LOCUS       NM_178414               2153 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus acyl-CoA synthetase medium-chain family member 4
            (Acsm4), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_178414
VERSION     NM_178414.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2153)
  AUTHORS   Matsuo,T., Isosaka,T., Hayashi,Y., Tang,L., Doi,A., Yasuda,A.,
            Hayashi,M., Lee,C.Y., Cao,L., Kutsuna,N., Matsunaga,S., Matsuda,T.,
            Yao,I., Setou,M., Kanagawa,D., Higasa,K., Ikawa,M., Liu,Q.,
            Kobayakawa,R. and Kobayakawa,K.
  TITLE     Thiazoline-related innate fear stimuli orchestrate hypothermia and
            anti-hypoxia via sensory TRPA1 activation
  JOURNAL   Nat Commun 12 (1), 2074 (2021)
   PUBMED   33824316
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2153)
  AUTHORS   Nishizumi,H., Miyashita,A., Inoue,N., Inokuchi,K., Aoki,M. and
            Sakano,H.
  TITLE     Primary dendrites of mitral cells synapse unto neighboring
            glomeruli independent of their odorant receptor identity
  JOURNAL   Commun Biol 2, 14 (2019)
   PUBMED   30652126
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2153)
  AUTHORS   Sato,T., Kobayakawa,R., Kobayakawa,K., Emura,M., Itohara,S.,
            Kizumi,M., Hamana,H., Tsuboi,A. and Hirono,J.
  TITLE     Supersensitive detection and discrimination of enantiomers by
            dorsal olfactory receptors: evidence for hierarchical odour coding
  JOURNAL   Sci Rep 5, 14073 (2015)
   PUBMED   26361056
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2153)
  AUTHORS   Aoki,M., Takeuchi,H., Nakashima,A., Nishizumi,H. and Sakano,H.
  TITLE     Possible roles of Robo1+ ensheathing cells in guiding dorsal-zone
            olfactory sensory neurons in mouse
  JOURNAL   Dev Neurobiol 73 (11), 828-840 (2013)
   PUBMED   23821580
REFERENCE   5  (bases 1 to 2153)
  AUTHORS   Nakashima,A., Takeuchi,H., Imai,T., Saito,H., Kiyonari,H., Abe,T.,
            Chen,M., Weinstein,L.S., Yu,C.R., Storm,D.R., Nishizumi,H. and
            Sakano,H.
  TITLE     Agonist-independent GPCR activity regulates anterior-posterior
            targeting of olfactory sensory neurons
  JOURNAL   Cell 154 (6), 1314-1325 (2013)
   PUBMED   24034253
REFERENCE   6  (bases 1 to 2153)
  AUTHORS   Yokoyama,T.K., Mochimaru,D., Murata,K., Manabe,H., Kobayakawa,K.,
            Kobayakawa,R., Sakano,H., Mori,K. and Yamaguchi,M.
  TITLE     Elimination of adult-born neurons in the olfactory bulb is promoted
            during the postprandial period
  JOURNAL   Neuron 71 (5), 883-897 (2011)
   PUBMED   21903081
REFERENCE   7  (bases 1 to 2153)
  AUTHORS   Duggan,C.D., DeMaria,S., Baudhuin,A., Stafford,D. and Ngai,J.
  TITLE     Foxg1 is required for development of the vertebrate olfactory
            system
  JOURNAL   J Neurosci 28 (20), 5229-5239 (2008)
   PUBMED   18480279
  REMARK    Erratum:[J Neurosci. 2008 Oct 29;28(44):following 11431.]
REFERENCE   8  (bases 1 to 2153)
  AUTHORS   Choi,P.S., Zakhary,L., Choi,W.Y., Caron,S., Alvarez-Saavedra,E.,
            Miska,E.A., McManus,M., Harfe,B., Giraldez,A.J., Horvitz,H.R.,
            Schier,A.F. and Dulac,C.
  TITLE     Members of the miRNA-200 family regulate olfactory neurogenesis
  JOURNAL   Neuron 57 (1), 41-55 (2008)
   PUBMED   18184563
REFERENCE   9  (bases 1 to 2153)
  AUTHORS   Kobayakawa,K., Kobayakawa,R., Matsumoto,H., Oka,Y., Imai,T.,
            Ikawa,M., Okabe,M., Ikeda,T., Itohara,S., Kikusui,T., Mori,K. and
            Sakano,H.
  TITLE     Innate versus learned odour processing in the mouse olfactory bulb
  JOURNAL   Nature 450 (7169), 503-508 (2007)
   PUBMED   17989651
REFERENCE   10 (bases 1 to 2153)
  AUTHORS   Hirota,J., Omura,M. and Mombaerts,P.
  TITLE     Differential impact of Lhx2 deficiency on expression of class I and
            class II odorant receptor genes in mouse
  JOURNAL   Mol Cell Neurosci 34 (4), 679-688 (2007)
   PUBMED   17350283
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132127.1 and BY588281.1.
            
            On Aug 21, 2009 this sequence version replaced NM_178414.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132127.1, BC048390.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2146              AK132127.1         2-2147
            2147-2153           BY588281.1         397-403
FEATURES             Location/Qualifiers
     source          1..2153
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 64.1 cM"
     gene            1..2153
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /note="acyl-CoA synthetase medium-chain family member 4"
                     /db_xref="GeneID:233801"
                     /db_xref="MGI:MGI:2681844"
     exon            1..145
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /inference="alignment:Splign:2.1.0"
     exon            146..389
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1931
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /EC_number="6.2.1.2"
                     /note="acyl-coenzyme A synthetase ACSM4, mitochondrial;
                     olfactory specific medium-chain acyl CoA synthetase"
                     /codon_start=1
                     /product="acyl-coenzyme A synthetase ACSM4, mitochondrial
                     precursor"
                     /protein_id="NP_848501.1"
                     /db_xref="CCDS:CCDS21784.1"
                     /db_xref="GeneID:233801"
                     /db_xref="MGI:MGI:2681844"
                     /translation="MKVLLHCQRLRFIWLAKPAGRHFHRDSQLWAPLTLDDFEAINRC
                     EKPLPKNFNFAADVLDQWSLKEKSGERPANPALWWVNGKGDEVKWSFQELGSLSRKAA
                     NVLTKPCGLQRGDRVAVILPRIPEWWLINVACMRTGLVFMPGTIQLTRKDILYRLQAS
                     KAKCIVASEEVAPAVDSIVSECPSLKTKLLVSPHHWDGWLNFQELLQSASEEHNCVET
                     GSQEPMAIYFTSGTTGSPKMAQHSQGSLGIGYTLCGRYWLDLTSSDIMWNMSDTGWIK
                     AAIGSVFSTWLRGACVFVHRMAQFDTDIFLDTLTTYPITTLCSAPTVYRMLVQKDLKR
                     YQFKRLRHCLTGGEPLNPEVLEQWKMQTGLELYEGYGQTEVGIICANRKGEAIKPGSM
                     GKGVVPYDVQIIDENGNILPSGKEGEIALRLKSDRPFCFFSEYVDNPEKTDATIRRNF
                     YVTGDRGVMDDDGYFWFVGRADDVIISSGYRIGPFEVESALIEHPAVVESAVVSSPDP
                     IRGEVVKAFIVLAAPYKCSNREKLTAELQDHVKNSTAPYKYPRKVEFVQELPKTITGK
                     IKRNVLRDQEWGRA"
     exon            390..600
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /inference="alignment:Splign:2.1.0"
     exon            601..808
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /inference="alignment:Splign:2.1.0"
     exon            809..952
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1109
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1189
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1313
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1394
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1496
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1624
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1724
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1844
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..2153
                     /gene="Acsm4"
                     /gene_synonym="O-MACS; OMACS"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcccaactg tacaccagag gctcggggcc acagtggcat agacatcatc aaaagaagag
       61 aaggcagaaa agaagcaact ttgtggcaga aacagccttt gggaaggagc gggaggcctt
      121 tctggatcag caggaccatt tgctggcatt tcccacttgc taccagaaaa taaagttttt
      181 caggaaccat gaaggttctc ctccactgtc agagacttag attcatctgg cttgccaagc
      241 cagccggccg gcacttccac agagattccc agctctgggc acctctgaca ctggatgact
      301 ttgaagccat caatcgctgt gagaagccat tacccaagaa ctttaacttt gcagcagatg
      361 ttctggacca gtggtcccta aaggagaagt ctggagagag gccagccaac ccagccctgt
      421 ggtgggtgaa tgggaaagga gatgaggtga agtggagctt ccaagaactg ggttccttgt
      481 cccgaaaggc tgccaatgtg ctcaccaagc cctgcggcct gcagagagga gaccgggtgg
      541 ctgtgattct gccccgtatc cctgaatggt ggctcatcaa tgtggcttgc atgagaacag
      601 ggcttgtatt catgccagga acgatccaac tgaccagaaa agacatcctc taccggctgc
      661 aagcatccaa ggccaagtgc attgtggcta gtgaggaagt ggcccccgca gtggactcca
      721 ttgtatcaga gtgtcccagc ctgaagacta aactcctggt gtctccacac cactgggatg
      781 gatggctcaa ctttcaggag ttacttcaat cggcctctga agagcacaat tgtgtggaga
      841 cgggaagtca agaaccaatg gccatttact tcaccagtgg gaccacaggc tcccccaaga
      901 tggctcagca ctcacagggc agccttggca ttgggtatac cctttgtgga aggtactggc
      961 tggacttgac atcctcagat atcatgtgga acatgtcaga cactggctgg atcaaggctg
     1021 ccattggtag tgtgttttct acatggcttc gaggggcctg tgtttttgtg caccggatgg
     1081 cccagttcga cactgatatc ttcctagaca cacttaccac atatcccatc acgaccctgt
     1141 gcagtgctcc tacggtgtac cggatgctcg tacaaaagga ccttaagaga tatcaattca
     1201 agaggctgcg gcactgcctg acaggagggg agccactcaa ccccgaagtg ctggaacagt
     1261 ggaagatgca aactgggctg gagctgtacg agggctacgg acagaccgaa gtgggaataa
     1321 tttgcgccaa tcgcaaagga gaagcaatta aaccaggttc catgggaaaa ggagtagtgc
     1381 cgtacgatgt gcagattata gatgaaaatg gaaatatcct accatccggc aaggaagggg
     1441 aaattgccct taggctgaag tccgatcggc ccttctgttt cttctctgaa tatgtggaca
     1501 atccagaaaa gacagatgcc acaataagaa gaaattttta tgtcactgga gacagaggag
     1561 tgatggatga tgacggatac ttttggtttg tcggcagagc tgatgatgtc attatatctt
     1621 ctgggtaccg aattgggcct tttgaagtag agagcgcact gatagagcac ccagcagtag
     1681 ttgagtcagc tgttgtcagc agtccagatc cgatccgagg agaggtggtg aaggcattta
     1741 ttgtactagc tgcaccctac aagtgctcca accgtgagaa gttaaccgct gaacttcagg
     1801 atcatgtgaa aaattcaaca gcaccttaca aatacccaag aaaagtggaa tttgttcaag
     1861 aactcccaaa gacaatcact gggaaaatca aacgcaacgt gttaagagac caggaatggg
     1921 gaagagcata gctggatgag aaccttgcta gaagtgatgc ggttggtttc agtaccagct
     1981 tcctgatagt tcaacggcta ctcttaaaat gcttgaacat tttttttcct atttcactct
     2041 taaaatgctt tgtctttcct gtttcgctct taaaatgctt taacacttgt ttttttcctg
     2101 cttgaaaata gttctatcta ggaaaacaat aaagaaacaa ccaaaatcta aac
//
