LOCUS       NM_013455               1486 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus acrosin prepropeptide (Acr), transcript variant 1,
            mRNA.
ACCESSION   NM_013455
VERSION     NM_013455.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1486)
  AUTHORS   Nakajima,R., Okano,H. and Noce,T.
  TITLE     JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during
            Spermatogenesis
  JOURNAL   PLoS One 11 (9), e0163466 (2016)
   PUBMED   27649575
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1486)
  AUTHORS   Cheng,S., Liang,X., Wang,Y., Jiang,Z., Liu,Y., Hou,W., Li,S.,
            Zhang,J. and Wang,Z.
  TITLE     The circadian Clock gene regulates acrosin activity of sperm
            through serine protease inhibitor A3K
  JOURNAL   Exp Biol Med (Maywood) 241 (2), 205-215 (2016)
   PUBMED   26264441
  REMARK    GeneRIF: SERPINA3K is involved in the Clock gene-mediated male
            fertility by regulating acrosin activity and provide the first
            evidence that SERPINA3K could be regulated by Clock gene via
            retinoic acid-related orphan receptor response elements.
REFERENCE   3  (bases 1 to 1486)
  AUTHORS   Pandey,R.R., Tokuzawa,Y., Yang,Z., Hayashi,E., Ichisaka,T.,
            Kajita,S., Asano,Y., Kunieda,T., Sachidanandam,R., Chuma,S.,
            Yamanaka,S. and Pillai,R.S.
  TITLE     Tudor domain containing 12 (TDRD12) is essential for secondary PIWI
            interacting RNA biogenesis in mice
  JOURNAL   Proc Natl Acad Sci U S A 110 (41), 16492-16497 (2013)
   PUBMED   24067652
REFERENCE   4  (bases 1 to 1486)
  AUTHORS   Kanemori,Y., Ryu,J.H., Sudo,M., Niida-Araida,Y., Kodaira,K.,
            Takenaka,M., Kohno,N., Sugiura,S., Kashiwabara,S. and Baba,T.
  TITLE     Two functional forms of ACRBP/sp32 are produced by pre-mRNA
            alternative splicing in the mouse
  JOURNAL   Biol Reprod 88 (4), 105 (2013)
   PUBMED   23426433
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1486)
  AUTHORS   Zhou,C., Kang,W. and Baba,T.
  TITLE     Functional characterization of double-knockout mouse sperm lacking
            SPAM1 and ACR or SPAM1 and PRSS21 in fertilization
  JOURNAL   J Reprod Dev 58 (3), 330-337 (2012)
   PUBMED   22362218
  REMARK    GeneRIF: ACR or PRSS21 or both may function cooperatively with
            SPAM1 in sperm/cumulus penetration
REFERENCE   6  (bases 1 to 1486)
  AUTHORS   Hameister,H., Schulz,W.A., Meyer,J., Thoma,S., Adolph,S., Gaa,A.
            and von Deimling,O.
  TITLE     Gene order and genetic distance of 13 loci spanning murine
            chromosome 15
  JOURNAL   Genomics 14 (2), 417-422 (1992)
   PUBMED   1358803
REFERENCE   7  (bases 1 to 1486)
  AUTHORS   Kremling,H., Keime,S., Wilhelm,K., Adham,I.M., Hameister,H. and
            Engel,W.
  TITLE     Mouse proacrosin gene: nucleotide sequence, diploid expression, and
            chromosomal localization
  JOURNAL   Genomics 11 (4), 828-834 (1991)
   PUBMED   1783391
REFERENCE   8  (bases 1 to 1486)
  AUTHORS   Watanabe,K., Baba,T., Kashiwabara,S., Okamoto,A. and Arai,Y.
  TITLE     Structure and organization of the mouse acrosin gene
  JOURNAL   J Biochem 109 (6), 828-833 (1991)
   PUBMED   1939002
REFERENCE   9  (bases 1 to 1486)
  AUTHORS   Kashiwabara,S., Arai,Y., Kodaira,K. and Baba,T.
  TITLE     Acrosin biosynthesis in meiotic and postmeiotic spermatogenic cells
  JOURNAL   Biochem Biophys Res Commun 173 (1), 240-245 (1990)
   PUBMED   1701633
REFERENCE   10 (bases 1 to 1486)
  AUTHORS   Klemm,U., Maier,W.M., Tsaousidou,S., Adham,I.M., Willison,K. and
            Engel,W.
  TITLE     Mouse preproacrosin: cDNA sequence, primary structure and
            postmeiotic expression in spermatogenesis
  JOURNAL   Differentiation 42 (3), 160-166 (1990)
   PUBMED   2111255
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122401.3.
            
            On Aug 22, 2022 this sequence version replaced NM_013455.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D00754.1, AK006695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC122401.3         126666-126758       c
            94-300              AC122401.3         125561-125767       c
            301-584             AC122401.3         125075-125358       c
            585-730             AC122401.3         121840-121985       c
            731-1486            AC122401.3         120517-121272       c
FEATURES             Location/Qualifiers
     source          1..1486
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.96 cM"
     gene            1..1486
                     /gene="Acr"
                     /note="acrosin prepropeptide"
                     /db_xref="GeneID:11434"
                     /db_xref="MGI:MGI:87884"
     exon            1..93
                     /gene="Acr"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1327
                     /gene="Acr"
                     /EC_number="3.4.21.10"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; preproacrosin"
                     /codon_start=1
                     /product="acrosin isoform 1 precursor"
                     /protein_id="NP_038483.1"
                     /db_xref="CCDS:CCDS27755.1"
                     /db_xref="GeneID:11434"
                     /db_xref="MGI:MGI:87884"
                     /translation="MVEMLPTVAVLVLAVSVVAKDNTTCDGPCGLRFRQNSQAGTRIV
                     SGQSAQLGAWPWMVSLQIFTSHNSRRYHACGGSLLNSHWVLTAAHCFDNKKKVYDWRL
                     VFGAQEIEYGRNKPVKEPQQERYVQKIVIHEKYNVVTEGNDIALLKITPPVTCGNFIG
                     PCCLPHFKAGPPQIPHTCYVTGWGYIKEKAPRPSPVLMEARVDLIDLDLCNSTQWYNG
                     RVTSTNVCAGYPEGKIDTCQGDSGGPLMCRDNVDSPFVVVGITSWGVGCARAKRPGVY
                     TATWDYLDWIASKIGPNALHLIQPATPHPPTTRHPMVSFHPPSLRPPWYFQHLPSRPL
                     YLRPLRPLLHRPSSTQTSSSLMPLLSPPTPAQPASFTIATQHMRHRTTLSFARRLQRL
                     IEALKMRTYPMKHPSQYSGPRNYHYRFSTFEPLSNKPSEPFLHS"
     exon            94..300
                     /gene="Acr"
                     /inference="alignment:Splign:2.1.0"
     exon            301..584
                     /gene="Acr"
                     /inference="alignment:Splign:2.1.0"
     exon            585..730
                     /gene="Acr"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1486
                     /gene="Acr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1463..1468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acr"
                     /note="hexamer: AATAAA"
     polyA_site      1486
                     /gene="Acr"
                     /note="major polyA site"
ORIGIN      
        1 aggttagggc aggagtatgg tagagatgct gccaactgtc gctgtgctgg tcttggcagt
       61 gtccgtggtt gccaaggata acaccacgtg tgatggtccc tgtgggttac gattcaggca
      121 gaactcacaa gcaggtaccc ggattgtcag tgggcagagt gcgcagcttg gggcctggcc
      181 ctggatggtc agcttacaga tcttcacgtc ccataacagc cgcaggtacc acgcctgtgg
      241 aggcagcctc ctgaactccc actgggtgct cacagctgcc cactgcttcg ataacaaaaa
      301 aaaagtctat gactggagac tggttttcgg agcacaagaa atcgaatatg gaagaaacaa
      361 gccagtgaaa gagccccagc aggagagata tgtgcagaag attgtcatcc atgagaaata
      421 caacgtagtg acggagggaa atgacattgc gctcttgaag atcactcctc ctgttacatg
      481 tgggaacttc attggaccct gctgtctacc tcattttaag gcgggtcctc cccaaatacc
      541 ccacacctgc tacgtgactg ggtggggata cataaaagag aaggccccca ggccatcacc
      601 tgtcctgatg gaagcacgtg tggacctcat tgacctcgac ctgtgtaact caacccagtg
      661 gtacaatggg cgtgtcacat cgactaatgt gtgtgcaggg tatcctgaag gcaagattga
      721 cacctgccag ggggacagtg gtgggcctct catgtgcaga gacaacgtcg acagcccctt
      781 tgtggtcgtg gggatcacga gctggggggt aggctgtgcc cgtgctaagc gtcccggagt
      841 ctacacagcc acctgggact acctggactg gattgcttcc aagatcggcc ctaacgcctt
      901 gcacttgatt cagccagcca cccctcatcc gccgactacc cgccatccga tggtctcttt
      961 tcaccctcct tctcttcgcc ctccttggta tttccaacac ctgccttctc gaccgcttta
     1021 cctgcgacca ctacggcctc tgctccatcg gccgtcttcg acccaaacct cctcatcact
     1081 catgcccctc ctctcgcccc caaccccagc ccagcctgca tcctttacca ttgctacaca
     1141 acacatgagg caccgcacaa cgctgtcttt tgctcggcgt ctccagcgcc tcatagaggc
     1201 cctgaagatg agaacttacc ctatgaaaca tccctcccag tacagtggac caaggaacta
     1261 ccactaccgc ttctccacgt ttgagcccct ttccaacaaa cccagcgagc ccttcctcca
     1321 ttcctgagaa aagagagatg agtgaaataa agtatatatt tgtatataaa tatatatgta
     1381 cactcgagga catgaacttc tgttttcttc aactcaaccc aaatcttcct ccatcaaatt
     1441 tacatcctcc ctgctcagct ccaataaaat ggaattgctc aatata
//
