LOCUS       NM_009606               1481 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus actin alpha 1, skeletal muscle (Acta1), transcript
            variant 2, mRNA.
ACCESSION   NM_009606
VERSION     NM_009606.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1481)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1481)
  AUTHORS   Li,Y., Ma,K., Dong,Z., Gao,S., Zhang,J., Huang,S., Yang,J.,
            Fang,G., Li,Y., Li,X., Welch,C., Griffin,E.L., Ramaswamy,P.,
            Valivullah,Z., Liu,X., Dong,J., Wang,D.W., Du,J., Chung,W.K. and
            Li,Y.
  TITLE     Frameshift variants in C10orf71 cause dilated cardiomyopathy in
            human, mouse, and organoid models
  JOURNAL   J Clin Invest 134 (12), e177172 (2024)
   PUBMED   38950288
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1481)
  AUTHORS   Liu,Y. and Lin,W.
  TITLE     Morphological and functional alterations of neuromuscular synapses
            in a mouse model of ACTA1 congenital myopathy
  JOURNAL   Hum Mol Genet 33 (3), 233-244 (2024)
   PUBMED   37883471
REFERENCE   4  (bases 1 to 1481)
  AUTHORS   Tinklenberg,J.A., Slick,R.A., Sutton,J., Zhang,L., Meng,H.,
            Beatka,M.J., Vanden Avond,M., Prom,M.J., Ott,E., Montanaro,F.,
            Heisner,J., Toro,R., Hardeman,E.C., Geurts,A.M., Stowe,D.F.,
            Hill,R.B. and Lawlor,M.W.
  TITLE     Different Mouse Models of Nemaline Myopathy Harboring Acta1
            Mutations Display Differing Abnormalities Related to Mitochondrial
            Biology
  JOURNAL   Am J Pathol 193 (10), 1548-1567 (2023)
   PUBMED   37419385
REFERENCE   5  (bases 1 to 1481)
  AUTHORS   Broadway-Stringer,S., Jiang,H., Wadmore,K., Hooper,C., Douglas,G.,
            Steeples,V., Azad,A.J., Singer,E., Reyat,J.S., Galatik,F.,
            Ehler,E., Bennett,P., Kalisch-Smith,J.I., Sparrow,D.B., Davies,B.,
            Djinovic-Carugo,K., Gautel,M., Watkins,H. and Gehmlich,K.
  TITLE     Insights into the Role of a Cardiomyopathy-Causing Genetic Variant
            in ACTN2
  JOURNAL   Cells 12 (5), 721 (2023)
   PUBMED   36899856
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1481)
  AUTHORS   Lucas,M., Goblet,C., Keller,A., Lamande,N., Gros,F., Whalen,R.G.
            and Lazar,M.
  TITLE     Modulation of embryonic and muscle-specific enolase gene products
            in the developing mouse hindlimb
  JOURNAL   Differentiation 51 (1), 1-7 (1992)
   PUBMED   1280607
REFERENCE   7  (bases 1 to 1481)
  AUTHORS   Miner,J.H., Miller,J.B. and Wold,B.J.
  TITLE     Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic
            mouse heart
  JOURNAL   Development 114 (4), 853-860 (1992)
   PUBMED   1618148
REFERENCE   8  (bases 1 to 1481)
  AUTHORS   Cox,R.D. and Buckingham,M.E.
  TITLE     Actin and myosin genes are transcriptionally regulated during mouse
            skeletal muscle development
  JOURNAL   Dev Biol 149 (1), 228-234 (1992)
   PUBMED   1728592
REFERENCE   9  (bases 1 to 1481)
  AUTHORS   Teeter,L.D., Petersen,D.D., Nebert,D.W. and Kuo,M.T.
  TITLE     Murine mdr-1, mdr-2, and mdr-3 gene expression: no coinduction with
            the Cyp1a-1 and Nmo-1 genes in liver by
            2,3,7,8-tetrachlorodibenzo-p-dioxin
  JOURNAL   DNA Cell Biol 10 (6), 433-441 (1991)
   PUBMED   2069718
REFERENCE   10 (bases 1 to 1481)
  AUTHORS   Lyons,G.E., Buckingham,M.E. and Mannherz,H.G.
  TITLE     alpha-Actin proteins and gene transcripts are colocalized in
            embryonic mouse muscle
  JOURNAL   Development 111 (2), 451-454 (1991)
   PUBMED   1893870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC147266.6 and M12866.1.
            
            On Jan 3, 2013 this sequence version replaced NM_009606.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M12866.1, BC014877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC147266.6         209921-209966       c
            47-1465             M12866.1           1-1419
            1466-1481           AC147266.6         206949-206964       c
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 72.26 cM"
     gene            1..1481
                     /gene="Acta1"
                     /gene_synonym="Acta-2; Acts; Actsk-1"
                     /note="actin alpha 1, skeletal muscle"
                     /db_xref="GeneID:11459"
                     /db_xref="MGI:MGI:87902"
     exon            1..84
                     /gene="Acta1"
                     /gene_synonym="Acta-2; Acts; Actsk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            85..225
                     /gene="Acta1"
                     /gene_synonym="Acta-2; Acts; Actsk-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1230
                     /gene="Acta1"
                     /gene_synonym="Acta-2; Acts; Actsk-1"
                     /note="alpha-actin-1"
                     /codon_start=1
                     /product="actin, alpha skeletal muscle"
                     /protein_id="NP_033736.1"
                     /db_xref="CCDS:CCDS22764.1"
                     /db_xref="GeneID:11459"
                     /db_xref="MGI:MGI:87902"
                     /translation="MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQG
                     VMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEE
                     HPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDG
                     VTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKL
                     CYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGI
                     HETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAP
                     PERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF"
     exon            226..550
                     /gene="Acta1"
                     /gene_synonym="Acta-2; Acts; Actsk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..712
                     /gene="Acta1"
                     /gene_synonym="Acta-2; Acts; Actsk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..904
                     /gene="Acta1"
                     /gene_synonym="Acta-2; Acts; Actsk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1086
                     /gene="Acta1"
                     /gene_synonym="Acta-2; Acts; Actsk-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1481
                     /gene="Acta1"
                     /gene_synonym="Acta-2; Acts; Actsk-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1443..1448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acta1"
                     /gene_synonym="Acta-2; Acts; Actsk-1"
                     /note="hexamer: ATTAAA"
     polyA_site      1472
                     /gene="Acta1"
                     /gene_synonym="Acta-2; Acts; Actsk-1"
                     /note="major polyA site"
ORIGIN      
        1 acctgtgcaa ggggacaggc ggtcacacgg acgtgaagcc tcacttccta ccctcggcac
       61 ccagggccag agtcagagca gcagaaacta gacaccatgt gcgacgaaga cgagaccacc
      121 gctcttgtgt gtgacaacgg ctctggcctg gtgaaagctg gctttgccgg ggatgatgcc
      181 cccagggctg tgttcccatc catcgtgggc cgaccccgtc accagggtgt catggtaggt
      241 atgggtcaga aggactccta cgtgggtgat gaggcccaga gcaagcgagg tatcctgacc
      301 ctgaagtacc ccattgaaca tggcatcatc accaactggg acgacatgga gaagatctgg
      361 caccacacct tctacaatga gctgcgtgtg gcccctgagg agcacccgac tctgctcacc
      421 gaggcccccc tgaaccccaa agctaaccgg gagaagatga ctcaaatcat gtttgagacc
      481 ttcaacgtgc ctgccatgta tgtggctatc caggcggtgc tgtccctcta tgcttccggc
      541 cgtaccaccg gcatcgtgtt ggattctggg gacggtgtca cccacaacgt gcccatctat
      601 gagggctatg ccctgccaca cgccatcatg cgtctggacc tggccggtcg cgacctcact
      661 gactacctga tgaaaatcct cactgagcgt ggctattcct tcgtgaccac agctgaacgt
      721 gagattgtgc gcgacatcaa agagaagctg tgctatgtgg ccctggactt cgagaatgag
      781 atggccaccg ctgcctcttc ctcctccctg gagaagagct atgagctgcc cgacgggcag
      841 gtcatcacca tcggcaatga gcgtttccgt tgcccggaga cgctcttcca gccttccttt
      901 atcggtatgg agtctgcggg gatccatgag accacctaca acagcatcat gaagtgcgac
      961 atcgacatca ggaaggacct gtatgccaac aacgtcatgt cagggggcac caccatgtac
     1021 cctggtatcg ctgaccgcat gcagaaggag atcacagctc tggctcccag caccatgaag
     1081 atcaagatca tcgccccccc tgagcgcaag tactcagtgt ggatcggtgg ctccatcctg
     1141 gcctcgctgt ccaccttcca gcagatgtgg atcaccaagc aggagtacga cgaggctggc
     1201 ccctccattg tgcaccgcaa atgcttctag gcgcactcgc gtctgcgttc gcgctctctc
     1261 tcctcaggac gacaatcgac aatcgtgctg tggttgcagg gtggccccgt cctccgccgt
     1321 ggctccatcg ccgccactgc agccggcgcc tgtttttgac gtgtacatag attgactcgt
     1381 tttacctcat tttgttattt ttcaaacaaa gccctgtgga aaggaaatgg aaaacttgaa
     1441 gcattaaagc cagccattct gttttgctcc aataaactgt g
//
