LOCUS       NM_009608               1461 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus actin, alpha, cardiac muscle 1 (Actc1), mRNA.
ACCESSION   NM_009608 XM_917242
VERSION     NM_009608.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1461)
  AUTHORS   Jang,J., Bentsen,M., Kim,Y.J., Kim,E., Garg,V., Cai,C.L., Looso,M.
            and Li,D.
  TITLE     Endocardial HDAC3 is required for myocardial trabeculation
  JOURNAL   Nat Commun 15 (1), 4166 (2024)
   PUBMED   38755146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1461)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1461)
  AUTHORS   Jacob,T., Annusver,K., Czarnewski,P., Dalessandri,T., Kalk,C.,
            Levra Levron,C., Campama Sanz,N., Kastriti,M.E., Mikkola,M.L.,
            Rendl,M., Lichtenberger,B.M., Donati,G., Bjorklund,A.K. and
            Kasper,M.
  TITLE     Molecular and spatial landmarks of early mouse skin development
  JOURNAL   Dev Cell 58 (20), 2140-2162 (2023)
   PUBMED   37591247
REFERENCE   4  (bases 1 to 1461)
  AUTHORS   Broadway-Stringer,S., Jiang,H., Wadmore,K., Hooper,C., Douglas,G.,
            Steeples,V., Azad,A.J., Singer,E., Reyat,J.S., Galatik,F.,
            Ehler,E., Bennett,P., Kalisch-Smith,J.I., Sparrow,D.B., Davies,B.,
            Djinovic-Carugo,K., Gautel,M., Watkins,H. and Gehmlich,K.
  TITLE     Insights into the Role of a Cardiomyopathy-Causing Genetic Variant
            in ACTN2
  JOURNAL   Cells 12 (5), 721 (2023)
   PUBMED   36899856
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1461)
  AUTHORS   Wang,Y., Elsherbiny,A., Kessler,L., Cordero,J., Shi,H., Serke,H.,
            Lityagina,O., Trogisch,F.A., Mohammadi,M.M., El-Battrawy,I.,
            Backs,J., Wieland,T., Heineke,J. and Dobreva,G.
  TITLE     Lamin A/C-dependent chromatin architecture safeguards naive
            pluripotency to prevent aberrant cardiovascular cell fate and
            function
  JOURNAL   Nat Commun 13 (1), 6663 (2022)
   PUBMED   36333314
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1461)
  AUTHORS   Keller,A., Ott,M.O., Lamande,N., Lucas,M., Gros,F., Buckingham,M.
            and Lazar,M.
  TITLE     Activation of the gene encoding the glycolytic enzyme beta-enolase
            during early myogenesis precedes an increased expression during
            fetal muscle development
  JOURNAL   Mech Dev 38 (1), 41-54 (1992)
   PUBMED   1525038
REFERENCE   7  (bases 1 to 1461)
  AUTHORS   Miner,J.H., Miller,J.B. and Wold,B.J.
  TITLE     Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic
            mouse heart
  JOURNAL   Development 114 (4), 853-860 (1992)
   PUBMED   1618148
REFERENCE   8  (bases 1 to 1461)
  AUTHORS   Niswander,L. and Martin,G.R.
  TITLE     Fgf-4 expression during gastrulation, myogenesis, limb and tooth
            development in the mouse
  JOURNAL   Development 114 (3), 755-768 (1992)
   PUBMED   1618140
REFERENCE   9  (bases 1 to 1461)
  AUTHORS   Dower,N.A., Seldin,M.F., Pugh,S. and Stone,J.C.
  TITLE     Organization and chromosomal locations of Rap1a/Krev sequences in
            the mouse
  JOURNAL   Mamm Genome 3 (3), 162-167 (1992)
   PUBMED   1617222
REFERENCE   10 (bases 1 to 1461)
  AUTHORS   Ott,M.O., Bober,E., Lyons,G., Arnold,H. and Buckingham,M.
  TITLE     Early expression of the myogenic regulatory gene, myf-5, in
            precursor cells of skeletal muscle in the mouse embryo
  JOURNAL   Development 111 (4), 1097-1107 (1991)
   PUBMED   1652425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY774015.1, AK169165.1 and AC133157.1.
            
            On Aug 19, 2015 this sequence version replaced NM_009608.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100600.1, AK168661.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                BY774015.1         8-71
            65-1450             AK169165.1         2-1387
            1451-1461           AC133157.1         60533-60543
FEATURES             Location/Qualifiers
     source          1..1461
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 57.55 cM"
     gene            1..1461
                     /gene="Actc1"
                     /gene_synonym="Actc-1"
                     /note="actin, alpha, cardiac muscle 1"
                     /db_xref="GeneID:11464"
                     /db_xref="MGI:MGI:87905"
     exon            1..114
                     /gene="Actc1"
                     /gene_synonym="Actc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            115..272
                     /gene="Actc1"
                     /gene_synonym="Actc-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1277
                     /gene="Actc1"
                     /gene_synonym="Actc-1"
                     /note="actin alpha cardiac; alpha-cardiac actin;
                     alphac-actin"
                     /codon_start=1
                     /product="actin, alpha cardiac muscle 1"
                     /protein_id="NP_033738.1"
                     /db_xref="CCDS:CCDS16564.1"
                     /db_xref="GeneID:11464"
                     /db_xref="MGI:MGI:87905"
                     /translation="MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQG
                     VMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEE
                     HPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDG
                     VTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKL
                     CYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGI
                     HETTYNSIMKCDIDIRKDLYANNVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAP
                     PERKYSVWIGGSILASLSTFQQMWISKQEYDEAGPSIVHRKCF"
     exon            273..597
                     /gene="Actc1"
                     /gene_synonym="Actc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..759
                     /gene="Actc1"
                     /gene_synonym="Actc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            760..951
                     /gene="Actc1"
                     /gene_synonym="Actc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1133
                     /gene="Actc1"
                     /gene_synonym="Actc-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1461
                     /gene="Actc1"
                     /gene_synonym="Actc-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1429..1434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Actc1"
                     /gene_synonym="Actc-1"
                     /note="hexamer: AATAAA"
     polyA_site      1456
                     /gene="Actc1"
                     /gene_synonym="Actc-1"
                     /note="major polyA site"
ORIGIN      
        1 ggctgctcca actgaccccg tccatcagag agctataaag ctgcgctcca ggcgactgac
       61 acccagtgcc tgccaccagc gccagcccag ctgaatccag ccgcccctag cacgcctaca
      121 gaacccacca aagctgtgcc aggatgtgtg acgacgagga gaccaccgct ttggtgtgtg
      181 acaatggctc cgggctggtg aaggccggct ttgcgggtga tgacgccccc agagctgtct
      241 tcccgtccat cgtgggtcgc ccacgtcacc agggtgtcat ggtgggtatg ggacagaagg
      301 actcctatgt aggtgatgaa gcccagagca agcgaggtat cctgactctg aagtacccca
      361 ttgaacatgg cattatcacc aactgggatg acatggagaa gatctggcac catacattct
      421 acaatgagct ccgtgtggcc ccagaggaac acccaaccct gctcactgaa gccccgctga
      481 accccaaggc caaccgtgag aagatgaccc agatcatgtt tgagaccttc aatgtgcctg
      541 ccatgtatgt cgccatccag gcagtgctgt ctctgtatgc ttctggaaga accacaggca
      601 ttgttctgga ttctggcgat ggtgtaactc ataatgttcc catctatgag ggttatgcct
      661 taccccatgc catcatgcgc ctggatctag ctggtcggga cctcactgac tacctcatga
      721 agatcctcac tgagcgcggg tactcctttg tcaccactgc tgaacgtgaa attgtccgtg
      781 acataaaaga aaaactgtgt tacgtcgccc tggattttga gaacgagatg gccacagctg
      841 catcttcctc ctctctggag aagagctatg aacttcctga cggccaggtc atcaccattg
      901 gcaacgagcg cttccgctgt ccagagactc tcttccagcc ctctttcatt ggtatggaat
      961 ctgctggcat tcatgaaact acttacaaca gcatcatgaa gtgtgacatc gatatccgca
     1021 aagacctgta tgccaacaat gtcctatctg gaggcaccac catgtaccct ggtattgccg
     1081 atcgtatgca aaaggaaatc actgcactgg ctcccagcac catgaagatc aagattattg
     1141 ctccccctga gcgtaaatac tctgtctgga ttgggggctc catcctggcc tctctgtcca
     1201 ccttccagca aatgtggatc agcaagcaag agtatgatga ggcaggccca tccattgtcc
     1261 accgcaagtg cttctgagat gtctctctct tagcctacct tatattcagg atgaccgtat
     1321 tgtgcttctt ggaatcctct gagccccctc cccatctctc atcagtcatt gtacagtttg
     1381 tttacacaag tgcagtttgt ttgtgcttca aatatttatt gctttataaa taaaccagac
     1441 caggacttgc aacctacaaa a
//
