LOCUS       NM_019811               2833 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus acyl-CoA synthetase short-chain family member 2
            (Acss2), mRNA.
ACCESSION   NM_019811
VERSION     NM_019811.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2833)
  AUTHORS   Rauckhorst,A.J., Sheldon,R.D., Pape,D.J., Ahmed,A.,
            Falls-Hubert,K.C., Merrill,R.A., Brown,R.F., Deshmukh,K.,
            Vallim,T.A., Deja,S., Burgess,S.C. and Taylor,E.B.
  TITLE     A hierarchical hepatic de novo lipogenesis substrate supply network
            utilizing pyruvate, acetate, and ketones
  JOURNAL   Cell Metab 37 (1), 255-273 (2025)
   PUBMED   39471817
REFERENCE   2  (bases 1 to 2833)
  AUTHORS   Li,X., Tang,X., Xiang,Y., Zhao,Z., Li,Y., Ding,Q., Zhang,L., Xu,J.,
            Zhao,L. and Chen,Y.
  TITLE     N-glycosylation of SCAP exacerbates hepatocellular inflammation and
            lipid accumulation via ACSS2-mediated histone H3K27 acetylation
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 326 (6), G697-G711 (2024)
   PUBMED   38591127
  REMARK    GeneRIF: N-glycosylation of SCAP exacerbates hepatocellular
            inflammation and lipid accumulation via ACSS2-mediated histone
            H3K27 acetylation.
REFERENCE   3  (bases 1 to 2833)
  AUTHORS   Lu,J., Hou,Y., Liu,S.X., Jin,B., Liu,J., Li,N., Zhu,Y., Zhang,Q.Y.,
            Wan,C., Feng,Y., Xie,J. and Jiang,C.M.
  TITLE     Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of
            renal epithelial tubular cells in sepsis-induced acute kidney
            injury by upregulating the KLF5/NF-kappaB pathway
  JOURNAL   Cell Commun Signal 22 (1), 187 (2024)
   PUBMED   38515158
  REMARK    GeneRIF: Acetyl-CoA synthetase 2 induces pyroptosis and
            inflammation of renal epithelial tubular cells in sepsis-induced
            acute kidney injury by upregulating the KLF5/NF-kappaB pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2833)
  AUTHORS   Liu,Y., Li,Z., Sun,T., Li,Z., Manyande,A., Xiang,H. and He,Z.
  TITLE     Gut microbiota regulates hepatic ischemia-reperfusion
            injury-induced cognitive dysfunction via the HDAC2-ACSS2 axis in
            mice
  JOURNAL   CNS Neurosci Ther 30 (2), e14610 (2024)
   PUBMED   38334013
  REMARK    GeneRIF: Gut microbiota regulates hepatic ischemia-reperfusion
            injury-induced cognitive dysfunction via the HDAC2-ACSS2 axis in
            mice.
REFERENCE   5  (bases 1 to 2833)
  AUTHORS   Miller,K.D., O'Connor,S., Pniewski,K.A., Kannan,T., Acosta,R.,
            Mirji,G., Papp,S., Hulse,M., Mukha,D., Hlavaty,S.I., Salcido,K.N.,
            Bertolazzi,F., Srikanth,Y.V.V., Zhao,S., Wellen,K.E., Shinde,R.S.,
            Claiborne,D.T., Kossenkov,A., Salvino,J.M. and Schug,Z.T.
  TITLE     Acetate acts as a metabolic immunomodulator by bolstering T-cell
            effector function and potentiating antitumor immunity in breast
            cancer
  JOURNAL   Nat Cancer 4 (10), 1491-1507 (2023)
   PUBMED   37723305
REFERENCE   6  (bases 1 to 2833)
  AUTHORS   Loikkanen,I., Haghighi,S., Vainio,S. and Pajunen,A.
  TITLE     Expression of cytosolic acetyl-CoA synthetase gene is
            developmentally regulated
  JOURNAL   Mech Dev 115 (1-2), 139-141 (2002)
   PUBMED   12049778
  REMARK    GeneRIF: Expression of cytosolic acetyl-CoA synthetase gene in mice
            is developmentally regulated
REFERENCE   7  (bases 1 to 2833)
  AUTHORS   Sone,H., Shimano,H., Sakakura,Y., Inoue,N., Amemiya-Kudo,M.,
            Yahagi,N., Osawa,M., Suzuki,H., Yokoo,T., Takahashi,A., Iida,K.,
            Toyoshima,H., Iwama,A. and Yamada,N.
  TITLE     Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by
            SREBP-1 and energy status
  JOURNAL   Am J Physiol Endocrinol Metab 282 (1), E222-E230 (2002)
   PUBMED   11739104
REFERENCE   8  (bases 1 to 2833)
  AUTHORS   Ikeda,Y., Yamamoto,J., Okamura,M., Fujino,T., Takahashi,S.,
            Takeuchi,K., Osborne,T.F., Yamamoto,T.T., Ito,S. and Sakai,J.
  TITLE     Transcriptional regulation of the murine acetyl-CoA synthetase 1
            gene through multiple clustered binding sites for sterol regulatory
            element-binding proteins and a single neighboring site for Sp1
  JOURNAL   J Biol Chem 276 (36), 34259-34269 (2001)
   PUBMED   11435428
REFERENCE   9  (bases 1 to 2833)
  AUTHORS   Fujino,T., Kondo,J., Ishikawa,M., Morikawa,K. and Yamamoto,T.T.
  TITLE     Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in
            the oxidation of acetate
  JOURNAL   J Biol Chem 276 (14), 11420-11426 (2001)
   PUBMED   11150295
REFERENCE   10 (bases 1 to 2833)
  AUTHORS   Luong,A., Hannah,V.C., Brown,M.S. and Goldstein,J.L.
  TITLE     Molecular characterization of human acetyl-CoA synthetase, an
            enzyme regulated by sterol regulatory element-binding proteins
  JOURNAL   J Biol Chem 275 (34), 26458-26466 (2000)
   PUBMED   10843999
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL844852.11.
            
            On Mar 21, 2007 this sequence version replaced NM_019811.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051432.1, AK093831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               AL844852.11        82595-82836
            243-438             AL844852.11        86533-86728
            439-530             AL844852.11        113743-113834
            531-634             AL844852.11        114028-114131
            635-707             AL844852.11        114351-114423
            708-783             AL844852.11        114655-114730
            784-898             AL844852.11        114907-115021
            899-1036            AL844852.11        120406-120543
            1037-1207           AL844852.11        120885-121055
            1208-1341           AL844852.11        121330-121463
            1342-1474           AL844852.11        121649-121781
            1475-1531           AL844852.11        121862-121918
            1532-1612           AL844852.11        122101-122181
            1613-1721           AL844852.11        123143-123251
            1722-1790           AL844852.11        125174-125242
            1791-1967           AL844852.11        125582-125758
            1968-2042           AL844852.11        126298-126372
            2043-2833           AL844852.11        126505-127295
FEATURES             Location/Qualifiers
     source          1..2833
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.26 cM"
     gene            1..2833
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /note="acyl-CoA synthetase short-chain family member 2"
                     /db_xref="GeneID:60525"
                     /db_xref="MGI:MGI:1890410"
     exon            1..242
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..2170
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /EC_number="6.2.1.1"
                     /EC_number="6.2.1.17"
                     /note="acetyl-Coenzyme A synthetase 1 (AMP forming);
                     acetyl-Coenzyme A synthetase 2 (AMP forming);
                     acetyl-Coenzyme A synthetase 2 (ADP forming); acetate--CoA
                     ligase; acyl-activating enzyme; acetyl-CoA synthetase 1;
                     propionate--CoA ligase"
                     /codon_start=1
                     /product="acetyl-coenzyme A synthetase, cytoplasmic"
                     /protein_id="NP_062785.2"
                     /db_xref="CCDS:CCDS16950.1"
                     /db_xref="GeneID:60525"
                     /db_xref="MGI:MGI:1890410"
                     /translation="MGLPEERRKSGSGSRAREETGAEGRVRGWSPPPEVRRSAHVPSL
                     QRYRELHRRSVEEPREFWGNIAKEFYWKTACPGPFLQYNFDVTKGKIFTEWMKGATTN
                     ICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTKITYRELLVQVCQFSNVLRKQGIQKG
                     DRVAIYMPMILELVVAMLACARLGALHSIVFAGFSAESLCERILDSSCCLLITTDAFY
                     RGEKLVNLKELADESLEKCREKGFPVRCCIVVKHLGRAELGMNDSPSQSPPVKRPCPD
                     VQICWNEGVDLWWHELMQQAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTIGGYM
                     LYVATTFKYVFDFHPEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDEG
                     RLWSIVDKYKVTKFYTAPTAIRMLMKFGDDPVTKHSRASLQVLGTVGEPINPEAWLWY
                     HRVVGSQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSASFPFFGVAPAILNESGEEL
                     EGEAEGYLVFKQPWPGIMRTVYGNHTRFETTYFKKFPGYYVTGDGCRRDQDGYYWITG
                     RIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFS
                     PTLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDTST
                     VADPSVINHLFSHRCLTTQ"
     exon            243..438
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..530
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..634
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..707
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..783
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..898
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1036
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1207
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1341
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1474
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1531
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1612
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1721
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1790
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1967
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2042
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2833
                     /gene="Acss2"
                     /gene_synonym="1110017C11Rik; ACAS; Acas1; Acas2; aceCS;
                     AceCS1; ACS; Acs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttttccccg ccccggcacc cgcagcgacc gcaacggcgg acaaggtgtt cggaacttga
       61 tgcgatgggg cttcccgagg agcggcgcaa gagcggcagt ggaagccggg ctcgtgagga
      121 gaccggcgcc gagggccggg tgcggggttg gtccccgccg ccggaggtca gacgctcggc
      181 gcacgtcccc tctctgcagc gctaccgcga gctgcaccgg cgttctgtgg aggagccacg
      241 ggagttttgg ggaaacattg ccaaggaatt ttactggaaa accgcatgcc ctggcccatt
      301 cctccagtac aactttgatg tgactaaagg gaaaatattc actgagtgga tgaaaggagc
      361 aactacaaac atctgctaca acgtgctgga tcgaaatgtc catgagaaaa aacttggcga
      421 caaagttgct ttttactggg agggcaatga gccaggggag accaccaaga tcacataccg
      481 tgaactcctg gtccaggtgt gtcagttcag caatgttctc cgtaaacagg gcattcagaa
      541 gggtgaccga gtggccatct acatgcctat gatcttggaa cttgtggtgg ctatgctggc
      601 atgcgctcgc cttggagctt tgcactccat tgtgtttgca ggcttctctg cagagtctct
      661 ctgtgaaagg atcttggatt ccagttgctg cctgctcatc actacagatg ccttctacag
      721 gggggaaaaa cttgtgaacc tgaaggagct ggctgatgag tccttggaga agtgccgaga
      781 gaagggcttc ccagtgagat gctgcattgt ggtcaaacat ctggggcggg cagagctggg
      841 catgaatgac tcccccagcc agtccccacc agttaagagg ccatgtccag atgtccagat
      901 ctgctggaac gaaggggttg acttatggtg gcatgaactc atgcagcagg caggagacga
      961 gtgtgagcct gagtggtgtg atgctgagga cccactcttc atcttgtaca ccagtggctc
     1021 cacaggcaaa cctaagggtg tggtgcacac aattggaggc tatatgctct atgtggctac
     1081 aactttcaag tatgtgtttg atttccaccc ggaagatgtg ttctggtgca cagcagacat
     1141 cggctggatc actggtcatt cctatgtcac ctatgggcca ctggctaatg gtgccactag
     1201 tgttttgttt gaggggatcc ccacataccc agatgaaggg cgcttgtgga gcattgtgga
     1261 caaatacaag gtgaccaagt tctacacggc accaacagcc atccggatgc tcatgaagtt
     1321 tggagatgat cctgtcacca agcatagccg ggcatccctg caggtgctgg gcacagtagg
     1381 tgaacccatc aaccctgaag cctggctatg gtaccaccgg gtagtaggtt cccagcgctg
     1441 ccccattgta gacaccttct ggcaaacaga aacaggtggc catatgctga cccctctccc
     1501 tggcgccaca cccatgaaac ctggttctgc ttctttccca ttcttcggtg tagcgcctgc
     1561 aatcctgaat gagtccgggg aggagctgga aggggaagct gaaggttatc tggtgttcaa
     1621 gcagccctgg ccagggatca tgcgcacagt ctatgggaac cacacacggt ttgagaccac
     1681 ctactttaag aagttccctg gctactatgt gaccggagat ggctgccgac gggatcagga
     1741 tggctattac tggatcacgg gcaggattga tgacatgctc aatgtgtctg gacatctcct
     1801 gagtacagca gaggtggaat cggcacttgt ggaacacgag gctgtcgcag aggcagctgt
     1861 ggtgggccac cctcatcctg tgaagggcga atgcctctac tgctttgtta ccttgtgtga
     1921 tggccatacc ttcagcccca cactcacaga ggaactcaag aagcagatta gagaaaagat
     1981 tggccccatt gccacaccag actacatcca gaatgcacct ggcttgccta aaacacgctc
     2041 agggaaaatc atgaggcgag ttctccggaa gattgctcag aatgaccatg acctggggga
     2101 tacatctacg gtggctgacc catctgtcat caaccatctc ttcagtcacc gctgcctgac
     2161 cacccagtga acaagactct tgtccaggat ttccctgtgc ttggctctcc aaatttctgc
     2221 ccatccatcc tgcccctcac acagtagtac tagttgacag tactagttgg ttgaaactag
     2281 ggagacagtt acctagacta ccaggtagaa gggacagggg tcaggtcaac ctcacactga
     2341 tatgctcctc gactagagag gtctccaagc ccagaacaga gacttgaaca ccatgtcctt
     2401 aaccaaagtc agctcttcag agtgtaaatg agggtctgac tggaagcagg gcagcagctg
     2461 taattcttcc agctctctcc aaaagcacca gttcttatct tgggcctgca ctaggcttta
     2521 gaaatgacag tttgtgagtc tatgaataat tattttttaa aaaactttgt tgtctctgtt
     2581 ctgagtctga attccttgca gatggtagca ttgtctacca gttggttcag tctccatagg
     2641 actttcatat catctgctac attgaaagaa taagatatac tgatcctaaa accaagggaa
     2701 ttaacattcc taatcctgca ctatgaacag aaccctgccc atgagaggca cttgtaggtg
     2761 aaactctctt ttcttgttct ttttgtgctc aagacccact gttataggaa taaagtttat
     2821 gagctcaaga aca
//
