LOCUS       NM_144932               2256 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus acyl-CoA synthetase family member 3 (Acsf3), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_144932
VERSION     NM_144932.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2256)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2256)
  AUTHORS   Head,P.E., Myung,S., Chen,Y., Schneller,J.L., Wang,C., Duncan,N.,
            Hoffman,P., Chang,D., Gebremariam,A., Gucek,M., Manoli,I. and
            Venditti,C.P.
  TITLE     Aberrant methylmalonylation underlies methylmalonic acidemia and is
            attenuated by an engineered sirtuin
  JOURNAL   Sci Transl Med 14 (646), eabn4772 (2022)
   PUBMED   35613279
REFERENCE   3  (bases 1 to 2256)
  AUTHORS   Bowman,C.E., Rodriguez,S., Selen Alpergin,E.S., Acoba,M.G.,
            Zhao,L., Hartung,T., Claypool,S.M., Watkins,P.A. and Wolfgang,M.J.
  TITLE     The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for
            Mitochondrial Protein Malonylation and Metabolic Efficiency
  JOURNAL   Cell Chem Biol 24 (6), 673-684 (2017)
   PUBMED   28479296
  REMARK    GeneRIF: an essential role for ACSF3 in dictating the metabolic
            fate of mitochondrial malonate and malonyl-CoA in mammalian
            metabolism
REFERENCE   4  (bases 1 to 2256)
  AUTHORS   Menendez-Montes,I., Escobar,B., Palacios,B., Gomez,M.J.,
            Izquierdo-Garcia,J.L., Flores,L., Jimenez-Borreguero,L.J.,
            Aragones,J., Ruiz-Cabello,J., Torres,M. and Martin-Puig,S.
  TITLE     Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch
            Essential for Cardiac Maturation
  JOURNAL   Dev Cell 39 (6), 724-739 (2016)
   PUBMED   27997827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK141579.1, AK144352.1, BQ177632.1, BI135241.1 and AA104822.1.
            
            On Sep 20, 2016 this sequence version replaced NM_144932.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1077              AK141579.1         2-1078
            1078-1735           AK144352.1         1191-1848
            1736-2091           BQ177632.1         286-641
            2092-2117           BI135241.1         127-152             c
            2118-2256           AA104822.1         215-353
FEATURES             Location/Qualifiers
     source          1..2256
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 71.97 cM"
     gene            1..2256
                     /gene="Acsf3"
                     /note="acyl-CoA synthetase family member 3"
                     /db_xref="GeneID:257633"
                     /db_xref="MGI:MGI:2182591"
     exon            1..105
                     /gene="Acsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            106..795
                     /gene="Acsf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1881
                     /gene="Acsf3"
                     /EC_number="6.2.1.76"
                     /note="acyl-CoA synthetase family member 3, mitochondrial;
                     malonate--CoA ligase ACSF3, mitochondrial"
                     /codon_start=1
                     /product="malonate--CoA ligase ACSF3, mitochondrial
                     precursor"
                     /protein_id="NP_659181.2"
                     /db_xref="CCDS:CCDS40505.1"
                     /db_xref="GeneID:257633"
                     /db_xref="MGI:MGI:2182591"
                     /translation="MPPHLALPFRRLFWSLASSQLIPRRHRGHSLLPTTPEAHTDGSV
                     PVFIRALAFGDRIALIDKYGHHTYRELYDRSLCLAQEICRLQGCKVGDLQEERVSFLC
                     SNDVSYVVAQWASWMSGGVAVPLYWKHPEAQLEYFIQDSRSSLVVVGQEYLERLSPLA
                     QRLGVPLLPLTPAVYHGATEKPTEQPVEESGWRDRGAMIFYTSGTTGRPKGALSTHRN
                     LAAVVTGLVHSWAWTKNDVILHVLPLHHVHGVVNKLLCPLWVGATCVMLPEFSAQQVW
                     EKFLSSEAPQITVFMAVPTVYSKLLDYYDKHFTQPHVQDFVRAVCKERIRLMVSGSAA
                     LPVPLLEKWRSATGHTLLERYGMTEIGMALSNPLTEARVPGSVGTPLPGVEVRIISEN
                     PQKGSPYIIHAEGNERGTKVTPGFEEKEGELLVRGPSVFREYWDKPEETKSAFTSDGW
                     FRTGDTAVFKDARYWIRGRTSVDIIKTGGYKVSALEIERHLLAHPSITDVAVIGVPDM
                     TWGQRVTAVVALQEGHSLSHGDLKEWARGVLAPYAVPSELLLVEEIPRNQMGKVNKKE
                     LLKQLYPSGQRSQPGQG"
     exon            796..951
                     /gene="Acsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1106
                     /gene="Acsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1252
                     /gene="Acsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1362
                     /gene="Acsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1489
                     /gene="Acsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1624
                     /gene="Acsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1736
                     /gene="Acsf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..2232
                     /gene="Acsf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2196..2201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acsf3"
                     /note="hexamer: AATAAA"
     polyA_site      2227
                     /gene="Acsf3"
                     /note="major polyA site"
ORIGIN      
        1 acttttaggt gtaggactca ttccggcccg cttcacctac ctggacaacc tcgcactccc
       61 gtgccccacc cctgacaccc ccaccccaac cccgcctgac cccagcccag ccagtggttt
      121 gtcggtgtga tgccacctca cttggcactg cccttcaggc gtctcttctg gtccttggcc
      181 tccagtcagc tgattcccag aagacaccga ggacatagcc tcctgcctac caccccagag
      241 gcccacacgg atgggagtgt cccggtattc atccgtgccc tggcctttgg ggacaggatt
      301 gcccttattg acaaatatgg ccatcacacc tacagggaac tgtatgatcg cagcctttgt
      361 ctggcccagg agatctgcag gcttcagggt tgtaaagttg gggacctcca ggaagaaagg
      421 gtctccttcc tgtgctccaa tgacgtctcc tacgttgtag cacagtgggc ctcctggatg
      481 agtggtggtg ttgctgtccc actgtactgg aagcaccctg aggcccagct ggagtatttc
      541 atccaggact cccggagctc tttggtggtg gttggccagg agtacttgga gcggctaagt
      601 ccactggctc agaggctggg agtccctctt ctgccgctca cgcctgccgt ctaccatgga
      661 gcaacagaga agcccacaga gcagccagtt gaagagagtg ggtggcgtga ccggggtgcc
      721 atgatcttct acaccagcgg gaccacaggg aggcccaagg gtgcactgag cacccaccgt
      781 aacctagccg ctgtggtgac tgggctggtc cactcatggg cgtggactaa aaacgatgtg
      841 atccttcacg tcctcccgct gcaccatgtc cacggcgtgg tcaacaagct gctctgtcca
      901 ctctgggtag gagccacctg tgtcatgctg ccggagttca gtgctcagca ggtttgggaa
      961 aaattcttga gttctgaagc cccacagatt accgtattca tggcagtgcc cactgtctac
     1021 agcaagctgc tggactacta tgacaagcat ttcacgcagc cccatgtcca ggattttgtg
     1081 cgtgcagttt gtaaagaaag aatcaggctg atggtctcag gttcggccgc tctgcctgtc
     1141 ccactgctgg agaagtggag gagcgccacg ggccacacgc tgctggagcg ctatggcatg
     1201 acagagatcg gcatggctct gtccaacccc ctgacggagg ctcgcgtgcc aggttctgtg
     1261 gggaccccat tgccaggagt ggaagtacgc atcatctcag aaaacccgca gaagggttcc
     1321 ccctacatca tccatgcaga gggaaacgag agggggacaa aggtgactcc agggttcgag
     1381 gaaaaggaag gggagctgct ggttagggga ccctcggtgt tccgagaata ctgggataag
     1441 ccagaagaaa cgaaaagtgc tttcacttcc gatggctggt tcagaacagg agacaccgcc
     1501 gtgttcaagg atgctaggta ctggatccga gggcgcacgt ctgtggacat catcaagact
     1561 ggaggctata aagtcagcgc cctggagatc gagcggcacc tgctggccca ccccagcatc
     1621 accgatgtcg ctgtaattgg agttcctgat atgacatggg gccagcgggt cacagctgtg
     1681 gttgctcttc aagaaggaca ttcactgtcc cacggggatc tcaaggagtg ggccagaggt
     1741 gtcctggccc cctatgctgt gccctcggag ctcctgctgg tggaggagat cccccggaac
     1801 cagatgggca aggtgaataa gaaggagctg ctcaaacagt tgtacccctc aggacagagg
     1861 agccagccag gccaaggcta gagaacccca aacaccccgc ggtcacgtgc tatgggcctc
     1921 ggatggaacc cctcccctcc tgcaatcagg ttgaccggaa tcaaaacctc tagggacgaa
     1981 tcaccaagtg agttccctca accccaggct gattgtccaa gcccaggtga ccctgaccac
     2041 tggctgtgtc ctcagtggtc cttgagatca ctggtgtgtg ccagtctcac aagcacagta
     2101 aggacacggc tgtggccagc tctccagtgc ccggggctgc tgcctctcct gagggcaggt
     2161 cccagagagt cagaggtgac agtgagaaga ggtgaaataa agacacaccg tgtagtgctt
     2221 ctctgactgt gaaaaaaaaa aaaaaaaaaa aaaaaa
//
