LOCUS       NM_027976               3167 bp    mRNA    linear   ROD 13-MAY-2024
DEFINITION  Mus musculus acyl-CoA synthetase long-chain family member 5
            (Acsl5), mRNA.
ACCESSION   NM_027976 XM_484816
VERSION     NM_027976.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3167)
  AUTHORS   Griffin,J.D., Zhu,Y., Reeves,A., Buhman,K.K. and Greenberg,A.S.
  TITLE     Intestinal Acyl-CoA synthetase 5 (ACSL5) deficiency potentiates
            postprandial GLP-1 & PYY secretion, reduces food intake, and
            protects against diet-induced obesity
  JOURNAL   Mol Metab 83, 101918 (2024)
   PUBMED   38499083
  REMARK    GeneRIF: Intestinal Acyl-CoA synthetase 5 (ACSL5) deficiency
            potentiates postprandial GLP-1 & PYY secretion, reduces food
            intake, and protects against diet-induced obesity.
REFERENCE   2  (bases 1 to 3167)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3167)
  AUTHORS   Hou,T., Tian,Y., Cao,Z., Zhang,J., Feng,T., Tao,W., Sun,H., Wen,H.,
            Lu,X., Zhu,Q., Li,M., Lu,X., Liu,B., Zhao,Y., Yang,Y. and Zhu,W.G.
  TITLE     Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic
            fatty liver disease by facilitating hepatic fatty acid oxidation
  JOURNAL   Mol Cell 82 (21), 4099-4115 (2022)
   PUBMED   36208627
  REMARK    GeneRIF: Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes
            nonalcoholic fatty liver disease by facilitating hepatic fatty acid
            oxidation.
REFERENCE   4  (bases 1 to 3167)
  AUTHORS   Fonseca,T.L., Russo,S.C., Luongo,C., Salvatore,D. and Bianco,A.C.
  TITLE     Inactivation of Type 3 Deiodinase Results in Life-long Changes in
            the Brown Adipose Tissue Transcriptome in the Male Mouse
  JOURNAL   Endocrinology 163 (5) (2022)
   PUBMED   35238380
REFERENCE   5  (bases 1 to 3167)
  AUTHORS   Luo,F., Smagris,E., Martin,S.A., Vale,G., McDonald,J.G.,
            Fletcher,J.A., Burgess,S.C., Hobbs,H.H. and Cohen,J.C.
  TITLE     Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi
            Compartment in Mice and Rats
  JOURNAL   Cell Mol Gastroenterol Hepatol 13 (3), 879-899 (2022)
   PUBMED   34923175
REFERENCE   6  (bases 1 to 3167)
  AUTHORS   de Jong,H., Neal,A.C., Coleman,R.A. and Lewin,T.M.
  TITLE     Ontogeny of mRNA expression and activity of long-chain acyl-CoA
            synthetase (ACSL) isoforms in Mus musculus heart
  JOURNAL   Biochim Biophys Acta 1771 (1), 75-82 (2007)
   PUBMED   17197235
REFERENCE   7  (bases 1 to 3167)
  AUTHORS   Brown,A.C., Olver,W.I., Donnelly,C.J., May,M.E., Naggert,J.K.,
            Shaffer,D.J. and Roopenian,D.C.
  TITLE     Searching QTL by gene expression: analysis of diabesity
  JOURNAL   BMC Genet 6, 12 (2005)
   PUBMED   15760467
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3167)
  AUTHORS   Marszalek,J.R., Kitidis,C., Dararutana,A. and Lodish,H.F.
  TITLE     Acyl-CoA synthetase 2 overexpression enhances fatty acid
            internalization and neurite outgrowth
  JOURNAL   J Biol Chem 279 (23), 23882-23891 (2004)
   PUBMED   15051725
  REMARK    GeneRIF: Acyl-CoA synthetase 2 has a role in fatty acid
            internalization and neurite outgrowth
            Erratum:[J Biol Chem. 2005 Mar 25;280(12):12064]
REFERENCE   9  (bases 1 to 3167)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 3167)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133100.5, BC031544.1 and AI838021.1.
            
            On Sep 21, 2005 this sequence version replaced NM_027976.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034942.1, SRR1660813.226872.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-720               AC133100.5         74738-75457         c
            721-3148            BC031544.1         155-2582
            3149-3167           AI838021.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3167
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 51.3 cM"
     gene            1..3167
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /note="acyl-CoA synthetase long-chain family member 5"
                     /db_xref="GeneID:433256"
                     /db_xref="MGI:MGI:1919129"
     exon            1..798
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            799..983
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     CDS             828..2879
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="fatty acid Coenzyme A ligase, long chain 5; LACS 5;
                     long-chain acyl-CoA synthetase 5; arachidonate--CoA
                     ligase"
                     /codon_start=1
                     /product="long-chain-fatty-acid--CoA ligase 5"
                     /protein_id="NP_082252.1"
                     /db_xref="CCDS:CCDS29908.1"
                     /db_xref="GeneID:433256"
                     /db_xref="MGI:MGI:1919129"
                     /translation="MLFIFNFLFSPLPTPALICLLTFGTAIFLWLINRPQPVLPLIDL
                     DNQSVGIEGGARRGAFQKNNDLILYYFSDAKTLYENFQRGLAVSDNGPCLGYRKPNQP
                     YKWISYKQVSDRAEYLGSCLLHKGYKSSQDQFVGIFAQNRPEWVISELACYTYSMVAV
                     PLYDTLGTEAIIFVINRADIPVVICDTPQKATMLVENVEKGLTPGLKTIILMDPFDDD
                     LMKRGEKCGVEMLSLHDAENIGKENFKKPVPPKPEDLSVICFTSGTTGDPKGAMLTHE
                     NVVSNMAAFLKFLEPIFQPTSDDVTISYLPLAHMFERLVQGILFSCGGKIGFFQGDIR
                     LLPDDMKALKPTVFPTVPRLLNRVYDKVQNEAKTPLKKFLLNLAIISKFNEVKNGIIR
                     RDSLWDKLVFSKIQGSLGGKVRLMITGAAPISTPVLTFFRAAMGCWVFEAYGQTECTG
                     GCSITSPGDWTAGHVGTPVACNFVKLEDVADMNYFSVNNEGEICIKGNNVFKGYLKDP
                     EKTQEVLDKDGWLHTGDIGRWLPNGTLKIVDRKKNIFKLAQGEYIAPEKIENVYSRSR
                     PVLQVFVHGESLRSFLIGVVVPDPDSLPSFAAKIGVKGSFEELCKNQCVKEAILEDLQ
                     KIGKEGGLKSFEQVKSIFVHPEPFTIENGLLTPTLKAKRVELAKFFQTQIKSLYESIE
                     E"
     exon            984..1092
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1157
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1259
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1359
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1538
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1571
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1623
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1697
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1775
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1910
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2045
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2141
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2214
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2303
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..2420
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2564
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2666
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2667..2738
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..2888
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3151
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3131..3136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /note="hexamer: AATAAA"
     polyA_site      3151
                     /gene="Acsl5"
                     /gene_synonym="1700030F05Rik; ACS2; ACS5; Facl5"
                     /note="major polyA site"
ORIGIN      
        1 atttcatcct taaacttggc ggggtgagag ccggagctga gctggtgtgt ctgcggaaag
       61 ggagccactt caactgaatg gctctctgcc cccgtggttc ctggcttatt tatctattct
      121 gttgtctctg cgaggtgcag aggtgcctgg ctttttgaat cagggaggtc tggggactgg
      181 cgaaaggagc tacacagaga aagagacagt cgtgctgcat ctaacctaag ggcggaggtc
      241 cctctagctg gactttcctg tcctgcgaac gcagcgggga acaacgtcac ctccgtttct
      301 ctggcaatga acccagggcc acctcaactc gttttcattt ggattttcat cttggagaag
      361 agctagtggg accagcggga gcaggtggac tgtgttgatg caaaggtggc tcgtgtttca
      421 gcccctgggg attgaggtta aaggctttga aaaccggcta gggtagcttt ggatatctgt
      481 ctcctcctag tcaaaagcgg ttccactttc agttgtgaag gaggagggaa aaaaaagcca
      541 aaccaggaag tgaagtcccc agcaccagca tgtcagaaag cccggctatg gcctggctgg
      601 gacagatcag ggcagggcag aagtggggcc actagccagg ctgcctgcct gcctgcctgc
      661 atggacgctc tgaagtcacc ctgcccgcgg agaagcccgg ggtgaggaag ggaggaccga
      721 ggctctcctg ccagcaagaa gccggagcca gaaagcctca ctcggaagct ccaaggcgtg
      781 cgtgcggccc ttcccagggt ctgaatttcc tgttggtatt cacaaagatg ctttttattt
      841 ttaacttctt gttttcccca cttccaactc cggccctgat ctgcctcctg acgtttggaa
      901 cggccatctt cctgtggctg atcaacagac ctcagccagt tttacctctc attgacttgg
      961 acaaccagtc tgtggggatt gagggaggag cacggagggg cgctttccag aagaacaatg
     1021 acctaatcct ttattacttc tcagacgcca agacgttgta tgaaaatttc caaagaggac
     1081 ttgctgtgtc tgacaatggg ccttgcttgg gatacagaaa gccaaaccag ccctacaaat
     1141 ggatctccta caaacaggtg tctgatcgag cagagtacct gggctcctgt cttttgcata
     1201 aaggatataa gtcatcacag gaccaatttg ttggcatctt tgctcaaaat aggccagagt
     1261 gggtcatctc tgagttagcc tgttacacat attccatggt agctgtcccc ctgtatgaca
     1321 cgctgggtac agaagccatc atctttgtca tcaacagggc tgatatccct gtggtcatct
     1381 gtgatacacc ccaaaaggca acaatgctag tagaaaatgt ggaaaagggc ctcacaccag
     1441 gcctgaagac gatcatcctc atggaccctt ttgatgacga cctgatgaaa agaggagaaa
     1501 agtgtggagt tgagatgtta tccctgcatg atgcggagaa tataggcaaa gagaacttca
     1561 aaaaaccagt gcctccgaag ccagaggatc tgagcgtcat ctgtttcacc agtggaacta
     1621 caggtgaccc caaaggagct atgctaaccc atgaaaatgt tgtttcaaac atggctgctt
     1681 tcctcaaatt tctggagcct atcttccagc ccacctctga tgatgtgacc atatcctacc
     1741 ttcccttggc tcatatgttt gagaggcttg tccagggtat cttattttcc tgtggaggca
     1801 aaattgggtt cttccaagga gatatccggt tgctacctga tgacatgaag gctttgaaac
     1861 ccacagtgtt tcctacagtg cctcgactcc ttaacagggt ctatgataag gtacaaaatg
     1921 aagccaagac acctttgaag aagttcttgt tgaacttggc tatcatcagt aaattcaatg
     1981 aagtgaaaaa tggcatcatt cggcgggaca gtttgtggga caagctcgtg ttttcaaaga
     2041 ttcaaggaag cctggggggg aaggttcgcc tcatgatcac tggagccgcc cccatctcca
     2101 ctccagtctt gacattcttc agggctgcaa tgggatgttg ggtgtttgaa gcttatggcc
     2161 aaacagaatg cacaggtgga tgttcaatta catcacctgg ggactggaca gcaggtcatg
     2221 ttgggactcc agtggcttgc aattttgtaa agctggaaga tgtggctgac atgaactact
     2281 tttcagtaaa caacgaaggc gagatctgca tcaaaggtaa caatgtgttc aaaggctacc
     2341 taaaggaccc agagaaaaca caggaagtac tggacaagga tggatggctt cacactgggg
     2401 acattggtcg ctggcttcca aatggaactc tgaaaattgt tgaccggaag aagaatattt
     2461 tcaagttggc acaaggagaa tacattgccc cagagaagat tgaaaatgtt tattccagga
     2521 gcagaccagt attgcaagtt tttgtccatg gggagagctt acggtcattc ctgatcggag
     2581 tggtggttcc cgacccagat tcacttccct catttgcagc caagatcggg gtaaagggat
     2641 catttgaaga actgtgcaaa aaccaatgtg taaaggaagc cattttagaa gacttgcaga
     2701 aaattgggaa agagggtggc ctgaaatcct ttgagcaggt caaaagtatc tttgtgcatc
     2761 cagagccctt cactattgaa aacggacttc tgacaccgac actgaaagcc aaacgagtag
     2821 agcttgccaa gttcttccag acacaaatca agagcctcta tgagagcatc gaggagtagt
     2881 agcttaagtt tgctgagctg gaagctgtgg gggaagaagt ggaaactatg tccagtgaac
     2941 ttttccagta aatgaagcaa gcactaaagt actgtcctga gttgggaaca aagcactgtg
     3001 ggcaaggtcg atgcaatgcc tgcactacag gcctgtcttc tgtggatctc tctccttggc
     3061 cttcagtccc tgcagtattt tactgtcaga tagcatgtgg tgcctctact tgtaaatgtc
     3121 aaatctttga aataaactat tacagatatt aaaaaaaaaa aaaaaaa
//
