LOCUS       NM_053178               2775 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus acyl-CoA synthetase bubblegum family member 1
            (Acsbg1), mRNA.
ACCESSION   NM_053178
VERSION     NM_053178.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2775)
  AUTHORS   Ye,X., Li,Y., Gonzalez-Lamuno,D., Pei,Z., Moser,A.B., Smith,K.D.
            and Watkins,P.A.
  TITLE     Role of ACSBG1 in Brain Lipid Metabolism and X-Linked
            Adrenoleukodystrophy Pathogenesis: Insights from a Knockout Mouse
            Model
  JOURNAL   Cells 13 (20), 1687 (2024)
   PUBMED   39451204
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2775)
  AUTHORS   Kanno,T., Nakajima,T., Kawashima,Y., Yokoyama,S., Asou,H.K.,
            Sasamoto,S., Hayashizaki,K., Kinjo,Y., Ohara,O., Nakayama,T. and
            Endo,Y.
  TITLE     Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint
            for tissue Treg cell homeostasis
  JOURNAL   Cell Rep 37 (6), 109921 (2021)
   PUBMED   34758300
  REMARK    GeneRIF: Acsbg1-dependent mitochondrial fitness is a metabolic
            checkpoint for tissue Treg cell homeostasis.
REFERENCE   3  (bases 1 to 2775)
  AUTHORS   Takeuchi,A., Takahashi,Y., Iida,K., Hosokawa,M., Irie,K., Ito,M.,
            Brown,J.B., Ohno,K., Nakashima,K. and Hagiwara,M.
  TITLE     Identification of Qk as a Glial Precursor Cell Marker that Governs
            the Fate Specification of Neural Stem Cells to a Glial Cell Lineage
  JOURNAL   Stem Cell Reports 15 (4), 883-897 (2020)
   PUBMED   32976762
REFERENCE   4  (bases 1 to 2775)
  AUTHORS   Liang,Q., Su,L., Zhang,D. and Jiao,J.
  TITLE     CD93 negatively regulates astrogenesis in response to MMRN2 through
            the transcriptional repressor ZFP503 in the developing brain
  JOURNAL   Proc Natl Acad Sci U S A 117 (17), 9413-9422 (2020)
   PUBMED   32291340
REFERENCE   5  (bases 1 to 2775)
  AUTHORS   Liang,Q., Xia,W., Li,W. and Jiao,J.
  TITLE     RNF20 controls astrocytic differentiation through epigenetic
            regulation of STAT3 in the developing brain
  JOURNAL   Cell Death Differ 25 (2), 294-306 (2018)
   PUBMED   28984873
REFERENCE   6  (bases 1 to 2775)
  AUTHORS   Fraisl,P., Forss-Petter,S., Zigman,M. and Berger,J.
  TITLE     Murine bubblegum orthologue is a microsomal very long-chain
            acyl-CoA synthetase
  JOURNAL   Biochem J 377 (Pt 1), 85-93 (2004)
   PUBMED   14516277
  REMARK    GeneRIF: Expression pattern and localization of bubblegum to
            microsomes.
REFERENCE   7  (bases 1 to 2775)
  AUTHORS   Pei,Z., Oey,N.A., Zuidervaart,M.M., Jia,Z., Li,Y., Steinberg,S.J.,
            Smith,K.D. and Watkins,P.A.
  TITLE     The acyl-CoA synthetase 'bubblegum' (lipidosin): further
            characterization and role in neuronal fatty acid beta-oxidation
  JOURNAL   J Biol Chem 278 (47), 47070-47078 (2003)
   PUBMED   12975357
  REMARK    GeneRIF: in neurons, mBG1-activated long-chain fatty acids are
            directed toward mitochondrial degradation
REFERENCE   8  (bases 1 to 2775)
  AUTHORS   Tang,P.Z., Tsai-Morris,C.H. and Dufau,M.L.
  TITLE     Cloning and characterization of a hormonally regulated rat long
            chain acyl-CoA synthetase
  JOURNAL   Proc Natl Acad Sci U S A 98 (12), 6581-6586 (2001)
   PUBMED   11381125
REFERENCE   9  (bases 1 to 2775)
  AUTHORS   Moriya-Sato,A., Hida,A., Inagawa-Ogashiwa,M., Wada,M.R.,
            Sugiyama,K., Shimizu,J., Yabuki,T., Seyama,Y. and Hashimoto,N.
  TITLE     Novel acyl-CoA synthetase in adrenoleukodystrophy target tissues
  JOURNAL   Biochem Biophys Res Commun 279 (1), 62-68 (2000)
   PUBMED   11112418
REFERENCE   10 (bases 1 to 2775)
  AUTHORS   Steinberg,S.J., Morgenthaler,J., Heinzer,A.K., Smith,K.D. and
            Watkins,P.A.
  TITLE     Very long-chain acyl-CoA synthetases. Human 'bubblegum' represents
            a new family of proteins capable of activating very long-chain
            fatty acids
  JOURNAL   J Biol Chem 275 (45), 35162-35169 (2000)
   PUBMED   10954726
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157591.2.
            
            On Mar 21, 2007 this sequence version replaced NM_053178.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB050554.1, BC057322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               AC157591.2         31321-31657
            338-438             AC157591.2         50510-50610
            439-659             AC157591.2         64580-64800
            660-748             AC157591.2         65248-65336
            749-869             AC157591.2         65655-65775
            870-950             AC157591.2         70450-70530
            951-1100            AC157591.2         70620-70769
            1101-1277           AC157591.2         71164-71340
            1278-1459           AC157591.2         75003-75184
            1460-1690           AC157591.2         77109-77339
            1691-1908           AC157591.2         78253-78470
            1909-2048           AC157591.2         83372-83511
            2049-2295           AC157591.2         83944-84190
            2296-2775           AC157591.2         87730-88209
FEATURES             Location/Qualifiers
     source          1..2775
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.7 cM"
     gene            1..2775
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /note="acyl-CoA synthetase bubblegum family member 1"
                     /db_xref="GeneID:94180"
                     /db_xref="MGI:MGI:2385656"
     exon            1..337
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..2381
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /EC_number="6.2.1.3"
                     /note="lipidosin; bubblegum; gonadotropin-regulated long
                     chain acyl CoA synthetase; lipodisin; lipidosis-related
                     protein lipidosin"
                     /codon_start=1
                     /product="long-chain-fatty-acid--CoA ligase ACSBG1"
                     /protein_id="NP_444408.1"
                     /db_xref="CCDS:CCDS23192.1"
                     /db_xref="GeneID:94180"
                     /db_xref="MGI:MGI:2385656"
                     /translation="MPRGSEAGYCCLSRDSNMPDSRDDQQQGASLGTSQDNSQTSSLI
                     DGQTLSKESPSHGLELSAPEKARAASLDGAEEALWTTRADGRVRLRLEPFCTQRPYTV
                     HQMFYEALDKYGNLSALGFKRKDKWERISYYQYYLIARKVAKGFLKLGLERAHSVAIL
                     GFNSPEWFFSAVGTVFAGGIVTGIYTTSSPEACQYISHDCRANVIVVDTQKQLEKILK
                     IWKDLPHLKAVVIYQEPPPKKMANVYTMEELIELGQEVPEEALDAIIDTQQPNQCCVL
                     VYTSGTTGNPKGVMLSQDNITWTARYGSQAGDIQPAEVQQEVVVSYLPLSHIAAQIYD
                     LWTGIQWGAQVCFADPDALKGTLVNTLREVEPTSHMGVPRVWEKIMERIQEVAAQSGF
                     IRRKMLLWAMSVTLEQNLTCPSNDLKPFTSRLADYLVLARVRQALGFAKCQKNFYGAA
                     PMTAETQRFFLGLNIRLYAGYGLSESTGPHFMSSPYNYRLYSSGRVVPGCRVKLVNQD
                     ADGIGEICLWGRTIFMGYLNMEDKTCEAIDSEGWLHTGDMGRLDADGFLYITGRLKEL
                     IITAGGENVPPVPIEEAVKMELPIISSAMLIGDQRKFLSMLLTLKCTLDPETSEPTDS
                     LTEQAVEFCQRVGSKASTVSEIVGQRDEAVYQAIHEGIQRVNANAAARPYHIQKWAIL
                     QRDFSISGGELGPTMKLKRLTVLEKYKDIIDSFYQEQKQ"
     exon            338..438
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            439..659
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            660..748
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            749..869
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            870..950
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1100
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1277
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1459
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1690
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1908
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2048
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2295
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2775
                     /gene="Acsbg1"
                     /gene_synonym="BG1; Bgm; E230019G03Rik; GR-LACS; Lpd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcagcggaa aaaccaggaa gaaaaggaaa gttttagtcc tgagcaattt actgcctagg
       61 aacattctga gcttctgaaa acagagagga aatggggccc tccgggtcac ttcaggcacc
      121 gcccacctca gccccatgcc cgccccccgc tgccccctca aggccagcct ctcactgtgg
      181 gagaccgcac tgtcttcggt gaatgcacac agcagatgcc acgcggttct gaagcaggat
      241 actgctgtct gtccagggac tccaacatgc ctgacagcag agatgatcag cagcaggggg
      301 ccagcttggg gacctcccaa gacaactcgc aaaccagctc cttaattgat gggcaaacac
      361 tctccaaaga gtctccaagt cacggtctcg agctctcagc tccagaaaag gcaagggctg
      421 cctctttgga tggtgcagag gaagcactat ggacaacccg ggcggatggg agagtgcgcc
      481 tgcgcctgga acctttctgt actcagcgtc cctataccgt gcaccagatg ttctacgagg
      541 ccctagataa gtacgggaac ctcagtgctc tgggcttcaa gcgcaaggac aagtgggagc
      601 gtatctctta ctaccagtac tacctgattg cacgcaaagt agccaaaggc ttcttgaagc
      661 tcggcctaga gcgtgcccac agcgtggcga tccttggctt caactctcca gaatggttct
      721 tctctgcagt gggcacagtg ttcgcagggg gcattgtcac tggcatctac accaccagct
      781 ccccggaggc ctgccagtac atctctcatg actgccgagc caatgtcatc gtggttgaca
      841 cacagaagca gctggaaaag atcctgaaga tctggaaaga cttgccacat ctaaaggcag
      901 tggtgatata ccaagaaccc cctccaaaga agatggctaa cgtgtacacg atggaggagc
      961 tcatagaact ggggcaagaa gtgcctgagg aggccctaga tgccatcatc gatacccagc
     1021 aacccaacca gtgctgtgtg ctcgtctaca catcaggcac cacgggaaac cccaagggtg
     1081 tgatgctgag tcaagacaat atcacatgga cagcacggta tggcagtcag gctggggaca
     1141 tccagccagc agaagtgcag caggaggtag tggtcagcta cttgcctctc agccacatcg
     1201 ctgcccagat ctacgacctg tggacaggca tccagtgggg agcccaggtc tgctttgcag
     1261 atccggacgc cctgaagggg accctggtaa acacactgcg ggaggtggag cccacatccc
     1321 acatgggagt gccgcgtgtg tgggagaaga tcatggaaag gatccaggag gtggccgctc
     1381 agtctggctt catccgccgc aagatgctgc tgtgggccat gtcagtcacc ttggaacaga
     1441 accttacctg ccctagcaat gacctgaagc ccttcaccag cagactggcg gattacctag
     1501 tgttagccag ggtccgtcag gctctgggct ttgccaagtg tcagaaaaac ttctacggag
     1561 cagctccgat gacggcagag acgcagcgct tcttcctggg cctcaacatc cgcctgtatg
     1621 caggctatgg cctcagcgag agcacaggcc cccacttcat gtccagcccc tacaactatc
     1681 ggctttacag ctccggcagg gtggtacccg gctgccgggt gaagctggtg aatcaggatg
     1741 cagatggcat cggtgagatc tgcctgtggg gccgcaccat cttcatgggt tatctgaaca
     1801 tggaggacaa aacctgtgag gccattgatt cggaaggctg gctgcacaca ggtgacatgg
     1861 gccgcctgga tgctgacggc ttcctctaca tcaccgggcg cctcaaagaa ttaatcatca
     1921 ctgcgggcgg cgagaacgtg cccccagtgc ctatcgagga ggccgtgaag atggagctgc
     1981 ccatcatcag cagtgccatg ctgatcgggg accagaggaa gttcctgtcc atgctgctaa
     2041 ccctgaagtg cacgctggac ccagagacgt ctgagcctac agacagcctg accgagcaag
     2101 ctgtggagtt ctgccagcgg gtgggcagca aggccagcac cgtctccgag atcgtggggc
     2161 agagagacga ggctgtgtac caggccattc acgaagggat ccagagggtg aacgcgaacg
     2221 ccgcagcccg gccctaccac atccagaagt gggccattct ccaacgtgac ttctccattt
     2281 caggtggaga actgggaccc accatgaaat tgaaacggct cacggttctg gagaagtaca
     2341 aagatatcat cgattctttt tatcaagagc aaaaacagta gtcaggagcc atgcttgtgg
     2401 cttctgctgg agaccagccc ggcaagcatc ttcctgagcg ccaggtgtct ccagtgggca
     2461 aaagaacctg tgacaagctg cttccaccct ttagttcagg gcagagcact gacatctcca
     2521 atgccttcac gtgcaagtag tttcaattct aaccactgct cctgttcagg tgtcaagcca
     2581 gaccattctc cttccaaaag agaaggaccg ctcactttgg cttcaggtcc aggcagatct
     2641 acaaggttct agttcacagg tctcccaggg ggcgctgttg gagagggaaa gggatggcaa
     2701 tcccattact aatgtgtgct gcagagacag cagtcacagc tcgcctgact taattctggc
     2761 ttcttggaaa ctagt
//
