LOCUS       NM_001033598            2561 bp    mRNA    linear   ROD 08-OCT-2024
DEFINITION  Mus musculus acyl-CoA synthetase long-chain family member 6
            (Acsl6), transcript variant 3, mRNA.
ACCESSION   NM_001033598
VERSION     NM_001033598.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2561)
  AUTHORS   Wang,Y., Becker,S., Finkelstein,S., Dyka,F.M., Liu,H.,
            Eminhizer,M., Hao,Y., Brush,R.S., Spencer,W.J., Arshavsky,V.Y.,
            Ash,J.D., Du,J., Agbaga,M.P., Vinberg,F., Ellis,J.M. and
            Lobanova,E.S.
  TITLE     Acyl-CoA synthetase 6 controls rod photoreceptor function and
            survival by shaping the phospholipid composition of retinal
            membranes
  JOURNAL   Commun Biol 7 (1), 1027 (2024)
   PUBMED   39169121
  REMARK    GeneRIF: Acyl-CoA synthetase 6 controls rod photoreceptor function
            and survival by shaping the phospholipid composition of retinal
            membranes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2561)
  AUTHORS   Kuroha,S., Katada,Y., Isobe,Y., Uchino,H., Shishikura,K.,
            Nirasawa,T., Tsubota,K., Negishi,K., Kurihara,T. and Arita,M.
  TITLE     Long chain acyl-CoA synthetase 6 facilitates the local distribution
            of di-docosahexaenoic acid- and ultra-long-chain-PUFA-containing
            phospholipids in the retina to support normal visual function in
            mice
  JOURNAL   FASEB J 37 (9), e23151 (2023)
   PUBMED   37585289
  REMARK    GeneRIF: Long chain acyl-CoA synthetase 6 facilitates the local
            distribution of di-docosahexaenoic acid- and
            ultra-long-chain-PUFA-containing phospholipids in the retina to
            support normal visual function in mice.
REFERENCE   3  (bases 1 to 2561)
  AUTHORS   Fernandez,R.F., Wilson,E.S., Diaz,V., Martinez-Gardeazabal,J.,
            Foguth,R., Cannon,J.R., Jackson,S.N., Hermann,B.P., Eells,J.B. and
            Ellis,J.M.
  TITLE     Lipid metabolism in dopaminergic neurons influences light
            entrainment
  JOURNAL   J Neurochem 165 (3), 379-390 (2023)
   PUBMED   36815399
REFERENCE   4  (bases 1 to 2561)
  AUTHORS   Xu,L., Liu,Q., Long,T., Peng,L., Li,F., Sun,Z. and Xie,Q.
  TITLE     Ectopic Acsl6 Overexpression Partially Improves
            Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte
            Hypertrophy In Vitro
  JOURNAL   J Cardiovasc Pharmacol 80 (6), 792-803 (2022)
   PUBMED   35976155
  REMARK    GeneRIF: Ectopic Acsl6 Overexpression Partially Improves
            Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte
            Hypertrophy In Vitro.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2561)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2561)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 2561)
  AUTHORS   Kee,H.J., Koh,J.T., Yang,S.Y., Lee,Z.H., Baik,Y.H. and Kim,K.K.
  TITLE     A novel murine long-chain acyl-CoA synthetase expressed in brain
            participates in neuronal cell proliferation
  JOURNAL   Biochem Biophys Res Commun 305 (4), 925-933 (2003)
   PUBMED   12767919
  REMARK    GeneRIF: Long-chain acyl-CoA synthetase expressed in brain
            participates in neuronal cell proliferation.
REFERENCE   8  (bases 1 to 2561)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (bases 1 to 2561)
  AUTHORS   Wenderfer,S.E., Slack,J.P., McCluskey,T.S. and Monaco,J.J.
  TITLE     Identification of 40 genes on a 1-Mb contig around the IL-4
            cytokine family gene cluster on mouse chromosome 11
  JOURNAL   Genomics 63 (3), 354-373 (2000)
   PUBMED   10704283
REFERENCE   10 (bases 1 to 2561)
  AUTHORS   Frazer,K.A., Ueda,Y., Zhu,Y., Gifford,V.R., Garofalo,M.R.,
            Mohandas,N., Martin,C.H., Palazzolo,M.J., Cheng,J.F. and Rubin,E.M.
  TITLE     Computational and biological analysis of 680 kb of DNA sequence
            from the human 5q31 cytokine gene cluster region
  JOURNAL   Genome Res 7 (5), 495-512 (1997)
   PUBMED   9149945
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147283.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding region and uses a downstream start codon, compared to
            variant 1. The resulting protein (isoform 3) has a shorter and
            distinct N-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147283.1, AY786363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2561              AK147283.1         2-2562
FEATURES             Location/Qualifiers
     source          1..2561
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.13 cM"
     gene            1..2561
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /note="acyl-CoA synthetase long-chain family member 6"
                     /db_xref="GeneID:216739"
                     /db_xref="MGI:MGI:894291"
     exon            1..99
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            100..320
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..2219
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="isoform 3 is encoded by transcript variant 3; fatty
                     acid Coenzyme A ligase, long chain 6;
                     long-chain-fatty-acid--CoA ligase 6; LACS 6; long-chain
                     acyl-CoA synthetase 6; arachidonate--CoA ligase"
                     /codon_start=1
                     /product="long-chain-fatty-acid--CoA ligase 6 isoform 3"
                     /protein_id="NP_001028770.1"
                     /db_xref="CCDS:CCDS24696.1"
                     /db_xref="GeneID:216739"
                     /db_xref="MGI:MGI:894291"
                     /translation="MQTQEILRILRLPELSDLGQFFRSLSATTLVSVGALAAVLAYWL
                     THRPKALQPPCNLLKQSEEVEDGGGARRSVIGGCTQLLTHYYDDARTMYQVFRRGLSI
                     SGNGPCLGFRKPEQPYQWLSYQEVAKRAEFLGSGLLQHDCKVGTEQFVGVFAQNRPEW
                     IIAELACYTYSMVVVPLYDTLGPGSISYIINTADICTVIVDKPHKATLLLEHVERKET
                     PGLKLVILMEPFEDALRERGKKCGVDIKSMQAIEDCGRENHHAPVPPRPDDLSIVCFT
                     SGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVV
                     YCHGGRVGFFQGDIRLLSDDMKALRPTIFPVVPRLLNRMYDKIFHQADTSLKRWLLEF
                     AAKRKQAEVRSGIIRNNSIWDELFFNKIQASLGGHVRMIVTGAAPASPTVLGFLRAAL
                     GCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDAEELNYWTCKGEGEI
                     CVKGPNVFKGYLKDEDRTKEALDSDGWLHTGDIGKWLPEGTLKIIDRKKHIFKLAQGE
                     YVAPEKIENIYIRSEPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKKGIEGTYQEL
                     CMKKELKKAILDDMVMLGKESGLHSFEQVKAIYIHCDMFSVQNGLLTPTLKAKRPELR
                     EYFKKQIEELYLVSV"
     exon            321..435
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            436..500
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            501..602
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            603..702
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            703..881
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            882..914
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            915..966
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1040
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1118
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1253
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1388
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1484
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1557
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1646
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1763
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1907
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2009
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2081
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2561
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2467
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /note="major polyA site"
     regulatory      2534..2539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /note="hexamer: ATTAAA"
     regulatory      2544..2549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /note="hexamer: AAGAAA"
     polyA_site      2554
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /note="major polyA site"
     polyA_site      2557
                     /gene="Acsl6"
                     /gene_synonym="A330035H04Rik; Facl6; LACS; Lacsl;
                     mKIAA0837"
                     /note="major polyA site"
ORIGIN      
        1 ggcacttcag catgtgcact ttctgggaca gaagccctgg acccccgctg ccatttgagc
       61 ctgcctagcc ataaaacctt ggaggccggt cgtgtggaga gattgctctc tcacttctgg
      121 agaagatgca gacccaggag atcctgagga tcctgcggct gcccgagcta tcggacttgg
      181 gccagttttt ccgcagcctc tcagctacca ccctcgtgag tgtgggtgca ctggctgccg
      241 tccttgccta ctggctcact caccggccaa aggccttgca accaccatgc aacctcctga
      301 agcagtcgga agaagtggag gacggtggtg gagcccggcg atctgtgatt gggggttgca
      361 ctcaattgct tacccattac tatgacgatg cccggaccat gtaccaggtg ttccgccgtg
      421 ggcttagcat ctcagggaat ggaccctgtc ttggcttccg gaagccagag caaccttacc
      481 agtggctgtc ctaccaagag gtggccaaaa gggctgaatt tctggggtcg gggcttctcc
      541 agcacgactg taaagtgggc acagagcagt tcgttggtgt ttttgcacaa aatcggccgg
      601 agtggatcat tgccgagctg gcctgctaca cgtattccat ggtggtggta ccgctctacg
      661 acaccctggg cccagggtct atcagctaca tcatcaatac tgcggacatt tgcacggtaa
      721 tcgtcgataa accccacaag gcaacacttc tgctggaaca cgtggagagg aaggagactc
      781 cgggcctcaa gctggtcatc ctcatggagc cgtttgagga cgccctgaga gagagaggaa
      841 agaagtgcgg ggtggacatc aagtccatgc aggctataga ggactgtggc cgagagaatc
      901 atcatgcccc cgtgccccca cggcctgatg acctctccat cgtgtgtttc acaagtggta
      961 caacagggaa ccccaaaggt gcaatgctca cccacgggaa cgtggtggcc gatttctcgg
     1021 gctttctgaa agtgacagag aaagtgatct ttccgagaca ggacgatgtg ctcatctcct
     1081 tcctgcctct ggctcacatg tttgagagag tgatccagtc tgttgtctac tgccacggag
     1141 ggcgcgtggg cttcttccag ggagacatcc gcctcctctc agatgacatg aaggctctcc
     1201 gccctaccat cttccctgtg gtcccacggc tgctgaatcg gatgtatgac aagatcttcc
     1261 accaggcaga cacctcacta aagcgctggc tcctggagtt tgcagcaaag cgcaagcagg
     1321 cagaggtccg gagcggaatc atcagaaaca atagtatctg ggatgaactc ttctttaata
     1381 agattcaggc cagtcttggt gggcatgtga ggatgattgt cactggagca gcccccgcgt
     1441 caccaacggt tctgggattc ctacgagcag ctctggggtg ccaggtctat gaaggttatg
     1501 ggcaaactga atgcacagct gggtgtacct tcacaacgcc aggggactgg acatcagggc
     1561 atgtaggggc acctctgccc tgcaaccaca tcaagctggt cgatgcagag gaactcaact
     1621 actggacctg caaaggagaa ggagagatat gtgtgaaagg accaaatgtg ttcaaaggct
     1681 acttaaaaga cgaggacagg acaaaggagg ccctggacag cgacggctgg cttcacactg
     1741 gagacattgg gaaatggctg ccggagggaa cactcaaaat cattgatcgg aaaaagcaca
     1801 tatttaaact tgctcagggg gaatatgttg cgccagagaa gatcgagaac atctacatcc
     1861 ggagtgagcc tgtggcacaa atctacgtcc acggggacag cttaaaggcc tttttggttg
     1921 gcattgtcgt gcctgaccct gaagtcatgc cttcctgggc tcagaagaaa ggaatcgaag
     1981 ggacctatca ggaactctgc atgaaaaagg aattgaagaa agccattctg gatgacatgg
     2041 tgatgctggg gaaagaaagc ggactgcatt cttttgaaca ggttaaagcc atttacatcc
     2101 attgtgacat gttctctgtt caaaatggtc tgctgacacc aacactaaag gctaagagac
     2161 cggagctgag agagtacttc aaaaagcaaa tagaagagct ttacttagtc tccgtgtgaa
     2221 gctccaggag ggcccgtctc agtccgatga actttgcagc aatattatag ttattcgtga
     2281 gagaaaggaa tcagaatgcc acagctcaaa gtgaacaagc acctgatttt tgcaactgag
     2341 cctttcctga cccaagaagt ctctaacaat attttctcta ccatcaccaa gtacacttta
     2401 tttttattaa atgatattgt agcaagctgc taaaaaaaat tatcgcaaac ggtaatgtaa
     2461 aaacaaatca agacactttc tgaagaactg tgtaccacta aaagtaatat attcgcaatg
     2521 ttcacagaat tccattaaac ataaagaaaa aacataactg a
//
