LOCUS       NM_001142804            4750 bp    mRNA    linear   ROD 11-FEB-2024
DEFINITION  Mus musculus acyl-CoA synthetase short-chain family member 3
            (Acss3), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_001142804
VERSION     NM_001142804.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4750)
  AUTHORS   Wang,L., Yuan,H., Li,W., Yan,P., Zhao,M., Li,Z., Zhao,H., Wang,S.,
            Wan,R., Li,Y., Yang,J., Pan,X., Rosas,I. and Yu,G.
  TITLE     ACSS3 regulates the metabolic homeostasis of epithelial cells and
            alleviates pulmonary fibrosis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (2), 166960 (2024)
   PUBMED   37979225
  REMARK    GeneRIF: ACSS3 regulates the metabolic homeostasis of epithelial
            cells and alleviates pulmonary fibrosis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121946.3, AC134457.4 and AC111014.6.
            
            On Jun 20, 2019 this sequence version replaced NM_001142804.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-350               AC121946.3         134588-134937       c
            351-495             AC134457.4         178040-178184       c
            496-684             AC134457.4         146561-146749       c
            685-819             AC134457.4         142597-142731       c
            820-960             AC134457.4         138446-138586       c
            961-1041            AC134457.4         117090-117170       c
            1042-1137           AC134457.4         116887-116982       c
            1138-1289           AC134457.4         97897-98048         c
            1290-1393           AC134457.4         82039-82142         c
            1394-1489           AC134457.4         60181-60276         c
            1490-1553           AC134457.4         56195-56258         c
            1554-1635           AC134457.4         45207-45288         c
            1636-1758           AC134457.4         41889-42011         c
            1759-1858           AC111014.6         137993-138092       c
            1859-2034           AC111014.6         137733-137908       c
            2035-4750           AC111014.6         134106-136821       c
FEATURES             Location/Qualifiers
     source          1..4750
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 55.66 cM"
     gene            1..4750
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /note="acyl-CoA synthetase short-chain family member 3"
                     /db_xref="GeneID:380660"
                     /db_xref="MGI:MGI:2685720"
     exon            1..350
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2103
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /EC_number="6.2.1.1"
                     /EC_number="6.2.1.17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     acyl-CoA synthetase short-chain family member 3,
                     mitochondrial; acetate--CoA ligase 3; propionate--CoA
                     ligase"
                     /codon_start=1
                     /product="acyl-CoA synthetase short-chain family member 3,
                     mitochondrial isoform 1"
                     /protein_id="NP_001136276.1"
                     /db_xref="CCDS:CCDS48688.1"
                     /db_xref="GeneID:380660"
                     /db_xref="MGI:MGI:2685720"
                     /translation="MKPSWLQCRKVTGAGTLGAPLPGSPSVRGAAVTRRALVAGFGGR
                     GCRALTTGSGGEYKTHFAASVADPERFWGKAAEQISWYKPWTKTLESRYPPSTSWFVE
                     GMLNICYNAIDRHIENGQGDKIAIIYDSPVTDTKATISYKEVLEQVSKLAGVLVKQGV
                     KKGDTVVIYMPMIPQAIYTMLACARIGAIHSLIFGGFASKELSTRIDHAKPKVVVTAS
                     FGIEPGRKVEYIPLLEEALRIGQHRPDRVLIYSRPNMEKVPLMSGRDLDWEEEMAKAQ
                     SHDCVPVLSEHPLYILYTSGTTGLPKGVVRPTGGYAVMLNWTMSSIYGLKPGEVWWAA
                     SDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVAALFTAPTAI
                     RAIRQQDPGAALGKQYSLTRFKTLFVAGERCDVETLEWSKKVFRVPVLDHWWQTETGS
                     PITASCIGLGNSKTPPPGQAGKCVPGYNVMILDDNMQKLKARSLGNIVVKLPLPPGAF
                     SGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRISAGAI
                     EESVLSHGTVADCAVVGKEDPLKGHVPLALCVLKKDVNASEEQVLEEIVKHVRQSIGP
                     VAAFRNAVFVKQLPKTRSGKIPRSTLSALVNGKPYKVTPTIEDPSIFGHIEEVLKQAV
                     "
     exon            351..495
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
     exon            496..684
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
     exon            685..819
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
     exon            820..960
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1041
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1137
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1289
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1393
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1489
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1553
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1635
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1758
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1858
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..2034
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..4750
                     /gene="Acss3"
                     /gene_synonym="8430416H19Rik; Gm874"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagctgttg ggactgcaaa ctgctccgac tgcagctagg gacagagaga aagtatgaag
       61 ccatcctggt tgcaatgtcg caaagtaaca ggcgccggga cgcttggggc acctctgcca
      121 ggatcccctt cagtaagagg agccgctgtg acccgaaggg ctttggtggc cgggtttggg
      181 ggcaggggct gcagggctct gaccaccggc agtggtggtg agtacaagac ccacttcgca
      241 gcctctgtgg ctgaccccga aagattctgg ggtaaagctg ctgagcagat cagttggtac
      301 aagccctgga ccaaaactct agagagcaga tacccgcctt ccacaagttg gtttgtggaa
      361 gggatgctga acatttgtta caatgctatt gatcggcaca ttgaaaatgg ccaaggggat
      421 aagattgcta tcatctatga cagtcccgtt acagacacca aagcaactat ctcctataag
      481 gaagtcttgg agcaggtctc taagctggct ggtgtcttgg tcaagcaggg tgtcaagaaa
      541 ggcgatacag tggtcatcta tatgcccatg atcccacaag caatatatac catgctggcg
      601 tgtgcaagga taggagcaat ccacagtctc atatttggag gatttgcatc caaagaatta
      661 agtacgcgca ttgatcatgc gaagcctaag gtggttgtta cggcatcatt tggcattgaa
      721 ccaggaagga aggtggagta catcccactt ctagaagaag ctctgaggat aggacagcac
      781 aggccagaca gagttctcat ttacagccgt ccaaacatgg agaaagttcc tttgatgtca
      841 ggtcgtgatc ttgattggga agaagaaatg gcaaaagccc agtctcatga ctgcgtgcct
      901 gttctctcag agcatccatt gtacattctc tacacatctg gaacaactgg gctgcctaag
      961 ggtgtggtta gacccactgg gggctatgct gtcatgttga actggacaat gtcttccata
     1021 tatggactca aacctggaga ggtatggtgg gcagcttctg acttaggctg ggttgttgga
     1081 cattcctata tttgctatgg gcctcttctc catggaaaca caacagtttt atatgaggga
     1141 aagcctgtgg gaacaccgga tgctggcgct tatttccgtg tgcttgcaga gcatggagtg
     1201 gctgccttgt ttacagcacc aactgcaatt agagccatcc gtcaacagga ccctggggca
     1261 gccttgggga agcagtactc tctgacaagg ttcaagacac tgtttgtagc tggggaaaga
     1321 tgtgatgtgg agaccctaga atggtccaaa aaagtcttcc gagttcccgt tctagaccat
     1381 tggtggcaaa cagagactgg atcccccatc acagcatcat gtattggatt aggtaactcc
     1441 aaaacacctc caccaggaca agcaggaaaa tgtgttccag gatacaatgt tatgattttg
     1501 gatgacaaca tgcaaaaact gaaggctaga agcttaggaa acattgtggt aaagttgcca
     1561 ttaccacctg gggctttttc aggactctgg aagaaccagg aagcattcaa gcatttatac
     1621 tttgagaaat ttcctggata ctatgacact atggatgccg gctacatgga tgaggaaggc
     1681 tacctatatg tgatgtcccg agtggatgat gtcataaacg ttgcaggcca caggatttct
     1741 gcaggcgcta ttgaggagtc agtcctctca cacggcactg tggctgactg cgctgtggtt
     1801 ggcaaggaag accccttgaa aggtcacgtc cccttagcac tctgcgtgtt gaagaaagac
     1861 gtaaatgcat cagaagaaca agttttggaa gagattgtga aacatgttag gcagagcatt
     1921 ggccctgtgg ctgcttttcg aaatgcggtt ttcgtcaaac agttacccaa aaccaggtct
     1981 ggcaaaattc cacggtctac actgtctgcc ctggttaatg gcaagcctta taaggtgacc
     2041 cctacgattg aggaccccag catttttggt cacattgaag aagtgctgaa gcaggctgtg
     2101 tgatttttgc ttcctacgtt caaccacttg gtcttaactt tctagctgga tttaagtcat
     2161 ttattttcta taaatgaata cttgaaacaa aatcccttat caactcagat gtgagctgta
     2221 gtgttttgtc agtctagtag cccctgaaag agactatata tattgtttca tgtgagccag
     2281 tttgcacaat tacctctttt ctgtaacatg gatcattata tgctatctag tgtattgagg
     2341 aacgtgtctt tggtgtacag ttttacaaat tcatgtgctt tacaaacaca ttttaatcaa
     2401 aaaatatctg aactataaat gtactttctg gagataggaa tcaaccacac tttgatcaaa
     2461 atctaaactg aaatcaaagt tggaatataa tttaaaaggt tattgtggag actcaaatgt
     2521 tgtctattat tttatagatg accactatgc ttttaggtaa ttatcaaaac agagtaggtt
     2581 gcttagcaac acaggacccc agggtggagc accccttcta tgttactagt tactgggtaa
     2641 ggagaggcat gtatctggta gagaatttcc aatgcattca ccaaatattt tgaagagatg
     2701 aagacttctg gaatcccctg tcatgattga ctctatgtgt ctggatgctt tcttttttcg
     2761 atagaatcaa gggatgtcct ccaattggaa aggcacgacg agaaggatgc tataagaaat
     2821 tgaaacattt tcaccatctg ctaaatgtca atacattttc atggccatgc taatatcaat
     2881 gagccttctt tcttctctgt ctctctgact ctctgtctgt ctctgtctct atctctgtct
     2941 ctgtctctgt ctctctctct ctgacaagga tgtgtttcct aagttggcct cagaaatcct
     3001 ggtcctcctg cctcttactc atagttgctg ggtttacttc caaattagca ctttttcctc
     3061 tcataagggt tgaacccaga gttctgtgca tgttagataa gcactcttct actgagctgt
     3121 accactggtg ctcaatgagt ttatagtggt tcttgtggtg cataatccaa caagtgattt
     3181 aagaacaata tatagcctta aatactagaa atcatatatt ccagcaaggg ccatccctat
     3241 cagatcccaa agaaatatgg ctcaggagag aggctttacc ttactgcaag agcctcttgt
     3301 tttcaagaga accccaaaca tttacttgta ttgcaagttt taatttgaat ttgaaaagat
     3361 attaaatatt ctaaaattat ggtctaacat acatttcttc tataaaatga tggagtcttt
     3421 tcaaaaattg gagataaggc tttattaagt ttaaagaaat atatccattt gctagagtaa
     3481 gaagtagtag ttgattaact agcttagagc tctacatgtg ttatttttta gaacgtacac
     3541 ttaattaaaa aaaaagtata ctgtatttat tgaacctctg agaggtcttg gaagagtttc
     3601 tcaattcttc agctttttgg aaatattatg aagagcatga tgtcctcaca gaatagtcca
     3661 aatagatgaa aaatggataa gtaacaatat atttggattt actggtcata aaagctatgc
     3721 atatcttaca taaggctctc attttaggcc tctttggtct gtgtcctaac agataaatcc
     3781 aaatacaaga aatataggtg agaactaaca gatggcaact tacttgtcat aaatattatt
     3841 acttgtcata tatattataa agactcattt ttaggcaact ttgggctgca gagtggataa
     3901 tgaatggctt ctcaaaggga agttttatta attaaactac tttctttatt ggtaatatta
     3961 aaaacagttt gttatcatct ttaattattt tggtattccg aatttaacca actgacattt
     4021 tgtaacttga agctcttgag tttcttgaat tattaattgt atatatacat tttatccatt
     4081 ttcacaactg tggggattac aaatcaataa tttttaatat gttagcatga aaatacagat
     4141 cattactttc tcgacatgaa ccaggtactt taagtttgtc attttcgtat ttgcccatta
     4201 taaactcagg cagatctaag aattgagtaa agttttcatc tttggatcat atgtagattt
     4261 tcctctttcc cagatctgag gggatacatc agcaagtaag catgggttat tttcccgtag
     4321 agagaatcta taaaaataaa ttaataaaac tgacaaaaca aatgaataaa caaaaaaaca
     4381 cagtttctca cacctgggaa ggagctgttt ttcttatgtt tcaatgagga aagccatctc
     4441 tcctgcagat agaggcagtt atcacggctg tggtgctaaa atgaagtcat cagactgctt
     4501 aaaacattgg gagaaaatta aagaactttc tattttaaaa tctccccatg aggtttctgt
     4561 tttgtcttgt ttgtcaaatc acatctaaaa tattttgaat tgaatgtgtc tttgatcgca
     4621 atgatacaat ccaagaaatg tgaccacact taaattcacc ttgatggtgt ccctgtgatc
     4681 ttgtacttta tgaaattttt aaatttgtaa gacacctgca aaaatgaaaa taaaagtacc
     4741 tttaatattt
//
