LOCUS       NM_009610               1341 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus actin, gamma 2, smooth muscle, enteric (Actg2), mRNA.
ACCESSION   NM_009610
VERSION     NM_009610.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1341)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1341)
  AUTHORS   Honeycutt,S.E., N'Guetta,P.Y., Hardesty,D.M., Xiong,Y.,
            Cooper,S.L., Stevenson,M.J. and O'Brien,L.L.
  TITLE     Netrin 1 directs vascular patterning and maturity in the developing
            kidney
  JOURNAL   Development 150 (22) (2023)
   PUBMED   37818607
REFERENCE   3  (bases 1 to 1341)
  AUTHORS   Cai,H., Xiao,Y., Chen,S., Lu,Y., Du,J., You,Y., Zhu,J., Zhou,J.,
            Cai,W. and Wang,Y.
  TITLE     Heterozygous Actg2R257C mice mimic the phenotype of megacystis
            microcolon intestinal hypoperistalsis syndrome
  JOURNAL   Neurogastroenterol Motil 35 (1), e14472 (2023)
   PUBMED   36264152
  REMARK    GeneRIF: Heterozygous Actg2[R257C] mice mimic the phenotype of
            megacystis microcolon intestinal hypoperistalsis syndrome.
REFERENCE   4  (bases 1 to 1341)
  AUTHORS   Deuper,L., Meuser,M., Thiesler,H., Jany,U.W.H., Rudat,C.,
            Hildebrandt,H., Trowe,M.O. and Kispert,A.
  TITLE     Mesenchymal FGFR1 and FGFR2 control patterning of the ureteric
            mesenchyme by balancing SHH and BMP4 signaling
  JOURNAL   Development 149 (17) (2022)
   PUBMED   36094016
REFERENCE   5  (bases 1 to 1341)
  AUTHORS   Wen,T., Liu,J., He,X., Dong,K., Hu,G., Yu,L., Yin,Q., Osman,I.,
            Peng,J., Zheng,Z., Xin,H., Fulton,D., Du,Q., Zhang,W. and Zhou,J.
  TITLE     Transcription factor TEAD1 is essential for vascular development by
            promoting vascular smooth muscle differentiation
  JOURNAL   Cell Death Differ 26 (12), 2790-2806 (2019)
   PUBMED   31024075
REFERENCE   6  (bases 1 to 1341)
  AUTHORS   Moore,K.J., D'Amore-Bruno,M.A., Korfhagen,T.R., Glasser,S.W.,
            Whitsett,J.A., Jenkins,N.A. and Copeland,N.G.
  TITLE     Chromosomal localization of three pulmonary surfactant protein
            genes in the mouse
  JOURNAL   Genomics 12 (2), 388-393 (1992)
   PUBMED   1346779
REFERENCE   7  (bases 1 to 1341)
  AUTHORS   Miwa,T., Manabe,Y., Kurokawa,K., Kamada,S., Kanda,N., Bruns,G.,
            Ueyama,H. and Kakunaga,T.
  TITLE     Structure, chromosome location, and expression of the human smooth
            muscle (enteric type) gamma-actin gene: evolution of six human
            actin genes
  JOURNAL   Mol Cell Biol 11 (6), 3296-3306 (1991)
   PUBMED   1710027
REFERENCE   8  (bases 1 to 1341)
  AUTHORS   Justice,M.J., Siracusa,L.D., Gilbert,D.J., Heisterkamp,N.,
            Groffen,J., Chada,K., Silan,C.M., Copeland,N.G. and Jenkins,N.A.
  TITLE     A genetic linkage map of mouse chromosome 10: localization of
            eighteen molecular markers using a single interspecific backcross
  JOURNAL   Genetics 125 (4), 855-866 (1990)
   PUBMED   1975791
REFERENCE   9  (bases 1 to 1341)
  AUTHORS   Kim,E., Kwon,Y.K., Trasler,J.M., Kozak,C.A. and Hecht,N.B.
  TITLE     The mouse smooth muscle gamma actin gene is on chromosome 6
  JOURNAL   Somat Cell Mol Genet 16 (3), 287-291 (1990)
   PUBMED   2360094
REFERENCE   10 (bases 1 to 1341)
  AUTHORS   Kim,E., Waters,S.H., Hake,L.E. and Hecht,N.B.
  TITLE     Identification and developmental expression of a smooth-muscle
            gamma-actin in postmeiotic male germ cells of mice
  JOURNAL   Mol Cell Biol 9 (5), 1875-1881 (1989)
   PUBMED   2747639
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY778654.1, AK168649.1 and AI154766.1.
            
            On Oct 3, 2007 this sequence version replaced NM_009610.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002042.1, AK146631.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BY778654.1         2-29
            29-1312             AK168649.1         2-1285
            1313-1341           AI154766.1         104-132
FEATURES             Location/Qualifiers
     source          1..1341
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..1341
                     /gene="Actg2"
                     /gene_synonym="Act-4; Act4; ACTA3; SMGA"
                     /note="actin, gamma 2, smooth muscle, enteric"
                     /db_xref="GeneID:11468"
                     /db_xref="MGI:MGI:104589"
     exon            1..72
                     /gene="Actg2"
                     /gene_synonym="Act-4; Act4; ACTA3; SMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            73..234
                     /gene="Actg2"
                     /gene_synonym="Act-4; Act4; ACTA3; SMGA"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1239
                     /gene="Actg2"
                     /gene_synonym="Act-4; Act4; ACTA3; SMGA"
                     /note="alpha-actin-3; gamma-2-actin; smooth muscle
                     gamma-actin"
                     /codon_start=1
                     /product="actin, gamma-enteric smooth muscle"
                     /protein_id="NP_033740.2"
                     /db_xref="CCDS:CCDS51822.1"
                     /db_xref="GeneID:11468"
                     /db_xref="MGI:MGI:104589"
                     /translation="MCEEETTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGV
                     MVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEH
                     PTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGV
                     THNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLC
                     YVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIH
                     ETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPP
                     ERKYSVWIGGSILASLSTFQQMWISKPEYDEAGPSIVHRKCF"
     exon            235..363
                     /gene="Actg2"
                     /gene_synonym="Act-4; Act4; ACTA3; SMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            364..474
                     /gene="Actg2"
                     /gene_synonym="Act-4; Act4; ACTA3; SMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            475..559
                     /gene="Actg2"
                     /gene_synonym="Act-4; Act4; ACTA3; SMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            560..721
                     /gene="Actg2"
                     /gene_synonym="Act-4; Act4; ACTA3; SMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            722..913
                     /gene="Actg2"
                     /gene_synonym="Act-4; Act4; ACTA3; SMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1095
                     /gene="Actg2"
                     /gene_synonym="Act-4; Act4; ACTA3; SMGA"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1315
                     /gene="Actg2"
                     /gene_synonym="Act-4; Act4; ACTA3; SMGA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1296..1301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Actg2"
                     /gene_synonym="Act-4; Act4; ACTA3; SMGA"
                     /note="hexamer: ATTAAA"
     polyA_site      1315
                     /gene="Actg2"
                     /gene_synonym="Act-4; Act4; ACTA3; SMGA"
                     /note="major polyA site"
ORIGIN      
        1 atattgctct ggtatttctg ccaaagacac cacggccctc agtctctcgg agaaggactt
       61 ctcacaccct tggtgctcca gcccccagct cattccaccg ctcccaccat gtgtgaagaa
      121 gagaccaccg cccttgtgtg tgacaatggc tctggcctgt gcaaggcagg ctttgcagga
      181 gatgatgccc ccagggctgt cttcccctcc attgtgggcc gccctagaca tcagggtgtg
      241 atggtgggaa tgggccagaa agacagctat gtgggggacg aggctcagag caagcgtggg
      301 atcctaactc tcaagtaccc tattgaacat ggcatcatca ccaactggga tgacatggag
      361 aagatctggc accactcctt ctacaatgag cttcgagtag caccagaaga gcaccccacc
      421 ctgctcacag aggcccccct aaaccccaaa gcaaacagag agaagatgac ccagatcatg
      481 ttcgaaacct tcaatgtccc tgccatgtat gttgctattc aggctgtgct ctcactctat
      541 gcatccggcc gtaccacagg catcgttctg gattcggggg atggcgtcac ccacaatgtc
      601 cccatctatg agggctatgc actgccccat gccatcatgc gtcttgacct ggctggacgg
      661 gatctcacag actacctcat gaagattctc acagaaagag gctattcctt tgtgaccaca
      721 gctgagagag aaattgtacg agacatcaag gagaagctgt gctatgtagc cctggatttc
      781 gagaatgaga tggccacagc agcttcatct tcttccctgg agaaaagcta cgagttgcct
      841 gatgggcagg tcatcactat tggcaacgag cgcttccgct gcccggagac cctcttccag
      901 ccttccttca ttggcatgga gtcagctgga attcatgaaa caacatacaa ttccatcatg
      961 aagtgtgaca ttgacatccg caaagatttg tatgctaaca atgtcctctc tgggggcact
     1021 accatgtacc ctggcattgc tgacaggatg cagaaggaaa tcacagcctt ggctcccagc
     1081 accatgaaga tcaagattat cgctcctcct gagcggaagt actcagtctg gattggcggc
     1141 tccatcctgg cctctctctc caccttccag caaatgtgga tcagcaagcc agagtatgat
     1201 gaggcagggc cctccattgt ccacaggaaa tgcttctaaa gtcagagggc cttctctggg
     1261 gatccccaca agactgctgt caccagccac agatcattaa aaccttcaag ccttaaaaaa
     1321 aaaaaaaaaa aaaaaaaaaa a
//
