LOCUS       NM_053115               2573 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus acyl-Coenzyme A oxidase 2, branched chain (Acox2),
            transcript variant 1, mRNA.
ACCESSION   NM_053115
VERSION     NM_053115.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2573)
  AUTHORS   Zhang,Y., Chen,Y., Zhang,Z., Tao,X., Xu,S., Zhang,X.,
            Zurashvili,T., Lu,Z., Bayascas,J.R., Jin,L., Zhao,J. and Zhou,X.
  TITLE     Acox2 is a regulator of lysine crotonylation that mediates hepatic
            metabolic homeostasis in mice
  JOURNAL   Cell Death Dis 13 (3), 279 (2022)
   PUBMED   35351852
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2573)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   3  (bases 1 to 2573)
  AUTHORS   Yubero,P., Hondares,E., Carmona,M.C., Rossell,M., Gonzalez,F.J.,
            Iglesias,R., Giralt,M. and Villarroya,F.
  TITLE     The developmental regulation of peroxisome proliferator-activated
            receptor-gamma coactivator-1alpha expression in the liver is
            partially dissociated from the control of gluconeogenesis and lipid
            catabolism
  JOURNAL   Endocrinology 145 (9), 4268-4277 (2004)
   PUBMED   15178647
REFERENCE   4  (bases 1 to 2573)
  AUTHORS   Huyghe,S., Casteels,M., Janssen,A., Meulders,L., Mannaerts,G.P.,
            Declercq,P.E., Van Veldhoven,P.P. and Baes,M.
  TITLE     Prenatal and postnatal development of peroxisomal
            lipid-metabolizing pathways in the mouse
  JOURNAL   Biochem J 353 (Pt 3), 673-680 (2001)
   PUBMED   11171065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025547.17.
            
            On Jun 11, 2009 this sequence version replaced NM_053115.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ238492.1, AK144243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               CT025547.17        45321-45518         c
            199-432             CT025547.17        43201-43434         c
            433-595             CT025547.17        42494-42656         c
            596-747             CT025547.17        42154-42305         c
            748-855             CT025547.17        41693-41800         c
            856-975             CT025547.17        39942-40061         c
            976-1091            CT025547.17        39382-39497         c
            1092-1264           CT025547.17        38003-38175         c
            1265-1427           CT025547.17        36403-36565         c
            1428-1618           CT025547.17        34434-34624         c
            1619-1798           CT025547.17        32763-32942         c
            1799-1904           CT025547.17        30222-30327         c
            1905-2122           CT025547.17        27760-27977         c
            2123-2255           CT025547.17        16658-16790         c
            2256-2573           CT025547.17        12010-12327         c
FEATURES             Location/Qualifiers
     source          1..2573
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 4.77 cM"
     gene            1..2573
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /note="acyl-Coenzyme A oxidase 2, branched chain"
                     /db_xref="GeneID:93732"
                     /db_xref="MGI:MGI:1934852"
     exon            1..198
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            199..432
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..2318
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /EC_number="1.17.99.3"
                     /note="branched chain acyl-CoA oxidase;
                     trihydroxycoprostanoyl-CoA oxidase;
                     3-alpha,7-alpha,
                     12-alpha-trihydroxy-5-beta-cholestanoyl-CoA
                     24-hydroxylase; THCA-CoA oxidase;
                     3-alpha,7-alpha,
                     12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase"
                     /codon_start=1
                     /product="peroxisomal acyl-coenzyme A oxidase 2"
                     /protein_id="NP_444345.2"
                     /db_xref="CCDS:CCDS36801.1"
                     /db_xref="GeneID:93732"
                     /db_xref="MGI:MGI:1934852"
                     /translation="MGNPGDRVSLGETWSREVHPDIDSERHSPSFSVERLTNILDGGI
                     PNTELRRRVESLIQRDPVFNLKHLYFMTRDELYEDAVQKRFHLEKLAWSLGWSEDGPE
                     RIYADRVLAGYNNLNLHGIAMNAIRSLGSDEQIAKWGQLGKNFQIITTYAQTELGHGT
                     YLQGLETEATYDATTQEFVIHSPTMTSIKWWPGDLGRTVTHAVVLAHLICLGARHGMH
                     AFIVPIRSLEDHTPLPGITVGDIGPKMGFENIDNGFLRLNHVRVPRENMLSRFAEVLP
                     DGTYQRLGTPQSNYLGMLVTRVQLLYKGFLPTLQKACTIAVRYAVIRHQSRLRPSDPE
                     AKILEYQTQQQKLLPQLAVSYALHFMTTSLLQFFHSSYSDILKRDFSLLPELHALSTG
                     MKAMSSDFCAQGTEICRRACGGHGYSKLSGLPTLVTQAIASCTYEGENTVLYLQVARF
                     LMKSYLQAQVSPGSIPQKPLPQSVMYLATPRPARCPAQTAADFRCPEVYTTAWAYVSA
                     RLIRDATQHTQTLMRSGVDQYDAWNQTSVIHLQAAKAHCYFLTVRNFKEAVEKLDNEP
                     EIQRVLQNLCDLYALNGILTNSGDFLHDGFLSGAQVDMARTAFLDLLPLIRKDAILLT
                     DAFDFSDHCLNSALGCYDGHVYQRLFEWAQKSPANTQENPAYKKYIRPLMQSWKPKL"
     exon            433..595
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            596..747
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            748..855
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            856..975
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1091
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1264
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1427
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1618
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1619..1798
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1904
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2122
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2255
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2573
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2554..2559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /note="hexamer: AATAAA"
     polyA_site      2573
                     /gene="Acox2"
                     /gene_synonym="THCCox"
                     /note="major polyA site"
ORIGIN      
        1 agagttgcct ggcacctgat acaatataca ccctttgccc aacgacactg gcaggaaaca
       61 gcagggcctc atgcaatact ctggcagagt ctgtaaatac cagcactttg aggaggagaa
      121 aggagtgtgg acaagagtct gaagattggg cctataggga agagccagcc cagcctacag
      181 cgctgtccca ggacagaggt tcttggtacc tcccggtgct cagagcagac cctaaaggaa
      241 gccaagtcct tcctgagaca ggcagatcca ggatggggaa cccaggggat cgagtgtcac
      301 tgggggagac ctggagcagg gaagtgcacc ctgacataga cagtgaaagg cactccccgt
      361 ccttcagtgt ggagcggctc accaacatcc ttgatggagg catcccaaac actgagctgc
      421 ggagaagagt tgaaagcctc atccaacgtg acccagtgtt taatttgaag catctttact
      481 tcatgacccg agatgagcta tatgaggatg cagttcaaaa gagattccat cttgagaagc
      541 tagcctggag cctgggctgg tcagaagacg gtcctgaacg catttatgct gacagagtcc
      601 ttgctggata taacaactta aacttacatg gtattgccat gaatgctatc agaagcctgg
      661 gctcagatga gcagattgct aaatggggcc aactcggcaa aaacttccaa atcatcacaa
      721 catatgccca gacagagctg ggacatggga catacctgca gggcctggag accgaagcaa
      781 cctatgatgc aaccacccag gagtttgtga tacacagccc tacaatgact tccatcaagt
      841 ggtggcctgg ggacttggga cggacagtca cccatgctgt ggtcctagcc catttgatct
      901 gcttaggagc ccggcatggc atgcatgcct tcattgtgcc catccggagc ctagaggacc
      961 acaccccact gccaggaata acagttgggg acataggccc caagatgggc ttcgaaaaca
     1021 tagacaatgg cttcctgcga ctgaaccacg tgagggttcc cagagagaac atgctcagtc
     1081 gctttgcaga ggtcttgcca gatggcacct accagaggct tgggacacca cagagcaatt
     1141 atcttggcat gttggtgaca cgggtgcagc tgctgtataa aggattccta cccaccctcc
     1201 agaaggcttg caccattgct gtgcgctacg cagtaatccg ccaccagtct cgtcttcggc
     1261 ctagtgaccc agaggcaaaa atcctggaat accagacaca gcagcagaaa ctcctgcctc
     1321 agcttgctgt gagctatgcc ttgcatttca tgaccaccag cctcttacaa ttcttccaca
     1381 gctcctacag tgatattctg aagagagact tcagcctcct gcctgagctc catgcactga
     1441 gcactggcat gaaggccatg tcttcagact tctgtgccca gggaacagag atctgccgca
     1501 gggcctgcgg gggtcatggc tactcaaagc tgagcggcct accgacactg gtcactcaag
     1561 cgatagcctc ttgcacgtat gagggtgaga atacggtgct ctacctgcaa gtggccaggt
     1621 ttctgatgaa gagctacctg caggctcaag tgtccccagg atccatacca cagaagcctc
     1681 tccctcagtc cgtcatgtat ctcgccacac caagaccagc caggtgccca gcccagacag
     1741 cagctgactt ccgctgccca gaagtctata ccacagcctg ggcatatgtg tctgccaggc
     1801 tcataagaga tgcaacacag catacacaga ccctcatgag atccggggtt gaccagtacg
     1861 atgcttggaa ccagacttct gtcatacacc ttcaggctgc taaggctcac tgctacttcc
     1921 tcactgtgag gaatttcaag gaagctgtgg agaaactaga caacgaacca gagattcagc
     1981 gtgtgcttca gaacctctgt gacctctatg ccttaaacgg tattctgact aactcagggg
     2041 actttctgca tgatggcttc ctgtctgggg cccaagtgga catggcaaga acagccttcc
     2101 tagacctgct tcccttgatc cggaaggacg ccatcttgtt aacagatgct tttgacttct
     2161 cggaccattg tttaaactct gcacttggct gttatgacgg acacgtctac caacgcctgt
     2221 ttgagtgggc tcagaagtcc ccagccaata ctcaggagaa ccctgcctat aagaagtata
     2281 ttagaccact gatgcaaagc tggaaaccca agctgtgaaa agccaaagga ttcaggacca
     2341 agcagcacca tggccttcct atggcacata tgcatataaa gaatttaaag cacggggtgg
     2401 cgtgcggctt gttcagatca gcgagtaaac tggtacatga aaggatgttc atcatattat
     2461 tctgctactg agtacatctg aaactttccc ttgtctgttt gtagtacgta tttggctaaa
     2521 tgctagaatt ttgctttaaa tacagcaaaa gctaataaac ttgttagtaa cta
//
