LOCUS       NM_207625               5280 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus acyl-CoA synthetase long-chain family member 4
            (Acsl4), transcript variant 1, mRNA.
ACCESSION   NM_207625
VERSION     NM_207625.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5280)
  AUTHORS   Qiu,Y., Wang,X., Sun,Y., Jin,T., Tang,R., Zhou,X., Xu,M., Gan,Y.,
            Wang,R., Luo,H., Liu,M. and Tang,X.
  TITLE     ACSL4-Mediated Membrane Phospholipid Remodeling Induces Integrin
            beta1 Activation to Facilitate Triple-Negative Breast Cancer
            Metastasis
  JOURNAL   Cancer Res 84 (11), 1856-1871 (2024)
   PUBMED   38471082
  REMARK    GeneRIF: ACSL4-Mediated Membrane Phospholipid Remodeling Induces
            Integrin beta1 Activation to Facilitate Triple-Negative Breast
            Cancer Metastasis.
REFERENCE   2  (bases 1 to 5280)
  AUTHORS   Zhang,H., Sun,Q., Dong,H., Jin,Z., Li,M., Jin,S., Zeng,X., Fan,J.
            and Kong,Y.
  TITLE     Long-chain acyl-CoA synthetase-4 regulates endometrial
            decidualization through a fatty acid beta-oxidation pathway rather
            than lipid droplet accumulation
  JOURNAL   Mol Metab 84, 101953 (2024)
   PUBMED   38710444
  REMARK    GeneRIF: Long-chain acyl-CoA synthetase-4 regulates endometrial
            decidualization through a fatty acid beta-oxidation pathway rather
            than lipid droplet accumulation.
REFERENCE   3  (bases 1 to 5280)
  AUTHORS   Li,Y., Fu,W., Xiang,J., Ren,Y., Li,Y., Zhou,M., Yu,J., Luo,Z.,
            Liu,E., Fu,Z., Liu,B. and Ding,F.
  TITLE     Long-chain acyl-CoA synthetase 4-mediated mitochondrial fatty acid
            metabolism and dendritic cell antigen presentation
  JOURNAL   Inflamm Res 73 (5), 819-839 (2024)
   PUBMED   38472395
  REMARK    GeneRIF: Long-chain acyl-CoA synthetase 4-mediated mitochondrial
            fatty acid metabolism and dendritic cell antigen presentation.
REFERENCE   4  (bases 1 to 5280)
  AUTHORS   Kao,Y.R., Chen,J., Kumari,R., Ng,A., Zintiridou,A., Tatiparthy,M.,
            Ma,Y., Aivalioti,M.M., Moulik,D., Sundaravel,S., Sun,D.,
            Reisz,J.A., Grimm,J., Martinez-Lopez,N., Stransky,S., Sidoli,S.,
            Steidl,U., Singh,R., D'Alessandro,A. and Will,B.
  TITLE     An iron rheostat controls hematopoietic stem cell fate
  JOURNAL   Cell Stem Cell 31 (3), 378-397 (2024)
   PUBMED   38402617
REFERENCE   5  (bases 1 to 5280)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 5280)
  AUTHORS   Kim,D., Reilly,A. and Lawrence,D.A.
  TITLE     Relationships between IFNgamma, IL-6, corticosterone, and Listeria
            monocytogenes pathogenesis in BALB/c mice
  JOURNAL   Cell Immunol 207 (1), 13-18 (2001)
   PUBMED   11161448
REFERENCE   7  (bases 1 to 5280)
  AUTHORS   Cho,Y.Y., Kang,M.J., Ogawa,S., Yamashita,Y., Fujino,T. and
            Yamamoto,T.T.
  TITLE     Regulation by adrenocorticotropic hormone and arachidonate of the
            expression of acyl-CoA synthetase 4, an arachidonate-preferring
            enzyme expressed in steroidogenic tissues
  JOURNAL   Biochem Biophys Res Commun 274 (3), 741-745 (2000)
   PUBMED   10924347
REFERENCE   8  (bases 1 to 5280)
  AUTHORS   Cao,Y., Murphy,K.J., McIntyre,T.M., Zimmerman,G.A. and
            Prescott,S.M.
  TITLE     Expression of fatty acid-CoA ligase 4 during development and in
            brain
  JOURNAL   FEBS Lett 467 (2-3), 263-267 (2000)
   PUBMED   10675551
REFERENCE   9  (bases 1 to 5280)
  AUTHORS   Li,Z., Jiang,H., Xie,W., Zhang,Z., Smrcka,A.V. and Wu,D.
  TITLE     Roles of PLC-beta2 and -beta3 and PI3Kgamma in
            chemoattractant-mediated signal transduction
  JOURNAL   Science 287 (5455), 1046-1049 (2000)
   PUBMED   10669417
REFERENCE   10 (bases 1 to 5280)
  AUTHORS   Vitelli,F., Meloni,I., Fineschi,S., Favara,F., Tiziana
            Storlazzi,C., Rocchi,M. and Renieri,A.
  TITLE     Identification and characterization of mouse orthologs of the
            AMMECR1 and FACL4 genes deleted in AMME syndrome: orthology of
            Xq22.3 and MmuXF1-F3
  JOURNAL   Cytogenet Cell Genet 88 (3-4), 259-263 (2000)
   PUBMED   10828604
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB857663.1, AB033886.1 and AL731672.12.
            
            On Sep 21, 2005 this sequence version replaced NM_207625.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033886.1, SRR1660815.197379.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               BB857663.1         2-192
            192-1321            AB033886.1         1-1130
            1322-1389           AL731672.12        151258-151325       c
            1390-1461           AB033886.1         1199-1270
            1462-1513           AL731672.12        151025-151076       c
            1514-1748           AB033886.1         1323-1557
            1749-1898           AL731672.12        146835-146984       c
            1899-2210           AB033886.1         1708-2019
            2211-2280           AL731672.12        136799-136868       c
            2281-2569           AB033886.1         2090-2378
            2570-5280           AL731672.12        125944-128654       c
FEATURES             Location/Qualifiers
     source          1..5280
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 63.12 cM"
     gene            1..5280
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /note="acyl-CoA synthetase long-chain family member 4"
                     /db_xref="GeneID:50790"
                     /db_xref="MGI:MGI:1354713"
     exon            1..231
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     exon            232..281
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     exon            282..811
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     CDS             461..2596
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /note="isoform 1 is encoded by transcript variant 1; fatty
                     acid-Coenzyme A ligase, long chain 4;
                     long-chain-fatty-acid--CoA ligase 4; mACS4; LACS 4;
                     long-chain acyl-CoA synthetase 4; arachidonate--CoA
                     ligase"
                     /codon_start=1
                     /product="long-chain-fatty-acid--CoA ligase 4 isoform 1"
                     /protein_id="NP_997508.1"
                     /db_xref="CCDS:CCDS30448.1"
                     /db_xref="GeneID:50790"
                     /db_xref="MGI:MGI:1354713"
                     /translation="MNLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAK
                     RIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVAKFGKKDSLGTREIL
                     SEENEMQPNGKVFKKLILGNYKWINYLEVNCRVNNFGSGLTALGLKPKNTIAIFCETR
                     AEWMIAAQTCFKYNFPLVTLYATLGREAVVHGLNESEASYLITSVELLESKLKAALVD
                     INCVKHIIYVDNKTINRAEYPEGLEIHSMQSVEELGAKPENLSVPPSRPTPSDMAIVM
                     YTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCF
                     TYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEM
                     NYVQKTLFKIGYDYKLEQIKKGYDAPLCNLILFKKVKALLGGNVRMMLSGGAPLSPQT
                     HRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYT
                     VHDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYCVDENGQRWFCTGDIGEFHPDGCLQ
                     IIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKKLT
                     LLAQQKGVEGSWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPET
                     GLVTDAFKLKRKELKNHYLKDIERMYGGK"
     exon            812..989
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1099
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1238
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1389
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1513
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1585
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1725
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1898
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..1973
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     exon            1974..2165
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2280
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2438
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..5280
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5258..5263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /note="hexamer: AATAAA"
     polyA_site      5280
                     /gene="Acsl4"
                     /gene_synonym="9430020A05Rik; ACS4; Facl4; Lacs4"
                     /note="major polyA site"
ORIGIN      
        1 cttttccggg ctcgcgccgg accccgcctc cgctggctgt ccgggttgcg cgcgcgccgc
       61 tgcggctctc tccctctctc tctctttttt tttccactgg tctccgcggc tcgcccctcc
      121 ttgccaggca gctccagagc tagcgggcac gcgagctcct ctccaggagc ttccttcctc
      181 ttaaggccgg gacccagtgg cagactcgta gcgagcgagg cagcaccttc gactcagatc
      241 acaggagata cacctgttct taaaagtgaa agaagaaatc tgtgtacttt attgctggct
      301 tccaaagatt actaactttt atctgtatca ctaaaattga attcccttgg ctatactgct
      361 actcttactg ctgcttccat tattgccttc tccaaaaacc taaggcttta agaagccaaa
      421 gaataacagc aaataaacgc catattagaa gccttccact atgaacctta agctaaatgt
      481 gctcaccatt atattgctgc ctgtccactt gttaataaca atatacagtg cccttatatt
      541 tattccatgg tattttctta ccaatgccaa gaagaaaaac gctatggcaa agagaataaa
      601 agctaagccc acttcagaca aacctggaag tccatatcgc tctgtcacac acttcgactc
      661 actagctgtc atagacatcc ctggagcaga tactctggat aaattatttg accatgctgt
      721 agccaaattt gggaagaagg acagccttgg aacccgggag atcctgagtg aagaaaatga
      781 aatgcagcca aatggaaagg tttttaagaa gttaattctt gggaattata aatggataaa
      841 ctatcttgaa gtgaactgca gagtgaataa ctttggaagt ggcctcactg cattgggact
      901 gaaaccaaag aacaccattg ccattttctg tgagaccagg gcagagtgga tgattgcagc
      961 acagacttgc tttaagtaca actttccact tgtgacttta tatgccacac ttggcagaga
     1021 agctgtagtt catggattaa atgaatctga ggcttcctat ctgattacta gtgttgagct
     1081 tctggaaagc aaactgaagg cggccttagt agatatcaat tgtgttaaac atatcattta
     1141 tgtggataat aagactatca atagagcaga gtaccctgag gggcttgaaa ttcacagcat
     1201 gcaatcagta gaggagctgg gagccaagcc agaaaacttg agcgttcctc caagtagacc
     1261 aaccccttca gacatggcca ttgtcatgta caccagtggt tctacgggcc gccccaaggg
     1321 agtgatgatg catcatagca atttgattgc tggaatgaca ggccagtgtg aacgtatccc
     1381 tggactagga ccgaaggaca catatattgg ctacttacct ttggctcatg tgctggaact
     1441 gacagcagag atatcatgct ttacctatgg ctgtaggatt ggatactctt caccccttac
     1501 actgtctgac cagtccagca aaatcaagaa gggaagcaag ggtgattgta ctgtactgaa
     1561 acccacactt atggccgctg ttccggaaat catggataga atttataaga atgttatgag
     1621 caaggttcaa gagatgaatt atgttcagaa aactctattt aaaatcgggt atgattacaa
     1681 attagagcaa atcaagaaag gctatgacgc ccctctttgt aatctgatac tgtttaaaaa
     1741 ggtgaaggct ctgctgggag ggaatgtccg catgatgctg tctggcggcg cgccactgtc
     1801 ccctcagaca caccgattca tgaatgtctg cttctgctgc cccattggtc agggatatgg
     1861 gctgacagaa tcatgtggtg ctggaacagt tactgaagtt actgactaca ctactggaag
     1921 agttggagct cctcttattt gctgtgaaat taaactgaaa gactggcagg aaggtggtta
     1981 tacagttcat gataagccga accccagagg tgagattgtg atcggtggcc agaatatctc
     2041 catgggatat tttaaaaacg aagagaaaac agcagaagat tattgtgttg atgaaaatgg
     2101 acaaaggtgg ttttgcactg gcgatattgg agaattccat cctgatggat gcttacagat
     2161 tatagatcgt aagaaagatc tggtaaagtt acaagcagga gaatatgtat ctcttgggaa
     2221 agtagaagct gcactgaaga attgtccact gatcgacaac atctgtgctt ttgccaaaag
     2281 tgaccagtcc tatgtgatca gttttgtggt tcctaaccag aaaaagttga ctcttttggc
     2341 acaacagaag ggggtagaag gatcttgggt tgatatttgc aataatcccg ccatggaagc
     2401 tgaaatactg aaagaaattc gagaagctgc aaatgccatg aaattggagc gatttgaaat
     2461 tccgatcaag gttcggttaa gcccagagcc atggaccccc gagactggtt tggtaacaga
     2521 tgccttcaag ctgaaaagga aggagttgaa gaaccattat ctcaaagaca ttgagcgaat
     2581 gtatgggggc aaataaaatg cggctctctg atttccattt gcacaggagg tggcctgatg
     2641 gtttttagtt ctagagttta agcctttgtt gatctccttg ttagaatata aggtgtatct
     2701 tctaaagaca tgaaataaaa acaaccaaaa gtcgttaaaa tagttgagtc tactttaact
     2761 tgcatagtcc tagtgaagct gagattgcaa agacatttcc ctttagctgt gttaagttta
     2821 gagcagaaat tctgtttttt aaaagtagcc ttatataccc ttgtttttat gaagagaaga
     2881 tactccatgc taaagtaaag aaattggact tggaatagat agaattgaag aaatttacag
     2941 cttccagcgt ctatgtcttc ctagttcaga agtttctata ataatgatga caaaattatg
     3001 tattaacact actcaaagca gaagcgccac caggctttga aatcctcttc caaccattta
     3061 tcttgaaggg aaaaaagatc agtcataatg tatggtatca gtatcttaga aggtattatc
     3121 ttaagatcat aattgtcata taggtcagac atagagtcat tgcaatattg tgaataatta
     3181 cagtgcctga agttaagact aaaacaacac acacctacca aaaatatctc ataatgtaat
     3241 gaagggaagc tgagaactaa agccagcatc tgtaattatt taaatgtctt aaaaggaatg
     3301 ttcacttttt aaaagtgacc tttctgtgtg taatgtggtt aaagactgag tgagaccaat
     3361 gggaatgtgt tagaaagtca atcagaattc aacaagattc attgcctttc tgttagaacg
     3421 ctggtggaat cctacgtatt caaaattagg atccttgtgt agcactgaac ctgggaaaga
     3481 gatttagact tggaatttaa atttgataac agggcttggt tttcaaatgt gcttgtatta
     3541 aattacattt gtaatttatg gtctgcttgc tgttgctgat tgattgttga tcagtagtgt
     3601 gcatttcaga gagcctttca ttttgcttta atttcagcaa agcgggttat gatacatgac
     3661 ttcctcaaaa tcttgttcaa acctacgggt gattaaatgt cttggatgag cctggggaag
     3721 ttaaagggaa gaaaacactg ttaccacttt tcctgtttgt gaagagtttt agaaactgga
     3781 aatgctagat ttgggagaag ggcagagtta cttgattaag gactgtctgt gaagtaactt
     3841 ggagtgtgag tttctttttg aatctttagc taaagtctgg aattatatat tcttgataga
     3901 tattcgcact tggaccatag ttactgtaaa aagcaaaaat tcttaatact gttattcttt
     3961 gcactttttc ataatcattt tatacacaca cacacacata cacatgtgta tgtgtgtata
     4021 taatatatat atatatatgt tgcttccatt gcgttgtaca gatgtgggcc accactacaa
     4081 caaaatgagt tctttgtgct ctaaaatatt tataaagaaa ttatttaaat gttatgtata
     4141 tggtggtaat aacgaaaaaa aatcatctgg tgttataagc aacagcgaag gtttttgtaa
     4201 aagtttcttt tcagtgttct gcaaaataaa atttgaggca agttttccct gaagttatat
     4261 gtgagtattc tcatgctacc atcttgcctt tgaagcgtga aaagacatta attatcaagt
     4321 agactactat tcagcttcta cttcctccta gtgcactgtt tatccttcaa gggtgttttt
     4381 tttttttttt ttttaaggct tttccaatat atgtatccca tttggaatgg tgatcttaaa
     4441 atgtgagtgc atgcatacta tcttatttaa gatacttgca ccccacccac tcccatctcc
     4501 cgaagctgga acactgccaa ctaggtcctt aagaatcacg caattaacac aaggttgggt
     4561 gctgctaatt cttcatgaaa atccaaacac gttaagggac cagggagatg ccactgcccc
     4621 cctgaatttt catcaaaaat agacacgttt atgtaaacag aactattttc catattcata
     4681 gtgacttttt aagtatttga gcctaaagat tttgatctcc atttttataa ctatttaaat
     4741 tgttcacaat tattacatgt tagccatcaa ataaagctgt gcttactatt gattataagt
     4801 gtgtgcattt ctaagttgaa cactcatgat ttttgcttta attacacgaa agggttttat
     4861 ttctttgata tttgtactca ttttttttta agtagactga aggtatgatt gtctgatttt
     4921 ttagaaatga aatacagatg aaagattcat agagtccaaa gcgagggaga atcctgtttc
     4981 tttattcata gagactgact atatctttgg ctatattttc ctggtagcat atgacaaatg
     5041 tttctacagt gagaagctga gaacaggtta aaagattgtg tggcgtttgg gaactggaga
     5101 gatacatttt aattttgaat gtagttatac attttatatt catatttgta ttttctgtta
     5161 aaatgcacga ttgtaggatt gttccttaga tttttgtgtt gactcttgaa aagctttctt
     5221 tgttcttatt tttaagtttg cacttgaatc ttataaaaat aaatccaccc atgttatcaa
//
