LOCUS       NM_016870               2734 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus acyl-CoA synthetase medium-chain family member 3
            (Acsm3), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_016870
VERSION     NM_016870.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2734)
  AUTHORS   Xiao,X., Li,R., Cui,B., Lv,C., Zhang,Y., Zheng,J., Hui,R. and
            Wang,Y.
  TITLE     Liver ACSM3 deficiency mediates metabolic syndrome via a lauric
            acid-HNF4alpha-p38 MAPK axis
  JOURNAL   EMBO J 43 (4), 507-532 (2024)
   PUBMED   38191811
  REMARK    GeneRIF: Liver ACSM3 deficiency mediates metabolic syndrome via a
            lauric acid-HNF4alpha-p38 MAPK axis.
REFERENCE   2  (bases 1 to 2734)
  AUTHORS   Choi,M.S., Kim,Y.J., Kwon,E.Y., Ryoo,J.Y., Kim,S.R. and Jung,U.J.
  TITLE     High-fat diet decreases energy expenditure and expression of genes
            controlling lipid metabolism, mitochondrial function and skeletal
            system development in the adipose tissue, along with increased
            expression of extracellular matrix remodelling- and
            inflammation-related genes
  JOURNAL   Br J Nutr 113 (6), 867-877 (2015)
   PUBMED   25744306
  REMARK    GeneRIF: Data suggest that expression of Acsm3 in adipose tissue
            can be regulated by dietary factors; here, expression of Acsm3 in
            white adipose tissue is down-regulated in obesity caused by
            high-fat diet.
REFERENCE   3  (bases 1 to 2734)
  AUTHORS   Areste,C., Melia,M.J., Isern,J., Tovar,J.L. and Meseguer,A.
  TITLE     Sex steroid regulation and identification of different
            transcription units of the SA gene in mouse kidney
  JOURNAL   J Endocrinol 183 (1), 101-114 (2004)
   PUBMED   15525578
REFERENCE   4  (bases 1 to 2734)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 2734)
  AUTHORS   Walsh,V., Somody,L., Farrell,A., Zhang,B., Brown,J., Pritchard,C.,
            Vincent,M. and Samani,N.J.
  TITLE     Analysis of the role of the SA gene in blood pressure regulation by
            gene targeting
  JOURNAL   Hypertension 41 (6), 1212-1218 (2003)
   PUBMED   12707288
  REMARK    GeneRIF: Analysis of the role of the SA gene in blood pressure
            regulation.
REFERENCE   6  (bases 1 to 2734)
  AUTHORS   Fujino,T., Takei,Y.A., Sone,H., Ioka,R.X., Kamataki,A., Magoori,K.,
            Takahashi,S., Sakai,J. and Yamamoto,T.T.
  TITLE     Molecular identification and characterization of two medium-chain
            acyl-CoA synthetases, MACS1 and the Sa gene product
  JOURNAL   J Biol Chem 276 (38), 35961-35966 (2001)
   PUBMED   11470804
REFERENCE   7  (bases 1 to 2734)
  AUTHORS   Karan,D., David,J.R. and Capy,P.
  TITLE     Molecular evolution of the AMP-forming Acetyl-CoA synthetase
  JOURNAL   Gene 265 (1-2), 95-101 (2001)
   PUBMED   11255012
REFERENCE   8  (bases 1 to 2734)
  AUTHORS   Takenaka,M., Imai,E., Kaneko,T., Ito,T., Moriyama,T., Yamauchi,A.,
            Hori,M., Kawamoto,S. and Okubo,K.
  TITLE     Isolation of genes identified in mouse renal proximal tubule by
            comparing different gene expression profiles
  JOURNAL   Kidney Int 53 (3), 562-572 (1998)
   PUBMED   9507200
REFERENCE   9  (bases 1 to 2734)
  AUTHORS   Ding,Y.P., Remmers,E.F., Du,Y., Longman,R.E., Goldmuntz,E.A.,
            Zha,H., Kotake,S., Cannon,G.W., Griffiths,M.M. and Wilder,R.L.
  TITLE     Genetic maps of polymorphic DNA loci on rat chromosome 1
  JOURNAL   Genomics 36 (2), 320-327 (1996)
   PUBMED   8812459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164158.3.
            
            On Mar 1, 2023 this sequence version replaced NM_016870.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcripts. The three transcript variants all encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC164158.3         86008-86039         c
            33-234              AC164158.3         80416-80617         c
            235-382             AC164158.3         79952-80099         c
            383-656             AC164158.3         78844-79117         c
            657-867             AC164158.3         78016-78226         c
            868-1075            AC164158.3         73095-73302         c
            1076-1219           AC164158.3         72334-72477         c
            1220-1376           AC164158.3         71743-71899         c
            1377-1456           AC164158.3         71428-71507         c
            1457-1580           AC164158.3         69814-69937         c
            1581-1661           AC164158.3         68531-68611         c
            1662-1763           AC164158.3         67286-67387         c
            1764-1891           AC164158.3         66113-66240         c
            1892-1991           AC164158.3         65923-66022         c
            1992-2111           AC164158.3         63021-63140         c
            2112-2734           AC164158.3         62094-62716         c
FEATURES             Location/Qualifiers
     source          1..2734
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 64.17 cM"
     gene            1..2734
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /note="acyl-CoA synthetase medium-chain family member 3"
                     /db_xref="GeneID:20216"
                     /db_xref="MGI:MGI:99538"
     exon            1..32
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            33..234
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            235..382
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            383..656
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     CDS             456..2198
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /EC_number="6.2.1.2"
                     /EC_number="6.2.1.17"
                     /note="SA hypertension-associated homolog; protein SA
                     homolog; butyrate--CoA ligase 3; middle-chain acyl-CoA
                     synthetase 3; butyryl-coenzyme A synthetase 3;
                     propionate--CoA ligase"
                     /codon_start=1
                     /product="acyl-coenzyme A synthetase ACSM3, mitochondrial"
                     /protein_id="NP_058566.3"
                     /db_xref="CCDS:CCDS21786.1"
                     /db_xref="GeneID:20216"
                     /db_xref="MGI:MGI:99538"
                     /translation="MVMLLRARCFQRLAIPDPMRVLYKDYRTATPQNFSNYESMKQDF
                     KIEIPEYFNFAKDVLDQWTNMEKAGKRLSNPAFWWIDGNGEELRWSFEELGLLSRKFA
                     NILTEACSLQRGDRVMVILPKIPEWWLANVACLRTGTVLIPGTTQLTQKDILYRLQSS
                     KAKCIITDDTLAPAVDAVAAKCENLHSKLIVSQHSREGWGNLKEMMKYASDSHTCVDT
                     KHDEMMAIYFTSGTTGPPKMIGHTHSSFGLGLSVNGRFWLDLIASDVMWNTSDTGWAK
                     SAWSSVFSPWTQGACVFAHYLPRFESTSILQTLSKFPITVFCSAPTAYRMLVQNDMSS
                     YKFNSLKHCVSAGEPINPEVMEQWRKKTGLDIYEGYGQTETVLICGNFKGMKIKPGSM
                     GKPSPAFDVKILDENGATLPPGQEGDIALQVLPERPFGLFTHYVDNPSKTASTLRGSF
                     YITGDRGYMDEDGYFWFVARSDDIILSSGYRIGPFEVESALIEHPSIAESAVVSSPDP
                     IRGEVVKAFIVLNPDYKSHDQEQLKKEIQEHVKKTTAPYKYPRKVEFIEELPKTVSGK
                     VKRNELRKKEWVTT"
     exon            657..867
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1075
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1219
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1376
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1456
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1580
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1661
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1763
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1891
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1991
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2111
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2734
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2712..2717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /note="hexamer: AATAAA"
     polyA_site      2734
                     /gene="Acsm3"
                     /gene_synonym="Sa; Sah"
                     /note="major polyA site"
ORIGIN      
        1 cactttgatc caccaccaac actaaagcag aggcaatgga cttggccaac atcctaaaga
       61 ccagtgaatc tctcacttga acacagaaac ttgtgtggag aatattgtta aagatttaat
      121 ccattaactc aactgatctt cagtgggacc taaagattat gcacttctga caggtgtcca
      181 agtggtgcag tggttcatag accataggct ctggatgagt ggatctccac ttgggtgaaa
      241 gacaaggagg ttcaagctgg atgatctcag agagttcaag atcaccgact cgtgaggttc
      301 tcacacagga agtggacacc tggagccgct ggatttcaaa tgcatccatt tcatcagcat
      361 gatgcctagc caccagatcc atctggatta gtctgcatgg aaatctcaca tgccaaaaca
      421 ttcaacaaca ctgatgctag ctagctcttg tcatcatggt gatgttactc cgtgctaggt
      481 gttttcagcg cctagcaatt cctgatccta tgagagtctt gtataaagat tacagaacag
      541 cgacccctca gaacttttcc aactatgagt ccatgaaaca agacttcaaa atagagattc
      601 cagagtattt caattttgca aaagatgtcc tggaccaatg gaccaatatg gaaaaggctg
      661 gaaagagact ttccaatcca gccttctggt ggatagatgg gaatggagaa gagctgagat
      721 ggagttttga agaacttggg ttgttatcca ggaaatttgc caacatactc acagaagcct
      781 gctccctgca aagaggagac agagtaatgg tgatactgcc caagatccca gagtggtggc
      841 ttgcaaatgt ggcctgtctg cgaacaggga cagttttaat tccaggaacc actcagctga
      901 cccagaaaga catcctctat agactacaat cttcaaaagc taagtgcatt attaccgatg
      961 atactttggc cccagcagta gatgccgtgg cagctaaatg tgaaaatctc cactccaaat
     1021 taattgtgtc tcagcactcc agagaaggct gggggaacct caaggagatg atgaaatatg
     1081 ccagtgacag ccacacttgt gtggacacaa aacacgacga gatgatggcc atctacttca
     1141 ccagtgggac aactgggcct cctaagatga ttggacacac ccacagcagc tttggtttag
     1201 gattgtctgt caatggaagg ttctggctgg atttgatagc ctccgatgtg atgtggaata
     1261 cttcagatac aggctgggca aagtctgcat ggagtagtgt tttttctcca tggacccaag
     1321 gagcatgtgt ttttgcacac tatttgcccc gttttgaatc aacttccatc ttgcaaaccc
     1381 tctccaagtt ccccatcact gtcttctgtt ctgcaccaac tgcctaccgg atgcttgttc
     1441 agaatgacat gagcagctat aagttcaaca gtttgaagca ctgtgtcagt gctggagaac
     1501 ctattaaccc tgaagtgatg gaacaatgga gaaagaagac gggcctagac atctatgaag
     1561 gatatggaca gacagaaacg gtgctgatct gtggaaattt caaggggatg aaaattaagc
     1621 ccggctcaat gggaaagcct tctcctgctt ttgatgtgaa gattttagat gaaaatggtg
     1681 ccactcttcc tcctggacaa gaaggggata ttgctcttca agttcttcct gagcgaccat
     1741 ttggcctttt tactcattat gtagataatc cttccaaaac ggcttcaact ctacgaggga
     1801 gtttctacat tactggggac agaggatata tggatgaaga tggctatttc tggtttgttg
     1861 caagatcaga tgatatcata ttatcttctg gttaccgaat tggaccattt gaggtagaaa
     1921 gtgccctcat agaacatcct tccatcgcag agtcagctgt tgtcagcagt ccagacccca
     1981 tcagaggaga ggtagtaaag gcttttattg tcctgaatcc tgattacaag tcccatgatc
     2041 aagagcaact gaaaaaggag atccaggagc acgtgaagaa gactacagcg ccttacaaat
     2101 accccagaaa ggtagaattt attgaagagc tgccgaagac tgtcagtggg aaggtcaaaa
     2161 gaaatgaact gaggaaaaag gaatgggtaa caacttgaac tcctcccact aatcacctgt
     2221 gtagctataa acacagtgtc tacaagtctg caggaaccac agattatgtg ggcagactgc
     2281 tttgaaactg gattgaaagt attttgtagt tatgacatca gagcctgaat tctgaaatca
     2341 aataatcatt attgaatcct tctgcattca tgtcaatgct cctgtaatct gccaacataa
     2401 aatgaatgtc gccagatgct gagatgtctt aaaatttatt ttaggagcag attctaaact
     2461 aaatctgtac ccaggcattt tcaaaacata actgaacaat tctaatatgc taatatacaa
     2521 atcagaacaa atcttcaaac tttgaaaaga accctatttt taagaaactg tcataattct
     2581 tagaatattt acctaaaact ttactagtca tatttttatt caagtaattt aaaaatagtt
     2641 tgaaatttgt ttgaaggtca aagtataaga gaaagctgtc acattctgtg gctagttatt
     2701 aaatttaacc taataaacat ggtttgtaaa aata
//
