LOCUS       NM_207668               4488 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus acid phosphatase 3 (Acp3), transcript variant 1, mRNA.
ACCESSION   NM_207668
VERSION     NM_207668.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4488)
  AUTHORS   Rahimi-Balaei,M., Buchok,M., Vihko,P., Parkinson,F.E. and
            Marzban,H.
  TITLE     Loss of prostatic acid phosphatase and alpha-synuclein cause motor
            circuit degeneration without altering cerebellar patterning
  JOURNAL   PLoS One 14 (9), e0222234 (2019)
   PUBMED   31509576
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4488)
  AUTHORS   Kirschenbaum,A., Izadmehr,S., Yao,S., O'Connor-Chapman,K.L.,
            Huang,A., Gregoriades,E.M., Yakar,S. and Levine,A.C.
  TITLE     Prostatic Acid Phosphatase Alters the RANKL/OPG System and Induces
            Osteoblastic Prostate Cancer Bone Metastases
  JOURNAL   Endocrinology 157 (12), 4526-4533 (2016)
   PUBMED   27783536
  REMARK    GeneRIF: These findings demonstrate that PAP secreted by PCa cells
            in OB bone metastases increases osteoprotegerin and plays a
            critical role in the vicious cross talk between cancer and bone
            cells.
REFERENCE   3  (bases 1 to 4488)
  AUTHORS   Nishida,K., Kubota,T., Matsumoto,S., Kato,J., Watanabe,Y.,
            Yamamoto,A., Furui,M., Ohishi,A. and Nagasawa,K.
  TITLE     Expression of Prostatic Acid Phosphatase in Rat Circumvallate
            Papillae
  JOURNAL   PLoS One 11 (6), e0158401 (2016)
   PUBMED   27348306
  REMARK    GeneRIF: PAP-immunoreactivity was present in type I and one of type
            III taste cells of taste buds. Thus, it is suggested that PAP might
            be a responsible ectoenzyme for metabolism of extracellular
            nucleotides, being involved in the regulation of taste signaling in
            taste buds.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4488)
  AUTHORS   Wu,C.H., Ho,W.Y., Lee,Y.C., Lin,C.L. and Hsieh,Y.L.
  TITLE     EXPRESS: NGF-trkA signaling modulates the analgesic effects of
            prostatic acid phosphatase in resiniferatoxin-induced neuropathy
  JOURNAL   Mol Pain 12, 1744806916656846 (2016)
   PUBMED   27306411
  REMARK    GeneRIF: functional PAP(thorn) neurons are essential for the
            analgesic effect, which is mediated by NGF-trkA signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4488)
  AUTHORS   Wright,B.D., Loo,L., Street,S.E., Ma,A., Taylor-Blake,B.,
            Stashko,M.A., Jin,J., Janzen,W.P., Frye,S.V. and Zylka,M.J.
  TITLE     The lipid kinase PIP5K1C regulates pain signaling and sensitization
  JOURNAL   Neuron 82 (4), 836-847 (2014)
   PUBMED   24853942
REFERENCE   6  (bases 1 to 4488)
  AUTHORS   Sowa,N.A., Vadakkan,K.I. and Zylka,M.J.
  TITLE     Recombinant mouse PAP has pH-dependent ectonucleotidase activity
            and acts through A(1)-adenosine receptors to mediate
            antinociception
  JOURNAL   PLoS One 4 (1), e4248 (2009)
   PUBMED   19158948
  REMARK    GeneRIF: PAP has species-conserved antinociceptive effects and has
            pH-dependent ectonucleotidase activity
REFERENCE   7  (bases 1 to 4488)
  AUTHORS   Zylka,M.J., Sowa,N.A., Taylor-Blake,B., Twomey,M.A., Herrala,A.,
            Voikar,V. and Vihko,P.
  TITLE     Prostatic acid phosphatase is an ectonucleotidase and suppresses
            pain by generating adenosine
  JOURNAL   Neuron 60 (1), 111-122 (2008)
   PUBMED   18940592
REFERENCE   8  (bases 1 to 4488)
  AUTHORS   Kang,S., Pinault,M., Pfefferle,L.D. and Elimelech,M.
  TITLE     Single-walled carbon nanotubes exhibit strong antimicrobial
            activity
  JOURNAL   Langmuir 23 (17), 8670-8673 (2007)
   PUBMED   17658863
REFERENCE   9  (bases 1 to 4488)
  AUTHORS   Quintero,I.B., Araujo,C.L., Pulkka,A.E., Wirkkala,R.S.,
            Herrala,A.M., Eskelinen,E.L., Jokitalo,E., Hellstrom,P.A.,
            Tuominen,H.J., Hirvikoski,P.P. and Vihko,P.T.
  TITLE     Prostatic acid phosphatase is not a prostate specific target
  JOURNAL   Cancer Res 67 (14), 6549-6554 (2007)
   PUBMED   17638863
REFERENCE   10 (bases 1 to 4488)
  AUTHORS   Roiko,K., Janne,O.A. and Vihko,P.
  TITLE     Primary structure of rat secretory acid phosphatase and comparison
            to other acid phosphatases
  JOURNAL   Gene 89 (2), 223-229 (1990)
   PUBMED   2373368
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076383.1, AK029273.1 and AC127422.4.
            
            On Apr 18, 2006 this sequence version replaced NM_207668.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1, also known as
            TM-PAP). This isoform is a transmembrane protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076383.1, BC139826.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AK076383.1         8-76
            70-1198             AK029273.1         56-1184
            1199-1998           AK076383.1         1206-2005
            1999-4488           AC127422.4         78150-80639
FEATURES             Location/Qualifiers
     source          1..4488
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 56.61 cM"
     gene            1..4488
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /note="acid phosphatase 3"
                     /db_xref="GeneID:56318"
                     /db_xref="MGI:MGI:1928480"
     exon            1..180
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1317
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /EC_number="3.1.3.2"
                     /EC_number="3.1.3.48"
                     /EC_number="3.1.3.5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; lysosomal acid phosphatase; prostatic acid
                     phosphatase; TMPase; 5'-nucleotidase;
                     ecto-5'-nucleotidase; thiamine monophosphatase;
                     fluoride-resistant acid phosphatase; protein tyrosine
                     phosphatase ACP3; acid phosphatase, prostate"
                     /codon_start=1
                     /product="prostatic acid phosphatase isoform 1 precursor"
                     /protein_id="NP_997551.1"
                     /db_xref="CCDS:CCDS23460.1"
                     /db_xref="GeneID:56318"
                     /db_xref="MGI:MGI:1928480"
                     /translation="MRAVPLPLSRTASLSLGFLLLLSLCLDPGQAKELKFVTLVFRHG
                     DRGPIETFPTDPITESSWPQGFGQLTQWGMEQHYELGSYIRKRYGRFLNDTYKHDQIY
                     IRSTDVDRTLMSAMTNLAALFPPEGISIWNPRLLWQPIPVHTVSLSEDRLLYLPFRDC
                     PRFEELKSETLESEEFLKRLHPYKSFLDTLSSLSGFDDQDLFGIWSKVYDPLFCESVH
                     NFTLPSWATEDAMIKLKELSELSLLSLYGIHKQKEKSRLQGGVLVNEILKNMKLATQP
                     QKYKKLVMYSAHDTTVSGLQMALDVYNGVLPPYASCHMMELYHDKGGHFVEMYYRNET
                     QNEPYPLTLPGCTHSCPLEKFAELLDPVISQDWATECMATSSHQVLRVILATTFCLVT
                     GILVILLLVLIRHGPCWQRDVYRNI"
     exon            181..276
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /inference="alignment:Splign:2.1.0"
     exon            277..363
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /inference="alignment:Splign:2.1.0"
     exon            364..516
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /inference="alignment:Splign:2.1.0"
     exon            517..615
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /inference="alignment:Splign:2.1.0"
     exon            616..708
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /inference="alignment:Splign:2.1.0"
     exon            709..841
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /inference="alignment:Splign:2.1.0"
     exon            842..924
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1028
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1198
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..4488
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4387..4392
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /note="hexamer: AATAAA"
     polyA_site      4407
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /note="major polyA site"
     regulatory      4464..4469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
                     /note="hexamer: AATAAA"
     polyA_site      4486
                     /gene="Acp3"
                     /gene_synonym="5'-NT; A030005E02Rik; Acpp; FRAP; Lap; PAP;
                     Ppal"
ORIGIN      
        1 ctcccgaagg cttctgaagt gcagcacctc ctaaggctgc ccaaagcagc tctctccccg
       61 accatgcgag ccgttcctct gcccctgagc cggacagcaa gcctcagcct tggcttcttg
      121 ctcctgcttt ctctctgcct ggacccaggc caagccaagg agttgaagtt tgtgacattg
      181 gtgtttcggc atggagaccg aggtcccatc gagacctttc ctaccgaccc cattacagaa
      241 tcctcgtggc cacaaggatt tggccaactc acccagtggg gcatggaaca gcactacgaa
      301 cttggaagtt atataaggaa aagatacgga agattcttga acgacaccta taagcatgat
      361 cagatttata tccggagcac agatgtggac aggactttga tgagtgctat gacaaacctt
      421 gcagccctgt ttcctccaga ggggatcagc atctggaatc ctagactgct ctggcagccc
      481 atcccagtgc acaccgtgtc tctctctgag gatcggttgc tgtacctgcc tttcagagac
      541 tgccctcgtt ttgaagaact caagagtgag actttagaat ctgaggaatt cttgaagagg
      601 cttcatccat ataaaagctt cctggacacc ttgtcgtcgc tgtcgggatt cgatgaccag
      661 gatctttttg gaatctggag taaagtttat gaccctttat tctgcgagag tgttcacaat
      721 ttcaccttgc cctcctgggc caccgaggac gccatgatta agttgaaaga gctatcagaa
      781 ttatctctgc tatcacttta tggaattcac aagcagaaag agaaatctcg actccaaggg
      841 ggcgtcctgg tcaatgaaat cctcaagaat atgaagcttg caactcagcc acagaagtat
      901 aaaaagctgg tcatgtattc cgcacacgac actaccgtga gtggcctgca gatggcgcta
      961 gatgtttata atggagttct gcctccctac gcttcttgcc acatgatgga attgtaccat
     1021 gataaggggg ggcactttgt ggagatgtac tatcggaatg agacccagaa cgagccctac
     1081 ccactcacgc tgccaggctg cacccacagc tgccctctgg agaagtttgc ggagctactg
     1141 gacccggtga tctcccagga ctgggccacg gagtgtatgg ccacaagcag ccaccaagtg
     1201 ctgagggtta tccttgccac tacattttgc ctggtaaccg ggatcctggt gatacttctg
     1261 cttgtcctca tccgccatgg gccctgctgg cagagagatg tgtatcggaa catctgaaca
     1321 gacagctgac cttggggacg tctctcaatg aagcagcacc ggcaagaagc tcttctgcca
     1381 tgcaggctct gtcctgccca tgccctccct ttagaactta cctagagttg gtgtgagctc
     1441 actgccacgg gggagagtgc agagctggca ggtcagttat gtctccttac cattgagctg
     1501 ttcacagggc taagatagga ctcttgcaag ggatgcctct gctcttttac acagaggtcc
     1561 tgaaagaaga agccaaattc caacccacct tgtgactatg aagacgaaag ggagagaaag
     1621 tggggtcagg atttaggtta gaacgcacta ggtaactcgg aatgttagac tagaagatcc
     1681 acagaaaaat gactttagtt atgtaatatg cttaattctc attctctctc tctctctctc
     1741 tcgctcactc actcgcaagc aattcaaacc cagcacttca taactgacaa atttctgtgt
     1801 gtacatccaa cacacacata catatatccg tatgcagaat gtctttaggt gacgtgttcg
     1861 attctcagaa accatagcat cattcacttt aagcacagct ccggtcattt tctctcattt
     1921 tcgtacagag aaataactga aaaacccatg agatgagttc accttcctca cgcccctcac
     1981 taccttattt ttatgcagtg ggtagtacat tcactttaaa attacgatat cttatactta
     2041 agggctgttt gttgctacta tgaaatgatt tttgttttta cttatttatt ttttactgtc
     2101 gtgccagact tcaaaatccc tgggtctaac acaagctcgg agagtactct atttgaatta
     2161 tgcccttagt cctctctgac ttttatacgg tgccaacaca gaaagtaaag taccctgtgg
     2221 gggggggtga caacctgctg gcttaagtcg tatttcttat tctaaagtag aaaactctag
     2281 acaagaggaa tgcagaagtc acatccagat ttcattttct gtgaccagtt ttattctgct
     2341 tttactacag atgagtcagg gccccatcaa acccctccat gactggcacc acccatgaag
     2401 tcattaggaa aaaaggccaa aatgtacttt atagcatgac aaactgctct ggacacacaa
     2461 gcattccact ggtgataaat tcgatctcat tcttcagtgg gttgccctac ttccttgggg
     2521 ttgcttaaag atctcgaaat atacctgagt ccatgctcac tctccaccca catgtgctct
     2581 tctgcagaaa aacgtagaca ttcaagctcc caaggccaca ctcagaattc actttgcagt
     2641 gctgtctaga tgtgggatgc tgggaccttt gacctgctct ccacgcagat ccccagcgca
     2701 tccctcaagc cccggaagcc cttctgttaa atgccactcg ctcacatcta tagtctgtat
     2761 ttttaatacc attctcagtg agccaaggtc attgaaaaca aaactcggag cccccctctc
     2821 atatgtgtgt atttatgtag catgtgataa tgtgcacacg ggtgggtgct gtcttctcac
     2881 gcatgcgcag agaacaaagg attatgtcac gtgtcctgtt ctattacttt tcttaccttg
     2941 agagaagatc tctcactgaa cccaaagcta ctctgacatc cagcaagccc cagtgatcct
     3001 cctggcttgt ctccacagca ctggggttac agggacacaa gggccacact cagcatttta
     3061 cataggtgct tgggacttga actcaagtcc tcatgcttgg acaacaaggg ctcttaccca
     3121 cctacccatc tgctcaatcc ccagttccta ccattgcttc gattactata tggaaagctc
     3181 tcaggctcaa tatcgcagtg ccctttatct tctgttggta aatactataa gcagttttca
     3241 tacactgtgg cagaatccca agtgacagat gagctatagg aatcatgcaa agaacacaaa
     3301 ggaactgtgg ggtgtcccag aaaataagca acgtcaacaa cagggcatgt gaactcccga
     3361 tactgataac tacttggtag atgagacaga tgtgaccatt ccagttgtca tggtgatgtt
     3421 gcaagagcgt cactagagct gcgatcacct ctgttgtgat gtgtgctccg tgtcatttga
     3481 gaagcctttg tggagaattt ccatgaagca gtcattagcg tgttgatagt aattacacaa
     3541 aaacactagt gatgcctata caggaaagca ctgagagagc gagcgctcga gtgctaggtt
     3601 gttccgagct ttagtggcaa agcacagaca gagaattgga gaacttgtga aaaaaaaaat
     3661 cccactgctt aaggaatggc gtacatgagg ctccgactgg cattcactgg gcagcttttt
     3721 acacaaaagc tgatattctc ttccctgaat tcacttgtgt ttcctgtctt cctgtccttt
     3781 ttctgtcttg ttctaatact cttagcactg attcctcaca gtcatggggg cttctgggta
     3841 aataaaagcc aaattataac ggctttctct tttaaaaccc tctccaagaa actatccaaa
     3901 caatcgtgaa atgttggcac cctagatagg gctaagagac acatatggtc acactcatgg
     3961 tcttaaatgg cctacagcca cgtttgtaat ggaaaacttt tttaggtgag atgaattata
     4021 atataaaaat ttatttaaca taatgcatgt aaaataacat ttcaacaaaa agtgttcatg
     4081 gaatattttt aagatgagtt tcatactaag tatttaaaaa tgtgatgtga tgttttgttc
     4141 caagttggag tagccacctt tgaggacttg ggagtcacta gtggctccca tgctgaatag
     4201 ttctggccta ggccattcga tgacagcctt ttttttaaag cagagagaac acatacatcc
     4261 tttatttgta aaatacactt tgggttattg tgaagaaata gacatcatcc ttaggactgg
     4321 aatgtagctc accaacaaag tgcttgccta gcataggtga gccctgagtt ccatccccag
     4381 taccacaata aagtcaagta aaacaaacac aacaggtcac ctttatcctg tgtcttcact
     4441 gttttttaat ctttggccaa actaataaaa tattgtctga aatgtttc
//
