LOCUS       NM_054094               2052 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus acyl-CoA synthetase medium-chain family member 1
            (Acsm1), transcript variant 1, mRNA; nuclear gene for mitochondrial
            product.
ACCESSION   NM_054094 XM_980952
VERSION     NM_054094.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2052)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2052)
  AUTHORS   Labialle,S., Marty,V., Bortolin-Cavaille,M.L., Hoareau-Osman,M.,
            Pradere,J.P., Valet,P., Martin,P.G. and Cavaille,J.
  TITLE     The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain
            controls neonatal metabolic adaptation
  JOURNAL   EMBO J 33 (19), 2216-2230 (2014)
   PUBMED   25124681
REFERENCE   3  (bases 1 to 2052)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2052)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 2052)
  AUTHORS   Oka,Y., Kobayakawa,K., Nishizumi,H., Miyamichi,K., Hirose,S.,
            Tsuboi,A. and Sakano,H.
  TITLE     O-MACS, a novel member of the medium-chain acyl-CoA synthetase
            family, specifically expressed in the olfactory epithelium in a
            zone-specific manner
  JOURNAL   Eur J Biochem 270 (9), 1995-2004 (2003)
   PUBMED   12709059
REFERENCE   6  (bases 1 to 2052)
  AUTHORS   Fujino,T., Takei,Y.A., Sone,H., Ioka,R.X., Kamataki,A., Magoori,K.,
            Takahashi,S., Sakai,J. and Yamamoto,T.T.
  TITLE     Molecular identification and characterization of two medium-chain
            acyl-CoA synthetases, MACS1 and the Sa gene product
  JOURNAL   J Biol Chem 276 (38), 35961-35966 (2001)
   PUBMED   11470804
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134587.3.
            
            On Feb 9, 2019 this sequence version replaced NM_054094.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022149.1, AB059428.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC134587.3         72601-72686
            87-278              AC134587.3         77287-77478
            279-489             AC134587.3         87851-88061
            490-697             AC134587.3         91239-91446
            698-838             AC134587.3         92854-92994
            839-998             AC134587.3         95364-95523
            999-1078            AC134587.3         107343-107422
            1079-1202           AC134587.3         109121-109244
            1203-1283           AC134587.3         110205-110285
            1284-1385           AC134587.3         110771-110872
            1386-1513           AC134587.3         113089-113216
            1514-1613           AC134587.3         113890-113989
            1614-1733           AC134587.3         115353-115472
            1734-2052           AC134587.3         116986-117304
FEATURES             Location/Qualifiers
     source          1..2052
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 64.02 cM"
     gene            1..2052
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /note="acyl-CoA synthetase medium-chain family member 1"
                     /db_xref="GeneID:117147"
                     /db_xref="MGI:MGI:2152200"
     exon            1..86
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /inference="alignment:Splign:2.1.0"
     exon            87..278
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1820
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /EC_number="6.2.1.2"
                     /EC_number="6.2.1.25"
                     /note="isoform 1 is encoded by transcript variant 1;
                     butyryl Coenzyme A synthetase 1; acyl-coenzyme A
                     synthetase ACSM1, mitochondrial; butyrate--CoA ligase 1;
                     lipoate-activating enzyme; middle-chain acyl-CoA
                     synthetase 1; butyryl-coenzyme A synthetase 1;
                     acetyl-Coenzyme A synthetase 3; benzoate--CoA ligase"
                     /codon_start=1
                     /product="acyl-coenzyme A synthetase ACSM1, mitochondrial
                     isoform 1"
                     /protein_id="NP_473435.1"
                     /db_xref="CCDS:CCDS21783.1"
                     /db_xref="GeneID:117147"
                     /db_xref="MGI:MGI:2152200"
                     /translation="MQWLKSFQICKVLQGFSLSPTQLHRRLFSRVGAPRWNDHDSPEE
                     FNFASDVLDYWAQMEEEGKRGPSPAFWWVNGQGDEIKWSFRKLRDLTCRTANVFEQIC
                     GLQQGDHLALILPRVPEWWLVTVGCMRTGIIFMPGTTQLKAKDILYRIQISRAKAIVT
                     TASLVPEVESVASECPDLKTKLVVSDHSHEGWLDFCSLIKSASPDHTCIKSKMKDPMA
                     IFFTSGTTGYPKMAKHNQGLAFRSYIPSCRKLLKLKTSDILWCMSDPGWILATVGCLI
                     EPWTSGCTVFIHHLPQFDPKVIVEVLFKYPITQCLAAPGVYRMVLQQKTSNLRFPTLE
                     HCTTGGESLLPEEYEQWKQRTGLSIHEVYGQSETGISSATLREMKIKRGSIGKAILPF
                     DLQIIDEKGNILPPNTEGYIGIRIKPTRPLGLFMEYENSPESTSEVECGDFYNSGDRA
                     TIDEEGYIWFLGRGDDVINASGYRIGPVEVENALAEHPAVAESAVVSSPDKDRGEVVK
                     AFIVLNPEFLSHDQEQLIKELQHHVKSVTAPYKYPRKVEFVSELPKTVTGKIKRKELR
                     NKEFGQL"
     exon            279..489
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /inference="alignment:Splign:2.1.0"
     exon            490..697
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /inference="alignment:Splign:2.1.0"
     exon            698..838
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /inference="alignment:Splign:2.1.0"
     exon            839..998
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1078
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1202
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1283
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1385
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1513
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1613
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1733
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..2052
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2028..2033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /note="hexamer: AATAAA"
     polyA_site      2052
                     /gene="Acsm1"
                     /gene_synonym="Acas3; Bucs1; Macs"
                     /note="major polyA site"
ORIGIN      
        1 agaactggga aagactgtgc acagagagca ggccttacaa gccgtctctc ctggctatag
       61 tctacctgtg tccttcacag taccaggact gccctaatat gcagtggctg aagagtttcc
      121 agatctgcaa agtcttacag ggcttctccc taagccccac ccagctgcac agacggttgt
      181 tttcaagagt tggagctcca agatggaatg accatgattc acctgaggag tttaactttg
      241 caagtgatgt cctggactac tgggctcaaa tggaggagga gggcaagaga ggaccaagtc
      301 cagccttttg gtgggtgaat ggccaaggag atgaaataaa gtggagcttc aggaagctga
      361 gggacctcac ctgtcgcact gccaacgtct ttgagcagat ttgtggcctg cagcaaggag
      421 atcacctggc cttgattctg ccccgagtgc ccgagtggtg gttggtgaca gtgggctgca
      481 tgcgaacagg gatcatcttc atgcctggga ctacccaact gaaagccaag gacattctct
      541 accgaataca aatatctcga gccaaagcca ttgtgaccac agctagcctt gtcccagagg
      601 tggaatctgt ggcttctgag tgtcctgatc tgaaaaccaa gctggtggtg tctgatcaca
      661 gccatgaagg gtggcttgat ttctgttcac tgattaaatc agcatcccca gaccatactt
      721 gtattaagtc aaagatgaag gatcccatgg ccatcttctt caccagtggg accacaggct
      781 accccaagat ggcaaagcac aaccagggac ttgccttccg gtcatatatc ccttcatgca
      841 gaaaattatt gaagctgaag acatctgaca tcttgtggtg catgtcagac ccaggatgga
      901 ttctggctac cgtggggtgc ctgatcgagc catggacatc aggatgtaca gtcttcatcc
      961 accacctccc tcaattcgac cccaaagtca ttgtagaggt actgttcaaa taccccatca
     1021 ctcagtgcct tgctgcccca ggcgtgtatc gaatggttct tcagcagaaa acctccaacc
     1081 tcaggttccc cacccttgag cattgcacta ctggtgggga gagcctgctg cctgaggagt
     1141 atgagcagtg gaagcaaagg acaggtcttt ccatccacga ggtctatgga cagtcagaaa
     1201 cggggatcag cagtgccacc ctccgggaaa tgaagatcaa gcgaggctcc atagggaagg
     1261 ccatcttacc ctttgacttg cagatcatcg atgaaaaggg caacatcctc ccacccaaca
     1321 ctgaaggata cattggcatc aggatcaagc ccaccaggcc tctaggcctc ttcatggaat
     1381 atgagaatag cccagagagc acatctgaag tggagtgtgg ggacttttac aatagtgggg
     1441 atagagcgac cattgatgaa gagggctaca tctggttctt gggaaggggc gatgatgtca
     1501 tcaatgcttc cgggtatcgc atcgggcctg tagaggtgga gaacgccttg gcggagcacc
     1561 cagcagtggc agagtctgcg gtggtgagca gcccggacaa ggatcgagga gaggtggtga
     1621 aggcgtttat tgtcctcaac ccagagttcc tgtcacacga tcaggaacag cttatcaaag
     1681 agctacagca tcatgtgaag tcagtgacgg caccatacaa gtaccccagg aaggtggagt
     1741 ttgtttcaga attgcccaaa actgtcacag gcaaaatcaa aaggaaggaa cttcgaaaca
     1801 aggagtttgg tcagctatga acagcaatca acccagagca tcctgtgacc tgaatccttg
     1861 gctgttgggg tcagggtggt gtgggatgac gatggaatgc aggaagggta aatgtggaag
     1921 agaaaaccaa gaccccaaca tttttgcttt cttcaaactc agttggtccc cttcctggat
     1981 accttcttct tccccttcca cagtgcactc tcagactgtt tgtggacaat aaaaatactg
     2041 acttgaatag ca
//
