LOCUS       NM_080575               3594 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus acyl-CoA synthetase short-chain family member 1
            (Acss1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_080575
VERSION     NM_080575.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3594)
  AUTHORS   He,Q., Ji,L., Wang,Y., Zhang,Y., Wang,H., Wang,J., Zhu,Q., Xie,M.,
            Ou,W., Liu,J., Tang,K., Lu,K., Liu,Q., Zhou,J., Zhao,R., Cai,X.,
            Li,N., Cao,Y. and Li,T.
  TITLE     Acetate enables metabolic fitness and cognitive performance during
            sleep disruption
  JOURNAL   Cell Metab 36 (9), 1998-2014 (2024)
   PUBMED   39163862
REFERENCE   2  (bases 1 to 3594)
  AUTHORS   Xu,G., Quan,S., Schell,J., Gao,Y., Varmazyad,M., Sreenivas,P.,
            Cruz,D., Jiang,H., Pan,M., Han,X., Palavicini,J.P., Zhao,P.,
            Sun,X., Marchant,E.D., Rasmussen,B.B., Li,G., Katsumura,S.,
            Morita,M., Munkacsy,E., Horikoshi,N., Chocron,E.S. and Gius,D.
  TITLE     Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered
            metabolism, cell senescence, and nonalcoholic fatty liver disease
  JOURNAL   Sci Adv 10 (20), eadj5942 (2024)
   PUBMED   38758779
  REMARK    GeneRIF: Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit
            altered metabolism, cell senescence, and nonalcoholic fatty liver
            disease.
REFERENCE   3  (bases 1 to 3594)
  AUTHORS   Cui,H., Hu,D., Liu,Y. and Zhao,J.
  TITLE     Identifying Acss1, Mtfp1 and Oxct1 as key regulators and promising
            biomarkers of sarcopenia in various models
  JOURNAL   Gene 896, 148053 (2024)
   PUBMED   38042218
  REMARK    GeneRIF: Identifying Acss1, Mtfp1 and Oxct1 as key regulators and
            promising biomarkers of sarcopenia in various models.
REFERENCE   4  (bases 1 to 3594)
  AUTHORS   Lu,J., Li,X.Q., Chen,P.P., Zhang,J.X., Liu,L., Wang,G.H., Liu,X.Q.,
            Jiang,T.T., Wang,M.Y., Liu,W.T., Ruan,X.Z. and Ma,K.L.
  TITLE     Activation of acetyl-CoA synthetase 2 mediates kidney injury in
            diabetic nephropathy
  JOURNAL   JCI Insight 8 (20), e165817 (2023)
   PUBMED   37870960
  REMARK    GeneRIF: Activation of acetyl-CoA synthetase 2 mediates kidney
            injury in diabetic nephropathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3594)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3594)
  AUTHORS   Warden,C.H., Stone,S., Chiu,S., Diament,A.L., Corva,P.,
            Shattuck,D., Riley,R., Hunt,S.C., Easlick,J., Fisler,J.S. and
            Medrano,J.F.
  TITLE     Identification of a congenic mouse line with obesity and body
            length phenotypes
  JOURNAL   Mamm Genome 15 (6), 460-471 (2004)
   PUBMED   15181538
REFERENCE   7  (bases 1 to 3594)
  AUTHORS   Diament,A.L., Farahani,P., Chiu,S., Fisler,J. and Warden,C.H.
  TITLE     A novel mouse Chromosome 2 congenic strain with obesity phenotypes
  JOURNAL   Mamm Genome 15 (6), 452-459 (2004)
   PUBMED   15181537
REFERENCE   8  (bases 1 to 3594)
  AUTHORS   Yamamoto,J., Ikeda,Y., Iguchi,H., Fujino,T., Tanaka,T., Asaba,H.,
            Iwasaki,S., Ioka,R.X., Kaneko,I.W., Magoori,K., Takahashi,S.,
            Mori,T., Sakaue,H., Kodama,T., Yanagisawa,M., Yamamoto,T.T., Ito,S.
            and Sakai,J.
  TITLE     A Kruppel-like factor KLF15 contributes fasting-induced
            transcriptional activation of mitochondrial acetyl-CoA synthetase
            gene AceCS2
  JOURNAL   J Biol Chem 279 (17), 16954-16962 (2004)
   PUBMED   14960588
  REMARK    GeneRIF: together with the trans-activation of the AceCS2 promoter,
            it is suggested that fasting-induced AceCS2 expression is largely
            contributed by KLF15
REFERENCE   9  (bases 1 to 3594)
  AUTHORS   Beigneux,A.P., Kosinski,C., Gavino,B., Horton,J.D., Skarnes,W.C.
            and Young,S.G.
  TITLE     ATP-citrate lyase deficiency in the mouse
  JOURNAL   J Biol Chem 279 (10), 9557-9564 (2004)
   PUBMED   14662765
REFERENCE   10 (bases 1 to 3594)
  AUTHORS   Fujino,T., Kondo,J., Ishikawa,M., Morikawa,K. and Yamamoto,T.T.
  TITLE     Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in
            the oxidation of acetate
  JOURNAL   J Biol Chem 276 (14), 11420-11426 (2001)
   PUBMED   11150295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146568.1 and AK173275.1.
            
            On Apr 24, 2009 this sequence version replaced NM_080575.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB046742.1, AK146568.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AK146568.1         2-40
            40-3594             AK173275.1         1-3555
FEATURES             Location/Qualifiers
     source          1..3594
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 74.74 cM"
     gene            1..3594
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /note="acyl-CoA synthetase short-chain family member 1"
                     /db_xref="GeneID:68738"
                     /db_xref="MGI:MGI:1915988"
     exon            1..356
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..2092
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /EC_number="6.2.1.1"
                     /EC_number="6.2.1.17"
                     /note="acetyl-coenzyme A synthetase 2-like, mitochondrial;
                     acetate--CoA ligase 2; acetyl-CoA synthetase 2;
                     propionate--CoA ligase"
                     /codon_start=1
                     /product="acetyl-coenzyme A synthetase 2-like,
                     mitochondrial precursor"
                     /protein_id="NP_542142.1"
                     /db_xref="CCDS:CCDS16859.1"
                     /db_xref="GeneID:68738"
                     /db_xref="MGI:MGI:1915988"
                     /translation="MAARSLGSGVGRLLRGLQGRSGQSGWSLSVSRSTATRLPGCVPA
                     AAQPGSYPALSAQAAQEPAAFWGPLARDTLVWDTPYHTVWDCDFRTGKIGWFLGGQLN
                     VSVNCLDQHVQKSPETIALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDR
                     VAIYMPVSPLAVAAMLACARIGAIHTVVFAGFSAESLAGRINDAKCKAVITFNQGLRG
                     GRVVELKKIVDEAVKSCPTVQHVLVAHRTDTKVPMGSLDIPLEQEMAKEAPVCTPESM
                     SSEDMLFMLYTSGSTGTPKGLVHTQAGYLLYAAMTHKLVFDYQPGDVFGCVADIGWIT
                     GHSYVVYGPLCNGATTVLFESTPVYPDAGRYWETVQRLKINQFYGAPTAVRLLLKYGD
                     AWVKKYDRSSLRTLGSVGEPINHEAWEWLHKVVGDGRCTLVDTWWQTETGGICIAPRP
                     SEDGAEILPGMAMRPFFGIVPVLMDEKGNVLEGGDVSGALCISQAWPGMARTIYGDHQ
                     RFVDAYFRAYPGYYFTGDGAHRTEGGYYQITGRMDDVINISGHRLGTAEIEDAMADHP
                     AVPETAVIGYPHDIKGEAAFAFIVLKDNISDENMVVNELKLSVATKIAKYAVPDQILV
                     VKRLPKTRSGKVMRRLLRKIITSRGQDLGDTTTLEDPSVITEILSAFQKYEEQRAATN
                     "
     exon            357..453
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..653
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..829
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            830..982
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1130
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1268
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1361
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1474
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1601
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1729
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1793
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1912
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..3594
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3569..3574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /note="hexamer: AATAAA"
     polyA_site      3594
                     /gene="Acss1"
                     /gene_synonym="1110032O15Rik; Acas2; Acas2l; AceCS2"
                     /note="major polyA site"
ORIGIN      
        1 aggggcgctc aggctaccgc acccgcgtgg ggcgtcgggc gagatggcgg cgcgcagcct
       61 cggcagcggt gtggggcgac tgctgcgtgg cctgcaaggg cgctctggac aatcggggtg
      121 gtcactgagc gtgtcccgct cgaccgccac ccgactcccg ggctgcgttc ctgcagcagc
      181 gcaaccaggc tcgtaccccg cgttgagcgc tcaggcagcc caggagccgg ccgccttctg
      241 ggggccgctg gcccgtgaca cactagtttg ggacactcct taccatactg tctgggactg
      301 tgacttcagg acgggcaaga tcggctggtt cctgggaggc cagttgaatg tgtctgtcaa
      361 ctgcctggat cagcatgtgc agaagtctcc tgagaccata gctttgatct gggagagaga
      421 tgaacctggg acagaagtga gaatcactta cagggagctt ctggagacca catgccgcct
      481 ggccaataca ctgaagagac atggagtgca ccgaggggac cgtgtggcca tctacatgcc
      541 tgtgtcccca ctggctgtgg cagcaatgct ggcctgtgcc aggattggag ctatccacac
      601 agtggtattt gctggcttta gtgcagagtc cttggctggg aggatcaatg atgccaaatg
      661 caaggctgtt atcaccttca accaaggact caggggaggg cgtgtggtgg agctgaagaa
      721 aatagtggat gaagctgtga agagctgccc aacagtccag catgtcctgg tggctcacag
      781 gacggacacc aaggttccca tggggagtct ggatatcccc cttgaacagg agatggccaa
      841 ggaggcccct gtttgcaccc ctgagagcat gagcagtgaa gacatgctct ttatgctcta
      901 cacctcaggg agcaccggga cacccaaggg actcgttcat acacaggcag gctatctact
      961 gtatgccgcc atgacgcaca agctcgtgtt tgactaccag ccaggtgatg tctttggctg
     1021 tgtggctgac atcggttgga tcacaggaca cagctatgtg gtgtatggac ccctctgcaa
     1081 tggagctacc acagtccttt ttgagagcac cccagtttac cctgatgctg gtcgttactg
     1141 ggagacagtg cagaggctaa agatcaacca gttctatggt gccccgacag ctgtccggct
     1201 gctgctgaag tatggggatg cctgggtgaa aaagtatgac cgctcttccc tgcgcacact
     1261 ggggtcagtg ggagagccta tcaaccacga agcctgggag tggctccaca aagtcgtggg
     1321 tgatggcaga tgtacactgg tggacacttg gtggcaaacg gaaactggag gcatctgcat
     1381 tgcaccacgg ccctcggaag atggggcaga gatcctcccg ggcatggcca tgaggccgtt
     1441 ttttggcatc gttcctgtac tcatggatga gaagggcaat gttttggagg gtggagatgt
     1501 ctctggggcc ttgtgtattt cccaagcttg gccaggcatg gcaaggacca tctatggtga
     1561 ccaccagagg ttcgtagatg cctacttcag agcgtaccca ggttattact tcactggaga
     1621 cggagctcac cggacagagg gtggctatta ccagatcacg gggcgcatgg atgatgtcat
     1681 caatatcagt ggtcatcgcc tggggactgc agagattgag gatgcaatgg ctgaccatcc
     1741 cgctgttcca gagactgctg tcattgggta ccctcatgat atcaaaggag aagctgcatt
     1801 tgccttcatt gtgctgaaag ataacatcag tgatgagaac atggtagtga atgaactcaa
     1861 attgtcggtg gccaccaaga tcgccaagta tgctgtgcct gaccagatcc tggtggtgaa
     1921 gcgtctcccc aaaaccagat ctgggaaagt gatgaggaga ctactgagga agatcatcac
     1981 cagcagggga caggatctag gggacaccac taccctggag gaccccagcg tcatcacaga
     2041 aatcttgagt gccttccaga agtatgaaga gcagcgggct gctaccaact gagaggtgtg
     2101 cctctgtgtt gttcagacaa ggctgcacag gacccctgga cgtcctcagg ggaagcaact
     2161 tcaaaagtgg cttgtttctt ccgaacacat gacccatcta ctgccctatt tgaagctgaa
     2221 gccccttttt ctttctcctg gggctcagag ggctgcttct ggaggctggg ggaaggcctt
     2281 tgtcatacat ctggtttcca gaatcaagtc ataattggca ctaagccagc acagggtgac
     2341 cagaggtctt agctccaaaa ctgtcatgct ttctccagat gtgtttagat acaaaacaca
     2401 aattattttt tttttgtact ttttctattt ggggagaata gcagaacatt tgagtataat
     2461 gtgaacattt agttacacac acacacacac acacacacac acacacacac accgtgggaa
     2521 gaatctccct tcttacctcc ccagggatga agataacaga atgcgctttt ttttaaaaat
     2581 tttattacca ttcaatgtgc ttaaagtcca aaccagacat gtttgtgcct ctggcacata
     2641 actctcctgc taatccaagt caccatgtcc aactcctgcg tctatttcat atttggttca
     2701 tttggtttat tttatgatcg aacaaactgg acaattctta cattttgtat ggtaggaatt
     2761 gcactcaggg cctcctgcac actaggcaag caagcgctct acctctgagc tgcacaccac
     2821 acctctaact cccaagaaga cggagtgaat gtcctctcct ttacttgtga aatcatttgg
     2881 gttcgtttct ctaagctgtg atctggaagg agtttctttc cccaaggtgc ctcatagtag
     2941 gagatcatat tgcttcaaac gtgtgaggtt gttcatggta gccagtgaaa actcgggtgt
     3001 ctttactaag cctctggtcc catctgaact gagatcctga agactctgcc tgtcctttct
     3061 tttgtggttg gggcagcaag aactcactgt ggtccaatga cgatgacact tggtgctcct
     3121 gagcaaggtc tcttttgatg tgccttaagt tctctggaca ttggtgagtg atgcaaatag
     3181 tgaagtcatg aaaagcttat tttgcagcta gattgtggct aagcatggga gggctgaagg
     3241 ggaggcagct ctgtgagcag ggcccctggg ggcaaaggaa gcctgttctg tctggtccac
     3301 agaacttagc tatatgggtg tttcagggta tcttagctac tgcacactta ctgtctgtcc
     3361 tgacgtcttg ggtaatgggg taaacatgct gacgctccca ggaggcggag cggttgtagt
     3421 atgaacaaat cttaatagtc ctttgttaca atcagcagtg aagagccatg tgatggacgt
     3481 ggctgagtat agttactgtg ccctttgaaa tggcctaggt ttctaggtta ctgatagaag
     3541 ctctcggaat gatttataga aatatccaaa taaagcttta ttttgttcac tgtc
//
