LOCUS       NM_021330               3107 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus acid phosphatase 1, soluble (Acp1), transcript variant
            2, mRNA.
ACCESSION   NM_021330
VERSION     NM_021330.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3107)
  AUTHORS   Jensen-Cody,S., Coyne,E.S., Ding,X., Sebin,A., Vogel,J.,
            Goldstein,J., Rosahl,T.W., Zhou,H.H., Jacobs,H., Champy,M.F.,
            About,G.B., Talukdar,S. and Zhou,Y.
  TITLE     Loss of low-molecular-weight protein tyrosine phosphatase shows
            limited improvement in glucose tolerance but causes mild cardiac
            hypertrophy in mice
  JOURNAL   Am J Physiol Endocrinol Metab 322 (6), E517-E527 (2022)
   PUBMED   35403438
REFERENCE   2  (bases 1 to 3107)
  AUTHORS   Stanford,S.M., Collins,M., Diaz,M.A., Holmes,Z.J., Gries,P.,
            Bliss,M.R., Lodi,A., Zhang,V., Tiziani,S. and Bottini,N.
  TITLE     The low molecular weight protein tyrosine phosphatase promotes
            adipogenesis and subcutaneous adipocyte hypertrophy
  JOURNAL   J Cell Physiol 236 (9), 6630-6642 (2021)
   PUBMED   33615467
  REMARK    GeneRIF: The low molecular weight protein tyrosine phosphatase
            promotes adipogenesis and subcutaneous adipocyte hypertrophy.
REFERENCE   3  (bases 1 to 3107)
  AUTHORS   Stanford,S.M., Aleshin,A.E., Zhang,V., Ardecky,R.J., Hedrick,M.P.,
            Zou,J., Ganji,S.R., Bliss,M.R., Yamamoto,F., Bobkov,A.A.,
            Kiselar,J., Liu,Y., Cadwell,G.W., Khare,S., Yu,J., Barquilla,A.,
            Chung,T.D.Y., Mustelin,T., Schenk,S., Bankston,L.A.,
            Liddington,R.C., Pinkerton,A.B. and Bottini,N.
  TITLE     Diabetes reversal by inhibition of the low-molecular-weight
            tyrosine phosphatase
  JOURNAL   Nat Chem Biol 13 (6), 624-632 (2017)
   PUBMED   28346406
REFERENCE   4  (bases 1 to 3107)
  AUTHORS   Wade,F., Quijada,P., Al-Haffar,K.M., Awad,S.M., Kunhi,M., Toko,H.,
            Marashly,Q., Belhaj,K., Zahid,I., Al-Mohanna,F., Stanford,S.M.,
            Alvarez,R., Liu,Y., Colak,D., Jordan,M.C., Roos,K.P., Assiri,A.,
            Al-Habeeb,W., Sussman,M., Bottini,N. and Poizat,C.
  TITLE     Deletion of low molecular weight protein tyrosine phosphatase
            (Acp1) protects against stress-induced cardiomyopathy
  JOURNAL   J Pathol 237 (4), 482-494 (2015)
   PUBMED   26213100
  REMARK    GeneRIF: Our data show that ablation of Lmptp inhibits pathological
            cardiac remodelling
REFERENCE   5  (bases 1 to 3107)
  AUTHORS   Fernandes,G.V., Cavagis,A.D., Ferreira,C.V., Olej,B., Leao Mde,S.,
            Yano,C.L., Peppelenbosch,M., Granjeiro,J.M. and Zambuzzi,W.F.
  TITLE     Osteoblast adhesion dynamics: a possible role for ROS and LMW-PTP
  JOURNAL   J Cell Biochem 115 (6), 1063-1069 (2014)
   PUBMED   24123071
  REMARK    GeneRIF: Data indicate there was no significant change in low
            molecular weight protein tyrosine phosphatase (LMW-PTP) expression
            at 30 min or 2 h.
REFERENCE   6  (bases 1 to 3107)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   7  (bases 1 to 3107)
  AUTHORS   O'Brien,S.J. and Nash,W.G.
  TITLE     Genetic mapping in mammals: chromosome map of domestic cat
  JOURNAL   Science 216 (4543), 257-265 (1982)
   PUBMED   7063884
REFERENCE   8  (bases 1 to 3107)
  AUTHORS   Stallings,R.L. and Siciliano,M.J.
  TITLE     Confirmational, provisional, and/or regional assignment of 15
            enzyme loci onto Chinese hamster autosomes 1, 2, and 7
  JOURNAL   Somatic Cell Genet 7 (6), 683-698 (1981)
   PUBMED   7323947
REFERENCE   9  (bases 1 to 3107)
  AUTHORS   Schafer,R., Doehmer,J., Rademacher,I. and Willecke,K.
  TITLE     Assignment of the gene for cytoplasmic glutamate-oxaloacetate
            transaminase to mouse chromosome 19 using chinese hamster x mouse
            somatic cell hybrids
  JOURNAL   Somatic Cell Genet 6 (6), 709-717 (1980)
   PUBMED   7444718
REFERENCE   10 (bases 1 to 3107)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160932.3 and AK082955.1.
            
            On Nov 2, 2007 this sequence version replaced NM_021330.3.
            
            Transcript Variant: This variant (2) includes an alternate in-frame
            exon, compared to variant 1. The resulting protein (isoform 2, also
            known as IF1) is the same length as isoform 1 but differs at an
            internal region, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082955.1, BC111893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC160932.3         56629-56684
            57-2477             AK082955.1         2-2422
            2478-3107           AK082955.1         2425-3054
FEATURES             Location/Qualifiers
     source          1..3107
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.0 cM"
     gene            1..3107
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /note="acid phosphatase 1, soluble"
                     /db_xref="GeneID:11431"
                     /db_xref="MGI:MGI:87881"
     exon            1..123
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..557
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /EC_number="3.1.3.2"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 is encoded by transcript variant 2;
                     LMW-PTPase; low molecular weight cytosolic acid
                     phosphatase; low molecular weight phosphotyrosine protein
                     phosphatase"
                     /codon_start=1
                     /product="low molecular weight phosphotyrosine protein
                     phosphatase isoform 2"
                     /protein_id="NP_067305.2"
                     /db_xref="CCDS:CCDS36427.1"
                     /db_xref="GeneID:11431"
                     /db_xref="MGI:MGI:87881"
                     /translation="MAEVGSKSVLFVCLGNICRSPIAEAVFRKLVTDEKVSDNWRIDS
                     AATSTYEVGNPPDYRGQNCMRKHGIHMQHIARQITKEDFATFDYILCMDESNLRDLNR
                     KSNQVKNCKAKIELLGSYDPQKQLIIEDPYYGNDSDFEVVYQQCLRCCKAFLEKTY"
     exon            124..197
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            198..311
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            312..373
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            374..479
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /inference="alignment:Splign:2.1.0"
     exon            480..3107
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1499..1504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /note="hexamer: AACAAG"
     polyA_site      1517
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /note="major polyA site"
     regulatory      2322..2327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /note="hexamer: ATTAAA"
     polyA_site      2340
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /note="major polyA site"
     regulatory      2750..2755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /note="hexamer: ATTAAA"
     polyA_site      2778
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
     regulatory      2838..2843
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /note="hexamer: AATACA"
     polyA_site      2860
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
     regulatory      2904..2909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /note="hexamer: AAGAAA"
     polyA_site      2932
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
     regulatory      3071..3076
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /note="hexamer: AATAAA"
     polyA_site      3103
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
ORIGIN      
        1 atgtccacgg tcagaaccct ggcagtgcgc atgcgcctcg tcccgacgcg gtttctgggc
       61 gccagggtct gcaccgaaac atggcagagg ttgggtccaa gtcagtgctg ttcgtgtgtc
      121 tcggtaacat ttgccggtca cccattgcag aagcagtatt caggaaactg gtaactgatg
      181 aaaaggtttc agataattgg aggatagaca gtgcggctac atccacctat gaagtgggga
      241 accctcctga ctatcgaggg cagaactgca tgagaaaaca tggcatccac atgcagcaca
      301 ttgcacggca gattacaaaa gaagactttg ccacattcga ttatatacta tgtatggatg
      361 aaagcaatct gagagatctc aatagaaaaa gtaatcaagt taaaaactgc aaagctaaaa
      421 ttgagctact tgggagctat gatccacaga aacagctcat cattgaagat ccctattatg
      481 gcaatgactc tgacttcgag gtggtgtacc agcaatgcct taggtgctgc aaggccttcc
      541 tggagaagac ttactagctg gtcctaagcc ccaccattga gcagctcact catcagtgct
      601 gtgcccaagg gtggtggcag tccttagccc cataccccac ctctcttttc agctgactta
      661 ctgtatatct ttaaaataat tgtaggtggg aattaggcat atgttcagaa ggataaaagc
      721 atttgagtca gacagtttga ggtgtggcta agcattctta gactaactaa acctctgacc
      781 ttgcggtgat tacaaaacag tggaacaagc aaatatggaa caaaagaaaa caaaaacaaa
      841 aacaaaaacc cagaaagtaa gagtgaccta gaaggtccat atcagcctct gagctcggca
      901 agcctgggtc gtctggtcta agtggagtgt gtgcatgacc cgcacccagt gtgccgtttg
      961 cttgccgtgt actctcttct ctaggctctc gttgtgacaa tagctccatt cacggcagcc
     1021 ttccagttaa cactggcagt ttaagctcag acacactgag ggtgttgagg gatttgagag
     1081 aggagacgct ggatgtgctg atgggcctgg gactccagca ggccgtcctg ggctggacag
     1141 tgacaccctg tctaaaaggg gaacaaaaat aacaacggat gggagcagca gatggataaa
     1201 gttaccatct tcagtcttac ttggtttttg tctactttcc tgagctttgt tcttgtttga
     1261 gccactttgc tttaaaaaaa aagtaagtgt gcttaaatac tggtatgtgt ttgtaagtgt
     1321 tctctcatgg gcaatttaca aagttatagg caagcaagag taatttttgt gtattttcag
     1381 aaaagagacc tcaaatttat atgaatgtat gtcagaaagg aacatgaatt caactgggaa
     1441 gttatcaaat acaactgaga tacaaatcca gtgtctgcct gcttcttact gacaagtgaa
     1501 caagatacct aaatgttgcc tccatgtgcc tttttatttg cttgagtgtg aagtttgggc
     1561 tctcagcctc tgtgttagaa agtaaagtga tgagatggat acacacaatg ctgtgttgga
     1621 tggcgatggg tgtctaattg agagactcca ggcactatcc ttatccttgg gccttcttca
     1681 tgtagctggt gctccctacc cgcttcccag ctgaaaaggt ggtaactgtc tgtcttagcc
     1741 tgtcttagct caggtcacta ctggtgagct ccagtcacgc agaacttgta gttagaagag
     1801 ccatcctgac gtctgaaagg aaggaagccc aggggcctag gaatatgcag tctcttcttg
     1861 gccagggctc ctctctcgaa ggaggaaagc ttacacctga ctcttccaga agaaagcagc
     1921 tatcccagca ccctctcaca gaaaggccat gatgtcccag caaaggcaga cacttcagct
     1981 gcctttttgg gctcctgtgg ggttttggtc agagtcttca caaaattaaa accgaggaag
     2041 ggagaggaca ggtagtcagc cacaaggagg aaatggatta agtcaaagct ctccacccta
     2101 cttcagtgct tgcttcagaa tctcagattt ctctttcagg tcataagatc ctattgtttt
     2161 cttgaaattt tacctgtgta tcttacacgc agatccttgg aatgtcaggt tctgctttgt
     2221 tctacggctg tctcaaacag cacagtgtgt ttataagggc tcatgaacag agaaattaac
     2281 tttttacatt caatcaaatt acatttgttt aaaatacagc cattaaattt taaaactgtt
     2341 ctcagggtgc ttcttggttt gacattctct tacaatcagg tagagatggt agatgtggag
     2401 tattgatggc taaatgagac caagcgatca ggagtttatg ttattcagta cttagtcaca
     2461 tctacacaca cacacacgca cacgtgtata tatatagtga acaatgtgta tgtatgttta
     2521 tatatacata tattctgagc cttgacattg ttatttaaga gtcattctga agactgttca
     2581 ttattccaaa cacttcattt atttccttgt atttattcac agtatttaca tattgtacaa
     2641 tacctggaat gtacttttac atttacagag gacaagtggg actggccttg gcatagccac
     2701 agatacatat gccactgttt tcaacacaac tgaggttttt ttggttttca ttaaaatttt
     2761 tcatgcagtt ccaaactata ctttgggatt ttaattgtag aatacaaaat gtcaaatcat
     2821 actatatgct ctatgaaaat acagtttaat gttctgccta tgtttctaaa gaaatattcc
     2881 ttgtggttcc acctaatctt aaaaagaaaa tacctcattt tacagaacaa tacatcaaat
     2941 gtggaatgtt gtctgttttt acaatcataa gagtggcaaa tctcactgac agatacactg
     3001 attcactgaa tgcatatttg taaactgtca gcaacataga aaatgcaaag gaattatgga
     3061 agagtgcaaa aataaatctc tgtccacagg aagtgggcat gaagatg
//
