LOCUS       NM_016845               1913 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus proacrosin binding protein (Acrbp), transcript variant
            1, mRNA.
ACCESSION   NM_016845
VERSION     NM_016845.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1913)
  AUTHORS   Nagashima,K., Usui,T. and Baba,T.
  TITLE     Behavior of ACRBP-deficient mouse sperm in the female reproductive
            tract
  JOURNAL   J Reprod Dev 65 (2), 97-102 (2019)
   PUBMED   30606959
  REMARK    GeneRIF: Male subfertility of ACRBP-deficient mice may be
            attributed to incompleteness of the acrosome reaction rather than
            impairment in sperm migration from the uterus to the oviduct.
REFERENCE   2  (bases 1 to 1913)
  AUTHORS   Zuo,X., Rong,B., Li,L., Lv,R., Lan,F. and Tong,M.H.
  TITLE     The histone methyltransferase SETD2 is required for expression of
            acrosin-binding protein 1 and protamines and essential for
            spermiogenesis in mice
  JOURNAL   J Biol Chem 293 (24), 9188-9197 (2018)
   PUBMED   29716999
  REMARK    GeneRIF: Setd2 deficiency results in complete loss of H3K36me3 and
            significantly decreases expression of thousands of genes, including
            those encoding acrosin-binding protein 1 (Acrbp1) and protamines,
            required for spermatogenesis.
REFERENCE   3  (bases 1 to 1913)
  AUTHORS   Kanemori,Y., Koga,Y., Sudo,M., Kang,W., Kashiwabara,S., Ikawa,M.,
            Hasuwa,H., Nagashima,K., Ishikawa,Y., Ogonuki,N., Ogura,A. and
            Baba,T.
  TITLE     Biogenesis of sperm acrosome is regulated by pre-mRNA alternative
            splicing of Acrbp in the mouse
  JOURNAL   Proc Natl Acad Sci U S A 113 (26), E3696-E3705 (2016)
   PUBMED   27303034
  REMARK    GeneRIF: ACRBP-null male mice showed a severely reduced fertility,
            because of malformation of the acrosome.
REFERENCE   4  (bases 1 to 1913)
  AUTHORS   Kanemori,Y., Ryu,J.H., Sudo,M., Niida-Araida,Y., Kodaira,K.,
            Takenaka,M., Kohno,N., Sugiura,S., Kashiwabara,S. and Baba,T.
  TITLE     Two functional forms of ACRBP/sp32 are produced by pre-mRNA
            alternative splicing in the mouse
  JOURNAL   Biol Reprod 88 (4), 105 (2013)
   PUBMED   23426433
  REMARK    GeneRIF: Two forms of Acrbp mRNA-wild-type Acrbp-W and variant
            Acrbp-V5 mRNAs-were generated by alternative splicing of Acrbp in
            the mouse.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1913)
  AUTHORS   Tardif,S., Guyonnet,B., Cormier,N. and Cornwall,G.A.
  TITLE     Alteration in the processing of the ACRBP/sp32 protein and sperm
            head/acrosome malformations in proprotein convertase 4 (PCSK4) null
            mice
  JOURNAL   Mol Hum Reprod 18 (6), 298-307 (2012)
   PUBMED   22357636
  REMARK    GeneRIF: Data suggest that the fertility defect in PCSK4
            (proprotein convertase subtilisin/kexin type 4) knockout mice is
            due, in part, to altered processing/proteolysis of ACRBP as well as
            structural abnormalities in sperm heads and acrosomes.
REFERENCE   6  (bases 1 to 1913)
  AUTHORS   Wang,G., Zhang,J., Moskophidis,D. and Mivechi,N.F.
  TITLE     Targeted disruption of the heat shock transcription factor (hsf)-2
            gene results in increased embryonic lethality, neuronal defects,
            and reduced spermatogenesis
  JOURNAL   Genesis 36 (1), 48-61 (2003)
   PUBMED   12748967
REFERENCE   7  (bases 1 to 1913)
  AUTHORS   Nayernia,K., Adham,I.M., Shamsadin,R., Muller,C., Sancken,U. and
            Engel,W.
  TITLE     Proacrosin-deficient mice and zona pellucida modifications in an
            experimental model of multifactorial infertility
  JOURNAL   Mol Hum Reprod 8 (5), 434-440 (2002)
   PUBMED   11994540
REFERENCE   8  (bases 1 to 1913)
  AUTHORS   Ono,T., Kurashige,T., Harada,N., Noguchi,Y., Saika,T., Niikawa,N.,
            Aoe,M., Nakamura,S., Higashi,T., Hiraki,A., Wada,H., Kumon,H.,
            Old,L.J. and Nakayama,E.
  TITLE     Identification of proacrosin binding protein sp32 precursor as a
            human cancer/testis antigen
  JOURNAL   Proc Natl Acad Sci U S A 98 (6), 3282-3287 (2001)
   PUBMED   11248070
REFERENCE   9  (bases 1 to 1913)
  AUTHORS   Tadros,H., Chretien,M. and Mbikay,M.
  TITLE     The testicular germ-cell protease PC4 is also expressed in
            macrophage-like cells of the ovary
  JOURNAL   J Reprod Immunol 49 (2), 133-152 (2001)
   PUBMED   11164898
REFERENCE   10 (bases 1 to 1913)
  AUTHORS   Baba,T., Niida,Y., Michikawa,Y., Kashiwabara,S., Kodaira,K.,
            Takenaka,M., Kohno,N., Gerton,G.L. and Arai,Y.
  TITLE     An acrosomal protein, sp32, in mammalian sperm is a binding protein
            specific for two proacrosins and an acrosin intermediate
  JOURNAL   J Biol Chem 269 (13), 10133-10140 (1994)
   PUBMED   8144514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY099028.1 and AK132705.1.
            
            On May 14, 2008 this sequence version replaced NM_016845.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132705.1, D17573.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                BY099028.1         1-32
            33-1913             AK132705.1         1-1881
FEATURES             Location/Qualifiers
     source          1..1913
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.17 cM"
     gene            1..1913
                     /gene="Acrbp"
                     /gene_synonym="OY-TES-1; sp32"
                     /note="proacrosin binding protein"
                     /db_xref="GeneID:54137"
                     /db_xref="MGI:MGI:1859515"
     exon            1..126
                     /gene="Acrbp"
                     /gene_synonym="OY-TES-1; sp32"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1706
                     /gene="Acrbp"
                     /gene_synonym="OY-TES-1; sp32"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; acrosin-binding protein, 60 kDa form"
                     /codon_start=1
                     /product="acrosin-binding protein isoform 1 precursor"
                     /protein_id="NP_058541.2"
                     /db_xref="CCDS:CCDS20542.1"
                     /db_xref="GeneID:54137"
                     /db_xref="MGI:MGI:1859515"
                     /translation="MMNLAAGFLLMLLEVLLLPGTPLSAEESPASTPGSPLSSTEYER
                     FFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESF
                     CQFAQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVESSAEVPPTSMTTPIVSHATATE
                     HQAFQPWPERLNNNVEELLQSSLSLGGKDQQSSRRPGQEQRKQEQIQEHKLEEAQEQE
                     EQEEEEEEEEAKQEEGQGTEAGLESVSRLQSDSEPKFQSQSLSSNPSFFTPRVREVES
                     APLMMKNIQELIRSAQEMDEMNELYDDSWRSQSTGSLQQLPHMETLMVLCYSIMENTC
                     TMTPTAKAWSYMEEEILGFGDSVCDNLGRRHTAACPLCAFCSLKLEQCHSEASVLRQK
                     CDASHKIPFISPLLSAQSISTGNQARIPDKGRFAGLEMYGGLSSEFWCNRLAMKGCED
                     DRVSNWLKAEFLSFQEGDFPTKICDTNYIQYPNYCSFKSQQCLLRNQNRKMSRMRCML
                     NERYNVLSLAKSEEVILRWSQEFSTLAIGQFG"
     exon            127..342
                     /gene="Acrbp"
                     /gene_synonym="OY-TES-1; sp32"
                     /inference="alignment:Splign:2.1.0"
     exon            343..437
                     /gene="Acrbp"
                     /gene_synonym="OY-TES-1; sp32"
                     /inference="alignment:Splign:2.1.0"
     exon            438..555
                     /gene="Acrbp"
                     /gene_synonym="OY-TES-1; sp32"
                     /inference="alignment:Splign:2.1.0"
     exon            556..1018
                     /gene="Acrbp"
                     /gene_synonym="OY-TES-1; sp32"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1151
                     /gene="Acrbp"
                     /gene_synonym="OY-TES-1; sp32"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1331
                     /gene="Acrbp"
                     /gene_synonym="OY-TES-1; sp32"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1499
                     /gene="Acrbp"
                     /gene_synonym="OY-TES-1; sp32"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1583
                     /gene="Acrbp"
                     /gene_synonym="OY-TES-1; sp32"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1913
                     /gene="Acrbp"
                     /gene_synonym="OY-TES-1; sp32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1897..1902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acrbp"
                     /gene_synonym="OY-TES-1; sp32"
                     /note="putative"
     polyA_site      1913
                     /gene="Acrbp"
                     /gene_synonym="OY-TES-1; sp32"
                     /note="putative"
ORIGIN      
        1 tcctgccttc ttcgcgctag cagcgaggct cggcccgttg gaggtcgctt tgttgtgaaa
       61 acgcgggtgg atcttcccag gccatgatga atctagctgc tggcttcctt ctgatgcttc
      121 tggaagtgct gctcctgcct ggaacacctc tttccgctga ggaatctcca gcctccactc
      181 caggcagccc tctctcgtcc actgagtatg aacgcttctt cgccctgctg accccaacct
      241 ggaaggcaga gaccacctgc cgcctccgtg ccacccacgg ctgccggaac cccactctcg
      301 ttcagttgga tcaatatgaa aaccacggat tggtaccaga tggtgctgtc tgctccgatc
      361 tcccttatgc ttcctggttt gagtccttct gccagtttgc tcagtatcgt tgctccaacc
      421 atgtctacta tgccaagagg gtccggtgct cccagcccgt ctccatccta tcccccaaca
      481 ctctcaagga ggtggagtct tcagcagaag ttcctcccac ttccatgacc acccccattg
      541 tgtcccatgc cacagccaca gaacaccagg ccttccagcc ttggcctgag cggctcaaca
      601 acaacgtgga ggagctgctg cagtcatcct tgtccctggg aggcaaggac caacagagca
      661 gtcggagacc aggccaggag cagcgcaagc aggagcagat ccaagaacat aagctagaag
      721 aagcgcagga gcaagaagag caggaagaag aggaagagga ggaggaagcc aagcaggaag
      781 aggggcaggg gacagaggcg ggtctggagt cagtgtccag gctgcagtca gactcagagc
      841 ccaagtttca atcccagtca ctgtcttcca acccgtcctt cttcactccc cgggtccgag
      901 aggtggagtc tgctccattg atgatgaaga atatccagga gctcattcgg tctgcccagg
      961 aaatggatga aatgaatgaa ctgtatgatg actcctggag aagccaaagc actggcagcc
     1021 tccagcagct gccccacatg gagaccctga tggtgctatg ctattccatt atggagaata
     1081 cctgcaccat gactcccaca gccaaggcct ggagctacat ggaggaggag atccttggct
     1141 tcggggattc ggtgtgtgac aatctcggaa ggcgacacac agctgcctgt cccctctgtg
     1201 cattctgctc cctgaagctg gagcagtgcc acagtgaagc cagtgtgctg cgccagaagt
     1261 gtgacgcttc ccacaagata cccttcatca gccccttgct ctcagcccag agcatatcca
     1321 cgggcaacca ggcgaggatc ccagataaag gacgatttgc tgggctagaa atgtacggag
     1381 gactcagctc agagttctgg tgcaaccggc ttgctatgaa gggctgtgaa gatgaccgag
     1441 tctccaactg gctcaaagct gagttcctta gcttccagga gggggatttc cccaccaaga
     1501 tttgtgacac aaactatatc cagtacccaa actactgttc cttcaaaagc cagcagtgcc
     1561 tgctgagaaa ccagaacaga aagatgtccc gcatgaggtg tatgctgaat gagaggtaca
     1621 acgtgctaag cctggctaag agcgaagagg tgatccttcg atggagccaa gagtttagca
     1681 ctttggctat aggccagttt ggatgagctg aggtctgtgt ccccccaccc cagctctacc
     1741 ttgctccatc gctctcagac tacatctgtc agttggcttc caggtgcccc tcatggggcc
     1801 tcctccctgg cccctacttg cattttcttt gggttgggag aacagtccca gagaggtgca
     1861 tgatgggagc tccgagtgcc ttgaagatta ccttcaaata aaatgtttat ctg
//
