacttc tctgaggacc atctcggtat tgtggaggac atcaagacga
      901 ggtgctgctt cgtggccctg gaccccattg aagagaagaa aatccctgcc cctgaacatg
      961 agatccatta taccctgcct gatgggaaag agatccgtct gggtcaggag aggttcctct
     1021 gctcggagat gttcttcaag ccatctctaa tcaagtccat gcagctgggc ctccacaccc
     1081 agacagtgtc ctgccttaac aaatgtgaca tagcactcaa acgagacctc atggggaaca
     1141 tcctgctctg tgggggcagc actatgctca ggggtttccc taaccgtctg cagaaggagc
     1201 tgagcagcat gtgccccaac gacacccccc aggtcaatgt gctgcccgag agagacactg
     1261 cagtctggac tggtgggtct atcctggcct cactccaggg ctttcaacca ctgtgggtcc
     1321 atcgcctgga gtacgaggaa catgggcctt tcttcctcta cagaaggtgc ttctgagcag
     1381 acacagcatg ctcaccgtgg tggcaatgcc agctttactg tgtgagggct gaaccttcta
     1441 caagtggtgt tgagttggca tgttcatttc tgtagcatta aaaacccctc gtgtctgtcc
     1501 ccttaaaaaa aaa
//
