LOCUS       NM_007393               1935 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus actin, beta (Actb), mRNA.
ACCESSION   NM_007393
VERSION     NM_007393.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1935)
  AUTHORS   Yokoyama,K., Hiraoka,Y., Abe,Y. and Tanaka,K.F.
  TITLE     Visualization of myelin-forming oligodendrocytes in the adult mouse
            brain
  JOURNAL   J Neurochem 169 (1), e16218 (2025)
   PUBMED   39233334
REFERENCE   2  (bases 1 to 1935)
  AUTHORS   Uchino,E., Kusumoto-Yoshida,I., Kashiwadani,H., Kanmura,Y.,
            Matsunaga,A. and Kuwaki,T.
  TITLE     Identification of hypothermia-inducing neurons in the preoptic area
            and activation of them by isoflurane anesthesia and central
            injection of adenosine
  JOURNAL   J Physiol Sci 74 (1), 33 (2024)
   PUBMED   38867187
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1935)
  AUTHORS   Sundby,L.J., Southern,W.M., Sun,J., Patrinostro,X., Zhang,W.,
            Yong,J. and Ervasti,J.M.
  TITLE     Deletion of exons 2 and 3 from Actb and cell immortalization lead
            to widespread, beta-actin independent alterations in gene
            expression associated with cell cycle control
  JOURNAL   Eur J Cell Biol 103 (2), 151397 (2024)
   PUBMED   38387258
  REMARK    GeneRIF: Deletion of exons 2 and 3 from Actb and cell
            immortalization lead to widespread, beta-actin independent
            alterations in gene expression associated with cell cycle control.
REFERENCE   4  (bases 1 to 1935)
  AUTHORS   Miyazaki,Y., Otsuka,T., Yamagata,Y., Endo,T., Sanbo,M., Sano,H.,
            Kobayashi,K., Inahashi,H., Kornau,H.C., Schmitz,D., Pruss,H.,
            Meijer,D., Hirabayashi,M., Fukata,Y. and Fukata,M.
  TITLE     Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize
            juxtaparanodal Kv1 channel clustering for short-term synaptic
            plasticity
  JOURNAL   Cell Rep 43 (1), 113634 (2024)
   PUBMED   38194969
REFERENCE   5  (bases 1 to 1935)
  AUTHORS   Iba,C., Abe,Y. and Tanaka,K.F.
  TITLE     Optogenetic demonstration of the involvement of SMA-negative mural
            cells in the regulation of cerebral blood flow
  JOURNAL   Front Physiol 14, 1322250 (2023)
   PUBMED   38187133
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1935)
  AUTHORS   Kaminska,B., Kaczmarek,L. and Grzelakowska-Sztabert,B.
  TITLE     Inhibitors of polyamine biosynthesis affect the expression of genes
            encoding cytoskeletal proteins
  JOURNAL   FEBS Lett 304 (2-3), 198-200 (1992)
   PUBMED   1618323
REFERENCE   7  (bases 1 to 1935)
  AUTHORS   Schevzov,G., Lloyd,C. and Gunning,P.
  TITLE     High level expression of transfected beta- and gamma-actin genes
            differentially impacts on myoblast cytoarchitecture
  JOURNAL   J Cell Biol 117 (4), 775-785 (1992)
   PUBMED   1577857
REFERENCE   8  (bases 1 to 1935)
  AUTHORS   Harris,D.E., Warshaw,D.M. and Periasamy,M.
  TITLE     Nucleotide sequences of the rabbit alpha-smooth-muscle and
            beta-non-muscle actin mRNAs
  JOURNAL   Gene 112 (2), 265-266 (1992)
   PUBMED   1555776
REFERENCE   9  (bases 1 to 1935)
  AUTHORS   Fowlis,G.A., Adelman,S., Knight,A.M. and Simpson,E.
  TITLE     PCR-analyzed microsatellites of the mouse genome--additional
            polymorphisms among ten inbred mouse strains
  JOURNAL   Mamm Genome 3 (4), 192-196 (1992)
   PUBMED   1611214
REFERENCE   10 (bases 1 to 1935)
  AUTHORS   Vandekerckhove,J. and Weber,K.
  TITLE     Actin amino-acid sequences. Comparison of actins from calf thymus,
            bovine brain, and SV40-transformed mouse 3T3 cells with rabbit
            skeletal muscle actin
  JOURNAL   Eur J Biochem 90 (3), 451-462 (1978)
   PUBMED   213279
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY094883.1, BY783897.1,
            AK150711.1, CX211008.1, AC144818.4, AK142426.1 and BY155324.1.
            
            On Sep 30, 2015 this sequence version replaced NM_007393.4.
            
            Summary: This gene encodes a member of the actin family of
            proteins. Actins are highly conserved proteins that are among the
            most abundant proteins in eukaryotic cells and are involved in cell
            motility, structure, and integrity. Localization, stability, and
            translation of the transcribed mRNA are regulated through the
            binding of multiple factors to its 3' UTR sequence. Homozygous
            knockout mice for this gene exhibit embryonic lethality. Numerous
            pseudogenes of this gene have been identified in the mouse genome.
            [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X03672.1, J04181.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 BY094883.1         1-1
            2-29                BY783897.1         2-29
            30-1294             AK150711.1         2-1266
            1295-1379           CX211008.1         329-413
            1380-1388           AC144818.4         75190-75198
            1389-1793           AK142426.1         1-405               c
            1794-1935           BY155324.1         285-426
FEATURES             Location/Qualifiers
     source          1..1935
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 81.8 cM"
     gene            1..1935
                     /gene="Actb"
                     /gene_synonym="Actx; beta-actin; E430023M04Rik"
                     /note="actin, beta"
                     /db_xref="GeneID:11461"
                     /db_xref="MGI:MGI:87904"
     exon            1..103
                     /gene="Actb"
                     /gene_synonym="Actx; beta-actin; E430023M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            104..232
                     /gene="Actb"
                     /gene_synonym="Actx; beta-actin; E430023M04Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1237
                     /gene="Actb"
                     /gene_synonym="Actx; beta-actin; E430023M04Rik"
                     /note="melanoma X-actin; actin, beta, cytoplasmic; A-X
                     actin-like protein"
                     /codon_start=1
                     /product="actin, cytoplasmic 1"
                     /protein_id="NP_031419.1"
                     /db_xref="CCDS:CCDS19833.1"
                     /db_xref="GeneID:11461"
                     /db_xref="MGI:MGI:87904"
                     /translation="MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVM
                     VGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHP
                     VLLTEAPLNPKANREKMTQIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVT
                     HTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCY
                     VALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHE
                     TTFNSIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPE
                     RKYSVWIGGSILASLSTFQQMWISKQEYDESGPSIVHRKCF"
     exon            233..472
                     /gene="Actb"
                     /gene_synonym="Actx; beta-actin; E430023M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            473..911
                     /gene="Actb"
                     /gene_synonym="Actx; beta-actin; E430023M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1093
                     /gene="Actb"
                     /gene_synonym="Actx; beta-actin; E430023M04Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1920
                     /gene="Actb"
                     /gene_synonym="Actx; beta-actin; E430023M04Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1889..1894
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Actb"
                     /gene_synonym="Actx; beta-actin; E430023M04Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1918
                     /gene="Actb"
                     /gene_synonym="Actx; beta-actin; E430023M04Rik"
                     /note="major polyA site"
ORIGIN      
        1 tataaaaccc ggcggcgcaa cgcgcagcca ctgtcgagtc gcgtccaccc gcgagcacag
       61 cttctttgca gctccttcgt tgccggtcca cacccgccac cagttcgcca tggatgacga
      121 tatcgctgcg ctggtcgtcg acaacggctc cggcatgtgc aaagccggct tcgcgggcga
      181 cgatgctccc cgggctgtat tcccctccat cgtgggccgc cctaggcacc agggtgtgat
      241 ggtgggaatg ggtcagaagg actcctatgt gggtgacgag gcccagagca agagaggtat
      301 cctgaccctg aagtacccca ttgaacatgg cattgttacc aactgggacg acatggagaa
      361 gatctggcac cacaccttct acaatgagct gcgtgtggcc cctgaggagc accctgtgct
      421 gctcaccgag gcccccctga accctaaggc caaccgtgaa aagatgaccc agatcatgtt
      481 tgagaccttc aacaccccag ccatgtacgt agccatccag gctgtgctgt ccctgtatgc
      541 ctctggtcgt accacaggca ttgtgatgga ctccggagac ggggtcaccc acactgtgcc
      601 catctacgag ggctatgctc tccctcacgc catcctgcgt ctggacctgg ctggccggga
      661 cctgacagac tacctcatga agatcctgac cgagcgtggc tacagcttca ccaccacagc
      721 tgagagggaa atcgtgcgtg acatcaaaga gaagctgtgc tatgttgctc tagacttcga
      781 gcaggagatg gccactgccg catcctcttc ctccctggag aagagctatg agctgcctga
      841 cggccaggtc atcactattg gcaacgagcg gttccgatgc cctgaggctc ttttccagcc
      901 ttccttcttg ggtatggaat cctgtggcat ccatgaaact acattcaatt ccatcatgaa
      961 gtgtgacgtt gacatccgta aagacctcta tgccaacaca gtgctgtctg gtggtaccac
     1021 catgtaccca ggcattgctg acaggatgca gaaggagatt actgctctgg ctcctagcac
     1081 catgaagatc aagatcattg ctcctcctga gcgcaagtac tctgtgtgga tcggtggctc
     1141 catcctggcc tcactgtcca ccttccagca gatgtggatc agcaagcagg agtacgatga
     1201 gtccggcccc tccatcgtgc accgcaagtg cttctaggcg gactgttact gagctgcgtt
     1261 ttacaccctt tctttgacaa aacctaactt gcgcagaaaa aaaaaaaata agagacaaca
     1321 ttggcatggc tttgtttttt taaatttttt ttaaagtttt tttttttttt tttttttttt
     1381 tttttaagtt tttttgtttt gttttggcgc ttttgactca ggatttaaaa actggaacgg
     1441 tgaaggcgac agcagttggt tggagcaaac atcccccaaa gttctacaaa tgtggctgag
     1501 gactttgtac attgttttgt tttttttttt ttttggtttt gtcttttttt aatagtcatt
     1561 ccaagtatcc atgaaataag tggttacagg aagtccctca ccctcccaaa agccaccccc
     1621 actcctaaga ggaggatggt cgcgtccatg ccctgagtcc accccgggga aggtgacagc
     1681 attgcttctg tgtaaattat gtactgcaaa aattttttta aatcttccgc cttaatactt
     1741 catttttgtt tttaatttct gaatggccca ggtctgaggc ctcccttttt tttgtccccc
     1801 caacttgatg tatgaaggct ttggtctccc tgggaggggg ttgaggtgtt gaggcagcca
     1861 gggctggcct gtacactgac ttgagaccaa taaaagtgca caccttacct tacacaaaca
     1921 aaaaaaaaaa aaaaa
//
