LOCUS       NM_001102404            1420 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus acid phosphatase 5, tartrate resistant (Acp5),
            transcript variant 2, mRNA.
ACCESSION   NM_001102404
VERSION     NM_001102404.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1420)
  AUTHORS   Rathod,B., Desai,S., Samvelyan,H.J., Bock,L., Wu,J., Ohlsson,C.,
            Palmquist,A., Alm,J.J., Newton,P.T., Andersson,G. and Windahl,S.H.
  TITLE     Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes bone
            length, regulates cortical and trabecular bone mass, and maintains
            growth plate architecture and width in a sex- and site-specific
            manner in mice
  JOURNAL   Bone 188, 117223 (2024)
   PUBMED   39111379
  REMARK    GeneRIF: Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes
            bone length, regulates cortical and trabecular bone mass, and
            maintains growth plate architecture and width in a sex- and
            site-specific manner in mice.
REFERENCE   2  (bases 1 to 1420)
  AUTHORS   Yang,S., Pei,L., Huang,Z., Zhong,Y., Li,J., Hong,Y., Long,H.,
            Chen,X., Zhou,C., Zheng,G., Zeng,C., Wu,H. and Wang,T.
  TITLE     Inhibition of tartrate-resistant acid phosphatase 5 can prevent
            cardiac fibrosis after myocardial infarction
  JOURNAL   Mol Med 30 (1), 89 (2024)
   PUBMED   38879488
  REMARK    GeneRIF: Inhibition of tartrate-resistant acid phosphatase 5 can
            prevent cardiac fibrosis after myocardial infarction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1420)
  AUTHORS   Veniaminova,N.A., Jia,Y.Y., Hartigan,A.M., Huyge,T.J., Tsai,S.Y.,
            Grachtchouk,M., Nakagawa,S., Dlugosz,A.A., Atwood,S.X. and
            Wong,S.Y.
  TITLE     Distinct mechanisms for sebaceous gland self-renewal and
            regeneration provide durability in response to injury
  JOURNAL   Cell Rep 42 (9), 113121 (2023)
   PUBMED   37715952
REFERENCE   4  (bases 1 to 1420)
  AUTHORS   Lai,Y., Guo,Y., Liao,C., Mao,C., Liu,J., Ren,C., Yang,W., Luo,L.
            and Chen,W.
  TITLE     Osteoclast differentiation and dynamic mRNA expression during mice
            embryonic palatal bone development
  JOURNAL   Sci Rep 13 (1), 15170 (2023)
   PUBMED   37704707
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1420)
  AUTHORS   Hariri,H., Kose,O., Bezdjian,A., Daniel,S.J. and St-Arnaud,R.
  TITLE     USP53 Regulates Bone Homeostasis by Controlling Rankl Expression in
            Osteoblasts and Bone Marrow Adipocytes
  JOURNAL   J Bone Miner Res 38 (4), 578-596 (2023)
   PUBMED   36726200
REFERENCE   6  (bases 1 to 1420)
  AUTHORS   Reddy,S.V., Kuzhandaivelu,N., Acosta,L.G. and Roodman,G.D.
  TITLE     Characterization of the 5'-flanking region of the human
            tartrate-resistant acid phosphatase (TRAP) gene
  JOURNAL   Bone 16 (5), 587-593 (1995)
   PUBMED   7654474
REFERENCE   7  (bases 1 to 1420)
  AUTHORS   Lacey,D.L., Erdmann,J.M. and Tan,H.L.
  TITLE     Interleukin 4 increases type 5 acid phosphatase mRNA expression in
            murine bone marrow macrophages
  JOURNAL   J Cell Biochem 54 (3), 365-371 (1994)
   PUBMED   8200916
REFERENCE   8  (bases 1 to 1420)
  AUTHORS   Reddy,S.V., Scarcez,T., Windle,J.J., Leach,R.J., Hundley,J.E.,
            Chirgwin,J.M., Chou,J.Y. and Roodman,G.D.
  TITLE     Cloning and characterization of the 5'-flanking region of the mouse
            tartrate-resistant acid phosphatase gene
  JOURNAL   J Bone Miner Res 8 (10), 1263-1270 (1993)
   PUBMED   8256664
REFERENCE   9  (bases 1 to 1420)
  AUTHORS   Cassady,A.I., King,A.G., Cross,N.C. and Hume,D.A.
  TITLE     Isolation and characterization of the genes encoding mouse and
            human type-5 acid phosphatase
  JOURNAL   Gene 130 (2), 201-207 (1993)
   PUBMED   8359686
REFERENCE   10 (bases 1 to 1420)
  AUTHORS   Grimes,R., Reddy,S.V., Leach,R.J., Scarcez,T., Roodman,G.D.,
            Sakaguchi,A.Y., Lalley,P.A. and Windle,J.J.
  TITLE     Assignment of the mouse tartrate-resistant acid phosphatase gene
            (Acp5) to chromosome 9
  JOURNAL   Genomics 15 (2), 421-422 (1993)
   PUBMED   8449511
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY084869.1, AK011915.1, AK010865.1 and BQ031772.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012911.1, BI415775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-360               BY084869.1         4-363
            361-711             AK011915.1         332-682
            712-1402            AK010865.1         681-1371
            1403-1420           BQ031772.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1420
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 8.38 cM"
     gene            1..1420
                     /gene="Acp5"
                     /gene_synonym="TRACP; TRAP"
                     /note="acid phosphatase 5, tartrate resistant"
                     /db_xref="GeneID:11433"
                     /db_xref="MGI:MGI:87883"
     exon            1..129
                     /gene="Acp5"
                     /gene_synonym="TRACP; TRAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1113
                     /gene="Acp5"
                     /gene_synonym="TRACP; TRAP"
                     /EC_number="3.1.3.2"
                     /note="tartrate-resistant acid phosphatase type 5; acid
                     phosphatase type V; TR-AP; trATPase; type 5 acid
                     phosphatase; tartrate-resistant acid ATPase"
                     /codon_start=1
                     /product="tartrate-resistant acid phosphatase type 5
                     precursor"
                     /protein_id="NP_001095874.1"
                     /db_xref="CCDS:CCDS22923.1"
                     /db_xref="GeneID:11433"
                     /db_xref="MGI:MGI:87883"
                     /translation="MDSWVVLLGLQIIWLPLLTHGTAPTPTLRFVAVGDWGGVPNAPF
                     HTAREMANAKEIARTVQTMGADFIMSLGDNFYFTGVHDASDKRFQETFEDVFSDRALR
                     NIPWYVLAGNHDHLGNVSAQIAYSKISKRWNFPSPYYRLRFKIPRTNITVAIFMLDTV
                     MLCGNSDDFASQQPKMPRDLGVARTQLSWLKKQLAAAKEDYVLVAGHYPIWSIAEHGP
                     TRCLVKNLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMDPSVRHQRKV
                     PNGYLRFHYGSEDSLGGFTHVEISPKEMTIIYVEASGKSLFKTSLPRRPRP"
     exon            130..396
                     /gene="Acp5"
                     /gene_synonym="TRACP; TRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            397..524
                     /gene="Acp5"
                     /gene_synonym="TRACP; TRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            525..870
                     /gene="Acp5"
                     /gene_synonym="TRACP; TRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1406
                     /gene="Acp5"
                     /gene_synonym="TRACP; TRAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1381..1386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acp5"
                     /gene_synonym="TRACP; TRAP"
                     /note="hexamer: AATAAA"
     polyA_site      1406
                     /gene="Acp5"
                     /gene_synonym="TRACP; TRAP"
                     /note="major polyA site"
ORIGIN      
        1 gggcaggcag ggagccgtgg gcgaaggctg gcccgcgccg cctcttccca actcgtgcag
       61 cccggagcga cccgccgcga atccgcagct cagttgggta gcacagcttg tcctggaccc
      121 accgccaaga tggattcatg ggtggtgctg ctgggcctac aaatcatatg gctcccactc
      181 ctgacccacg gtacagcccc cactcccacc ctgagatttg tggctgtggg cgactgggga
      241 ggggtcccca atgccccatt ccacacagcc cgggaaatgg ccaatgccaa agagatcgcc
      301 agaaccgtgc agacgatggg cgctgacttc atcatgtctc tgggggacaa tttctacttc
      361 actggagtgc acgatgccag cgacaagagg ttccaggaga cctttgagga cgtgttctct
      421 gaccgtgccc ttcgcaacat cccctggtat gtgctggctg gaaaccatga tcaccttggc
      481 aacgtctctg cacagattgc atactctaag atctccaagc gctggaactt ccccagccct
      541 tactaccgtt tgcgcttcaa aattccacgt acaaacataa ctgtggccat ctttatgctg
      601 gacacagtga tgctgtgtgg caactcagat gactttgcca gtcagcagcc caaaatgcct
      661 cgagacctgg gagtggcccg cactcagctg tcctggctca aaaagcagtt ggcagcagcc
      721 aaggaggact acgttttggt ggccggccac taccccatct ggtccatcgc cgagcacgga
      781 cccacgcgct gccttgtcaa gaacttgcga ccattgttag ccacatacgg ggtcactgcc
      841 tacctgtgtg gacatgacca caacctgcag tatcttcagg acgagaacgg tgtgggctat
      901 gtgctgagtg gggccggcaa cttcatggat ccctctgtgc gacatcaacg aaaggtcccc
      961 aacggctact tgcggtttca ctatggatct gaggactccc tgggcggctt cacacatgtg
     1021 gagataagcc ccaaagaaat gaccatcata tatgtggaag cctctggaaa atcactcttt
     1081 aagaccagcc tcccaaggag acccagaccc tgaacaccac gagagtcctg cttgtccgct
     1141 aacgggtgtg agggaggagg cgtctgcagg cgtggtgggt gggccctgtg aggacctcac
     1201 tcacggcagc ttctctgccc tggtactctg gcagagaggg aaggggaacc aaggggctta
     1261 cttacaggaa agaagtatgc ccacaccaac tgatcccaca gccaggctca ccccttttag
     1321 ggtagagctt tcttgggaac gggctttcct ttcagtcaag tcttactgtc actgctattc
     1381 aataaaacaa tgctttgtct ccagaaaaaa aaaaaaaaaa
//
