LOCUS       NM_009609               1920 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus actin, gamma, cytoplasmic 1 (Actg1), transcript
            variant 1, mRNA.
ACCESSION   NM_009609 NM_013798 XM_193346
VERSION     NM_009609.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1920)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1920)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1920)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1920)
  AUTHORS   Capriati,M., Hao,C., D'Cruz,S.C., Monfort,C., Chevrier,C.,
            Warembourg,C. and Smagulova,F.
  TITLE     Genome-wide analysis of sex-specific differences in the
            mother-child PELAGIE cohort exposed to organophosphate metabolites
  JOURNAL   Sci Rep 13 (1), 8003 (2023)
   PUBMED   37198424
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1920)
  AUTHORS   Liu,H., He,L., Cheng,Q., Luo,W., Zhao,T. and Yang,D.
  TITLE     Validation of superior reference genes in mouse submandibular
            glands under developmental and functional regeneration states
  JOURNAL   Int J Mol Med 50 (5) (2022)
   PUBMED   36069228
REFERENCE   6  (bases 1 to 1920)
  AUTHORS   Schevzov,G., Lloyd,C. and Gunning,P.
  TITLE     High level expression of transfected beta- and gamma-actin genes
            differentially impacts on myoblast cytoarchitecture
  JOURNAL   J Cell Biol 117 (4), 775-785 (1992)
   PUBMED   1577857
REFERENCE   7  (bases 1 to 1920)
  AUTHORS   Kim,E., Waters,S.H., Hake,L.E. and Hecht,N.B.
  TITLE     Identification and developmental expression of a smooth-muscle
            gamma-actin in postmeiotic male germ cells of mice
  JOURNAL   Mol Cell Biol 9 (5), 1875-1881 (1989)
   PUBMED   2747639
REFERENCE   8  (bases 1 to 1920)
  AUTHORS   Peter,B., Man,Y.M., Begg,C.E., Gall,I. and Leader,D.P.
  TITLE     Mouse cytoskeletal gamma-actin: analysis and implications of the
            structure of cloned cDNA and processed pseudogenes
  JOURNAL   J Mol Biol 203 (3), 665-675 (1988)
   PUBMED   3210229
REFERENCE   9  (bases 1 to 1920)
  AUTHORS   Rienhoff,H.Y. Jr. and Groudine,M.
  TITLE     Regulation of amyloid A gene expression in cultured cells
  JOURNAL   Mol Cell Biol 8 (9), 3710-3716 (1988)
   PUBMED   3221863
REFERENCE   10 (bases 1 to 1920)
  AUTHORS   Vandekerckhove,J. and Weber,K.
  TITLE     Actin amino-acid sequences. Comparison of actins from calf thymus,
            bovine brain, and SV40-transformed mouse 3T3 cells with rabbit
            skeletal muscle actin
  JOURNAL   Eur J Biochem 90 (3), 451-462 (1978)
   PUBMED   213279
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK153446.1 and CX567990.1.
            
            On Sep 11, 2015 this sequence version replaced NM_009609.2.
            
            Summary: Actins are highly conserved proteins that are involved in
            various types of cell motility and maintenance of the cytoskeleton.
            In vertebrates, three main groups of actin isoforms, alpha, beta,
            and gamma, have been identified. The alpha actins are found in
            muscle tissues and are a major constituent of the contractile
            apparatus. The beta and gamma actins co-exist in most cell types as
            components of the cytoskeleton, and as mediators of internal cell
            motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic
            actin found in non-muscle cells. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153446.1, AF195094.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1903              AK153446.1         1-1903
            1904-1920           CX567990.1         772-788
FEATURES             Location/Qualifiers
     source          1..1920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.07 cM"
     gene            1..1920
                     /gene="Actg1"
                     /gene_synonym="Actg; Actl; E51"
                     /note="actin, gamma, cytoplasmic 1"
                     /db_xref="GeneID:11465"
                     /db_xref="MGI:MGI:87906"
     exon            1..71
                     /gene="Actg1"
                     /gene_synonym="Actg; Actl; E51"
                     /inference="alignment:Splign:2.1.0"
     exon            72..200
                     /gene="Actg1"
                     /gene_synonym="Actg; Actl; E51"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1205
                     /gene="Actg1"
                     /gene_synonym="Actg; Actl; E51"
                     /note="isoform 1 is encoded by transcript variant 1;
                     actin, cytoplasmic 2; beta-actin FE-3; gamma-actin"
                     /codon_start=1
                     /product="actin, cytoplasmic 2 isoform 1"
                     /protein_id="NP_033739.1"
                     /db_xref="CCDS:CCDS25730.1"
                     /db_xref="GeneID:11465"
                     /db_xref="MGI:MGI:87906"
                     /translation="MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVM
                     VGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHP
                     VLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVT
                     HTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCY
                     VALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHE
                     TTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPE
                     RKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF"
     exon            201..440
                     /gene="Actg1"
                     /gene_synonym="Actg; Actl; E51"
                     /inference="alignment:Splign:2.1.0"
     exon            441..879
                     /gene="Actg1"
                     /gene_synonym="Actg; Actl; E51"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1061
                     /gene="Actg1"
                     /gene_synonym="Actg; Actl; E51"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1908
                     /gene="Actg1"
                     /gene_synonym="Actg; Actl; E51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1883..1888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Actg1"
                     /gene_synonym="Actg; Actl; E51"
                     /note="hexamer: AATAAA"
     polyA_site      1906
                     /gene="Actg1"
                     /gene_synonym="Actg; Actl; E51"
                     /note="major polyA site"
ORIGIN      
        1 ggtctcacac tccgccgccg gcttacactg cgcttcttgc cgctcctccg tcgccgccgc
       61 gtccttcgcc gatcgcaatg gaagaagaaa tcgccgcact cgtcattgac aatggctccg
      121 gcatgtgcaa agccggcttt gctggcgacg acgcccccag ggccgtgttc ccttccatcg
      181 tagggcgccc ccgacaccag ggcgtcatgg tgggcatggg ccagaaagac tcatacgtgg
      241 gtgacgaggc ccagagcaag aggggtatcc tgaccctgaa gtaccctatc gaacacggca
      301 ttgtcactaa ctgggacgac atggagaaga tctggcacca caccttctac aatgagctgc
      361 gtgtggctcc tgaggagcac ccggtgcttc tgaccgaggc ccccctgaac cccaaagcta
      421 acagagagaa gatgacgcag ataatgtttg aaaccttcaa taccccagcc atgtacgtgg
      481 ccattcaggc ggtgctgtcc ttgtatgcat ctgggcgcac cactggcatt gtcatggact
      541 ctggtgacgg ggtcacacac acagtgccca tctatgaggg ctacgccctt ccccacgcca
      601 tcttgcgtct ggacctggct ggccgggacc tgacagacta cctcatgaag atcctgactg
      661 aacggggcta cagctttacc accactgctg agagggaaat tgttcgtgac ataaaggaga
      721 agctgtgcta tgttgccctg gattttgagc aagaaatggc tactgctgca tcatcttcct
      781 ccttggagaa gagttacgag ctgcccgacg ggcaggtgat caccattggc aatgagcggt
      841 tccggtgtcc ggaggcactc ttccagcctt ccttcctggg catggagtcc tgtggtatcc
      901 atgagaccac tttcaactcc atcatgaagt gtgatgtgga tatccgcaaa gacctgtatg
      961 ccaatacagt gctgtctggt ggtaccacca tgtacccagg cattgctgac aggatgcaga
     1021 aggagatcac agccctagca cctagcacga tgaagattaa gatcattgct ccccctgagc
     1081 gcaagtactc agtctggatc ggtggctcca ttctggcctc actgtccacc ttccagcaga
     1141 tgtggatcag caagcaggag tatgatgagt caggcccctc catcgtccac cgcaaatgct
     1201 tctagatgga ctgagcaggt gccaggcatc tgctgcatga gctgatattg aagtatcaat
     1261 ttgccctggc aaatgtacac acctcatgct agcctcatga aactggaata agcctttgaa
     1321 aagaaatttg tccttgaagc ttgtatctga tatcagcact ggatcgtaga acttgttgct
     1381 gatttttgac cttgtattca agttaactgc tcccttggta tatgtttaat accctgtgca
     1441 tatcttgatt tagtccttag ttcatgtggc tcggtcactt gggggctggg gagagcacgc
     1501 tgtagatgag aaagccccag cctggtggat ctctgtgagc accactgagt gatctgtgca
     1561 gggtattaac caacagcaga cttccaggat ttcctgaggc tggcaagggt tcctgaacca
     1621 gttaccactc cttcttgcca gtctaacagg gtgggaaagt ccgagcctta ggacccagtt
     1681 tcagttctgg tttcttccct cctgaccacc atcggttgtt agttgccttg agttgggaac
     1741 gtttgcatcg acacctgtaa atgtattcat tctttaattt atgtaaggtt ttttgtactc
     1801 aattctttaa gaaatgacaa attttggttt tctactgttc aatgagaaca ttaggcccca
     1861 gcaacacgtc attgtgtaaa gaaataaaag tgctgcagta actgaccaaa aaaaaaaaaa
//
