LOCUS       NM_001409075            3972 bp    mRNA    linear   ROD 13-NOV-2024
DEFINITION  Mus musculus acyl-CoA synthetase long-chain family member 3
            (Acsl3), transcript variant 4, mRNA.
ACCESSION   NM_001409075
VERSION     NM_001409075.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3972)
  AUTHORS   Han,S., Guo,J., Kong,C., Li,J., Lin,F., Zhu,J., Wang,T., Chen,Q.,
            Liu,Y., Hu,H., Qiu,T., Cheng,F. and Zhou,J.
  TITLE     ANKRD1 aggravates renal ischaemia-reperfusion injury via promoting
            TRIM25-mediated ubiquitination of ACSL3
  JOURNAL   Clin Transl Med 14 (9), e70024 (2024)
   PUBMED   39285846
  REMARK    GeneRIF: ANKRD1 aggravates renal ischaemia-reperfusion injury via
            promoting TRIM25-mediated ubiquitination of ACSL3.
REFERENCE   2  (bases 1 to 3972)
  AUTHORS   Li,C., Zhang,Y., Shen,J., Bao,H., Zhao,Y., Li,D., Li,S., Liu,Y.,
            Yang,J., Zhou,Z., Gao,K., Zhao,L., Pei,Y., Lu,Y., Pan,Z. and Cai,B.
  TITLE     Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3
            of Structural, Metabolic, and Contractile Related Genes
  JOURNAL   Adv Sci (Weinh) 11 (11), e2305992 (2024)
   PUBMED   38196272
REFERENCE   3  (bases 1 to 3972)
  AUTHORS   Saliakoura,M., Sebastiano,M.R., Nikdima,I., Pozzato,C. and
            Konstantinidou,G.
  TITLE     Restriction of extracellular lipids renders pancreatic cancer
            dependent on autophagy
  JOURNAL   J Exp Clin Cancer Res 41 (1), 16 (2022)
   PUBMED   34998392
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3972)
  AUTHORS   Deng,Y., Zhou,C., Mirza,A.H., Bamigbade,A.T., Zhang,S., Xu,S. and
            Liu,P.
  TITLE     Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet dynamics
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1866 (7), 158923 (2021)
   PUBMED   33713834
  REMARK    GeneRIF: Rab18 binds PLIN2 and ACSL3 to mediate lipid droplet
            dynamics.
REFERENCE   5  (bases 1 to 3972)
  AUTHORS   Rossi Sebastiano,M., Pozzato,C., Saliakoura,M., Yang,Z., Peng,R.W.,
            Galie,M., Oberson,K., Simon,H.U., Karamitopoulou,E. and
            Konstantinidou,G.
  TITLE     ACSL3-PAI-1 signaling axis mediates tumor-stroma cross-talk
            promoting pancreatic cancer progression
  JOURNAL   Sci Adv 6 (44) (2020)
   PUBMED   33127675
  REMARK    GeneRIF: ACSL3-PAI-1 signaling axis mediates tumor-stroma
            cross-talk promoting pancreatic cancer progression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3972)
  AUTHORS   de Jong,H., Neal,A.C., Coleman,R.A. and Lewin,T.M.
  TITLE     Ontogeny of mRNA expression and activity of long-chain acyl-CoA
            synthetase (ACSL) isoforms in Mus musculus heart
  JOURNAL   Biochim Biophys Acta 1771 (1), 75-82 (2007)
   PUBMED   17197235
REFERENCE   7  (bases 1 to 3972)
  AUTHORS   Pei,Z., Fraisl,P., Berger,J., Jia,Z., Forss-Petter,S. and
            Watkins,P.A.
  TITLE     Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport
            protein 3 catalyzes fatty acid activation but not fatty acid
            transport in MA-10 cells
  JOURNAL   J Biol Chem 279 (52), 54454-54462 (2004)
   PUBMED   15469937
REFERENCE   8  (bases 1 to 3972)
  AUTHORS   Rohozinski,J. and Bishop,C.E.
  TITLE     The mouse juvenile spermatogonial depletion (jsd) phenotype is due
            to a mutation in the X-derived retrogene, mUtp14b
  JOURNAL   Proc Natl Acad Sci U S A 101 (32), 11695-11700 (2004)
   PUBMED   15289605
REFERENCE   9  (bases 1 to 3972)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3972)
  AUTHORS   Boettger-Tong,H.L., Rohozinski,J., Agoulnik,A.I., Dohmae,K.,
            Nishimune,Y., Levy,N. and Bishop,C.E.
  TITLE     Identification and sequencing the juvenile spermatogonial depletion
            critical interval on mouse chromosome 1 reveals the presence of
            eight candidate genes
  JOURNAL   Biochem Biophys Res Commun 288 (5), 1129-1135 (2001)
   PUBMED   11700028
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156613.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.896413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AC156613.9         95466-95686         c
            222-361             AC156613.9         90289-90428         c
            362-779             AC156613.9         71559-71976         c
            780-957             AC156613.9         65155-65332         c
            958-1067            AC156613.9         63191-63300         c
            1068-1206           AC156613.9         61349-61487         c
            1207-1357           AC156613.9         59223-59373         c
            1358-1435           AC156613.9         58430-58507         c
            1436-1559           AC156613.9         57365-57488         c
            1560-1631           AC156613.9         57069-57140         c
            1632-1771           AC156613.9         56540-56679         c
            1772-1944           AC156613.9         54401-54573         c
            1945-2019           AC156613.9         53739-53813         c
            2020-2211           AC156613.9         52109-52300         c
            2212-2326           AC156613.9         49969-50083         c
            2327-2484           AC156613.9         48178-48335         c
            2485-3972           AC156613.9         45824-47311         c
FEATURES             Location/Qualifiers
     source          1..3972
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 40.84 cM"
     gene            1..3972
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /note="acyl-CoA synthetase long-chain family member 3"
                     /db_xref="GeneID:74205"
                     /db_xref="MGI:MGI:1921455"
     exon            1..221
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     exon            222..361
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     exon            362..779
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..2642
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.2"
                     /EC_number="6.2.1.15"
                     /note="isoform c is encoded by transcript variant 4; fatty
                     acid Coenzyme A ligase, long chain 3;
                     long-chain-fatty-acid--CoA ligase 3; long-chain acyl-CoA
                     synthetase 3; arachidonate--CoA ligase; medium-chain
                     acyl-CoA ligase Acsl3; fatty acid CoA ligase Acsl3"
                     /codon_start=1
                     /product="fatty acid CoA ligase Acsl3 isoform c"
                     /protein_id="NP_001396004.1"
                     /db_xref="GeneID:74205"
                     /db_xref="MGI:MGI:1921455"
                     /translation="MNNHVSSTPSTMKLKQTINPILLYFIHFIISLYTILTYIPFYFL
                     CESKQEKPNQIKAKPVSSKPDSAYRSINSVDGLASVLYPGCDTLDKVFMYAKNKFKNK
                     RLLGTREILNEEDEIQPNGKIFKKVILGHYNWLSYEDVFIRALDFGNGLQMLGQKPKA
                     NIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHGLNETEVTNIITSKELLQ
                     TKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGVIVHTMAAVQALGVKANVEKKAHSKP
                     LPSDIAVIMYTSGSTGIPKGVMISHSNIIASITGMARRIPRLGQITGHEPAAAVELWR
                     NRKVHQPASLREEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKK
                     GSKGDTSVLKPTLMAAVPEIMDRIYKNVMNKVNEMSAFQRNLFILAYNYKMEQISKGC
                     STPLCDRFVFRNVRRLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESTG
                     AGTITEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQNVTMGYY
                     KNEAKTKTDFFEDENGQRWLCTGDIGEFDPDGCLKIIDRKKDLVKLQAGEYVSLGKVE
                     AALKNLPLIDNICAYANSYHSYVIGFVVPNQKELTELARTKGFKGTWEELCNSSEMEN
                     EVLKVLSEAAISASLEKFEIPLKIRLSPDPWTPETGLVTDAFKLKRKELKTHYQADIE
                     RMYGRK"
     exon            780..957
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1067
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1206
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1357
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1435
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1559
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1631
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1771
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1944
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2019
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2211
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2326
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2484
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..3972
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3176..3181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /note="hexamer: AATAAA"
     regulatory      3180..3185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /note="hexamer: AATATA"
     polyA_site      3195
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /note="major polyA site"
     polyA_site      3203
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /note="major polyA site"
     regulatory      3947..3952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
                     /note="hexamer: AATAAA"
     polyA_site      3972
                     /gene="Acsl3"
                     /gene_synonym="2610510B12Rik; Acs3; Facl3; LACS 3;
                     Pro2194"
ORIGIN      
        1 agacgctgct cagccggcgc ccgggaaacg tcgctgcggt tgtggccgcg gtcgcgggct
       61 cggacgagga ggcggcggca gagcgggagg ctgagccggc agcaggcggt cgtccccgtc
      121 tcgcagggcg gccccagcag ctgcgtcagg gtcctgagga ggtggcgctg ggcaggagcc
      181 gctctgagga gcagccaggc ctgcgtgggt cggagcccgc gggtcttact gtttactcct
      241 tgaacttgct gtgaggctca ggttggcctt gaacttgaga tccatctgtc ttagcctcct
      301 gagtggcata tcaccaactt tgggttgctg agtggattgc catccgtgta tataacactt
      361 gattctcatt gaaatctgtt aattctattt tttgaacact tatgaataac cacgtatctt
      421 caacaccatc aaccatgaag ctaaaacaaa ccatcaaccc catactttta tatttcatac
      481 attttataat atcactctat actattttaa catacatccc attttatttt ttgtgtgagt
      541 caaaacaaga gaaaccaaac caaattaaag caaaacctgt cagttccaaa ccggactctg
      601 catacagatc tatcaacagt gtggatggct tggcttcagt gctgtatcct ggctgcgata
      661 cacttgataa agtctttatg tatgcaaaaa acaaatttaa aaacaaaaga ctattgggaa
      721 cacgtgaaat tttaaatgag gaagatgaaa tacagccaaa tggaaaaatt tttaaaaagg
      781 ttattctggg gcactataat tggctttcct atgaagatgt cttcatccga gcccttgact
      841 ttggaaatgg gttacaaatg ttgggccaga aaccaaaggc caacatcgcc atcttctgtg
      901 agaccagggc tgagtggatg atcgctgcac aggcgtgttt tatgtataac ttccagcttg
      961 ttacactgta tgctactctg ggaggtccag ccattgttca tggactgaat gagacagagg
     1021 tgaccaacat cattactagc aaagaactct tgcaaacaaa gctgaaggat atagtctctt
     1081 tggtcccacg tctgcggcat atcattactg ttgatgggaa gcctccaacc tggtctgagt
     1141 tccccaaagg tgtcattgta cacaccatgg ctgcagtgca ggctctagga gtgaaggcca
     1201 acgtggaaaa gaaagctcac agcaaaccac tgccctcaga tattgcagta atcatgtaca
     1261 caagtgggtc cacaggaatt ccaaagggag tcatgatctc acacagcaac atcattgctt
     1321 ctataacggg gatggcgaga aggattccaa gactggggca gatcaccggg cacgaaccag
     1381 cagctgcagt tgaattgtgg agaaaccgca aggttcacca accggccagc ctgagagagg
     1441 aagatgtgta tattggctac ttgcccctgg cacatgttct agaattaagt gctgagcttg
     1501 tgtgtctttc tcatggatgc cgaatcggct actcttcacc acagacatta gcagatcagt
     1561 cttcaaaaat aaaaaaagga agcaaaggag acacatccgt gctgaagcca acactgatgg
     1621 cagctgttcc ggaaatcatg gatcggatct acaaaaatgt catgaataaa gtgaatgaaa
     1681 tgagtgcttt tcaacgaaac ttgtttattt tggcatataa ttataagatg gaacagattt
     1741 caaaagggtg tagtactcca ctgtgtgacc gctttgtttt ccggaatgtc cgaaggctgc
     1801 tgggtggaaa tattcgcctt ttactgtgtg gtggtgctcc gctttctgca acaacgcagc
     1861 gattcatgaa tatctgtttc tgctgtcccg ttggtcaggg gtatggactc acagaatcta
     1921 ctggggctgg aacaattaca gaagtgtggg actacaatac cggcagagtg ggagcaccat
     1981 tagtttgctg tgaaatcaaa ttaaagaact gggaggaagg tggctatttt aatactgaca
     2041 aaccacatcc cagaggtgaa attcttattg gtggccaaaa tgtgacaatg gggtactaca
     2101 aaaatgaagc aaaaacaaag acagatttct ttgaagatga aaatggacag cggtggctgt
     2161 gcactggaga tattggagag tttgaccctg acggctgtct gaagatcatt gaccgtaaaa
     2221 aggaccttgt gaaactacag gcaggagagt acgtttctct cgggaaagta gaggcagctt
     2281 tgaagaacct cccactgata gataacattt gtgcgtatgc aaacagctac cattcttacg
     2341 taattgggtt tgttgtgcca aatcaaaagg aacttacaga gctagctaga acaaaaggat
     2401 ttaaaggaac ttgggaagag ctgtgtaaca gcagcgagat ggaaaatgag gtccttaaag
     2461 tgctttctga agctgctatt tcagcaagtc tggaaaagtt tgaaattcca ctaaaaatac
     2521 gtttgagccc tgacccatgg actcccgaaa ctggtctggt gacagatgcc ttcaagttga
     2581 aacgtaaaga gcttaaaaca cactaccagg cagacattga gcggatgtat ggaagaaaat
     2641 aattagtttt ggcattggtt tgctacagcg agctcagatc aaataggaaa atacttgaaa
     2701 tgtatgtctc gggccgaggc aaactccatt cctcatatta aatcccggct gttacttctc
     2761 actacgtcac catttttaac tgacaggatt agtaaagtat taagacagca aactcgtgtc
     2821 tgtctgttcc ttcccctgct ccagtttgct tctggcatct gtgactgtgc ttgtcaacag
     2881 gagacttttt cagaatcgta ctggggaagc agcgatttta cagcctcaag tttttaaaca
     2941 tgatttatat gttctgtaca gttgttcagt ttgtaacttt ttaaagtttg gatgtataga
     3001 aggataaata ggaaatataa aaattggtta tttggggggc ttttttactt attgtattta
     3061 aaaataaaag ggtatcaatg tgaaattatg tacattttaa atgcttatga atcaagtcat
     3121 tgttgaacaa aagatttgtt gctgtgtaat tattgtcttg tatgcatttg agagaaataa
     3181 atatactcag acttatgttt taagaaattt cgaatatatg cctgacactg ttgggtttat
     3241 atacttgctt tttctgttgg ggaaaacagt ttgcttggca ctgcattgaa gtgaaagagc
     3301 aagtaggggt acataacagt tcactcacag agcagctcac cacagagcag cggtggccat
     3361 gggtgtggtg gtgggtgagg ggaaccaggg ctctggagtt tcgctcacat cacaaagtac
     3421 ttgtttagag acatcctagg acagtgttct ctgtgttctc gtatgttgtg tgttggacag
     3481 ttttgtcctt gttgaaattt aactcttacc tttggagaaa ctttgtaaag gaggggaagt
     3541 gtgttaatac taggagccga aaatttacca tggttgctgg agagcatttg tgtctgcctg
     3601 atggcttgcc ttcagaatga ttgtgttaaa atatttttat aaaaatgatt taagtcacgt
     3661 gtgtatgtgt gcatgcagtg attaaagatg tcagaagggg gcgtctgatc ctctgaaatg
     3721 agttaaaagc tgtggtgaac caaattctac tttctgtaag actggagcat gctcttaaat
     3781 gctgagctgt cgttccagca ctctttcaaa ggatttgttt ttctttttta aaaaatagaa
     3841 tgtaagtaag cttcaatgct tttggaaaga tactaacaat tgtgacttga aatgtcagct
     3901 taaaaggcag tgtctcacca gtacagtaat ggctgattga acagcaaata aagctggtta
     3961 gtccgcatca ga
//
