LOCUS       NM_178758               2505 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus acyl-CoA synthetase medium-chain family member 5
            (Acsm5), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_178758 XM_001002982 XM_001002996 XM_001003001 XM_979608
            XM_979651 XM_979684 XM_989322 XM_989384 XM_989414
VERSION     NM_178758.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2505)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2505)
  AUTHORS   Cao,Y., Li,J., Qiu,S., Ni,S. and Duan,Y.
  TITLE     ACSM5 inhibits ligamentum flavum hypertrophy by regulating lipid
            accumulation mediated by FABP4/PPAR signaling pathway
  JOURNAL   Biol Direct 18 (1), 75 (2023)
   PUBMED   37957699
  REMARK    GeneRIF: ACSM5 inhibits ligamentum flavum hypertrophy by regulating
            lipid accumulation mediated by FABP4/PPAR signaling pathway.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC095985.1.
            
            On or before Jan 29, 2007 this sequence version replaced
            XM_001002996.1, XM_001003001.1, XM_001002982.1, XM_989384.1,
            XM_989414.1, XM_989322.1, XM_979651.1, XM_979684.1, XM_979608.1,
            NM_178758.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095985.1, AK050458.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2505
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 63.94 cM"
     gene            1..2505
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /note="acyl-CoA synthetase medium-chain family member 5"
                     /db_xref="GeneID:272428"
                     /db_xref="MGI:MGI:2444086"
     exon            1..173
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            174..393
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1929
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /EC_number="6.2.1.2"
                     /note="acyl-coenzyme A synthetase ACSM5, mitochondrial"
                     /codon_start=1
                     /product="acyl-coenzyme A synthetase ACSM5, mitochondrial
                     precursor"
                     /protein_id="NP_848873.1"
                     /db_xref="CCDS:CCDS40106.1"
                     /db_xref="GeneID:272428"
                     /db_xref="MGI:MGI:2444086"
                     /translation="MRLWLRGLACQALRSSWGVCRIHTQPPPPPIPEVVATWEAISLG
                     RQPVPEYFNFAHDVLDVWSQLEKTGHRPPNPAFWWVNGSGTEVKWTFEELGKQSRKAA
                     NVLEGVCGLQPGDRMMLVLPRLPDWWLISVACMRTGVVMIPGVSQLTAKDLKYRLQAA
                     RAKSIVTSDALAPQVDAISADCPSLQTKLLVSDTSRPGWINFRELLRAASPEHNCVRT
                     RSGDSVAIYFTSGTTGAPKMVEHSQSSYGLGFVASGRRWMALTESDIFWNTTDTGWVK
                     AAWTLFSAWSNGACIFVHELPRVDAKTILNTLCRFPITTLCCVPTLFRLLVQEDLTRY
                     KFQCLRHCLTGGEALNPDVRDKWKSQTGLELHEGYGQSETVVICGNSRNSTIKSGSMG
                     KASPPYDVQIVDEEGNVLPPGKEGNIAVRIKPTRPFCFFNCYLDNPEKTAASEQGDFY
                     ITGDRAHMDEDGYFWFLGRNDDVINSSSYRIGPVEVESALAEHPAVLESAVVSSPDPI
                     RGEVVKAFIVLSPAYASHDPEALTRELQEHVKTVTAPYKYPRKVAFISELPKTVSGKI
                     LRSKLRNQEWGR"
     exon            394..604
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            605..812
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            813..956
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1110
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1190
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1314
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1395
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1497
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1625
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1725
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1845
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2491
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2362..2367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /note="hexamer: TATAAA"
     polyA_site      2385
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /note="major polyA site"
     regulatory      2470..2475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2491
                     /gene="Acsm5"
                     /gene_synonym="C730019D22; C730027J19Rik"
                     /note="major polyA site"
ORIGIN      
        1 tgaagctgct gacttctaac cctgttttct ccaggctgtg cttggggcta aagctccctg
       61 tcccaatcct gccttcatcg cttctgggga aatcttctca ggagctttta ggtctgcctt
      121 gctgctgcag tgaaacgcag atgccttttg tgtacctcag attttaaaac aaggcagaag
      181 ttgatagaag tcatgaggtt gtggctaaga ggcctggcct gccaggctct gaggagttcc
      241 tggggagtct gcaggattca cacacagcca ccacctcccc cgatccctga ggtggtagct
      301 acctgggaag ccatcagcct ggggaggcag ccagtgcccg agtacttcaa ctttgctcat
      361 gatgtgttgg atgtgtggag tcagctggaa aagacagggc accggccccc aaatcctgca
      421 ttctggtggg tgaacggctc aggaacagaa gtcaagtgga catttgagga gctggggaag
      481 cagtcgagga aggcagccaa tgtcttagag ggtgtgtgtg gcctgcaacc tggagacaga
      541 atgatgctgg tgcttccgag actcccagat tggtggctga tcagcgtggc ttgtatgcga
      601 acaggtgtgg tcatgatccc aggagtctcc cagctgacag cgaaggatct caagtatcgg
      661 ctgcaggctg ccagggccaa gtctatcgtc accagtgatg ccctagctcc gcaagtggat
      721 gccatcagtg ctgactgtcc ctccctccaa accaagcttc tggtgtctga caccagccgt
      781 ccaggctgga tcaatttccg agaactcctg agagcggctt ctccagagca caactgtgtg
      841 agaaccagaa gtggagattc agtggccatc tacttcacca gtggaaccac aggggccccc
      901 aagatggtgg aacattccca gtccagctat ggattgggtt ttgtggccag tggaaggagg
      961 tggatggcct tgactgagtc tgacatattc tggaacacaa ctgacactgg atgggtgaaa
     1021 gcagcctgga ccctcttctc tgcctggtcc aatggagctt gcatttttgt gcatgagctg
     1081 ccccgagttg atgccaaaac tattctaaat actctctgca ggttcccaat aaccaccctg
     1141 tgctgtgtcc caaccctctt ccggctgctt gtacaagagg atctgacaag gtacaagttc
     1201 caatgtctga ggcactgttt gacgggtgga gaggccctca accctgatgt gagggacaag
     1261 tggaagagcc agacaggcct ggagctccat gaaggctatg gacaatcaga aacagttgtc
     1321 atctgtggca attcaagaaa ctcgacaatc aagtctggat ctatggggaa agcaagccca
     1381 ccttacgatg tgcagattgt agatgaggag ggcaatgtcc tgcctccagg aaaagaggga
     1441 aatattgctg tccgaatcaa gcctactaga cccttctgtt tcttcaactg ctatctggac
     1501 aatcccgaga agacagcagc atcagagcaa ggagactttt acatcactgg ggacagagca
     1561 catatggacg aggatggcta cttttggttc ttggggagaa atgatgatgt aatcaactct
     1621 tcaagctacc ggattggtcc tgttgaagta gagagtgcac ttgctgagca tccagctgtc
     1681 ctggagtctg ctgtggtcag cagcccagac cccatccggg gagaggtggt aaaggcattt
     1741 atagtccttt ctccagccta tgcatctcat gacccagaag ccctgaccag ggaactccag
     1801 gagcatgtga agacagtgac tgctccatac aagtacccca ggaaggtggc ttttatttca
     1861 gaactgccaa agacggtttc tggaaagatc ctaaggagta aattgagaaa ccaagagtgg
     1921 gggagatgaa atgcaaccca agagagatgc tgcgatgcac tgaaggttct gaaggagaag
     1981 gaagtggggc aggccagctc ctccttggag tactatccct tcaaagaata gatatcaaag
     2041 atggtcagct ttcaaatggg cattttggga taatgctgga aaatgtaaga gcatccctgg
     2101 tccagagctc acatacactg cccagtccag caaatgccct acagcttaat ttccctctct
     2161 gaagacatcc tcagcattgc ttttaccaag agaactctgt tttcctggga cagacaaatc
     2221 ggcacagcct tagggcatcc ttggtctcat tatgccagtg ggaatgaatg tgaccctttg
     2281 gatgaagtca tttggcaaca gcatctggga cataacattg actgtcatac ccttccattt
     2341 agacacactt ttgggactca ctataaagaa aagattcgaa atgcagaaaa catttgatat
     2401 acaaagatat tcagtgagat agtgcttaaa actgaaaaca cacacaactg ccaaagcaat
     2461 agagaaataa ttaaatcaat caacaatgta aaaaaaaaaa aaaaa
//
