LOCUS       NP_067305                158 aa            linear   ROD 28-APR-2025
DEFINITION  low molecular weight phosphotyrosine protein phosphatase isoform 2
            [Mus musculus].
ACCESSION   NP_067305
VERSION     NP_067305.2
DBSOURCE    REFSEQ: accession NM_021330.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 158)
  AUTHORS   Jensen-Cody,S., Coyne,E.S., Ding,X., Sebin,A., Vogel,J.,
            Goldstein,J., Rosahl,T.W., Zhou,H.H., Jacobs,H., Champy,M.F.,
            About,G.B., Talukdar,S. and Zhou,Y.
  TITLE     Loss of low-molecular-weight protein tyrosine phosphatase shows
            limited improvement in glucose tolerance but causes mild cardiac
            hypertrophy in mice
  JOURNAL   Am J Physiol Endocrinol Metab 322 (6), E517-E527 (2022)
   PUBMED   35403438
REFERENCE   2  (residues 1 to 158)
  AUTHORS   Stanford,S.M., Collins,M., Diaz,M.A., Holmes,Z.J., Gries,P.,
            Bliss,M.R., Lodi,A., Zhang,V., Tiziani,S. and Bottini,N.
  TITLE     The low molecular weight protein tyrosine phosphatase promotes
            adipogenesis and subcutaneous adipocyte hypertrophy
  JOURNAL   J Cell Physiol 236 (9), 6630-6642 (2021)
   PUBMED   33615467
  REMARK    GeneRIF: The low molecular weight protein tyrosine phosphatase
            promotes adipogenesis and subcutaneous adipocyte hypertrophy.
REFERENCE   3  (residues 1 to 158)
  AUTHORS   Stanford,S.M., Aleshin,A.E., Zhang,V., Ardecky,R.J., Hedrick,M.P.,
            Zou,J., Ganji,S.R., Bliss,M.R., Yamamoto,F., Bobkov,A.A.,
            Kiselar,J., Liu,Y., Cadwell,G.W., Khare,S., Yu,J., Barquilla,A.,
            Chung,T.D.Y., Mustelin,T., Schenk,S., Bankston,L.A.,
            Liddington,R.C., Pinkerton,A.B. and Bottini,N.
  TITLE     Diabetes reversal by inhibition of the low-molecular-weight
            tyrosine phosphatase
  JOURNAL   Nat Chem Biol 13 (6), 624-632 (2017)
   PUBMED   28346406
REFERENCE   4  (residues 1 to 158)
  AUTHORS   Wade,F., Quijada,P., Al-Haffar,K.M., Awad,S.M., Kunhi,M., Toko,H.,
            Marashly,Q., Belhaj,K., Zahid,I., Al-Mohanna,F., Stanford,S.M.,
            Alvarez,R., Liu,Y., Colak,D., Jordan,M.C., Roos,K.P., Assiri,A.,
            Al-Habeeb,W., Sussman,M., Bottini,N. and Poizat,C.
  TITLE     Deletion of low molecular weight protein tyrosine phosphatase
            (Acp1) protects against stress-induced cardiomyopathy
  JOURNAL   J Pathol 237 (4), 482-494 (2015)
   PUBMED   26213100
  REMARK    GeneRIF: Our data show that ablation of Lmptp inhibits pathological
            cardiac remodelling
REFERENCE   5  (residues 1 to 158)
  AUTHORS   Fernandes,G.V., Cavagis,A.D., Ferreira,C.V., Olej,B., Leao Mde,S.,
            Yano,C.L., Peppelenbosch,M., Granjeiro,J.M. and Zambuzzi,W.F.
  TITLE     Osteoblast adhesion dynamics: a possible role for ROS and LMW-PTP
  JOURNAL   J Cell Biochem 115 (6), 1063-1069 (2014)
   PUBMED   24123071
  REMARK    GeneRIF: Data indicate there was no significant change in low
            molecular weight protein tyrosine phosphatase (LMW-PTP) expression
            at 30 min or 2 h.
REFERENCE   6  (residues 1 to 158)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   7  (residues 1 to 158)
  AUTHORS   O'Brien,S.J. and Nash,W.G.
  TITLE     Genetic mapping in mammals: chromosome map of domestic cat
  JOURNAL   Science 216 (4543), 257-265 (1982)
   PUBMED   7063884
REFERENCE   8  (residues 1 to 158)
  AUTHORS   Stallings,R.L. and Siciliano,M.J.
  TITLE     Confirmational, provisional, and/or regional assignment of 15
            enzyme loci onto Chinese hamster autosomes 1, 2, and 7
  JOURNAL   Somatic Cell Genet 7 (6), 683-698 (1981)
   PUBMED   7323947
REFERENCE   9  (residues 1 to 158)
  AUTHORS   Schafer,R., Doehmer,J., Rademacher,I. and Willecke,K.
  TITLE     Assignment of the gene for cytoplasmic glutamate-oxaloacetate
            transaminase to mouse chromosome 19 using chinese hamster x mouse
            somatic cell hybrids
  JOURNAL   Somatic Cell Genet 6 (6), 709-717 (1980)
   PUBMED   7444718
REFERENCE   10 (residues 1 to 158)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160932.3 and AK082955.1.
            
            On Jun 9, 2003 this sequence version replaced NP_067305.1.
            
            Transcript Variant: This variant (2) includes an alternate in-frame
            exon, compared to variant 1. The resulting protein (isoform 2, also
            known as IF1) is the same length as isoform 1 but differs at an
            internal region, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082955.1, BC111893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..158
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 13.0 cM"
     Protein         1..158
                     /product="low molecular weight phosphotyrosine protein
                     phosphatase isoform 2"
                     /EC_number="3.1.3.2"
                     /EC_number="3.1.3.48"
                     /note="LMW-PTPase; low molecular weight cytosolic acid
                     phosphatase; low molecular weight phosphotyrosine protein
                     phosphatase"
                     /calculated_mol_wt=18061
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P11064; propagated from
                     UniProtKB/Swiss-Prot (Q9D358.3)"
     Region          7..155
                     /region_name="LMWPTP"
                     /note="Low molecular weight protein tyrosine phosphatase;
                     cd16343"
                     /db_xref="CDD:319971"
     Site            order(13..20,51,130,132)
                     /site_type="active"
                     /db_xref="CDD:319971"
     Site            132
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P24666; propagated from
                     UniProtKB/Swiss-Prot (Q9D358.3)"
     Site            133
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P24666; propagated from
                     UniProtKB/Swiss-Prot (Q9D358.3)"
     CDS             1..158
                     /gene="Acp1"
                     /gene_synonym="4632432E04Rik; Acp-1; Lmptp; LMW-PTP"
                     /coded_by="NM_021330.4:81..557"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS36427.1"
                     /db_xref="GeneID:11431"
                     /db_xref="MGI:MGI:87881"
ORIGIN      
        1 maevgsksvl fvclgnicrs piaeavfrkl vtdekvsdnw ridsaatsty evgnppdyrg
       61 qncmrkhgih mqhiarqitk edfatfdyil cmdesnlrdl nrksnqvknc kakiellgsy
      121 dpqkqliied pyygndsdfe vvyqqclrcc kaflekty
//
