LOCUS       NM_001302163            3927 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus acyl-CoA synthetase long-chain family member 1
            (Acsl1), transcript variant 1, mRNA.
ACCESSION   NM_001302163 XM_006509263
VERSION     NM_001302163.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3927)
  AUTHORS   Dong H, Zhong W, Zhang W, Hao L, Guo W, Yue R, Sun X, Sun Z,
            Bataller R and Zhou Z.
  TITLE     Loss of long-chain acyl-CoA synthetase 1 promotes hepatocyte death
            in alcohol-induced steatohepatitis
  JOURNAL   Metabolism 138, 155334 (2023)
   PUBMED   36349655
  REMARK    GeneRIF: Loss of long-chain acyl-CoA synthetase 1 promotes
            hepatocyte death in alcohol-induced steatohepatitis.
REFERENCE   2  (bases 1 to 3927)
  AUTHORS   Thevkar-Nagesh P, Habault J, Voisin M, Ruff SE, Ha S, Ruoff R, Chen
            X, Rawal S, Zahr T, Szabo G, Rogatsky I, Fisher EA and Garabedian
            MJ.
  TITLE     Transcriptional regulation of Acsl1 by CHREBP and NF-kappa B in
            macrophages during hyperglycemia and inflammation
  JOURNAL   PLoS One 17 (9), e0272986 (2022)
   PUBMED   36054206
  REMARK    GeneRIF: Transcriptional regulation of Acsl1 by CHREBP and NF-kappa
            B in macrophages during hyperglycemia and inflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3927)
  AUTHORS   Li Y, Yang M, Tan J, Shen C, Deng S, Fu X, Gao S, Li H, Zhang X and
            Cai W.
  TITLE     Targeting ACSL1 promotes cardiomyocyte proliferation and cardiac
            regeneration
  JOURNAL   Life Sci 294, 120371 (2022)
   PUBMED   35122795
  REMARK    GeneRIF: Targeting ACSL1 promotes cardiomyocyte proliferation and
            cardiac regeneration.
REFERENCE   4  (bases 1 to 3927)
  AUTHORS   Rubinow KB, Wall VZ, Nelson J, Mar D, Bomsztyk K, Askari B, Lai MA,
            Smith KD, Han MS, Vivekanandan-Giri A, Pennathur S, Albert CJ, Ford
            DA, Davis RJ and Bornfeldt KE.
  TITLE     Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and
            lipopolysaccharide and is required for phospholipid turnover in
            stimulated macrophages
  JOURNAL   J Biol Chem 288 (14), 9957-9970 (2013)
   PUBMED   23426369
  REMARK    GeneRIF: Acyl-CoA synthetase 1 is induced by Gram-negative bacteria
            and lipopolysaccharide and is required for phospholipid turnover in
            stimulated macrophages
REFERENCE   5  (bases 1 to 3927)
  AUTHORS   Ellis JM, Mentock SM, Depetrillo MA, Koves TR, Sen S, Watkins SM,
            Muoio DM, Cline GW, Taegtmeyer H, Shulman GI, Willis MS and Coleman
            RA.
  TITLE     Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty
            Acid oxidation and induces cardiac hypertrophy
  JOURNAL   Mol Cell Biol 31 (6), 1252-1262 (2011)
   PUBMED   21245374
  REMARK    GeneRIF: Acsl1 is required for heart fatty acid oxidation.
            Heart-specific Acsl1 deficiency causes cardiac hypertrophy.
REFERENCE   6  (bases 1 to 3927)
  AUTHORS   Li LO, Ellis JM, Paich HA, Wang S, Gong N, Altshuller G, Thresher
            RJ, Koves TR, Watkins SM, Muoio DM, Cline GW, Shulman GI and
            Coleman RA.
  TITLE     Liver-specific loss of long chain acyl-CoA synthetase-1 decreases
            triacylglycerol synthesis and beta-oxidation and alters
            phospholipid fatty acid composition
  JOURNAL   J Biol Chem 284 (41), 27816-27826 (2009)
   PUBMED   19648649
  REMARK    GeneRIF: Results describe a knock-out model of acyl-CoA
            synthetase-1 (ACSL1) and its effects in liver and in whole body
            metabolism.
REFERENCE   7  (bases 1 to 3927)
  AUTHORS   de Jong H, Neal AC, Coleman RA and Lewin TM.
  TITLE     Ontogeny of mRNA expression and activity of long-chain acyl-CoA
            synthetase (ACSL) isoforms in Mus musculus heart
  JOURNAL   Biochim Biophys Acta 1771 (1), 75-82 (2007)
   PUBMED   17197235
REFERENCE   8  (bases 1 to 3927)
  AUTHORS   Carninci P, Waki K, Shiraki T, Konno H, Shibata K, Itoh M, Aizawa
            K, Arakawa T, Ishii Y, Sasaki D, Bono H, Kondo S, Sugahara Y, Saito
            R, Osato N, Fukuda S, Sato K, Watahiki A, Hirozane-Kishikawa T,
            Nakamura M, Shibata Y, Yasunishi A, Kikuchi N, Yoshiki A, Kusakabe
            M, Gustincich S, Beisel K, Pavan W, Aidinis V, Nakagawara A, Held
            WA, Iwata H, Kono T, Nakauchi H, Lyons P, Wells C, Hume DA,
            Fagiolini M, Hensch TK, Brinkmeier M, Camper S, Hirota J, Mombaerts
            P, Muramatsu M, Okazaki Y, Kawai J and Hayashizaki Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (bases 1 to 3927)
  AUTHORS   Schaffer JE and Lodish HF.
  TITLE     Expression cloning and characterization of a novel adipocyte long
            chain fatty acid transport protein
  JOURNAL   Cell 79 (3), 427-436 (1994)
   PUBMED   7954810
REFERENCE   10 (bases 1 to 3927)
  AUTHORS   Weiner FR, Smith PJ, Wertheimer S and Rubin CS.
  TITLE     Regulation of gene expression by insulin and tumor necrosis factor
            alpha in 3T3-L1 cells. Modulation of the transcription of genes
            encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1
  JOURNAL   J Biol Chem 266 (35), 23525-23528 (1991)
   PUBMED   1684180
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC138367.14, BY142492.1,
            BY094311.1, AK149406.1, AC119267.8 and BY393025.1.
            
            [WARNING] On Oct 11, 2023 this sequence was replaced by
            NM_001302163.2.
            
            On Oct 7, 2014 this sequence version replaced XM_006509263.1.
            
            Summary: The protein encoded by this gene belongs to a family of
            acyl coenzyme A synthetase proteins, which convert long chain fatty
            acids to acyl CoA products via an ATP-dependent pathway. This
            enzyme is enriched in heart, liver and adipose tissue, where it
            functions in lipid synthesis and mitochondrial and peroxisomal
            beta-oxidation. In addition, it is expressed in monocytes and
            macrophages where it appears to have a functionally distinct role
            in mediating inflammatory and innate immune responses. A pseudogene
            of this gene is found on chromosome 5. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161189.1, SRR10223971.8537.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC138367.14        125009-125017       c
            10-139              BY142492.1         2-131
            140-526             BY094311.1         1-387
            527-3866            AK149406.1         386-3725
            3867-3867           AC119267.8         186108-186108       c
            3868-3927           BY393025.1         342-401
FEATURES             Location/Qualifiers
     source          1..3927
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 26.36 cM"
     gene            1..3927
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /note="acyl-CoA synthetase long-chain family member 1"
                     /db_xref="GeneID:14081"
                     /db_xref="MGI:MGI:102797"
     exon            1..196
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            197..423
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..2328
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /EC_number="6.2.1.3"
                     /EC_number="6.2.1.15"
                     /EC_number="6.2.1.24"
                     /note="fatty acid Coenzyme A ligase, long chain 2;
                     long-chain acyl-CoA synthetase 1; acetyl-Coenzyme A
                     synthetase 1 (ADP forming); acetate-CoA ligase; acetyl-CoA
                     synthetase; phytanate--CoA ligase; arachidonate--CoA
                     ligase"
                     /codon_start=1
                     /product="long-chain-fatty-acid--CoA ligase 1"
                     /protein_id="NP_001289092.1"
                     /db_xref="CCDS:CCDS22291.1"
                     /db_xref="GeneID:14081"
                     /db_xref="MGI:MGI:102797"
                     /translation="MEVHELFRYFRMPELIDIRQYVRTLPTNTLMGFGAFAALTTFWY
                     ATRPKALKPPCDLSMQSVEIAGTTDGIRRSAVLEDDKLLVYYYDDVRTMYDGFQRGIQ
                     VSNNGPCLGSRKPNQPYEWISYKEVAELAECIGSGLIQKGFKPCSEQFIGLFSQNRPE
                     WVIVEQGCFSYSMVVVPLYDTLGADAITYIVNKAELSVIFADKPEKAKLLLEGVENKL
                     TPCLKIIVIMDSYGSDLVERGKKCGVEIISLKALEDLGRVNRVKPKPPEPEDLAIICF
                     TSGTTGNPKGAMITHQNIINDCSGFIKATESAFIASTDDVLISFLPLAHMFETVVECV
                     MLCHGAKIGFFQGDIRLLMDDLKVLQPTIFPVVPRLLNRMFDRIFGQANTSLKRWLLD
                     FASKRKEAELRSGIVRNNSLWDKLIFHKIQSSLGGKVRLMITGAAPVSATVLTFLRTA
                     LGCQFYEGYGQTECTAGCCLSLPGDWTAGHVGAPMPCNYVKLVDVEEMNYLASKGEGE
                     VCVKGANVFKGYLKDPARTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQG
                     EYIAPEKIENIYLRSEAVAQVFVHGESLQAFLIAVVVPDVESLPSWAQKRGLQGSFEE
                     LCRNKDINKAILDDLLKLGKEAGLKPFEQVKGIAVHPELFSIDNGLLTPTLKAKRPEL
                     RNYFRSQIDELYATIKI"
     exon            424..541
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            542..606
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..708
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..808
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            809..987
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1020
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1072
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1146
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1224
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1359
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1494
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1590
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1663
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1752
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1869
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2013
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2115
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2187
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..3899
                     /gene="Acsl1"
                     /gene_synonym="Acas; Acas1; Acs; Facl2; FACS; LACS 1;
                     LACS1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtctgcta gttaccttta gcccagtggg cagcggtgta ggactcggca tgtgacaaat
       61 gccctgaaag accttggcag gcctggtaag cacccgctga gctgccctgg cccccacccc
      121 acccccagcc tcactgccct tttctgattc tgctgcggtg tgtcacctag cagtcagctg
      181 tcggatggca cagatgaatt ctgcatagag aaccaccaac ccagaaccat ggaagtccat
      241 gaattgttcc ggtattttcg aatgccagag ctgattgaca ttcggcagta cgtgcgcacc
      301 cttccaacca acaccctcat ggggtttggg gcttttgcag cgctcaccac cttctggtat
      361 gccaccaggc ctaaggccct gaagccacca tgtgacctct ccatgcagtc agtggaaata
      421 gcgggtacca ctgatggtat tcgaagatca gcagtccttg aagatgacaa gctcttggtg
      481 tactactacg acgatgtcag aaccatgtac gatggcttcc agagggggat tcaggtgtca
      541 aataatggtc cttgtttagg ttctcggaag ccaaaccagc cctatgagtg gatttcctac
      601 aaagaggtgg cagaactggc tgagtgcata ggctccgggc tgatccagaa ggggttcaag
      661 ccttgctccg agcagttcat cggcctcttc tctcaaaaca gacccgagtg ggtgatcgtc
      721 gagcaaggat gcttctctta ctcaatggtg gtcgtcccgc tctatgacac ccttggagct
      781 gacgccatca cctacatagt gaacaaagct gaactctctg tgatttttgc tgacaagcca
      841 gaaaaagcca aactcttatt agaaggtgta gaaaacaagt taacaccatg ccttaaaatc
      901 atagtcatca tggactccta cggcagtgat ctggtggaac gaggcaagaa gtgtggggtg
      961 gaaatcatca gcctcaaagc tctggaggac cttggaagag tgaacagagt gaagcccaag
     1021 cctccagaac ccgaagatct tgcgataatt tgtttcacaa gtggaactac aggcaacccc
     1081 aaaggagcaa tgatcactca ccaaaacatt ataaacgact gctcaggttt tataaaagca
     1141 acagagagtg cattcatcgc ttccacagat gatgtgctga tatctttctt gcctctcgcc
     1201 catatgtttg agaccgttgt agagtgtgta atgctgtgtc atggagctaa gataggattt
     1261 ttccaaggag atatcaggct gcttatggac gacctcaagg tgcttcagcc caccatcttc
     1321 cctgtggttc ccaggctgct gaaccggatg ttcgacagaa tttttggaca agcaaacact
     1381 tccttgaagc gatggctgtt ggactttgcc tccaaaagga aagaggcgga gcttcgcagt
     1441 ggcatcgtca gaaacaacag cctgtgggat aaactcatct tccacaagat acagtcgagc
     1501 ctgggtggga aagtccggct gatgatcaca ggagcagccc cggtgtctgc cacagtgctg
     1561 acgtttctga ggacagcgct cggctgccag ttctatgaag gctacggaca gaccgagtgc
     1621 actgctggtt gctgcctgag cttgcccgga gactggacgg caggccatgt tggagccccc
     1681 atgccttgca attatgtaaa gcttgtggat gtggaagaaa tgaattacct ggcatccaag
     1741 ggcgagggtg aggtgtgtgt gaaaggggca aatgtgttca aaggctactt gaaagaccca
     1801 gcaagaacag ctgaagccct ggataaagat ggctggttac acacggggga cattggaaaa
     1861 tggctgccaa atggcacctt gaagattatc gacaggaaaa agcacatatt taaactagcc
     1921 caaggagagt acatagcacc agaaaagatt gaaaatatct acctgcggag tgaagccgtg
     1981 gcccaggtgt ttgtccacgg agaaagcttg caggcctttc tcatagcagt tgtggtaccc
     2041 gacgttgaga gcctaccgtc ctgggcacag aagagaggct tacaagggtc cttcgaagaa
     2101 ctgtgcagga acaaggatat caataaagct atcctggacg acttgttgaa acttgggaag
     2161 gaagccggtc tgaagccatt tgaacaggtc aaaggcattg ctgtgcaccc ggaattattt
     2221 tctattgaca acggccttct gactccaaca ctgaaggcga agaggccaga gctacggaac
     2281 tatttcaggt cgcagataga tgaactgtac gccaccatca agatctaacg tgaggaagga
     2341 tacttagaag aaatggcgca tctccacaat cctcctcgta ccaatggcct tcgagttggt
     2401 aactttgcct gcagcgagtg tgggaaagga aatgccctgc cgccggactt gtccacgggg
     2461 tcttaccata gggatagtcg agggcacgga acactgcctt acttacagtc acctgtgttg
     2521 cagcccatga tcccggggac acacaatttc caaaacgagc cttaaacatt gtaaagggga
     2581 acccataaaa gtgctaagtt atttaagact tcttcaacca ataaggtgga tgctacaagt
     2641 tctgtctcct gtttttctaa ctgaggggtt aggacttatt ctttctgata tgtctgctgc
     2701 ttgctgcgcg ttttgcagct gtctgctgct ctgaagagca ccgtacactg gaggaaagct
     2761 gtccctttaa gaacaactgt ccaggctgaa gaaagtcaca gtggaccaga ggttttcctt
     2821 ttgaacccct cctccccctt gcccctttcc ctcaccacct cacatacagt acactcacat
     2881 gacctttctg gtttgtaagg gttccacacg gtccctgttt gcgcctgctg gaacatgagg
     2941 ttttcagtaa actaaagagc agaccctctt cagaacatgt gggtgtccag tctcagaaag
     3001 aaaaaaaaaa tggcggctca ctcaaacgtt ctcagactcc tctccaaatc tggtctcctg
     3061 cctccctccc cctcgtccca ggggttataa gaaatcctgc cttagactct gcaatgaaga
     3121 tggtatttca aagaacgccc tggagcggcc atgctcaact gtgacatctc caccgctctc
     3181 cacctgctcc ctcgtggaag cagcccatgt tggtaatggc cactgggctc cctcgtggaa
     3241 gcagcccatg ttggtaacgg ccactgggct ccctcgtggt tttcctggca aatgataatg
     3301 cggtgattac cttgcttttt ttcccctccc agttaaactc aggcaaagca tgtcttcaaa
     3361 actatgtagg gagctgatat acatgggtac ttattaaaat ggacagtaac aagtaaatat
     3421 ccttattata caactacctg atttatgtga aatgcatttg acaagccaaa aatctgggat
     3481 gaagaaatct gaggggaata aaatcatacc ctgggattca cttcccaagg tatatatatt
     3541 ttttaagtta atttgggaaa ttaacagcat ttcactttac tgcaagtctt tgccacatcc
     3601 gacctatcca agctgttgtt tatacatttg aagccactgt tgttggctgt gtgacagtgc
     3661 gtgtgttatt gaagcacaac tgggtttgca ctaaagaatc atcattgtaa taacactatt
     3721 tggtagccta acttcatact cgtattctta attgcacagg aagtcgctaa tttgtcacaa
     3781 cggggttttg aatgtttgct ttcagtgttg gctatttcta tgttttataa accaaaacag
     3841 aatttccaaa aacaatgaag gaaaccaaaa taaatatttc tgcatttgga gtgagtggaa
     3901 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
