LOCUS       NM_153807               3069 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus acyl-CoA synthetase family member 2 (Acsf2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_153807
VERSION     NM_153807.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3069)
  AUTHORS   Chen,J., Feng,Q., Qiao,Y., Pan,S., Liang,L., Liu,Y., Zhang,X.,
            Liu,D., Liu,Z. and Liu,Z.
  TITLE     ACSF2 and lysine lactylation contribute to renal tubule injury in
            diabetes
  JOURNAL   Diabetologia 67 (7), 1429-1443 (2024)
   PUBMED   38676722
  REMARK    GeneRIF: ACSF2 and lysine lactylation contribute to renal tubule
            injury in diabetes.
REFERENCE   2  (bases 1 to 3069)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3069)
  AUTHORS   Shi,H., Qi,H., Xie,D., Zhuang,J., Qi,H., Dai,Y. and Wu,J.
  TITLE     Inhibition of ACSF2 protects against renal ischemia/reperfusion
            injury via mediating mitophagy in proximal tubular cells
  JOURNAL   Free Radic Biol Med 198, 68-82 (2023)
   PUBMED   36764625
  REMARK    GeneRIF: Inhibition of ACSF2 protects against renal
            ischemia/reperfusion injury via mediating mitophagy in proximal
            tubular cells.
REFERENCE   4  (bases 1 to 3069)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3069)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 3069)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL645764.15
            and AL645809.8.
            
            On Nov 17, 2006 this sequence version replaced NM_153807.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018371.1, AK153582.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AL645764.15        19208-19351         c
            145-340             AL645809.8         95413-95608         c
            341-469             AL645809.8         94902-95030         c
            470-523             AL645809.8         94606-94659         c
            524-642             AL645809.8         93942-94060         c
            643-808             AL645809.8         93651-93816         c
            809-904             AL645809.8         92994-93089         c
            905-1062            AL645809.8         92683-92840         c
            1063-1154           AL645809.8         92321-92412         c
            1155-1231           AL645809.8         91690-91766         c
            1232-1339           AL645809.8         85191-85298         c
            1340-1491           AL645809.8         83620-83771         c
            1492-1633           AL645809.8         81843-81984         c
            1634-1744           AL645809.8         81245-81355         c
            1745-1813           AL645809.8         81020-81088         c
            1814-3069           AL645809.8         79482-80737         c
FEATURES             Location/Qualifiers
     source          1..3069
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 58.9 cM"
     gene            1..3069
                     /gene="Acsf2"
                     /note="acyl-CoA synthetase family member 2"
                     /db_xref="GeneID:264895"
                     /db_xref="MGI:MGI:2388287"
     exon            1..144
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1864
                     /gene="Acsf2"
                     /EC_number="6.2.1.2"
                     /note="acyl-CoA synthetase family member 2, mitochondrial;
                     medium-chain acyl-CoA ligase ACSF2, mitochondrial"
                     /codon_start=1
                     /product="medium-chain acyl-CoA ligase ACSF2,
                     mitochondrial precursor"
                     /protein_id="NP_722502.1"
                     /db_xref="CCDS:CCDS25259.1"
                     /db_xref="GeneID:264895"
                     /db_xref="MGI:MGI:2388287"
                     /translation="MAVYHGMLRFGRLCIASLGARGPRTLLSRPRPNSKLQSVRALSS
                     GMVNCTNPLPIGGLSYIQGHTDSHLVNTTVGECLDATAQRFPDREALVILHENIRLNF
                     AQLKEEVDKAASGLLSIGLRKGDRLGMWGPNSYAWVLIQLATAQAGIILVSVNPAYQS
                     SELEYVLRKVGCKGIVFPKQFKTQQYYDILKQVCPELEKAQPGALKSERLPDLTTVIS
                     VDAPLPGTLLLDDIVAAGGKEQNLAQLRYNQRFLSCYDPINIQFTSGTTGNPKGATLS
                     HHNIVNNSMLIGQRLKMPTKTAEELRLVLPSPLYHCLGSVGGTMVSMMHGATLLLSSP
                     SFNGKKALEAISREKGTLLYGTPTMFVDILNQPDFSSYDFTSIRGGVIAGSPAPPELI
                     RAIINKMNMKELVVVYGTTENSPVTFMNFPEDTLEQKAGSVGRIMPHTEAQIVNVETG
                     ELTNLNVPGELYIRGYCVMQGYWGEPQKTFETVGQDKWYRTGDIALMDEQGFCKIVGR
                     SKDMIIRGGENIYPAELEDFFLKHPQVQEAQVVGVKDERMGEEICACIRLKSGETTTA
                     EEIKAFCKGKISHFKIPRYIVFVEGYPLTISGKIQKFKLREQMEQHLKL"
     exon            145..340
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            341..469
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            470..523
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            524..642
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            643..808
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..904
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1062
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1154
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1231
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1339
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1491
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1633
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..1744
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1813
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..3069
                     /gene="Acsf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcggaag cgagccatgg ctgtctatca cgggatgctg cgcttcggga ggctgtgtat
       61 cgcgagcctg ggggcgcggg gcccccggac gctgctctct cgccctcggc cgaactcgaa
      121 gttgcagagt gtccgcgctc tcagttctgg aatggtgaac tgcaccaacc ccttgcccat
      181 cggaggcctc agctacattc agggccacac cgactcccat cttgtgaaca caactgtggg
      241 cgagtgcctt gacgccacgg cgcagaggtt ccccgacaga gaggctttgg ttatcctcca
      301 tgaaaacatc aggctgaact ttgcgcagct caaggaggag gtggacaaag ctgcttctgg
      361 tcttctgagc attggcctcc gcaagggtga ccggctgggc atgtggggac ccaactccta
      421 tgcctgggta cttattcagc tggctactgc ccaggcaggc atcatcctgg tgtctgtgaa
      481 cccagcctac cagtcctcag aactggaata tgtcctcaga aaggtaggct gcaaaggtat
      541 tgtgtttccc aaacaattca agacccagca gtactacgac atcctgaagc aggtctgtcc
      601 tgagctggaa aaggctcagc caggggcctt gaagagtgag agactcccag acctgactac
      661 agtcatctca gtggatgccc ctctgccggg gaccctgctc ctggatgata ttgtggcagc
      721 cggtggcaag gaacagaacc tagcccagct gcggtacaac cagcggttct tgtcctgcta
      781 cgaccccatc aacatccagt tcacctcggg gacaactgga aaccccaagg gggccactct
      841 ttcccaccac aacatcgtaa acaactccat gctgataggc cagcgtctga agatgcccac
      901 aaagactgca gaggagttgc gcttggtcct gcccagtccc ctgtaccact gcctgggctc
      961 cgtggggggc acaatggtgt ctatgatgca tggtgccact ctcctcctgt cttctccaag
     1021 cttcaatggc aagaaggcat tggaagccat cagcagagag aaaggcaccc tcctgtatgg
     1081 cacacccacg atgtttgtgg atattctgaa tcagccagac ttctccagtt atgatttcac
     1141 aagcattcgt ggaggtgtga ttgctgggtc cccagcaccc ccggaattga ttcgagccat
     1201 catcaacaag atgaacatga aggagctggt ggttgtttat ggaaccacag agaacagtcc
     1261 cgtgaccttc atgaactttc ccgaggacac cctggagcag aaggctggta gtgtgggcag
     1321 aattatgcct cacacggagg cccagattgt gaatgtggag acgggtgagc tgaccaacct
     1381 gaacgtgcct ggggagctgt atatccgagg gtactgcgtc atgcagggct actggggtga
     1441 gccacagaag accttcgaga cggtcggaca agacaagtgg tatcggacag gagacattgc
     1501 tttgatggat gaacagggct tctgcaagat cgtcggccga tcgaaggata tgatcatccg
     1561 tggcggtgag aacatctacc ctgcagagct ggaggacttc ttcctcaagc acccacaggt
     1621 gcaggaagcg caggtggttg gggtgaagga cgagcggatg ggggaggaaa tctgtgcttg
     1681 cattcggctg aagagcggag agaccaccac ggcggaggag atcaaagctt tctgcaaagg
     1741 gaagatttcc cactttaaga ttccccgata catcgtgttt gttgaaggct atcctctcac
     1801 catctcagga aagatccaga aattcaaact ccgagagcag atggaacagc atctaaaact
     1861 gtgaagcaaa ggagggtcct cccagccctc ccagagcccc tcagtcctcc cacaaaaagg
     1921 agggtcctca tagccctccc agagcccctc agtcctccca caaaaaggag ggtcctcccc
     1981 agagcccctc agtcctccca cacaaaggag agtcctctca gctctcccag agcccctcag
     2041 ccctcccaca caaaggaggg tcctcccagc cctcccagag cccctcagcc ctcccacaca
     2101 aaggaggttc ctcccagctc tcccagagcc cctcagccct cccacacaaa ggagggtcct
     2161 cacagccctc cccagagccc ttcagtcctc ccacacaaag gagggccccg agtcctcctc
     2221 aggccccttg tcgtctttgt gacttggtgt aaagacttcc ctgtttggcc agtgtctggc
     2281 tggtgtgctc actctgtagc tcttgtgtga tggagaaggg aagagacagg agggcagcca
     2341 gcaccctcag acctaatttc ccagcacttt gctgtctgtg cattagttac ttaatctaag
     2401 ccccactctg tcctcttgaa attccaagcc acccttattt ttttctttct ttttggtttt
     2461 ttgttttgtt tttgtttgtt tggctttttt tgtttgtttt gttgttttcc cttgagacag
     2521 gatcgtcctc tgtacccctg gttgcacagg gtagatcagg ctggtttcga acttaaagag
     2581 atctcattgc ccctgcctcc ggggtgctgg atcagtcttt tgtgctacca tgcctggttt
     2641 ttgtatgatt tattcattta atcatttttc aaattgtggc cacagatcag tccagaaatg
     2701 agggttctgt tttgcttgtt ttccaaggct gggaacctta aagcccctca cgaatacata
     2761 agcacccttc cctggcctgc actcccggcc caataattat tgttttgttg ttgaaataac
     2821 agttttgagt gctggagagg gggctcagtg gttaagagga ctgactgctc tcccagaaga
     2881 tctgagtttg attcctagca cccacatttg gcagctcaca actaccttta agtccaccta
     2941 cagacaatgg atgatctctt ctggcctctg tgccccctgc gtgtctcccc tgcccccccc
     3001 cccccccccc cccgcacatg gtatgtgctt acatagacac atgcaaataa atcaaaacaa
     3061 atccgtgaa
//
